Lettere di illustri letterati scritte alla celebre poetessa Paolina Grismondi, nata contessa Secco-Suardo, fra le arcadi Lesbia Cidonia.

Letters in French or Italian.

In morte della contessa Sofia Serristori avvenuta in Pisa il XXI marzo; ode ...

Mode of access: Internet.

Trattato di Domenico di Guido Mellini dell' origine, fatti, costumi, e lodi di Matelda, la gran contessa d'Italia : diuiso in due parti.

Includes index.

Magnetic susceptibility dataset from the Danian Contessa Highway section, Gubbio, Italy

We studied a high-resolution multiproxy data set, including magnetic susceptibility (MS), CaCO3 content, and stable isotopes (d18O and d13C), from the stratigraphic interval covering the uppermost Maastrichtian and the lower Danian, represented by the pelagic limestones of the Scaglia Rossa Formation continuously exposed in the classic sections of the Bottaccione Gorge and the Contessa Highway near Gubbio, Italy. Variations in all the proxy series are periodic and reflect astronomically forced climate changes (i.e., Milankovitch cycles). In particular, the MS proxy reflects variations in the terrigenous dust input in this pelagic, deep-marine environment. We speculate that the dust is mainly eolian in origin and that the availability and transport of dust are influenced by variations in the vegetation cover on the Maastrichtian-Paleocene African or Asian zone, which were respectively located at tropical to subtropical latitudes to the south or far to the east of the western Tethyan Umbria-Marche Basin, and were characterized by monsoonal circulation. The dynamics of monsoonal circulation are known to be strongly dependent on precession-driven and obliquity-driven changes in insolation. We propose that a threshold mechanism in the vegetation coverage may explain eccentricity-related periodicities in the terrigenous eolian dust input. Other mechanisms, both oceanic and terrestrial, that depend on the precession amplitude modulated by eccentricity, can be evoked together with the variation of dust influx in the western Tethys to explain the detected eccentricity periodicity in the d13C record. Our interpretations of the d18O and MS records suggest a warming event ~400 k.y. prior to the Cretaceous-Paleogene (K-Pg) boundary, and a period of climatic and environmental instability in the earliest Danian. Based on these multiproxy phase relationships, we propose an astronomical tuning for these sections; this leads us to an estimate of the timing and duration of several late Maastrichtian and Danian biostratigraphic and magnetostratigraphic events.

Recueil de lettres originales et d'une copie de pièce indiquée comme telle dans le dépouillement qui suit.

Contient : 1 Lettre du roi « CHARLES » IX au « duc de Nemoux,... A Angers, le XXVIIe jour de janvier 1570 » ; 2 Lettre de « FRANÇOYS [duc D'ALENÇON]... à madame... de Ferrare,... A Paris, le XIXme janvier 1570 » ; 3 Lettre de « JAQUES DE SAVOYE [duc DE NEMOURS]... à madame [Renée de France, duchesse de Ferrare]... Du Boys de Vincennes, ce IIIe fevrier 1570 » ; 4 Lettre de « LEONOR D'ORLEANS [duc DE LONGUEVILLE]... à monseigneur... le duc de Nemoux,... De Gaillon, ce VIIIme jour de fevrier 1570 » ; 5 Lettre d'« E[MMANUEL] PHILIBERT [duc DE SAVOIE]... à... monseigneur le duc de Genevoys et d'Annemours,... De Thurin, ce XIIIe de febvrier 1570 » ; 6 Lettre de « JAQUES DE SAVOYE [duc DE NEMOURS]... à madame [Renée de France, duchesse de Ferrare]... De Vincennes, ce XXIIIe de fevrier 1570 » ; 7 Lettre de « MONTMORENCY,... à monsieur... le duc de Nemoux,... D'Angers, le XXIIIIme jour de febvrier 1570 » ; 8 Lettre, en italien, de « LUCRETIA DA ESTE,... a... madama di Ferrara, duchessa di Chiartres,... Di Ferrara, il primo di marzo LXX » ; 9 Lettre, en italien, de la « contessa DELLA MIRANDOLA,... all' illmo... duca di Nemours,... Della Mirandola, il primo di marzo 1570 » ; 10 Lettre de « CATERINE [DE MEDICIS]... à... madame de Nemours,... Du Plesi Masé, cet IIIme de mars 1570 » ; 11 Lettre, en italien, de la « contessa DELLA MIRANDOLA,... all' illmo... duca di Nemours,... Della Mirandola, il 3 di marzo 1570 » ; 12 Lettre du roi « CHARLES » IX au « duc de Nemours,... A Angers, le VIme jour de mars 1570 » ; 13 Lettre d'« ENTRAIGUES,... à monseigneur... le duc de Nemours,... A Marcossis, ce deuxme de mars 1570 » ; 14 Lettre de « FRANÇOYS [duc D'ALENÇON]... à... madame la duchesse de Ferrare,... De Paris, ce VIIme jour de mars 1570 » ; 15 Lettre de « CATERINE [DE MEDICIS]... à... monseigneur le duc de Nemoux,... D'Enger, cet VIme jour de mars 1570 » ; 16 « Coppie du pouvoir faict de par le roy pour le gouvernement de monseigneur le mareschal de Cossé » en Bretagne. « Donné à Angers, le dernier jour de janvier... mil cinq cens soixante dix » ; 17 Lettre de « JAQUES DE SAVOYE [duc DE NEMOURS]... à madame [Renée de France, duchesse de Ferrare]... De Paris, ce VIIe de mars 1570 » ; 18 Lettre, en italien, de « HIPPOLITO, cardinale DI FERRARA,... a... madama la duchessa di Nemours,... Di Roma, alli 10 d'aprile 1570 » ; 19 Lettre du maréchal « DE COSSE » à « madame [de Nemours]... De Bloys, le seizme jour de mars 1570 » ; 20 Lettre de « NIGOLAS DE LORRAINE [comte DE VAUDEMONT]... à monsieur... le duc de Nemoux et de Genefvois,... De Nommeni, ce XXIII mars 1570 » ; 21 Lettre de « MONTMORENCY,... à monsieur... le duc de Nemoux,... D'Angiers, le dernier jour de mars 1570 » ; 22 Lettre d'« ANNE D'EST [duchesse DE NEMOURS]... à madame [Renée de France, duchesse de Ferrare]... 1570 » ; 23 Lettre de « CLAUDE DE LORRAINE [duc D'AUMALE]... à monsieur... le duc de Nemours,... D'Ennet, le IIe jour d'avril 1570 » ; 24 Lettre du maréchal « DE COSSE,... à monsieur... le duc de Nemours,... D'Orleans, ce IIe avril 1570 » ; 25 Lettre, en italien, de « GUIDO UBALDO DE PUTTI,... al... signor Francesco Putti,... D'il Passetto, a di II de appril 1570 » ; 26 Lettre du maréchal « DE COSSE,... à madame... la duchesse de Ferrare,... D'Orleans, ce Ve apvril 1570 » ; 27 Lettre d'« ANNE D'EST,... à madame... la duchesse de Ferrare,... De Paris, ce VIIIe avril 1570 » ; 28 Lettre de « HENRY », duc D'ANJOU, au « duc de Nemoux,... A Chasteaubriant, le XIIme jour d'avril 1570 » ; 29 Lettre, en italien, de « CHIARA LAMBERTI,... à... madama Renea di Francia,... Di Ferrara, ad 6 maggio 1570 » ; 30 Lettre, en italien, de « BARRARA, duchessa DI FERRARA,... a madama di Ferrara, duchessa di Chiartres,... Di Ferrara, a XI di maggio del LXX » ; 31 Minute de lettre de « RENEE DE FRANCE,... à ma fille, madame la duchesse de Nemours,... De Montargis, ce XVIe jour de may 1570 » ; 32 Lettre du maréchal « DE COSSE,... à madame... la duchesse de Ferrare,... Du camp de Gien, ce XXIme jour de may 1570 » ; 33 Lettre de « CATERINE [DE MEDICIS]... à... madame de Nemours,... D'Argenten, cet XXme jour de jouyn 1570 » ; 34 Lettre, en italien, de « LEONORA DI ESTE,... a... madama di Ferrara,... Di Ferrara, il XXIX giugno nel LXX » ; 35 Lettre d'« E[MMANUEL] PHILIBERT [duc DE SAVOIE]... à madame la duchesse de Ferrare,... De Thurin, ce dernier d'aoust 1570 » ; 36 Lettre de « GATERINE [DE MEDICIS]... à... madame de Nemoux,... De Mouseaulx, cet XIIIme de settembre 1570 » ; 37 Lettre, en italien de « fratre AUGUSTINO rig°... » à « madama di Ferrara,... duchessa di Chiartres,... Di Ferrara, ai XXVIII di settembre M.D.LXX » ; 38 Lettre, en italien, du « duca D'URBINO [GUI-URALD II]... a... madama Renea [di Francia], duchessa di Ferrara,... Dell' Imperiale, il di VIII di ottobre del LXX » ; 39 Lettre, en italien, de « LUIGI, cardinale D'ESTE,... a... madama di Ferrara,... Di Ferrara, a XI d'ottobre del LXX » ; 40 Lettre de la reine « MARIE [STUART]... à... monseigneur le duc de Nemours,... A Chatysworth, le dernier jour d'octobre 1570 » ; 41 Lettre d'« E[MMANUEL] PHILIBERT [duc DE SAVOIE]... à... monsieur le duc de Genevoys et de Nemours,... De Thurin, le 28 novembre 1570 » ; 42 « Double de la minute des lettres de jussion » du roi CHARLES IX pour le payement des pensions de Renée de France, douairière de Ferrare, 1570 ; 43 Lettre, en italien, des « antiani e gonfalonier di giustizia della republica di Lucca... all' illme... duca di Nemors,... Del nostro palazzo, il di XIIII di decembre M.D.LXX » ; 44 Lettre de « CORNELIA CARACCIOLA,... à madame... la duchesse de Ferrare,... De Chasteauneuf, ce 21 jour de decembre 1570 » ; 45 Lettre des « generaulx des vivres, SERRES » et « LILENDOUZE » à « madame la duchesse de Ferrare,... A Orleans, le XIme avril 1570 » ; 46 Lettre, en italien, de « LUIGI, cardinale D'ESTE,... all' illme... duca di Nemours,... Di Ferrara, l'ultimo di giugno del LXX » ; 47 Lettre, en italien, de « FRANCESCHINO DAL GONDENO,... a... madama la duchessa di Ferrara,... Di Ferrara, a II di luglio M.D.LXX » ; 48 Lettre, en italien, de « ALFONSO D'ESTE,... a... madama di Ferrara,... Di Ferrara, il di III luglio nel LXX » ; 49 Lettre de « HENRY [duc D'ANJOU]... à... madame la duchesse de Ferrare,... A Gaillon, le VIe jour de juillet 1570 » ; 50 Lettre d'« ENTRAIGUES,... à madame [Renée de France, duchessè de Ferrare]... De Gyen, se XIIIe juillet 1570 » ; 51 Lettre du maréchal « A[RTUS] DE COSSE,... à madame... la duchesse de Ferrare,... Du camp de Villeneuve le Roy, le XVme de juillet 1570 » ; 52 Minute de lettre, sans signature ni adresse, sur la conclusion de la paix entre le roi Charles IX et « ceulx de la religion... De Montargis, ce IIe aoust 1570 » ; 53 Lettre du roi « CHARLES » IX au « duc de Nemoux,... A St Germain en Laye, le IIIe jour de aoust 1570 » ; 54 Lettre du roi « CHARLES [IX]... à monseigneur le president de Metz... A St Germain en Laye, le XIIIIe jour de aoust 1570 »

An integrated stratigraphic record of the Palaeocene-lower Eocene at Gubbio (Italy): new insights into the early Palaeogene hyperthermals and carbon isotope excursions

Terra Nova, 24, 380386, 2012 Abstract A high-resolution, integrated stratigraphic framework (stable isotope stratigraphy, standard calcareous nannofossil and foraminiferal biostratigraphy, magnetostratigraphy) together with geochemical and rock magnetic properties analyses of a complete and well-preserved succession at Contessa Valley (Gubbio, central Italy) have offered an excellent opportunity to identify and constrain the Palaeocene to early Eocene hyperthermals and carbon isotope excursions (CIEs). In addition, we provide the first evidence in the Tethys Ocean of CIEs, previously identified in the Pacific, Atlantic and Southern Oceans, highlighting their global significance and of some unknown CIEs. Their characteristics are compared with those reported for deep-sea cores and other land-based sections to test whether the signature associated with CIEs documented in our composite section might give evidence for tracing them over wider areas. The Contessa composite section thus represents a reference succession also for insight into the magnetobiochronostratigraphy and the magnitude of early Palaeogene hyperthermals and CIEs.

Ribosomal and Immune Transcripts Associate with Relapse in Acquired ADAMTS13-Deficient Thrombotic Thrombocytopenic Purpura.

Approximately 40% of patients who survive acute episodes of thrombotic thrombocytopenic purpura (TTP) associated with severe acquired ADAMTS13 deficiency experience one or more relapses. Risk factors for relapse other than severe ADAMTS13 deficiency and ADAMTS13 autoantibodies are unknown. ADAMTS13 autoantibodies, TTP episodes following infection or type I interferon treatment and reported ensuing systemic lupus erythematosus in some patients suggest immune dysregulation. This cross-sectional study asked whether autoantibodies against RNA-binding proteins or peripheral blood gene expression profiles measured during remission are associated with history of prior relapse in acquired ADAMTS13-deficient TTP. Peripheral blood from 38 well-characterized patients with autoimmune ADAMTS13-deficient TTP in remission was examined for autoantibodies and global gene expression. A subset of TTP patients (9 patients, 24%) exhibited a peripheral blood gene signature composed of elevated ribosomal transcripts that associated with prior relapse. A non-overlapping subset of TTP patients (9 patients, 24%) displayed a peripheral blood type I interferon gene signature that associated with autoantibodies to RNA-binding proteins but not with history of relapse. Patients who had relapsed bimodally expressed higher HLA transcript levels independently of ribosomal transcripts. Presence of any one potential risk factor (ribosomal gene signature, elevated HLA-DRB1, elevated HLA-DRB5) associated with relapse (OR = 38.4; p = 0.0002) more closely than any factor alone or all factors together. Levels of immune transcripts typical of natural killer (NK) and T lymphocytes positively correlated with ribosomal gene expression and number of prior episodes but not with time since the most recent episode. Flow cytometry confirmed elevated expression of cell surface markers encoded by these transcripts on T and/or NK cell subsets of patients who had relapsed. These data associate elevated ribosomal and immune transcripts with relapse history in acquired, ADAMTS13-deficient TTP.

Late Cretaceous to Eocene calcareous nannofossil distribution near Gubbio, Italy

Using a modified sample preparation technique, we have been able to establish a detailed lower Campanian to upper Eocene nannofossil stratigraphy in the Bottaccione and Contessa Highway sections near Gubbio. Appearance and extinction levels of virtually all the commonly used calcareous nannofossil zonal markers have been recognized and can now be closely correlated with the planktonic foraminifera zonation and the magnetic reversal stratigraphy previously established in these sections. Comparisons with the nannofossil calibrations of the oceanic magnetic anomaly sequence in Deep Sea Drilling Project (DSDP) sites suggest that magmetic Subchrons C17N and C25N are missing in the Bottaccione section. The observed variability of the relative stratigraphic position of most plankton events is confirmed to less than one magnetic subchron. Absolute abundance, paleobiogeographic restriction, and differential preservation render some of the traditionally used biostratigraphic events less reliable than others.

Natural remanent magnetization (NRM) from ODP Site 1263 covering magnetochron C20r and C21n and high-resolution bulk carbon isotope (d13C) records from Sites 702 and 1263

To explore cause and consequences of past climate change, very accurate age models such as those provided by the astronomical timescale (ATS) are needed. Beyond 40 million years the accuracy of the ATS critically depends on the correctness of orbital models and radioisotopic dating techniques. Discrepancies in the age dating of sedimentary successions and the lack of suitable records spanning the middle Eocene have prevented development of a continuous astronomically calibrated geological timescale for the entire Cenozoic Era. We now solve this problem by constructing an independent astrochronological stratigraphy based on Earth's stable 405 kyr eccentricity cycle between 41 and 48 million years ago (Ma) with new data from deep-sea sedimentary sequences in the South Atlantic Ocean. This new link completes the Paleogene astronomical timescale and confirms the intercalibration of radioisotopic and astronomical dating methods back through the Paleocene-Eocene Thermal Maximum (PETM, 55.930 Ma) and the Cretaceous-Paleogene boundary (66.022 Ma). Coupling of the Paleogene 405 kyr cyclostratigraphic frameworks across the middle Eocene further paves the way for extending the ATS into the Mesozoic.

The Ras/Rac1/Cdc42/SEK/JNK/c-Jun Cascade Is a Key Pathway by Which Agonists Stimulate DNA Synthesis in Primary Cultures of Rat Hepatocytes

The ability of signaling via the JNK (c-Jun NH2-terminal kinase)/stress-activated protein kinase cascade to stimulate or inhibit DNA synthesis in primary cultures of adult rat hepatocytes was examined. Treatment of hepatocytes with media containing hyperosmotic glucose (75 mM final), tumor necrosis factor α (TNFα, 1 ng/ml final), and hepatocyte growth factor (HGF, 1 ng/ml final) caused activation of JNK1. Glucose, TNFα, or HGF treatments increased phosphorylation of c-Jun at serine 63 in the transactivation domain and stimulated hepatocyte DNA synthesis. Infection of hepatocytes with poly-l-lysine–coated adenoviruses coupled to constructs to express either dominant negatives Ras N17, Rac1 N17, Cdc42 N17, SEK1−, or JNK1− blunted the abilities of glucose, TNFα, or HGF to increase JNK1 activity, to increase phosphorylation of c-Jun at serine 63, and to stimulate DNA synthesis. Furthermore, infection of hepatocytes by a recombinant adenovirus expressing a dominant-negative c-Jun mutant (TAM67) also blunted the abilities of glucose, TNFα, and HGF to stimulate DNA synthesis. These data demonstrate that multiple agonists stimulate DNA synthesis in primary cultures of hepatocytes via a Ras/Rac1/Cdc42/SEK/JNK/c-Jun pathway. Glucose and HGF treatments reduced glycogen synthase kinase 3 (GSK3) activity and increased c-Jun DNA binding. Co-infection of hepatocytes with recombinant adenoviruses to express dominant- negative forms of PI3 kinase (p110α/p110γ) increased basal GSK3 activity, blocked the abilities of glucose and HGF treatments to inhibit GSK3 activity, and reduced basal c-Jun DNA binding. However, expression of dominant-negative PI3 kinase (p110α/p110γ) neither significantly blunted the abilities of glucose and HGF treatments to increase c-Jun DNA binding, nor inhibited the ability of these agonists to stimulate DNA synthesis. These data suggest that signaling by the JNK/stress-activated protein kinase cascade, rather than by the PI3 kinase cascade, plays the pivotal role in the ability of agonists to stimulate DNA synthesis in primary cultures of rat hepatocytes.

Il racconto breve nella letteratura bulgara moderna: Dejan Enev

Il progetto di tesi consiste in una proposta di traduzione di tre racconti brevi dello scrittore bulgaro Dejan Enev, introdotti da un excursus sulla short story nel panorama letterario in Bulgaria. Le proposte di traduzione sono accompagnate dal relativo commento, che si incentra soprattutto sulla difficoltà del traduttore nel decidere tra i vari approcci da adottare. Si fa un costante riferimento al concetto di perdita delle sfumature di significato delle parole e alla scelta di quale aspetto di esse preservare a discapito di altri.

Carbon isotope record of 3 profiles from Campanian-Maastrichtian

Carbon-isotope stratigraphy has proven to be a powerful tool in the global correlation of Cretaceous successions. Here we present new, high-resolution carbon-isotope records for the Global Boundary Stratotype Section and Point (GSSP) of the Maastrichtian stage at Tercis les Bains (France), the Bottaccione and Contessa sections at Gubbio (Italy), and the coastal sections at Norfolk (UK) to provide a global d13C correlation between shelf-sea and oceanic sites. The new d13C records are correlated with d13C-stratigraphies of the boreal chalk sea (Trunch borehole, Norfolk, UK, Lägerdorf-Kronsmoor-Hemmoor section, northern Germany, Stevns-1 core, Denmark), the tropical Pacific (ODP-Hole 1210B, Shatsky Rise) and the South Atlantic and Southern Ocean (DSDP Hole 525A, ODP Hole 690C) by using an assembled Gubbio d13C record as a reference curve. The global correlation allows the identification of significant high-frequency d13C variations that occur superimposed on prominent Campanian-Maastrichtian events, namely the Late Campanian Event (LCE), the Campanian-Maastrichtian Boundary Event (CMBE), the mid-Maastrichtian Event (MME), and the Cretaceous-Paleogene transition (KPgE). The carbon-isotope events are correlated with the geomagnetic polarity scale recalculated using the astronomical 40Ar/39Ar calibration of the Fish Canyon sanidine. This technique allows the evaluation of the relative timing of base occurrences of stratigraphic index fossils such as ammonites, planktonic foraminifera and calcareous nannofossils. Furthermore, the Campanian-Maastrichtian boundary, as defined in the stratotype at Tercis, can be precisely positioned relative to carbon-isotope stratigraphy and the geomagnetic polarity timescale. The average value for the age of the Campanian-Maastrichtian boundary is 72.1 ± 0.1 Ma, estimated by three independent approaches that utilize the Fish Canyon sanidine calibration and Option 2 of the Maastrichtian astronomical timescale. The CMBE covers a time span of 2.5 Myr and reflects changes in the global carbon cycle probably related to tectonic processes than to glacioeustasy. The duration of the high-frequency d13C variations instead coincides with the frequency band of long eccentricity, indicative of orbital forcing of changes in climate and the global carbon cycle.