Genome-wide computational identification of microRNAs and their targets in the deep-branching eukaryote Giardia lamblia

Using a combined computational program. we identified 50 potential microRNAs (miRNAs) in Giardia lamblia. one of the most primitive unicellular eukaryotes. These miRNAs are unique to G. lamblia and no homologues have been found in other organisms; miRNAs.

Application of an optimisation algorithm to configure an internal fixation device

Fractures of long bones are sometimes treated using various types of fracture fixation devices including internal plate fixators. These are specialised plates which are used to bridge the fracture gap(s) whilst anatomically aligning the bone fragments. The plate is secured in position by screws. The aim of such a device is to support and promote the natural healing of the bone. When using an internal fixation device, it is necessary for the clinician to decide upon many parameters, for example, the type of plate and where to position it; how many and where to position the screws. While there have been a number of experimental and computational studies conducted regarding the configuration of screws in the literature, there is still inadequate information available concerning the influence of screw configuration on fracture healing. Because screw configuration influences the amount of flexibility at the area of fracture, it has a direct influence on the fracture healing process. Therefore, it is important that the chosen screw configuration does not inhibit the healing process. In addition to the impact on the fracture healing process, screw configuration plays an important role in the distribution of stresses in the plate due to the applied loads. A plate that experiences high stresses is prone to early failure. Hence, the screw configuration used should not encourage the occurrence of high stresses. This project develops a computational program in Fortran programming language to perform mathematical optimisation to determine the screw configuration of an internal fixation device within constraints of interfragmentary movement by minimising the corresponding stress in the plate. Thus, the optimal solution suggests the positioning and number of screws which satisfies the predefined constraints of interfragmentary movements. For a set of screw configurations the interfragmentary displacement and the stress occurring in the plate were calculated by the Finite Element Method. The screw configurations were iteratively changed and each time the corresponding interfragmentary displacements were compared with predefined constraints. Additionally, the corresponding stress was compared with the previously calculated stress value to determine if there was a reduction. These processes were continued until an optimal solution was achieved. The optimisation program has been shown to successfully predict the optimal screw configuration in two cases. The first case was a simplified bone construct whereby the screw configuration solution was comparable with those recommended in biomechanical literature. The second case was a femoral construct, of which the resultant screw configuration was shown to be similar to those used in clinical cases. The optimisation method and programming developed in this study has shown that it has potential to be used for further investigations with the improvement of optimisation criteria and the efficiency of the program.

NEW METHODOLOGY FOR THE ESTIMATION OF ENERGY CONSUMPTION IN A DOUBLE-TUBE-SOCKET (DTS (R)) PNEUMATIC CONVEYING

A new methodology based on the use of CFD is proposed to estimate the energy consumptions in a DTS (DOUBLE-TUBE-SOCKET) pneumatic conveying. A simple computational program based on this methodology is developed. It can directly give the lowest energy consumption and the compatible gas consumption by only input the distance of conveying and the conveying tonnage. This computational program has been validated through our experimental work.

Simulation of characteristic electrochemical behavior of azobenzene derivative self-assembled monolayers

The characteristic electrochemical mechanics of azobenzene derivative self-assembled monolayers is discussed in present paper. It is presented that the structure inhibition is one of the most important factors in the increase of electrochemical reactive energy. A corresponding mathematical model was established based on Levich and Marcus's theory. Moreover, computational program was written to simulate the decrease of apparent rate constant (k(app)) of electron transfer with increasing surface concentration.

A new combined joules supercritical rankine cycle exergetic analysis and optimization

The application of a supercritical Rankine cycle in combined cycles does not happen in today’s thermoelectric power stations. Nevertheless, the most recent development in gas turbines, that allows a high efficiency and high exhaust gases temperatures, and the improvement of high pressure and temperature alloys, makes this cycle possible. This study’s intent is to prove the viability of this combined cycle, since it can break the 60% efficiency barrier, which is the plafond in actual power stations. To attain this target, several configurations for this cycle have been simulated, optimized and analyzed [1]. The simulations were done with the computational program IPSEpro [2] and the optimizations were effectuated with software developed for the effect, using the DFP method [3]. In parallel with the optimization that claims the cycle’s efficiency maximization, an exergetic analysis was also made [4] to all the cycle components. In opposite to what happens in subcritical combined cycles, it was demonstrated that in supercritical combined cycles the higher efficiency takes place with a single steam pressure in the heat recovery steam generator (HRSG).

Fractal dimension applied to plant identification

This article discusses methods to identify plants by analysing leaf complexity based on estimating their fractal dimension. Leaves were analyzed according to the complexity of their internal and external shapes. A computational program was developed to process, analyze and extract the features of leaf images, thereby allowing for automatic plant identification. Results are presented from two experiments, the first to identify plant species from the Brazilian Atlantic forest and Brazilian Cerrado scrublands, using fifty leaf samples from ten different species, and the second to identify four different species from genus Passiflora, using twenty leaf samples for each class. A comparison is made of two methods to estimate fractal dimension (box-counting and multiscale Minkowski). The results are discussed to determine the best approach to analyze shape complexity based on the performance of the technique, when estimating fractal dimension and identifying plants. (C) 2008 Elsevier Inc. All rights reserved.

Análise de treliças planas viscoelásticas com deformações finitas e pórticos planos viscoelásticos com vigas mistas

Este trabalho compõe-se de duas partes. A primeira parte propõe-se a apresentar um estudo e um programa computacional para a análise não linear geométrica de treliças planas com propriedades: viscoelásticas. Na segunda parte, tem-se o estudo e um programa sobre pórticos planos com propriedades viscoelásticas, usando o modelo reológico standard e o dado pelo CEB. Leva-se em consideração o efeito de temperatura e retração nesta análise. Estende-se o trabalho sobre pórtico para o estudo sobre vigas mistas, levando em consideração a mudança da linha neutra. A formulação está baseada no método dos elementos finitos para grandes deformações, particularizada para treliça e pórtico. É feita a descrição de ambos os programas e rodados diversos exemplos.

Um modelo elasto-viscoplástico para análise de peças de concreto estrutural, submetidas a estados planos de tensão, através do método dos elementos finitos

O objetivo deste trabalho é desenvolver um modelo computacional, baseado no método dos elementos finitos, para o estudo de peças de concreto armado e protendido submetidas a estados planos de tensão. O estudo abrange situações de carga de curta e longa duração, onde consideram-se fluência e retração do concreto e relaxação do aço. São utilizados modelos constitutivos elasto-viscoplásticos para descrever o comportamento dos materiais. Implementou-se um modelo de camadas superpostas para melhor representar o comportamento do concreto, onde o material é composto de diversas camadas que sofrem a mesma deformação. Cada camada possui diferentes características materiais e a tensão total é obtida pela soma das diferentes contribuições de cada camada. Para a fissuração da concreto, utilizou-se um modelo de fissuras distribuídas, que leva em conta a contribuição do concreto entre fissuras. Tanto a amadura passiva como a de pratensão são introduzidas no modelo como uma linha de material mais rígido dentro do elemento de concreto. Os deslocamentos ao longo da armadura são referenciados aos deslocamentos nodais do elemento de concreto. Deste modo, obtém-se uma matriz de rigidez para a armadura com as mesmas dimensões que a matriz de rigidez do elemento de concreto, A matriz de rigidez do elemento concreto-aço é a soma das duas matrizes. Considera-se aderência perfeita entre o concreto e o aço. Os resultados obtidos com esse programa computacionai são comparados com valores experimentais disponíveis.

Análise elastoplástica de grelhas planas de concreto armado

O objetivo deste trabalho é apresentar um programa computacional para analisar problemas elastoplásticos com pequenas deformações em grelhas planas de concreto armado, utilizando o método dos deslocamentos. O material é definido através de um critério de escoamento generalizado que leva em consideração o efeito dos esforços de corte, momento fletor e momento torsor nas seções críticas e apresenta endurecimento isótropo. Uma solução incremental empregando o método da matriz de rigidez tangente foi adotado. Algumas comparações foram feitas com resultados experimentais, numéricos e teóricos.

Análise genético-quantitativa de pesos aos 8, 12, 18 e 24 meses de idade em um rebanho da raça Guzerá

O objetivo deste trabalho foi obter estimativas de herdabilidades, correlações genéticas, tendências genéticas e correlações de rank dos touros, para os pesos aos 8, 12, 18 e 24 meses de idade, no rebanho Guzerá do Campus da UNESP, Ilha Solteira, SP. As herdabilidades e os valores genéticos dos animais foram estimados por modelo animal, usando o programa computacional MTDFREML. As correlações genéticas (Pearson) e de rank dos touros (Spearman) foram obtidas pelo procedimento CORR do SAS, utilizando os valores genéticos dos animais, enquanto as tendências genéticas foram calculadas pelo procedimento REG do SAS, utilizando a média anual dos referidos valores genéticos. O modelo estatístico para a análise genética incluiu os efeitos fixos de grupo contemporâneo e a covariável idade da vaca ao parto (efeitos linear e quadrático), e os efeitos aleatórios genético aditivo direto, genético aditivo materno, de ambiente permanente da vaca e residual. As estimativas obtidas para a herdabilidade direta foram 0,14; 0,08; 0,08 e 0,13 e para materna, 0,01; 0,02; 0,02 e 0,05, respectivamente, para os pesos aos 8, 12, 18 e 24 meses de idade. As estimativas dos coeficientes de correlação genética foram positivas e de alta magnitude entre todos os pesos estudados. As tendências genéticas anuais foram baixas e significativas apenas para os pesos aos 8 e 18 meses de idade. As correlações de rank dos touros foram moderadas e significativas, implicando em razoável manutenção de posição de classificação dos touros, quando se comparam, dois a dois, os pesos estudados.

Modelo matemático para otimização dos custos de um sistema híbrido eólico-solar : aplicação no bombeamento de petróleo

This work purposes the application of a methodology to optimize the implantation cost of an wind-solar hybrid system for oil pumping. The developed model is estimated the implantation cost of system through Multiple Linear Regression technique, on the basis of the previous knowledge of variables: necessary capacity of storage, total daily energy demand, wind power, module power and module number. These variables are gotten by means of sizing. The considered model not only can be applied to the oil pumping, but also for any other purposes of electric energy generation for conversion of solar, wind or solar-wind energy, that demand short powers. Parametric statistical T-student tests had been used to detect the significant difference in the average of total cost to being considered the diameter of the wind, F by Snedecor in the variance analysis to test if the coefficients of the considered model are significantly different of zero and test not-parametric statistical by Friedman, toverify if there is difference in the system cost, by being considered the photovoltaic module powers. In decision of hypothesis tests was considered a 5%-significant level. The configurations module powers showed significant differences in total cost of investment by considering an electrical motor of 3 HP. The configurations module powers showed significant differences in total cost of investment by considering an electrical motor of 5 HP only to wind speed of 4m/s and 6 m/s in wind of 3 m, 4m and 5 m of diameter. There was not significant difference in costs to diameters of winds of 3 m and 4m. The mathematical model and the computational program may be used to others applications which require electrical between 2.250 W and 3.750 W. A computational program was developed to assist the study of several configurations that optimizes the implantation cost of an wind-solar system through considered mathematical model

"Eu pensei que ia sair daqui falando inglês": um estudo sistêmico-funcional sobre papéis sociais atribuídos por alunos de um curso de Letras/Inglês

Research in the area of teacher training in English as a Foreign Language (CELANI, 2003, 2004, 2010; PAIVA, 2000, 2003, 2005; VIEIRA-ABRAHÃO, 2010) articulates the complexity of beginning teachers classroom contexts aligned with teaching language as a social and professional practice of the teacher in training. To better understand this relationship, the present study is based on a corpus of transcribed interviews and questionnaires applied to 28 undergraduate students majoring in Letters/English emphasis, at a public university located in the interior of the Western Amazon region, soliciting their opinions about the reforms made in the curriculum of this Major. Interviews and questionnaires were used as data collection instruments to trace a profile of the students organized in Group 1, with freshmen and sophomore undergraduates who are following the 2009 curriculum, and Group 2, with junior and senior undergraduates who are following the 2006 curriculum. The objectives are to identify, to characterize and to analyze the types of pronouns, roles and social actors represented in the opinions of these students in relation to their teacher training curriculum. The theoretical support focuses on the challenge of historical and contemporary routes from English teachers initial education programs (MAGALHÃES; LIBERALLI, 2009; PAVAN; SILVA, 2010; ALVAREZ, 2010; VIANA, 2011; PAVAN, 2012). Our theoretical perspective is based on the Systemic Functional Grammar of Halliday (1994), Halliday and Hasan (1989), Halliday and Matthiessen (2004), Eggins (1994; 2004) and Thompson (2004). We focus on the concept of the Interpersonal meaning, specifically regarding the roles articulated in the studies by Delu (1991), Thompson and Thetela (1995), and in the Portuguese language such as Ramos (1997), Silva (2006) and Cabral (2009). Moreover, we ascribe van Leeuwen s (1997; 2003) theory of Representation of Social Actors as a theoretical framework in order to identify the sociological aspect of social actors represented in the students discourse. Within this scenario, the analysis unfolds on three levels: grammatical (pronouns), semantic (roles), and discursive (social actors). For the analysis of interpersonal realizations present in the students opinions, we use the computational program WordSmith Tools (SCOTT, 2010) and its applications Wordlist and Concord to quantify the occurrences of the pronouns I, You and They, which characterize the roles and social actors of the corpus. The results show that the students assigned the following roles to themselves: (i) apprentice to express their initial process of English language learning; (ii) freshman to reveal their choice of Major in Letters/English emphasis; (iii) future teacher to relate their expectations towards a practicing professional. To assign the roles to professors in the major, the students used the metaphor of modality (I think) to indicate the relationship of teacher training, while they are in the role of a student and as a future teacher. From these evidences the representation of the students as social actors emerges in roles such as: (i) active roles; (ii) passive roles and (iii) personalized roles. The social actors represented in the opinions of the students reflect the inclusion of these roles assigned to the actions expressed about their experiences and expectations derived from their teacher training classroom

Determination of the numerical parameters of a continuous damage model for the structural analysis of clay brick masonry

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Modelagem matemática aplicada ao controle biológico de Ceratitis capitata Wiedemann (Diptera: Tephritidae) por Diachasmimorpha longicaudata Ashmed (Hymenoptera: Braconidae) em Citrus

O modelo matemático apresentado tem como objetivos: (1) simular as dinâmicas populacionais de um sistema hospedeiro parasitóide de três níveis tróficos composto pelas populações de mosca-do-mediterrâneo Ceratitis capitata (Wiedemann), vespa braconídea parasitóide Diachasmimorpha longicaudata (Ashmed) e frutos cítricos; (2) auxiliar no melhor entendimento dos principais fatores biológicos e ecológicos que regem as interações populacionais e (3) colaborar com programas mais eficientes de controle biológico para o sistema em questão. A metodologia empregada baseou-se na formulação de sistemas de equações de diferenças que descrevessem os processos de interação do sistema trófico. Posteriormente, foram elaboradas resoluções numéricas desses sistemas de equações e sua representação gráfica, utilizando-se o programa computacional Matlab, versão 6.1. Os dados biológicos e ecológicos necessários para a formulação das equações matemáticas foram fornecidos por especialistas em controle de C. capitata e retirados da literatura referente ao controle biológico das moscas-das-frutas em plantações de citros no Brasil, principalmente através da utilização de vespas parasitóides, como D. longicaudata. Os resultados obtidos nas simulações sugerem que o modelo proposto descreve adequadamente o sistema ecológico em questão e permite entender melhor suas principais características biológicas e ecológicas. em conseqüência pode auxiliar na escolha do modo e momento para liberação da vespa parasitóide para o controle mais efetivo de C. capitata.

An approach of optimal sensitivity applied in the tertiary loop of the automatic generation control

This paper proposes an approach of optimal sensitivity applied in the tertiary loop of the automatic generation control. The approach is based on the theorem of non-linear perturbation. From an optimal operation point obtained by an optimal power flow a new optimal operation point is directly determined after a perturbation, i.e., without the necessity of an iterative process. This new optimal operation point satisfies the constraints of the problem for small perturbation in the loads. The participation factors and the voltage set point of the automatic voltage regulators (AVR) of the generators are determined by the technique of optimal sensitivity, considering the effects of the active power losses minimization and the network constraints. The participation factors and voltage set point of the generators are supplied directly to a computational program of dynamic simulation of the automatic generation control, named by power sensitivity mode. Test results are presented to show the good performance of this approach. (C) 2008 Elsevier B.V. All rights reserved.