Further evidence for linkage of Gilles de la Tourette syndrome (GTS) susceptibility loci on chromosomes 2p11, 8q22 and 11q23-24 in South African Afrikaners

Utilizing DNA samples from 91 Afrikaner nuclear families with one or more affected children, five genomic regions on chromosomes 2p, 8q, 11q, 20q, and 21q that gave evidence for association with GTS in previous case-control association studies were investigated for linkage and association with GTS. Highly polymorphic markers with mean heterozygosity of 0.77 were typed and resulting genotypes evaluated using single marker transmission disequilibrium (TDT), single marker haplotype relative risk (HRR), and multi-marker "extended" TDT and HRR methods. Single marker TDT analysis showed evidence for linkage or association, with p-values near 0.05, for markers D2S139, GATA28F12, and D11S1377 on chromosomes 2p11, 8q22 and 11q23-24, respectively. Extended, two-locus TDT and HRR analysis provided further evidence for linkage or association on chromosome 2 with p-values of 0.007 and 0.025, and chromosome 8 with p-values of 0.059 and 0.013, respectively. These results provide important additional evidence for the location of GTS susceptibility loci.

Rondom de Ander in "Na die geliefde land" van Karel Schoeman

The aim of this article is to analyse the novel "Na die geliefde land" (1972) by Karel Schoeman, by interpreting the function of 'hulle' ('they') as a category of alienation/distancing. Schoeman presented a future vision of South Africa controlled by an unidentified group of 'them' and showed Afrikaners as a marginalized group, forced to live on farms. A narrow political interpretation dominated in the reception of this book, which was treated as a simulation of the development of the political situation in South Africa. The key argument of this article is that the indeterminate representation of the situation after the revolution is not a weakness of this novel, but a conscious strategy of the author. The article argues that problems concerning political revolution ('Who', 'Why', 'When') are not that relevant in a reading of the novel because "Na die geliefde land" deals mainly with an Afrikaner community’s reactions to a changed situation.

A cooperação entre Estados «Párias» : o caso Israel-África do Sul

Quis o curso da história que os destinos da África do Sul e de Israel se cruzassem. Dois «povos eleitos» - afrikaners e judeus - partilharam incompreensões, rejeições e isolamentos. As diferenças separaram-nos, mas os estigmas presentes na sociedade internacional contemporânea reaproximaram-nos. Encerrados no «laager» e em «Massada», respetivamente, afrikaners e judeus encontraram um importante caminho da sobrevivência nacional numa cooperação estreita, até mesmo nos domínios mais sensíveis.

O mito Mandela e o sonho de uma nação arco-íris

Nelson Mandela has been an example of fighting and going over the adversities since his prison in 1962 until his election to be the president of South Africa in 1994. His effort against the apartheid in South Africa might be compared to a classical hero according to the anthropological view of Eliade (1972), Campbell (1991; 2007) and Propp’s structuralist perspective (1984). His journey toward heroism and his strategies to get the adhesion of the white minority (Afrikaners) to his purposes of joining the races in South Africa will be analyzed in this article with the theoretical support of the Greimasian semiotics, Propp’s studies (1984) and anthropology. The movie Invictus will be the object of analysis as it shows the moment of Mandela’s social-political fight as the president, with the support of the local rugby team in order to have the racial integration in the country and the political support of the white minority.

Molecular and genealogical evidence for a founder effect in Fanconi anemia families of the Afrikaner population of South Africa

Fanconi anemia (FA) is a rare, genetically heterogeneous autosomal recessive disorder associated with progressive aplastic anemia, congenital abnormalities, and cancer. FA has a very high incidence in the Afrikaner population of South Africa, possibly due to a founder effect. Previously we observed allelic association between polymorphic markers flanking the FA group A gene (FANCA) and disease chromosomes in Afrikaners. We genotyped 26 FA families with microsatellite and single nucleotide polymorphic markers and detected five FANCA haplotypes. Mutation scanning of the FANCA gene revealed association of these haplotypes with four different mutations. The most common was an intragenic deletion of exons 12–31, accounting for 60% of FA chromosomes in 46 unrelated Afrikaner FA patients, while two other mutations accounted for an additional 20%. Screening for these mutations in the European populations ancestral to the Afrikaners detected one patient from the Western Ruhr region of Germany who was heterozygous for the major deletion. The mutation was associated with the same unique FANCA haplotype as in Afrikaner patients. Genealogical investigation of 12 Afrikaner families with FA revealed that all were descended from a French Huguenot couple who arrived at the Cape on June 5, 1688, whereas mutation analysis showed that the carriers of the major mutation were descendants of this same couple. The molecular and genealogical evidence is consistent with transmission of the major mutation to Western Germany and the Cape near the end of the 17th century, confirming the existence of a founder effect for FA in South Africa.

The history of the great Boer trek and the origin of the South African republics,

"Consists of five lectures delivered to the Literary society of Pietermaritzburg in 1852-5."

Fifty years of the history of the republic in South Africa (1795-1845)

Reprint of the 1899 ed.