Sequential release of BMP-7 and VEGF from the PLGA/AK-Gelatin Composite Scaffolds

Vascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMP-7) are key regulators of angiogenesis and osteogenesis during bone regeneration. The aim of this study was to investigate the possibility of realizing sequential release of the two growth factors using a novel composite scaffold. Poly(lactic-co-glycolic acid) (PLGA)-Akermanite (AK) microspheres were used to make the composite scaffold, which was then loaded with BMP-7, followed by embedding in a gelatin hydrogel matrix loaded with VEGF. The release profiles of the growth factors were studied and selected osteogenic related markers of bone marrow stromal cells (BMSCs) were analysed. It was shown that the composite scaffolds exhibited a fast initial burst release of VEGF within the first 3 days and a sustained slow release of BMP-7 over the full period of 20 days. The in vitro proliferation and differentiation of the BMSCs cultured in the osteogenic medium were enhanced by 1 to 2 times, resulting from the additionally and sequentially release of growth factors from the PLGA-AK/gelatin composite scaffolds.

IKT-ak lehen hezkuntzan: mugikorraren eragina ikasleen errendimendu akademikoan

[eus] IKTekiko (Informazio eta Komunikazio Teknologiak) menpekotasuna, oso gai eztabaidatua da gaur egun, batik bat, guraso eta hezitzaileak kezkatzen dituena. Mugikorra aipaturiko teknologia horien barne dagoenez, horretaz egiten den erabilera ezagutzeaz gain, ikerketa honen helburu nagusia mugikorraren erabileraren eta errendimendu akademikoaren arteko korrelazio posible bat aurkitzea da. Horretarako, Euskal Autonomia Erkidegoari dagozkion Lehen Hezkuntzako 5. eta 6. mailetako 39 ikasleko lagina erabili da. Emaitzek, aipaturiko korrelazioa erakusten dute. Beraz, prebentzioaren garrantzia azpimarratzeko asmoz, menpekotasun jokaeraren garapena ekiditeko zenbait gako ematen dira.

A experiência ficcional de Gérard Aké Loba: utopia e construção da identidade pós-colonial

A experiência ficcional de Gérard Aké Loba — Kocoumbo, l’étudiant noir(1960), Les fils de Kouretcha (1970), Les dépossédés (1973) e Le sas des parvenus(1990), ancorada na dinâmica de culturas, no respeito e na honorabilidade do Eu e do Outro, centra-se na problemática da utopia e da construção da identidade pós-colonial. Considerando que a Literatura, enquanto sistema semiótico de produção e recepção de textos, se encontra vinculada a uma visão do mundo, iremos ver como nela se manifestam as relações entre o Ocidente (Europeu) e as regiões da África francófona (Costa do Marfim) no percurso das metamorfoses que conduzem ao Pós-Colonialismo. Procuraremos, de igual modo, problematizar a utopia, e também a distopia, comungando da proposta de Éric Aunoble2, para quem estas questões deverão ser compreendidas na sua relação com o tempo e com a historicidade presente por tentarem responder “aux attentes de leurs temps”.

Ms. hebr. oct. 145 - Ele Toledot Yitsḥak

Vorbesitzer: Mardokai Šemūʾēl Ghirondi ; Abraham Merzbacher

Maḥazē mekîrat Yôsēf : ein ṭeaṭer šṭik in 7 akṭin un in 17 szenen ; giformirṭ noch di besṭe un gleichsṭe deos fun gemore ...

fun Eljakim Tzunzer

Blonzende šṭeren : a roman in 2 ṭeil ; 1. ṭeil: akṭioren

Digitalisat der Ausg. Warša, 1913

Dvoyre'le meyuḥeses̀ : lebensbild in 4 akṭen

fun Y. Gordin [[Elektronische Ressource]]

Elishe Ben Avuje : drama in 4 akṭen

fun Jankev Gordin

Goṭ, mensh un ṭayvl : drama in 4 akṭen miṭ a prolog

fun Jankev Gordin

R. Barukh Sofer's Sefer-Torah : a ṭragedye in 4 akṭen

Nisan Shapu

Der lumpen-proleṭarier : a drame in 4 akṭen ; fun judišen leben in der rusiš-qomunisṭišer despoṭie

A. Ben-Dōv had-Dayyān