Vocabulario básico multilingüe para el aprendizaje del español como segunda lengua.

Adjunta material de apoyo para los profesores

Rastros : textos para lectores nuevos.

Recopilación de textos literarios para neolectores adultos. Su objetivo es servir de material de trabajo para la iniciación a la lectura. Las lecturas están agrupadas en bloques atendiendo al grado de dificultad, y en unidades didácticas junto a las que se incluye una ficha de trabajo con ejercicios de comprensión lectora, expresión oral y escrita, etc. y orientaciones didácticas sobre otras aplicaciones posibles de cada texto.

Educación de adultos : evaluación de centros y de experiencias.

Este trabajo es Premio de Investigación Pedagógica otorgado por el Consejo General de los Colegios Oficiales de Doctores y Licenciados, en su XII Convocatoria, 1996

Legislación comercial. Auxiliar de comercio interior.

En cubierta: 'Experimental'. Módulo de Auxiliar de comercio interior. Título tomado de la cubierta

Cúpulas comerciais para produção de geléia real e rainhas em colméias de abelhas Apis mellifera

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

7/11 1960 Kunnioitettu Herra Ministerineuvoston Puheenjohtaja

Kirje 7.11.1960

Hki 7/9 1943

Kirje 7.9.1943

Search for three-jet resonances in pp collisions at root s=7 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Carbon dioxide insufflation in colonoscopy is safe: a prospective trial of 347 patients

Available evidence suggests that the use of CO(2) insufflation in endoscopy is more comfortable for the patient. The safety of CO(2) use in colonoscopy remains contentious, particularly in sedated patients. The objective of the present prospective trial was to assess the safety of CO(2) colonoscopies. Methods. 109 patients from our previous randomized CO(2) colonoscopy study and an additional 238 subsequent consecutive unselected patients who had a routine colonoscopy performed in a private practice were enrolled from April 2008 through September 2008. All but 2 patients were sedated. All patients were routinely monitored with transcutaneous CO(2) measurement. Volumes of CO(2) administered were correlated with capnographic measurements from transcutaneous monitoring. Results. Of the 347 patients examined, 57% were women; mean (SD) age of participants was of 60.2 years (12.8). Mean propofol dosage was 136 mg (64 mg). Mean CO(2) values were 34.7 mm Hg (5.3) at baseline, 38.9 mm Hg (5.5) upon reaching the ileum, and 36.9 mm Hg (5.0) at examination's end. Mean maximum increase of CO(2) was 4.5 mm Hg (3.6). No correlation was observed between volume of CO(2) administered and increase in level of CO(2) (correlation coefficient: 0.01; P value: 0.84). No complications were observed. Conclusions. The present prospective study, which was based on one of the largest sedated patient sample reported to date in this setting, provides compelling evidence that CO(2) insufflation in colonoscopy is safe and unassociated with relevant increases in transcutaneously measured levels of CO(2).

Doxorubicin Affects Expression of Proteins of Neuronal Pathways in MCF-7 Breast Cancer Cells.

In the present article, we report on the semi-quantitative proteome analysis and related changes in protein expression of the MCF-7 breast cancer cell line following treatment with doxorubicin, using the precursor acquisition independent from ion count (PAcIFIC) mass spectrometry method. PAcIFIC represents a cost-effective and easy-to-use proteomics approach, enabling for deep proteome sequencing with minimal sample handling. The acquired proteomic data sets were searched for regulated Reactome pathways and Gene Ontology annotation terms using a new algorithm (SetRank). Using this approach, we identified pathways with significant changes (≤0.05), such as chromatin organization, DNA binding, embryo development, condensed chromosome, sequence-specific DNA binding, response to oxidative stress and response to toxin, as well as others. These sets of pathways are already well-described as being susceptible to chemotherapeutic drugs. Additionally, we found pathways related to neuron development, such as central nervous system neuron differentiation, neuron projection membrane and SNAP receptor activity. These later pathways might indicate biological mechanisms on the molecular level causing the known side-effect of doxorubicin chemotherapy, characterized as cognitive impairment, also called 'chemo brain'. Mass spectrometry data are available via ProteomeXchange with identifier PXD002998.