Chemical characterization and acaricide potential of essential oil from aerial parts of Tagetes patula L. (Asteraceae) against engorged adult females of Rhipicephalus sanguineus (Latreille, 1806)

Rhipicephalus sanguineus, commonly known as the brown dog tick, is one of the most widely distributed species of tick. In dogs, it can cause anemia and provide the transmission of pathogenic microorganisms such as Babesia canis, Ehrlichia canis, Hepatozoon canis, Anaplasma platys, and Mycoplasma haemocanis. To man, it can transmit the intracellular parasites Rickettsia rickettsii and Rickettsia conorii, the causative agents of the Rocky Mountain spotted fever in the Americas and Mediterranean and spotted fever in Europe and North Africa. Its control is performed by applying synthetic formulations composed of pyrethroids; however, continued use of these products results in environmental damage and acquisition of resistance. Alternatively, studies with botanical insecticides have been increasingly recurrent. Therefore, this study aimed to test the efficacy of essential oil of Tagetes patula, a ruderal species widely described in the literature for its insecticidal properties, in engorged females of R. sanguineus by the adults immersion test (AIT) and impregnated paper disk test (IPDT). The essential oil used, through gas chromatography coupled to mass spectrometry, revealed the presence of 55 compounds, being the 4-vinyl guaiacol and gamma terpinene the majority ones. The AIT compared to the IPDT was more efficient in inhibiting oviposition of tick; however, the eggs laid by the females submitted to saturated atmosphere with essential oil, from IPDT, not hatched, interrupted their development cycle. Besides being a pioneer work, the results presented here contributes to new researches, aiming the incorporation of essential oil in an acaricide for use in the environment. © 2013 Springer-Verlag Berlin Heidelberg.

Effects of sample solvent composition and injection volume on chromatographic peak profiles of methyl w- benzimidazolecarbamate and 3-butyl1-2,4-dioxo[1,2-a]-s- triazinobenzimidazole in RP-HPLC

The effects of sample solvent composition and the injection volume, on the chromatographic peak profiles of two carbamate derivatives, methyl 2-benzimidazolecarbamate (MBC) and 3-butyl-2,4-dioxo[1,2-a]-s-triazinobenzimidazole (STB), were studied using reverse phase high performance liquid chromatograph. The study examined the effects of acetonitrile percentage in the sample solvent from 5 to 50%, effects of methanol percentage from 5 to 50%, effects of pH increase from 4.42 to 9.10, and effect of increasing buffer concentration from ° to 0.12M. The effects were studied at constant and increasing injection mass and at four injection volumes of 10, 50, 100 and 200 uL. The study demonstrated that the amount and the type of the organic solvents, the pH, and the buffer strength of the sample solution can have a pronounced effect on the peak heights, peak widths, and retention times of compounds analysed. MBC, which is capable of intramolecular hydrogen bonding and has no tendency to ionize, showed a predictable increase .in band broadening and a decrease in retention times at higher eluting strengths of the sample solvent. STB, which has a tendency to ionize or to strongly interact with the sample solvent, was influenced in various ways by the changes in ths sample solvent composition. The sample solvent effects became more pronounced as the injection volume increased and as the percentage of organic solvent in the sample solution became greater. The peak height increases for STB at increasing buffer concentrations became much more pronounced at higher analyte concentrations. It was shown that the widely accepted procedure of dissolving samples in the mobile phase does not yield the most efficient chromatograms. For that reason samples should be dissolved in the solutions with higher aqueous content than that of the mobile phase whenever possible. The results strongly recommend that all the samples and standards, regardless whether the standards are external or internal, be analysed at a constant sample composition and a constant injection volume.

Livret officiel de la Fête des vignerons se célébrant à Vevey les 4,5,7,8,10 et 11 août 1905.

Mode of access: Internet.

Estudio filológico-literario comparativo del relato del funeral de Augusto contado por el biógrafo Suetonio ("Aug."100) y por el historiador Tácito ("Ann."1.8-10)

[ES] Este trabajo se propone el análisis comparativo, bajo el punto de vista filológico y literario, del relato del funeral de Augusto en el biógrafo Suetonio ("Aug."100) y en el historiador Tácito ("Ann."1.8-10). En primer lugar se remarca la importancia política y social del "funus publicum" en Roma, objeto del relato. Sigue un detenido y minucioso análisis en el que se trata de poner de relieve las semejanzas y, sobre todo, las diferencias entre el relato de Suetonio y el de Tácito en cuanto a los datos aportados, la secuenciación de los mismos y, especialmente, en cuanto a la focalización que sobre ellos y sobre el conjunto del relato muestran uno y otro autor. Finalmente se trata de explicar las diferencias, importantes, entre ambos relatos en virtud del género literario (biografía-historia), de la intención y propósito concretos de cada una de las dos obras ("Vita Augusti" de Suetonio y "Annales" de Tácito) y de la distinta personalidad intelectual de cada uno de los dos autores.

9,10-Dihydroxy-1,8-cineole (1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane-10,11-diol)

The title compound (3) has been synthesized and its presence sought in the urinary metabolites of the brushtail possum. © CSIRO 2001

Left ventricular Systolic function and outcome after in-hospital cardiac arrest

Background - The effect of prearrest left ventricular ejection fraction ( LVEF) on outcome after cardiac arrest is unknown. Methods and Results - During a 26-month period, Utstein-style data were prospectively collected on 800 consecutive inpatient adult index cardiac arrests in an observational, single-center study at a tertiary cardiac care hospital. Prearrest echocardiograms were performed on 613 patients ( 77%) at 11 +/- 14 days before the cardiac arrest. Outcomes among patients with normal or nearly normal prearrest LVEF ( >= 45%) were compared with those of patients with moderate or severe dysfunction ( LVEF < 45%) by chi(2) and logistic regression analyses. Survival to discharge was 19% in patients with normal or nearly normal LVEF compared with 8% in those with moderate or severe dysfunction ( adjusted odds ratio, 4.8; 95% confidence interval, 2.3 to 9.9; P < 0.001) but did not differ with regard to sustained return of spontaneous circulation ( 59% versus 56%; P = 0.468) or 24-hour survival ( 39% versus 36%; P = 0.550). Postarrest echocardiograms were performed on 84 patients within 72 hours after the index cardiac arrest; the LVEF decreased 25% in those with normal or nearly normal prearrest LVEF ( 60 +/- 9% to 45 +/- 14%; P < 0.001) and decreased 26% in those with moderate or severe dysfunction ( 31 +/- 7% to 23 +/- 6%, P < 0.001). For all patients, prearrest beta-blocker treatment was associated with higher survival to discharge ( 33% versus 8%; adjusted odds ratio, 3.9; 95% confidence interval, 1.8 to 8.2; P < 0.001). Conclusions - Moderate and severe prearrest left ventricular systolic dysfunction was associated with substantially lower rates of survival to hospital discharge compared with normal or nearly normal function.

Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease

Background: Past studies have shown that mean values of Interleukin-6 (IL-6) and C-reactive protein (CRP) do not change significantly in COPD patients over a one-year period. However, longer period follow-up studies are still lacking. Thus, the aim of this study is to evaluate plasma CRP and IL-6 concentration over three years in COPD patients and to test the association between these inflammatory mediators and disease outcome markers. Methods: A cohort of 77 outpatients with stable COPD was evaluated at baseline, and 53 (mean FEV1, 56% predicted) were included in the prospective study. We evaluated Interleukin-6 (IL-6), C-reactive protein (CRP), six-minute walking distance (6MWD), and body mass index (BMI) at baseline and after three years. Plasma concentration of IL-6 was measured by high sensitivity ELISA, and CRP was obtained by high sensitivity particle-enhanced immunonephelometry. Results: IL-6 increased significantly after 3 years compared to baseline measurements [0.8 (0.5-1.3) vs 2.4 (1.3-4.4) pg/ml; p < 0.001] and was associated with worse 6MWD performance. In the Cox regression, increased IL-6 at baseline was associated with mortality [Hazard Ratio (95% CI) = 2.68 (0.13, 1.84); p = 0.02]. CRP mean values did not change [5 (1.6-7.9) vs 4.7 (1.7-10) pg/L; p = 0.84], although eleven patients (21%) presented with changes >3 mg/L in CRP after 3 years. Conclusions: The systemic inflammatory process, evaluated by IL-6, seems to be persistent, progressive and associated with mortality and worse physical performance in COPD patients. Trial registration: No.:NCT00605540. © 2013 Ferrari et al; licensee BioMed Central Ltd.

Evolução da interleucina 6 e da proteína C-Reativa em pacientes com DPOC no período de três anos

Pós-graduação em Fisiopatologia em Clínica Médica - FMB

Studien zur Fuggergeschichte.

Vols. 10-17, 19-20, 22-<33> issued also as Schwäbische Forschungsgemeinschaft bei der Kommission für Bayerische Landesgeschichte. Reihe 4, Bd. 1-8, 10-16, 18-<24>

1.° Ars judiciaria secundùm novem Judices : authore anonymo. — 2.° Anonymi liber de inundatione Nili. — 3.° Anonymi liber de coloribus. — 4.° Anonymi liber de bona fortuna. — 5.° Anonymi libellus de lineis invisibilibus. — 6.° Liber de morte Aristotelis. — 7.° Liber de intelligentia Aristotelis. — 8.° Liber de causa motûs animalium. — 9.° Liber de juventute et senectute. — 10.° Liber de respiratione. — 11.° Aristotelis liber de morte et vita.

Colbertinus

1.° Caii Plinii Secundi epistolarum libri decem : primi initium et decimi finis desiderantur. — 2.° Ejusdem panegyricus Trajano dictus. — 3.° Latini Pacati Drepanii panegyricus Theodosio dictus. — 4.° Claudii Mamertini Juliano Imperatori gratiarum actio de Consulatu suo. — 5.° Nazarii panegyricus Constantino, Caesari, dictus. — 6.° Eumenii gratiarum actio Constantino, Augusto, Flaviensium nomine. — 7.° Ejusdem panegyricus Constantino, Augusto, dictus. — 8.° Incerti authoris panegyricus Maximiano et Constantino dictus. — 9.° Eumenii panegyricus Constantio, Caesari, dictus. — 10.° Ejusdem oratio pro restaurandis scholis. — 11.° Claudii Mamertini panegyricus Maximiano, Augusto, dictus. — 12.° Genethliacus Maximiani : authore eodem. — 13.° Incerti authoris panegyricus Constantino, Augusto, dictus : finis desideratur.

Bigotianus

1.° Collectio canonum, Decretalium summorum Pontificum, et sententiarum orthodoxorum Patrum, juxta rerum ordinem digesta et in septuaginta sex capitula distributa : authore anonymo. — 2.° Ordo quomodo agatur Concilium ab Episcopis. — 3.° Canon Evangeliorum. — 4.° Anonymi tractatus de Deo uno et trino, de Angelis, de Prophetis et de Apostolis. — 5.° Fragmentum de gradibus affinitatis, sive potius consanguinitatis. — 6.° Anonymi tractatus de astronomia. — 7.° Explicatio locorum Novi Testamenti, ubi de Jesu Christo. — 8.° Gennadii, Massiliensis, definitiones dogmatum ecclesiasticorum. — 9.° Expositio missae : authore anonymo. — 10.° Isidori, Hispalensis, de officiis ecclesiasticis fragmentum

Sancti Martialis Lemovicensis