Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease


Autoria(s): Ferrari, Renata; Tanni, Suzana E.; Caram, Laura M.O.; Corrêa, Corina; Corrêa, Camila Renata; Godoy, Irma de
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

20/02/2013

Resumo

Background: Past studies have shown that mean values of Interleukin-6 (IL-6) and C-reactive protein (CRP) do not change significantly in COPD patients over a one-year period. However, longer period follow-up studies are still lacking. Thus, the aim of this study is to evaluate plasma CRP and IL-6 concentration over three years in COPD patients and to test the association between these inflammatory mediators and disease outcome markers. Methods: A cohort of 77 outpatients with stable COPD was evaluated at baseline, and 53 (mean FEV1, 56% predicted) were included in the prospective study. We evaluated Interleukin-6 (IL-6), C-reactive protein (CRP), six-minute walking distance (6MWD), and body mass index (BMI) at baseline and after three years. Plasma concentration of IL-6 was measured by high sensitivity ELISA, and CRP was obtained by high sensitivity particle-enhanced immunonephelometry. Results: IL-6 increased significantly after 3 years compared to baseline measurements [0.8 (0.5-1.3) vs 2.4 (1.3-4.4) pg/ml; p < 0.001] and was associated with worse 6MWD performance. In the Cox regression, increased IL-6 at baseline was associated with mortality [Hazard Ratio (95% CI) = 2.68 (0.13, 1.84); p = 0.02]. CRP mean values did not change [5 (1.6-7.9) vs 4.7 (1.7-10) pg/L; p = 0.84], although eleven patients (21%) presented with changes >3 mg/L in CRP after 3 years. Conclusions: The systemic inflammatory process, evaluated by IL-6, seems to be persistent, progressive and associated with mortality and worse physical performance in COPD patients. Trial registration: No.:NCT00605540. © 2013 Ferrari et al; licensee BioMed Central Ltd.

Identificador

http://dx.doi.org/10.1186/1465-9921-14-24

Respiratory Research, v. 14, n. 1, 2013.

1465-9921

1465-993X

http://hdl.handle.net/11449/74616

10.1186/1465-9921-14-24

WOS:000317734600001

2-s2.0-84873948021

2-s2.0-84873948021.pdf

Idioma(s)

eng

Relação

Respiratory Research

Direitos

openAccess

Palavras-Chave #Biomarkers #Chronic Obstructive Pulmonary Disease #Exercise #Inflammation #C reactive protein #interleukin 6 #biological marker #IL6 protein, human #adult #body mass #chronic obstructive lung disease #clinical evaluation #controlled study #disease association #disease duration #disease exacerbation #enzyme linked immunosorbent assay #exercise tolerance #female #follow up #human #major clinical study #male #mortality #nutritional status #outcome assessment #prediction #proportional hazards model #prospective study #protein blood level #walking #blood #Brazil #exercise test #middle aged #prevalence #risk factor #statistics #survival #survival rate #Biological Markers #C-Reactive Protein #Exercise Test #Exercise Tolerance #Female #Follow-Up Studies #Humans #Interleukin-6 #Male #Middle Aged #Prevalence #Pulmonary Disease, Chronic Obstructive #Risk Factors #Survival Analysis #Survival Rate
Tipo

info:eu-repo/semantics/article