In Memoriam: Herbert E Wright Jr 1917-2015

Herbert E Wright Jr was one of the foremost Quaternary scientists of the last century. He made wide ranging contributions to our understanding of the late-Quaternary of North and South America, Europe, Asia and Africa. This was based largely on reconstructing palaeoenvironments from lake sediments and included the important implications for glacial, vegetational, fire and climatic history, geoarchaeology and conservation. Many of his inter-disciplinary research projects involved fieldwork with his graduate students and co-workers from the University of Minnesota where he created and led the renowned Limnological Research Center. Perhaps his most outstanding contribution was as an instigator of the Co-operative Holocene Mapping Project (COHMAP). This triggered a paradigm shift in Holocene climatic research involving the comparison of climate-model simulations of past climates with palaeoclimatic data.

“Y…a mí me parece que es porque los niños ganaron" : relato y análisis de una experiencia pedagógica

Este relato presenta una experiencia pedagógica desarrollada con un grupo de niños de 2º ciclo, en proceso de alfabetización, que asisten a una escuela de recuperación - modalidad de Educación Especial - de la Ciudad Autónoma de Buenos Aires. Se analizan momentos clave de la experiencia a partir de los aportes de las teorías genéticas del desarrollo en el marco de la perspectiva interdisciplinaria (Elichiry, 2009). Se interpela el uso de categorías que históricamente se han utilizado y aún se utilizan para describir a los niños que habitan nuestras escuelas y se propone una reflexión sobre prácticas de enseñanza, de manera de ofertar entornos favorecedores que promuevan las potencialidades de los alumnos. El trabajo se inscribe en el marco de la documentación narrativa de experiencias pedagógicas que posibilita poner a prueba “lo que sucede" y “lo que nos sucede" en el trabajo diario, recuperando y reconstruyendo las voces de los diferentes actores (Suarez, 2007).

Probability sampling protocol of classification maps from spaceborne/airborne image

To deliver sample estimates provided with the necessary probability foundation to permit generalization from the sample data subset to the whole target population being sampled, probability sampling strategies are required to satisfy three necessary not sufficient conditions: (i) All inclusion probabilities be greater than zero in the target population to be sampled. If some sampling units have an inclusion probability of zero, then a map accuracy assessment does not represent the entire target region depicted in the map to be assessed. (ii) The inclusion probabilities must be: (a) knowable for nonsampled units and (b) known for those units selected in the sample: since the inclusion probability determines the weight attached to each sampling unit in the accuracy estimation formulas, if the inclusion probabilities are unknown, so are the estimation weights. This original work presents a novel (to the best of these authors' knowledge, the first) probability sampling protocol for quality assessment and comparison of thematic maps generated from spaceborne/airborne Very High Resolution (VHR) images, where: (I) an original Categorical Variable Pair Similarity Index (CVPSI, proposed in two different formulations) is estimated as a fuzzy degree of match between a reference and a test semantic vocabulary, which may not coincide, and (II) both symbolic pixel-based thematic quality indicators (TQIs) and sub-symbolic object-based spatial quality indicators (SQIs) are estimated with a degree of uncertainty in measurement in compliance with the well-known Quality Assurance Framework for Earth Observation (QA4EO) guidelines. Like a decision-tree, any protocol (guidelines for best practice) comprises a set of rules, equivalent to structural knowledge, and an order of presentation of the rule set, known as procedural knowledge. The combination of these two levels of knowledge makes an original protocol worth more than the sum of its parts. The several degrees of novelty of the proposed probability sampling protocol are highlighted in this paper, at the levels of understanding of both structural and procedural knowledge, in comparison with related multi-disciplinary works selected from the existing literature. In the experimental session the proposed protocol is tested for accuracy validation of preliminary classification maps automatically generated by the Satellite Image Automatic MapperT (SIAMT) software product from two WorldView-2 images and one QuickBird-2 image provided by DigitalGlobe for testing purposes. In these experiments, collected TQIs and SQIs are statistically valid, statistically significant, consistent across maps and in agreement with theoretical expectations, visual (qualitative) evidence and quantitative quality indexes of operativeness (OQIs) claimed for SIAMT by related papers. As a subsidiary conclusion, the statistically consistent and statistically significant accuracy validation of the SIAMT pre-classification maps proposed in this contribution, together with OQIs claimed for SIAMT by related works, make the operational (automatic, accurate, near real-time, robust, scalable) SIAMT software product eligible for opening up new inter-disciplinary research and market opportunities in accordance with the visionary goal of the Global Earth Observation System of Systems (GEOSS) initiative and the QA4EO international guidelines.

Development and implementation of an air quality integrated assessment modelling system for the Iberian Peninsula

La mejora de la calidad del aire es una tarea eminentemente interdisciplinaria. Dada la gran variedad de ciencias y partes involucradas, dicha mejora requiere de herramientas de evaluación simples y completamente integradas. La modelización para la evaluación integrada (integrated assessment modeling) ha demostrado ser una solución adecuada para la descripción de los sistemas de contaminación atmosférica puesto que considera cada una de las etapas involucradas: emisiones, química y dispersión atmosférica, impactos ambientales asociados y potencial de disminución. Varios modelos de evaluación integrada ya están disponibles a escala continental, cubriendo cada una de las etapas antesmencionadas, siendo el modelo GAINS (Greenhouse Gas and Air Pollution Interactions and Synergies) el más reconocido y usado en el contexto europeo de toma de decisiones medioambientales. Sin embargo, el manejo de la calidad del aire a escala nacional/regional dentro del marco de la evaluación integrada es deseable. Esto sin embargo, no se lleva a cabo de manera satisfactoria con modelos a escala europea debido a la falta de resolución espacial o de detalle en los datos auxiliares, principalmente los inventarios de emisión y los patrones meteorológicos, entre otros. El objetivo de esta tesis es presentar los desarrollos en el diseño y aplicación de un modelo de evaluación integrada especialmente concebido para España y Portugal. El modelo AERIS (Atmospheric Evaluation and Research Integrated system for Spain) es capaz de cuantificar perfiles de concentración para varios contaminantes (NO2, SO2, PM10, PM2,5, NH3 y O3), el depósito atmosférico de especies de azufre y nitrógeno así como sus impactos en cultivos, vegetación, ecosistemas y salud como respuesta a cambios porcentuales en las emisiones de sectores relevantes. La versión actual de AERIS considera 20 sectores de emisión, ya sea equivalentes a sectores individuales SNAP o macrosectores, cuya contribución a los niveles de calidad del aire, depósito e impactos han sido modelados a través de matrices fuentereceptor (SRMs). Estas matrices son constantes de proporcionalidad que relacionan cambios en emisiones con diferentes indicadores de calidad del aire y han sido obtenidas a través de parametrizaciones estadísticas de un modelo de calidad del aire (AQM). Para el caso concreto de AERIS, su modelo de calidad del aire “de origen” consistió en el modelo WRF para la meteorología y en el modelo CMAQ para los procesos químico-atmosféricos. La cuantificación del depósito atmosférico, de los impactos en ecosistemas, cultivos, vegetación y salud humana se ha realizado siguiendo las metodologías estándar establecidas bajo los marcos internacionales de negociación, tales como CLRTAP. La estructura de programación está basada en MATLAB®, permitiendo gran compatibilidad con software típico de escritorio comoMicrosoft Excel® o ArcGIS®. En relación con los niveles de calidad del aire, AERIS es capaz de proveer datos de media anual y media mensual, así como el 19o valor horario más alto paraNO2, el 25o valor horario y el 4o valor diario más altos para SO2, el 36o valor diario más alto para PM10, el 26o valor octohorario más alto, SOMO35 y AOT40 para O3. En relación al depósito atmosférico, el depósito acumulado anual por unidad de area de especies de nitrógeno oxidado y reducido al igual que de azufre pueden ser determinados. Cuando los valores anteriormente mencionados se relacionan con características del dominio modelado tales como uso de suelo, cubiertas vegetales y forestales, censos poblacionales o estudios epidemiológicos, un gran número de impactos puede ser calculado. Centrándose en los impactos a ecosistemas y suelos, AERIS es capaz de estimar las superaciones de cargas críticas y las superaciones medias acumuladas para especies de nitrógeno y azufre. Los daños a bosques se calculan como una superación de los niveles críticos de NO2 y SO2 establecidos. Además, AERIS es capaz de cuantificar daños causados por O3 y SO2 en vid, maíz, patata, arroz, girasol, tabaco, tomate, sandía y trigo. Los impactos en salud humana han sido modelados como consecuencia de la exposición a PM2,5 y O3 y cuantificados como pérdidas en la esperanza de vida estadística e indicadores de mortalidad prematura. La exactitud del modelo de evaluación integrada ha sido contrastada estadísticamente con los resultados obtenidos por el modelo de calidad del aire convencional, exhibiendo en la mayoría de los casos un buen nivel de correspondencia. Debido a que la cuantificación de los impactos no es llevada a cabo directamente por el modelo de calidad del aire, un análisis de credibilidad ha sido realizado mediante la comparación de los resultados de AERIS con los de GAINS para un escenario de emisiones determinado. El análisis reveló un buen nivel de correspondencia en las medias y en las distribuciones probabilísticas de los conjuntos de datos. Las pruebas de verificación que fueron aplicadas a AERIS sugieren que los resultados son suficientemente consistentes para ser considerados como razonables y realistas. En conclusión, la principal motivación para la creación del modelo fue el producir una herramienta confiable y a la vez simple para el soporte de las partes involucradas en la toma de decisiones, de cara a analizar diferentes escenarios “y si” con un bajo coste computacional. La interacción con políticos y otros actores dictó encontrar un compromiso entre la complejidad del modeladomedioambiental con el carácter conciso de las políticas, siendo esto algo que AERIS refleja en sus estructuras conceptual y computacional. Finalmente, cabe decir que AERIS ha sido creado para su uso exclusivo dentro de un marco de evaluación y de ninguna manera debe ser considerado como un sustituto de los modelos de calidad del aire ordinarios. ABSTRACT Improving air quality is an eminently inter-disciplinary task. The wide variety of sciences and stakeholders that are involved call for having simple yet fully-integrated and reliable evaluation tools available. Integrated AssessmentModeling has proved to be a suitable solution for the description of air pollution systems due to the fact that it considers each of the involved stages: emissions, atmospheric chemistry, dispersion, environmental impacts and abatement potentials. Some integrated assessment models are available at European scale that cover each of the before mentioned stages, being the Greenhouse Gas and Air Pollution Interactions and Synergies (GAINS) model the most recognized and widely-used within a European policy-making context. However, addressing air quality at the national/regional scale under an integrated assessment framework is desirable. To do so, European-scale models do not provide enough spatial resolution or detail in their ancillary data sources, mainly emission inventories and local meteorology patterns as well as associated results. The objective of this dissertation is to present the developments in the design and application of an Integrated Assessment Model especially conceived for Spain and Portugal. The Atmospheric Evaluation and Research Integrated system for Spain (AERIS) is able to quantify concentration profiles for several pollutants (NO2, SO2, PM10, PM2.5, NH3 and O3), the atmospheric deposition of sulfur and nitrogen species and their related impacts on crops, vegetation, ecosystems and health as a response to percentual changes in the emissions of relevant sectors. The current version of AERIS considers 20 emission sectors, either corresponding to individual SNAP sectors or macrosectors, whose contribution to air quality levels, deposition and impacts have been modeled through the use of source-receptor matrices (SRMs). Thesematrices are proportionality constants that relate emission changes with different air quality indicators and have been derived through statistical parameterizations of an air qualitymodeling system (AQM). For the concrete case of AERIS, its parent AQM relied on the WRF model for meteorology and on the CMAQ model for atmospheric chemical processes. The quantification of atmospheric deposition, impacts on ecosystems, crops, vegetation and human health has been carried out following the standard methodologies established under international negotiation frameworks such as CLRTAP. The programming structure isMATLAB ® -based, allowing great compatibility with typical software such as Microsoft Excel ® or ArcGIS ® Regarding air quality levels, AERIS is able to provide mean annual andmean monthly concentration values, as well as the indicators established in Directive 2008/50/EC, namely the 19th highest hourly value for NO2, the 25th highest daily value and the 4th highest hourly value for SO2, the 36th highest daily value of PM10, the 26th highest maximum 8-hour daily value, SOMO35 and AOT40 for O3. Regarding atmospheric deposition, the annual accumulated deposition per unit of area of species of oxidized and reduced nitrogen as well as sulfur can be estimated. When relating the before mentioned values with specific characteristics of the modeling domain such as land use, forest and crops covers, population counts and epidemiological studies, a wide array of impacts can be calculated. When focusing on impacts on ecosystems and soils, AERIS is able to estimate critical load exceedances and accumulated average exceedances for nitrogen and sulfur species. Damage on forests is estimated as an exceedance of established critical levels of NO2 and SO2. Additionally, AERIS is able to quantify damage caused by O3 and SO2 on grapes, maize, potato, rice, sunflower, tobacco, tomato, watermelon and wheat. Impacts on human health aremodeled as a consequence of exposure to PM2.5 and O3 and quantified as losses in statistical life expectancy and premature mortality indicators. The accuracy of the IAM has been tested by statistically contrasting the obtained results with those yielded by the conventional AQM, exhibiting in most cases a good agreement level. Due to the fact that impacts cannot be directly produced by the AQM, a credibility analysis was carried out for the outputs of AERIS for a given emission scenario by comparing them through probability tests against the performance of GAINS for the same scenario. This analysis revealed a good correspondence in the mean behavior and the probabilistic distributions of the datasets. The verification tests that were applied to AERIS suggest that results are consistent enough to be credited as reasonable and realistic. In conclusion, the main reason thatmotivated the creation of this model was to produce a reliable yet simple screening tool that would provide decision and policy making support for different “what-if” scenarios at a low computing cost. The interaction with politicians and other stakeholders dictated that reconciling the complexity of modeling with the conciseness of policies should be reflected by AERIS in both, its conceptual and computational structures. It should be noted however, that AERIS has been created under a policy-driven framework and by no means should be considered as a substitute of the ordinary AQM.

A CONSTRUÇÃO DA IDENTIDADE DO SER PROFISSIONAL SECRETÁRIO NA REGIÃO DO GRANDE ABC

A região do Grande ABC é caracterizada por ser local que retrata, de forma singular, os conflitos, as mudanças e o impacto da globalização no País e no mundo. Diferentes setores, articulados, construíram o Planejamento Regional para a região, que se deparava com a flexibilização, o desemprego estrutural e a diminuição nos postos de trabalho das grandes montadoras, de indústrias de autopeças, entre outras, e descobriu caminhos de enfrentamento para o processo que avassalou o Brasil e o mundo. Isso exigiu a profissionalização de quem ocupava a função de Secretário, para atender ao perfil das multinacionais. A partir daí, o Secretariado Executivo vem se consolidando como uma profissão de caráter inteligente e intelectual, considerado como analítico-simbólico. O Secretário rompeu com seu antigo perfil, enfrentando a concorrência de profissionais de outras áreas, e desempenha hoje um papel de assessoria adjunta, gerenciando processos e facilitando tomadas de decisão. É um profissional de formação intelectual diferenciada, com competências técnicas, comportamentais e estratégicas. Assim, esta pesquisa teve como objetivo analisar o processo de construção da identidade do ser profissional Secretário na região do Grande ABC; levantar os espaços ocupados por esse profissional, através de mapeamento dos postos que ocupa, e construir uma linha do tempo dessa profissão na região. Para atender aos objetivos, foi utilizada pesquisa documental, a construção de uma linha do tempo e a história oral temática, procedendo-se à coleta e à análise dos dados de sete profissionais Secretários atuantes na região do Grande ABC. O diálogo interdisciplinar entre teoria e os discursos evidenciou que ainda existe um estereótipo cultural quanto à profissão nas organizações, mas há um respeito, ainda que velado, dos superiores e colegas, conquistado por sua persistência e profissionalização. Os resultados demonstram que a identidade do ser profissional Secretário é construída em suas experiências vividas no passado e no presente, o que lhe proporciona um esboço de valores individuais e profissionais que são revistos nas diversas organizações em que atuam ou atuaram e dentro do contexto regional estudado, gerando variações em suas identidades.(AU)

A CONSTRUÇÃO DA IDENTIDADE DO SER PROFISSIONAL SECRETÁRIO NA REGIÃO DO GRANDE ABC

A região do Grande ABC é caracterizada por ser local que retrata, de forma singular, os conflitos, as mudanças e o impacto da globalização no País e no mundo. Diferentes setores, articulados, construíram o Planejamento Regional para a região, que se deparava com a flexibilização, o desemprego estrutural e a diminuição nos postos de trabalho das grandes montadoras, de indústrias de autopeças, entre outras, e descobriu caminhos de enfrentamento para o processo que avassalou o Brasil e o mundo. Isso exigiu a profissionalização de quem ocupava a função de Secretário, para atender ao perfil das multinacionais. A partir daí, o Secretariado Executivo vem se consolidando como uma profissão de caráter inteligente e intelectual, considerado como analítico-simbólico. O Secretário rompeu com seu antigo perfil, enfrentando a concorrência de profissionais de outras áreas, e desempenha hoje um papel de assessoria adjunta, gerenciando processos e facilitando tomadas de decisão. É um profissional de formação intelectual diferenciada, com competências técnicas, comportamentais e estratégicas. Assim, esta pesquisa teve como objetivo analisar o processo de construção da identidade do ser profissional Secretário na região do Grande ABC; levantar os espaços ocupados por esse profissional, através de mapeamento dos postos que ocupa, e construir uma linha do tempo dessa profissão na região. Para atender aos objetivos, foi utilizada pesquisa documental, a construção de uma linha do tempo e a história oral temática, procedendo-se à coleta e à análise dos dados de sete profissionais Secretários atuantes na região do Grande ABC. O diálogo interdisciplinar entre teoria e os discursos evidenciou que ainda existe um estereótipo cultural quanto à profissão nas organizações, mas há um respeito, ainda que velado, dos superiores e colegas, conquistado por sua persistência e profissionalização. Os resultados demonstram que a identidade do ser profissional Secretário é construída em suas experiências vividas no passado e no presente, o que lhe proporciona um esboço de valores individuais e profissionais que são revistos nas diversas organizações em que atuam ou atuaram e dentro do contexto regional estudado, gerando variações em suas identidades.(AU)

A CONSTRUÇÃO DA IDENTIDADE DO SER PROFISSIONAL SECRETÁRIO NA REGIÃO DO GRANDE ABC

A região do Grande ABC é caracterizada por ser local que retrata, de forma singular, os conflitos, as mudanças e o impacto da globalização no País e no mundo. Diferentes setores, articulados, construíram o Planejamento Regional para a região, que se deparava com a flexibilização, o desemprego estrutural e a diminuição nos postos de trabalho das grandes montadoras, de indústrias de autopeças, entre outras, e descobriu caminhos de enfrentamento para o processo que avassalou o Brasil e o mundo. Isso exigiu a profissionalização de quem ocupava a função de Secretário, para atender ao perfil das multinacionais. A partir daí, o Secretariado Executivo vem se consolidando como uma profissão de caráter inteligente e intelectual, considerado como analítico-simbólico. O Secretário rompeu com seu antigo perfil, enfrentando a concorrência de profissionais de outras áreas, e desempenha hoje um papel de assessoria adjunta, gerenciando processos e facilitando tomadas de decisão. É um profissional de formação intelectual diferenciada, com competências técnicas, comportamentais e estratégicas. Assim, esta pesquisa teve como objetivo analisar o processo de construção da identidade do ser profissional Secretário na região do Grande ABC; levantar os espaços ocupados por esse profissional, através de mapeamento dos postos que ocupa, e construir uma linha do tempo dessa profissão na região. Para atender aos objetivos, foi utilizada pesquisa documental, a construção de uma linha do tempo e a história oral temática, procedendo-se à coleta e à análise dos dados de sete profissionais Secretários atuantes na região do Grande ABC. O diálogo interdisciplinar entre teoria e os discursos evidenciou que ainda existe um estereótipo cultural quanto à profissão nas organizações, mas há um respeito, ainda que velado, dos superiores e colegas, conquistado por sua persistência e profissionalização. Os resultados demonstram que a identidade do ser profissional Secretário é construída em suas experiências vividas no passado e no presente, o que lhe proporciona um esboço de valores individuais e profissionais que são revistos nas diversas organizações em que atuam ou atuaram e dentro do contexto regional estudado, gerando variações em suas identidades.(AU)

Designing and managing collaborative enterprises in the automotive industry

This paper presents the findings of a recently completed research project. It sheds light upon the appropriate governance of inter-firm relationships, in order to achieve competitive success for the whole partnership and its individual members. An exploratory study in the German automotive industry using inductive Grounded Theory was conducted, in order to form a set of propositions that were then validated. The research has resulted in the consolidation of these propositions into a novel concept termed Collaborative Enterprise Governance, which draws on an inter-disciplinary body of knowledge. The core of the concept is a competence based contingency framework that helps enterprise managers in selecting the most appropriate governance strategy (i.e. enterprise structure) for an inter-firm relationships within automotive supply networks (i.e. enterprises), depending on various exogenous and endogenous factors.

The language of business interviewing:a study in cross-cultural communication

The study examines the concept of cultural determinism in relation to the business interview, analysing differences in language use between English, French and West German native speakers. The approach is multi- and inter-disciplinary combining linguistic and business research methodologies. An analytical model based on pragmatic and speech act theory is developed to analyse language use in telephone market research interviews. The model aims to evaluate behavioural differences between English, French and West German respondents in the interview situation. The empirical research is based on a telephone survey of industrial managers, conducted in the three countries in the national language of each country. The telephone interviews are transcribed and compared across languages to discover how managers from each country use different language functions to reply to questions and requests. These differences are assessed in terms of specific cultural parameters: politeness, self-assuredness and fullness of response. Empirical and descriptive studies of national character are compared with the survey results, providing the basis for an evaluation of the relationship between management culture and national culture on a contrastive and comparative cross-cultural basis. The project conclusions focus on the implications of the findings both for business interviewing and for language teaching.

A dynamic model for the activated sludge treatment of coke oven effluents

This is an Inter-Disciplinary Higher Degree (IHD) thesis about Water Pollution Control in the Iron and Steel Industry. After examining the compositions, and various treatment methods, for the major effluent streams from a typical Integrated Iron and Steel works, it was decided to concentrate investigative work on the activated-sludge treatment of coke-oven effluents. A mathematical model of this process was developed in an attempt to provide a tool for plant management that would enable improved performance, and enhanced control of Works Units. The model differs from conventional models in that allowance is made for the presence of two genera of microorganisms, each of which utilises a particular type of substrate as its energy source. Allowance is also made for the inhibitive effect of phenol on thiocyanate biodegradation, and for the self-toxicity of the bacteria when present in a high substrate concentration environment. The enumeration of the kinetic characteristics of the two groups of micro-organisms was shown to be of major importance. Laboratory experiments were instigated in an attempt to determine accurate values of these coefficients. The use of the Suspended Solids concentration was found to be too insensitive a measure of viable active mass. Other measures were investigated, and Adenosine Triphosphate concentration was chosen as the most effective measure of bacterial populations. Using this measure, a model was developed for phenol biodegradation from experimental results which implicated the possibility of storage of substate prior to metabolism. A model for thiocyanate biodegradation was also developed, although the experimental results indicate that much work is still required in this area.

Knowledge-based systems and engineering software

The work described was carried out as part of a collaborative Alvey software engineering project (project number SE057). The project collaborators were the Inter-Disciplinary Higher Degrees Scheme of the University of Aston in Birmingham, BIS Applied Systems Ltd. (BIS) and the British Steel Corporation. The aim of the project was to investigate the potential application of knowledge-based systems (KBSs) to the design of commercial data processing (DP) systems. The work was primarily concerned with BIS's Structured Systems Design (SSD) methodology for DP systems development and how users of this methodology could be supported using KBS tools. The problems encountered by users of SSD are discussed and potential forms of computer-based support for inexpert designers are identified. The architecture for a support environment for SSD is proposed based on the integration of KBS and non-KBS tools for individual design tasks within SSD - The Intellipse system. The Intellipse system has two modes of operation - Advisor and Designer. The design, implementation and user-evaluation of Advisor are discussed. The results of a Designer feasibility study, the aim of which was to analyse major design tasks in SSD to assess their suitability for KBS support, are reported. The potential role of KBS tools in the domain of database design is discussed. The project involved extensive knowledge engineering sessions with expert DP systems designers. Some practical lessons in relation to KBS development are derived from this experience. The nature of the expertise possessed by expert designers is discussed. The need for operational KBSs to be built to the same standards as other commercial and industrial software is identified. A comparison between current KBS and conventional DP systems development is made. On the basis of this analysis, a structured development method for KBSs in proposed - the POLITE model. Some initial results of applying this method to KBS development are discussed. Several areas for further research and development are identified.

Doctoral work in translation studies as an interdisciplinary mutual learning process:how a translator, teacher educator and linguistic typologist worked together

The focus of this paper is on the doctoral research training experienced by one of the authors and the ways in which the diverse linguistic and disciplinary perspectives of her two supervisors (co-authors of this paper) mediated the completion of her study. The doctoral candidate is a professional translator/interpreter and translation teacher. The paper describes why and how she identified her research area and then focused on the major research questions in collaboration with her two supervisors, who brought their differing perspectives from the field of linguistics to this translation research, even though they are not translators by profession or disciplinary background and do not speak Korean. In addition, the discussion considers the focus, purpose and theoretical orientation of the research itself (which addressed questions of readability in translated English-Korean texts through detailed analysis of a corpus and implications for professional translator training) as well as the supervisory and conceptual processes and practices involved. The authors contend that doctoral research of this kind can be seen as a mutual learning process and that inter-disciplinary research can make a contribution not only to the development of rigorous research in the field of translation studies but also to the other disciplinary fields involved.

The relative influence of organisational commitment and job-satisfaction on service quality of customer-contact employees in banking call centres

An inter-disciplinary approach is adopted to provide a deeper understanding of the human resource-service quality relationship. The paper tests the relationships organisational commitment and job satisfaction have with service quality of customer-contact employees. Hypotheses are constructed by reviewing literature in the areas of human resource management and services marketing. A study comprising 342 employees was conducted in four telephone call centres of a major UK retail bank. Investigates how different forms of organisational commitment and job satisfaction influence the service quality delivered by contact employees. Findings indicate that job satisfaction and organisational commitment of employees have a significant impact on service quality delivered. The affective component of commitment was found to be more important than job satisfaction in determining service quality of customer-contact employees.

The role of time and risk preferences in adherence to physician advice on health behaviour change

Acknowledgements The Interdisciplinary Chronic Disease Collaboration (ICDC) is funded through the Alberta Heritage Foundation for Medical Research (AHFMR) Inter-disciplinary Team Grants Program. AHFMR is now Alberta Innovates – Health Solutions (AI-HS). The funding agreement ensured the authors’ independence in designing the study, interpreting the data, writing, and publishing the report. The Chief Scientist Office of the Scottish Government Health and Social Care Directorates funds HERU. The views expressed in this paper are those of the authors only and not those of the funding bodies.

Functional Evaluation of Causal Mutations Identified in Human Genetic Studies

Human genetics has been experiencing a wave of genetic discoveries thanks to the development of several technologies, such as genome-wide association studies (GWAS), whole-exome sequencing, and whole genome sequencing. Despite the massive genetic discoveries of new variants associated with human diseases, several key challenges emerge following the genetic discovery. GWAS is known to be good at identifying the locus associated with the patient phenotype. However, the actually causal variants responsible for the phenotype are often elusive. Another challenge in human genetics is that even the causal mutations are already known, the underlying biological effect might remain largely ambiguous. Functional evaluation plays a key role to solve these key challenges in human genetics both to identify causal variants responsible for the phenotype, and to further develop the biological insights from the disease-causing mutations.

We adopted various methods to characterize the effects of variants identified in human genetic studies, including patient genetic and phenotypic data, RNA chemistry, molecular biology, virology, and multi-electrode array and primary neuronal culture systems. Chapter 1 is a broader introduction for the motivation and challenges for functional evaluation in human genetic studies, and the background of several genetics discoveries, such as hepatitis C treatment response, in which we performed functional characterization.

Chapter 2 focuses on the characterization of causal variants following the GWAS study for hepatitis C treatment response. We characterized a non-coding SNP (rs4803217) of IL28B (IFNL3) in high linkage disequilibrium (LD) with the discovery SNP identified in the GWAS. In this chapter, we used inter-disciplinary approaches to characterize rs4803217 on RNA structure, disease association, and protein translation.

Chapter 3 describes another avenue of functional characterization following GWAS focusing on the novel transcripts and proteins identified near the IL28B (IFNL3) locus. It has been recently speculated that this novel protein, which was named IFNL4, may affect the HCV treatment response and clearance. In this chapter, we used molecular biology, virology, and patient genetic and phenotypic data to further characterize and understand the biology of IFNL4. The efforts in chapter 2 and 3 provided new insights to the candidate causal variant(s) responsible for the GWAS for HCV treatment response, however, more evidence is still required to make claims for the exact causal roles of these variants for the GWAS association.

Chapter 4 aims to characterize a mutation already known to cause a disease (seizure) in a mouse model. We demonstrate the potential use of multi-electrode array (MEA) system for the functional characterization and drug testing on mutations found in neurological diseases, such as seizure. Functional characterization in neurological diseases is relatively challenging and available systematic tools are relatively limited. This chapter shows an exploratory research and example to establish a system for the broader use for functional characterization and translational opportunities for mutations found in neurological diseases.

Overall, this dissertation spans a range of challenges of functional evaluations in human genetics. It is expected that the functional characterization to understand human mutations will become more central in human genetics, because there are still many biological questions remaining to be answered after the explosion of human genetic discoveries. The recent advance in several technologies, including genome editing and pluripotent stem cells, is also expected to make new tools available for functional studies in human diseases.