Trois trios pour le clavecin ou piano-forte avec violon [et] violoncelle : oeuvre 41. Liv. II [Música notada]

ContieneSonata IV, op. 42Sonata VSonata VI.

Protective anti-tumor immunity induced by vaccination with recombinant adenoviruses encoding multiple tumor-associated cytotoxic T lymphocyte epitopes in a string-of-beads fashion

Vaccines harboring genes that encode functional oncoproteins are intrinsically hazardous, as their application may lead to introduction of these genes into normal cells and thereby to tumorigenesis. On the other hand, oncoproteins are especially attractive targets for immunotherapy of cancer, as their expression is generally required for tumor growth, making the arisal of tumor variants lacking these antigens unlikely. Using murine tumor models, we investigated the efficacy of polyepitope recombinant adenovirus (rAd) vaccines, which encode only the immunogenic T cell epitopes derived from several oncogenes, for the induction of protective anti-tumor immunity. We chose to employ rAd, as these are safe vectors that do not induce the side effects associated with, for example, vaccinia virus vaccines. A single polyepitope rAd was shown to give rise to presentation of both H-2 and human leukocyte antigen-restricted cytotoxic T lymphocyte (CTL) epitopes. Moreover, vaccination with a rAd encoding H-2-restricted CTL epitopes, derived from human adenovirus type 5 early region 1 and human papilloma virus type 16-induced tumors, elicited strong tumor-reactive CTL and protected the vaccinated animals against an otherwise lethal challenge with either of these tumors. The protection induced was superior compared with that obtained by vaccination with irradiated tumor cells. Thus, vaccination with polyepitope rAd is a powerful approach for the induction of protective anti-tumor immunity that allows simultaneous immunization against multiple tumor-associated T cell epitopes, restricted by various major histocompatibility complex haplotypes.

Cysteine String Protein Functions Directly in Regulated Exocytosis

Cysteine string protein (Csp) is essential for neurotransmitter release in Drosophila. It has been suggested that Csp functions by regulating the activity of presynaptic Ca2+ channels, thus controlling exocytosis. We have examined the effect of overexpressing Csp1 in PC12 cells, a neuroendocrine cell line. PC12 cell clones overexpressing Csp1 did not show any changes in morphology, granule number or distribution, or in the levels of other key exocytotic proteins. This overexpression did not affect intracellular Ca2+ signals after depolarization, suggesting that Csp1 has no gross effect on Ca2+ channel activity in PC12 cells. In contrast, we show that Csp1 overexpression enhances the extent of exocytosis from permeabilized cells in response to Ca2+ or GTPγS in the absence of Ca2+. Because secretion from permeabilized cells is not influenced by Ca2+ channel activity, this represents the first demonstration that Csp has a direct role in regulated exocytosis.

Quantisation of the bosonic string

In this work we review the basic principles of the theory of the relativistic bosonic string through the study of the action functionals of Nambu-Goto and Polyakov and the techniques required for their canonical, light-cone, and path-integral quantisation. For this purpose, we briefly review the main properties of the gauge symmetries and conformal field theory involved in the techniques studied.

Antitrust on the ‘G string’: What’s behind the Commission’s investigations of Google and Gazprom? CEPS Commentary, 15 June 2015

The past few weeks have marked a shift of gear in EU antitrust enforcement. First, the new European Commissioner for Competition Margarethe Vestager announced on April 15th that the Commission had sent a Statement of Objections to Google, arguing that the giant IT company abused its dominant position in the “general Internet search” market and also in the market for mobile operating systems, apps and services. Exactly one week later, she also sent a Statement of Objections to Gazprom for having created artificial barriers to trade between certain EU countries, preventing gas flows and competition across national borders and charging unfair prices in five Central and Eastern European countries. It is indeed hard to recall any other time in which two investigations of this size – both potentially leading to billions of euros of fines – have been launched almost simultaneously.

Basic principles of violin playing : a report prepared for the MENC Committee on String Instruction in the Schools

Mode of access: Internet.

The Star collection of instrumental music; arranged for wind and string instruments, and for the use of small bands and orchestras.

Contains arrangements of songs, selections from operas, dances, etc.

Trios for piano, violin, and violoncello.

Trio I in E♭, op. 1, no. 1.--Trio II in G, op. 1, no. 2.--Trio III in C minor, op. 1, no. 3.--Trio IV in B♭, op. 11.--Trio V in D, op. 70, no. 1.--Trio VI in E♭, op. 70, no. 2.--Trio VII in B♭, op. 97.

Sechs Trios f[ür] 2 Violinen u[nd] Violoncell (B[asso] c[ontinuo]) (1746) /

Each volume has score and 3 parts.

Streichquartett, op. 54 no. 1, G moll = [music] : String quartet, G minor /

Duration: ca.. 25 min.

Concerto grosso for string orchestra, no. 5, D major. [music] /

"Edition Eulenburg, no. 268".

Two sketches for string quartet based on Indian themes.

Mode of access: Internet.

Molly on the shore; Irish reel on 2 Cork reel tunes set for string four-some or string band.

For 2 violins, viola, violoncello.

String quartet (dedicated to his colleagues of the Philharmonic String Quartet) Op. 14.

Mode of access: Internet.