Indications of Conical Emission of Charged Hadrons at the BNL Relativistic Heavy Ion Collider

Three-particle azimuthal correlation measurements with a high transverse momentum trigger particle are reported for pp, d + Au, and Au + Au collisions at root(S)NN = 200 GeV by the STAR experiment. Dijet structures are observed in pp, d + Au and peripheral Au + Au collisions. An additional structure is observed in central Au + Au data, signaling conical emission of correlated charged hadrons. The conical emission angle is found to be theta = 1.37 +/- 0.02(stat)(-0.07)(+0.06)(syst), independent of p perpendicular to.

Beam-energy and system-size dependence of dynamical net charge fluctuations

We present measurements of net charge fluctuations in Au+Au collisions at s(NN)=19.6, 62.4, 130, and 200 GeV, Cu+Cu collisions at s(NN)=62.4 and 200 GeV, and p+p collisions at s=200 GeV using the dynamical net charge fluctuations measure nu(+-,dyn). We observe that the dynamical fluctuations are nonzero at all energies and exhibit a modest dependence on beam energy. A weak system size dependence is also observed. We examine the collision centrality dependence of the net charge fluctuations and find that dynamical net charge fluctuations violate 1/N(ch) scaling but display approximate 1/N(part) scaling. We also study the azimuthal and rapidity dependence of the net charge correlation strength and observe strong dependence on the azimuthal angular range and pseudorapidity widths integrated to measure the correlation.

Deletion of the Basement Membrane Heparan Sulfate Proteoglycan Type XVIII Collagen Causes Hypertriglyceridemia in Mice and Humans

Background: Lipoprotein lipase (Lpl) acts on triglyceride-rich lipoproteins in the peripheral circulation, liberating free fatty acids for energy metabolism or storage. This essential enzyme is synthesized in parenchymal cells of adipose tissue, heart, and skeletal muscle and migrates to the luminal side of the vascular endothelium where it acts upon circulating lipoproteins. Prior studies suggested that Lpl is immobilized by way of heparan sulfate proteoglycans on the endothelium, but genetically altering endothelial cell heparan sulfate had no effect on Lpl localization or lipolysis. The objective of this study was to determine if extracellular matrix proteoglycans affect Lpl distribution and triglyceride metabolism. Methods and Findings: We examined mutant mice defective in collagen XVIII (Col18), a heparan sulfate proteoglycan present in vascular basement membranes. Loss of Col18 reduces plasma levels of Lpl enzyme and activity, which results in mild fasting hypertriglyceridemia and diet-induced hyperchylomicronemia. Humans with Knobloch Syndrome caused by a null mutation in the vascular form of Col18 also present lower than normal plasma Lpl mass and activity and exhibit fasting hypertriglyceridemia. Conclusions: This is the first report demonstrating that Lpl presentation on the lumenal side of the endothelium depends on a basement membrane proteoglycan and demonstrates a previously unrecognized phenotype in patients lacking Col18.

Functional characterization of the Aspergillus nidulans methionine sulfoxide reductases (msrA and msrB)

Proteins are subject to modification by reactive oxygen species (ROS), and oxidation of specific amino acid residues can impair their biological function, leading to an alteration in cellular homeostasis. Sulfur-containing amino acids as methionine are the most vulnerable to oxidation by ROS, resulting in the formation of methionine sulfoxide [Met(O)] residues. This modification can be repaired by methionine sulfoxide reductases (Msr). Two distinct classes of these enzymes, MsrA and MsrB, which selectively reduce the two methionine sulfoxide epimers, methionine-S-sulfoxide and methionine-R-sulfoxide, respectively, are found in virtually all organisms. Here. we describe the homologs of methionine sulfoxide reductases, msrA and msrB, in the filamentous fungus Aspergillus nidulans. Both single and double inactivation mutants were viable, but more sensitive to oxidative stress agents as hydrogen peroxide, paraquat, and ultraviolet light. These strains also accumulated more carbonylated proteins when exposed to hydrogen peroxide indicating that MsrA and MsrB are active players in the protection of the cellular proteins from oxidative stress damage. (C) 2009 Elsevier Inc. All rights reserved.

Temporal and spatial distribution of anurans in the Pampa Region (Santa Maria, RS).

The present study aimed to determine the richness, occurrence constancy, reproductive modes. standard of abundance distribution, season of vocalization and to test correlation among climatic variables and activity of vocalization of anurans in a region of the Pampa Biome, Santa Maria, Rio Grande do Sul State. During the period of Novernber/2001 to October/2002 monthly collections were carried out utilizing the `survey at breeding site` method and examination of specimens kept in the Colecao Herpetologica do Setor de Zoologia da Universidade Federal de Santa Maria (ZUFSM). Tire Occurrence of 25 species of anurans was recorded. The anurofauna recorded represents 30% of the species known to Occur in Rio Grande do Sul, and comprises species generally associated with grasslands in this state and neighboring countries. Four reproductive modes were recorded: mode 1 (14 species: 58.3%) mode 11 and 30 (9 species` 37.5%) and mode 24 (1 species; 4.2%). The low diversification of reproductive modes is likely related to the homogeneity of the grassland habitat. Most species were constant or accessory in the Study area and the species abundance distribution patterns fit in the Broken Stick and Log-normal models. characterized by homogeneity of species abundance distribution. Most species showed great plasticity in habitat. but few were plastic in vocalization sites use. There was a weak positive correlation between species richness and precipitation. There was also a weak positive correlation between the abundance of species calling activity and maximum average temperatures. These correlations indicated that, in the study area. the abundance of calling males is more affected by the temperature, and species richness is more affected by precipitation, despite the fact that significantly higher species richness occurs during the hottest period of the year. These results showed that the climatological variables examined were not enough to explain the seasonal occurrence of species, thus the influence of other environmental variables merit to be tested in future studies.

Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection

Because CD4(+) T cells play a key role in aiding cellular immune responses, we wanted to assess whether increasing numbers of gene-engineered antigen-restricted CD4(+) T cells could enhance an antitumor response mediated by similarly gene-engineered CD8(+) T cells. In this study, we have used retroviral transduction to generate erbB2-reactive mouse T-cell populations composed of various proportions of CD4(+) and CD8(+) cells and then determined the antitumor reactivity of these mixtures. Gene-modified CD4(+) and CD8(+) T cells were shown to specifically secrete Tc1 (T cytotoxic-1) or Tc2 cytokines, proliferate, and lyse erbB2(+) tumor targets following antigen ligation in vitro. In adoptive transfer experiments using severe combined immunodeficient (scid) mice, we demonstrated that injection of equivalent numbers of antigen-specific engineered CD8(+) and CD4(+) T cells led to significant improvement in survival of mice bearing established lung metastases compared with transfer of unfractionated (largely CD8(+)) engineered T cells. Transferred CD4(+) T cells had to be antigen-specific (not just activated) and secrete interferon gamma (IFN-gamma) to potentiate the antitumor effect. Importantly, antitumor responses in these mice correlated with localization and persistence of gene-engineered T cells at the tumor site. Strikingly, mice that survived primary tumor challenge could reject a subsequent re-challenge. Overall, this study has highlighted the therapeutic potential of using combined transfer of antigen-specific gene-modified CD8(+) and CD4(+) T cells to significantly enhance T-cell adoptive transfer strategies for cancer therapy.

Surgical correction of Tessier number 0 cleft

The no. 0-14 cleft involves the midline of the face and cranium. It may include both a true and a false median cleft lip, with or without associated hypotelorism or hypertelorism. The no. 0 cleft is the most common of the craniofacial clefts. The objective of this study was to review the functional outcome and aesthetic results of the different techniques applied for each case. We have conducted a retrospective analysis of our series consisting of 32 cases of Tessier no. 0 cleft, in the period between 1997 and 2007. The patients were divided into 2 groups: those with the true median cleft and those with the false median cleft. The clinical findings, lip malformation, alveolar cleft, nasal appearance, septal involvement, associated deformities, and surgical procedures, were all reviewed. Holoprosencephaly was present in 9 cases, with a false median cleft upper lip and an absence of the premaxilla, septum, and columella (only 1 patient underwent lip and columella reconstruction at 2 years of age). Nine patients had an incomplete median cleft lip. Seven of these cases had associated median alveolar cleft, and 1 had an intranasal tumor, associated with lipoma of corpus callosum, characteristic of the Pai syndrome. Six cases of a bifid nose were seen, 2 of which were associated with an alveolar median cleft and hypertelorism. An isolated median alveolar cleft was present in 7 cases, 2 of them associated with a no. 30 cleft. This article presents a large series of Tessier no. 0 cleft, describing the differences between the false and the true median cleft. The surgical procedures may vary in relation to the type of involvement.

Mucosal and systemic anti-GAG immunity induced by neonatal immunization with HIV LAMP/gag DNA vaccine in mice

Vaccines capable of inducing mucosal immunity in early postnatal life until adulthood, protecting early sexual initiation, should be considered as strategies to vaccination against HIV. The HIV-1 GAG protein as a chimera with the lysosome-associated membrane protein (LAMP/gag), encoded by a DNA vaccine, is targeted to the endosomal/lysosomal compartment that contains class II MHC molecules and has been shown to be immunogenic in adult mice. Assuming that one such strategy could help to overcome the immunological immaturity in the early postnatal period, we have evaluated the systemic and mucosal immunogenicity of LAMP/gag immunization in neonatal mice. Intranasal immunization with LAMP/gag vaccine induced higher levels of sIgA and IgG anti-GAG antibodies in intestinal washes than did the gag vaccine. The combination of ID injections and the IN protocol with the chimeric vaccine promoted the increase of Ab levels in sera. Both vaccines induced splenic IFN-gamma- secreting cells against GAG peptide pools, as well as in vivo cytotoxic T lymphocyte (CTL) function, and increased the percentage of CD8+ T cells to the immunodominant class I peptide in gut and spleen. However, only the chimeric vaccine was able to enhance Th1/Th2 cytokine secretion in response to class II GAG peptide and to enhance IL-4-secreting cells against GAG peptides and p24 protein stimuli. Long-lasting humoral and cellular responses were detected until adult age, following neonatal immunization with the chimeric vaccine. The LAMP/gag vaccination was able to induce potent GAG-specific T and B cell immune responses in early life which are essential to elicit sustained and long-lasting mucosal and systemic humoral response. (C) 2010 Elsevier GmbH. All rights reserved.

Community-acquired Klebsiella pneumoniae bacteremia: Global differences in clinical patterns

We initiated a worldwide collaborative study, including 455 episodes of bacteremia, to elucidate the clinical patterns of Klebsiella pneumoniae. Historically, community-acquired pneumonia has been consistently associated with K. pneumoniae. Only four cases of community-acquired bacteremic K. pneumoniae pneumonia were seen in the 2-year study period in the United States, Argentina, Europe, or Australia; none were in alcoholics. In contrast, 53 cases of bacteremic K. pneumoniae pneumonia were observed in South Africa and Taiwan, where an association with alcoholism persisted (p=0.007). Twenty-five cases of a distinctive syndrome consisting of K. pneumoniae bacteremia in conjunction with community-acquired liver abscess, meningitis, or endophthalmitis were observed. A distinctive form of K. pneumoniae infection, often causing liver abscess, was identified, almost exclusively in Taiwan.

Viol??ncia contra a mulher: Lei Maria da Penha

Trata da Lei 11.340/2006, Lei Maria da Penha, que aborda a viol??ncia contra a mulher, viol??ncia dom??stica e viol??ncia familiar

G??nero, ra??a e espa??os de poder: o caso de Maria Ant??nia e Geraldo

O caso relata uma situa????o de promo????o em ??rg??o p??blico na qual dois funcion??rios ??? uma mulher negra e um homem branco - se mostram como candidatos ao cargo. S??o apresentados os perfis e habilidades profissionais dos dois servidores e, ao final, a decis??o tomada pelo Secret??rio, chefe de ambos. O estudo suscita discuss??es sobre pr??ticas discriminat??rias nos espa??os de poder das institui????es p??blicas e o papel do dirigente para combater ou difundir tais pr??ticas. Pode ser aplicado em cursos sobre lideran??a, gest??o de pessoas e ??tica e servi??o p??blico

Caso Maria Rita

O caso retrata conflito entre interesse coletivo e interesses individuais ao narrar o problema de uma moradora de baixa renda cuja casa, assim como as de outros moradores, dever?? ser removida para alargamento da avenida em que est?? localizada. A prefeitura prop??e uma indeniza????o aos moradores, mas confere prazo curto e op????es limitadas para o acordo. A moradora Maria Rita defronta-se com as consequ??ncias desfavor??veis da remo????o e sente-se pressionada a fechar um acordo. O caso vem sendo usado para ilustrar processo e t??cnicas de negocia????o, mas tamb??m pode ser aplicado em cursos sobre ??tica

Programa de melhoria do atendimento aos usu??rios do ambulat??rio Maria da Gl??ria

Este projeto refere-se ?? implementa????o de um conjunto de a????es destinadas ?? melhoria do atendimento e do ambiente f??sico do ambulat??rio Maria da Gl??ria, no Hospital Escola da Faculdade de Medicina do Tri??ngulo Mineiro, onde s??o atendidos diariamente mais de 1000 usu??rios. Neste mesmo ambiente convivem, aproximadamente, 600 pessoas entre professores, m??dicos, servidores e alunos. Foram realizados treinamentos espec??ficos para a humaniza????o do atendimento ao p??blico, e efetuadas mudan??as no padr??o de cor do Hospital, visando a cria????o de um ambiente mais agrad??vel. Pesquisa realizada junto aos usu??rios constata que o ??ndice de reclama????es do p??blico caiu em torno de 89%

O sentido de ser professor de Educação Física pelos “modos de ser sendo junto ao outro no mundo” perverso- fascista e democrático: a vivência real & no filme “Má Educação”

Quais são os “modos de ser sendo junto ao outro no mundo” professores de Educação Física da Prefeitura Municipal da Serra, ES, situados no que se denomina “real” e do professor de Educação Física padre José no filme “Má Educação” de Pedro Almodóvar situado no que se denomina “ficcional”? Que contribuições reflexivas podem trazer tais dados (analisados hermeneuticamente) para a Formação Continuada de professores de Educação Física [3]? OBJETIVO: Descrever os “modos de ser sendo junto ao outro no mundo” de [1] professores de Educação Física que trabalham em escolas públicas da Prefeitura Municipal da Serra, ES & do [2] padre José, personagem ficcional, professor de Educação Física no filme espanhol de 2004 “Má Educação” fazendo-o primeiramente através de uma pesquisa clássica (descritiva e hermenêutica) e depois uma literaturalizada e artística (hermenêutica). MARCO TEÓRICO: Trata-se de uma proposta discursiva (teórica) fenomenológica existencial de tendência marxista criada por Pinel; METODOLOGIA: Tratou-se de uma pesquisa fenomenológica existencial seguindo recomendações de Forghieri (2001) e Pinel (2006; 2012) - dentre outros. Os 29 professores de Educação Física foram provocados a mostrarem os seus “modos de ser sendo junto ao outro no mundo” do ofício professor de Educação Física. Depois essa mesma provocação foi feita ao personagem do filme. RESULTADOS & DISCUSSÃO: Descreveram-se [1] os “modos de ser sendo junto ao outro no mundo” dos professores de Educação Física na dimensão do real e do ficcional (cinema), e não se objetivou comparação por mais que isso tenha ficado evidente. Esses professores, em 2011/2012, experienciando uma democracia (im)perfeita brasileira [que tem até tendências neofascistas], mais ainda assim democracia - foram compreendidos sempre tomando um norte/ rumo/ direção em subjetivação pelos Guias de Sentido (GS – Pinel) democráticos reconhecimento [demanda do grupo em ser valorizado, reconhecido], em (im) potência [impotência e potencia possível de vir a lume sempre; a força e seu outro lado, a fragilidade de ser], afetando [o que se pratica e pensa/sente afeta a si mesmo, o outro e o mundo; o afetar produz mais subjetivações], sonhando [há demanda sempre de realizar projetos de vida; o projeto de ser sempre devir, em construção sempre; é uma precisão imprecisa], saudavelmente insano [o quão perto pode estar a experienciar a sanidade e a loucura e o quanto uma loucura é sã, pois criativa, inventiva, produtiva, opositora ao estabelecido] – eles mesmos junto ao outro no mundo tornando-se sujeitos. [2] Já o professor de Educação Física padre José da película almodovariana é um professor que de imediato pode ser apreendido como sólido e fixo na sua perversão fascista, ele como parte legitimadora do Estado espanhol de Franco, na década de 60, provavelmente em 1964, que é, na ficção, o espaço-tempo de José e suas ações pedagógicas e psicológicas (e de Educação Física). Mas não é apenas o fascismo que torna o fascista um criador de um cotidiano fascista, pois afinal, paralelamente a ele, no concreto e na ficção, haviam pessoas generosas, resistentes e resilientes que atuavam contra essas pressões quase na maioria das vezes advindas do todo (Estado) – eram pessoas democráticas individualmente e em pequenos e grandes grupos; eram exemplo de resistência contra o estabelecido pela ideologia dominante de então. José numa instituição fascista não conseguiu refletir e agir diferentemente, isto é, com mais saúde mental, escolhendo (na liberdade) ser fascista, ser menor (pouco) – optou não ser-mais. Finalmente os mesmos dados são apresentados em outra estética possível e sempre aberta, inconclusa, devir... As artes e a poesia (bem como a literatura) procuram cuidadosamente desvelar os “modos de ser junto ao outro no mundo” professor de Educação Física do mundo real e do imaginário (fílmico) desvelando muitas vezes indissociados. PÓSCRITO: O autor descreve as possíveis implicações do seu estudo para educação física pautado sempre em uma proposta de criar um discursso insubmisso focando na ideia de que uma pesquisa demanda narrar a vida, e literaturalizar a ciência.