Policy change to create supportive environments for physical activity and healthy eating : which options are the most realistic for local government?

The objective is to identify and test regulatory options for creating supportive environments for physical activity and healthy eating among local governments in Victoria, Australia. A literature review identified nine potential areas for policy intervention at local government level, including the walking environment and food policy. Discussion documents were drafted which summarized the public health evidence and legal framework for change in each area. Levels of support for particular interventions were identified through semi-structured interviews conducted with key informants from local government. We conducted 11 key informant interviews and found support for policy intervention to create environments supportive of physical activity but little support for policy changes to promote healthy eating. Participants reported lack of relevance and competing priorities as reasons for not supporting particular interventions. Promoting healthy eating environments was not considered a priority for local government above food safety. There is a real opportunity for action to prevent obesity at local government level (e.g. mandate the promotion of healthy eating environments). For local government to have a role in the promotion of healthy food environments, regulatory change and suitable funding are required.

Attacking anonymous web browsing at local area networks through browsing dynamics

The majority of current anonymous systems focus on improving anonymity at the network and website level in order to defend against traffic analysis attacks. However, the vulnerability of the connections between end users and the anonymous network do not attract any attention yet. For the first time, we reveal an end user browsing dynamics based attack on anonymous browsing systems at the LAN where the victim locates. This new attack method is fundamentally different from existing attack methodologies. In general, web surfers browse the web following certain patterns, such as requesting a web page, viewing it and requesting another page. The browsing pattern of a victim can be clearly observed by a local adversary when the victim is viewing the web without protection. Unfortunately, browsing dynamics releases rich information for attacking even though the web page content is encrypted. In order to show how a local eavesdropper can decipher which pages have been viewed with the knowledge of user browsing dynamics and the public information of a given website, we established a specific hidden Markov model to represent browsing dynamics for the website. By using this model, we can then identify the optimal of the accessed pages using the Viterbi algorithm. In order to confirm the effectiveness of the revealed attack method, we have conducted extensive experiments on a real data set. The results demonstrated that the attack accuracy can be more than 80%. A few possible counter-attack strategies are discussed at the end of the paper.

The idea of creative reuse urbanism — the roles of local creativities in culturally sustainable place-making : Tokyo, Bangkok, Singapore

Gentrification is a part of the process of urban renewal which generates significant, and often negative, social impact on existing neighborhood structures, as it tends to be driven predominantly by simple rules of an economy and imperatives of a globalized, "free" market, insensitive to the subtleties of local culture and values. This idea of creative reuse urbanism questions the necessity of extreme, damaging impacts of gentrification. It argues for an urbanism which is culturally rooted, locally related and deeply contextualized. This chapter shows that such urbanism is not just another utopian concept, but a living reality. Examples from Tokyo, Bangkok and Singapore demonstrate a rich spectrum of possibilities, a kind of pre-gentrification which has the capacity to get involved in creative reuse and recycling of existing stocks and inheritances, thus becoming a positive contributor to sustainable urban regeneration. Presented reused buildings and introduced activities are active ingredients in larger process of place-making in the three cities. Tokyo, Bangkok and Singapore were observed through the lenses of sustainability and cultural difference, with main focus on intersections between the practices of reuse and local creativity.

Dynamic threshold determination by local and global edge evaluation

In this paper we consider two methods for automatically determining values for thresholding edge maps. In contrast to most other related work they are based on the figural rather than statistical properties of the edges. The first approach applies a local edge evaluation measure based on edge continuity and edge thinness to determine the threshold on edge magnitude. The second approach is more global and considers complete connected edge curves. The curves are mapped onto an edge curve length/average magnitude feature space, and a robust technique is developed to partition this feature space into true and false edge regions. A quantitative assessment of the results on synthetic data shows that the global method performs better than the local method. Furthermore, a qualitative assessment of its application to a variety of real images shows that it reliably produces good results.

Pharmacological and local toxicity studies of a liposomal formulation for the novel local anaesthetic ropivacaine

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Non-local interactions and the dynamics of dispersal in immature insects

A simple mathematical model is developed to explain the appearance of oscillations in the dispersal of larvae from the food source in experimental populations of certain species of blowflies. The life history of the immature stage in these flies, and in a number of other insects, is a system with two populations, one of larvae dispersing on the soil and the other of larvae that burrow in the soil to pupate. The observed oscillations in the horizontal distribution of buried pupae at the end of the dispersal process are hypothesized to be a consequence of larval crowding at a given point in the pupation substrate. It is assumed that dispersing larvae are capable of perceiving variations in density of larvae buried at a given point in the substrate of pupation, and that pupal density may influence pupation of dispersing larvae. The assumed interaction between dispersing larvae and the larvae that are burrowing to pupate is modeled using the concept of non-local effects. Numerical solutions of integro-partial differential equations developed to model density-dependent immature dispersal demonstrate that variation in the parameter that governs the non-local interaction between dispersing and buried larvae induces oscillations in the final horizontal distribution of pupae. (C) 1997 Academic Press Limited.

A presença da produção científica da Unesp de Botucatu na imprensa local: o caso do Diário da Serra

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A local-global scheme for tracking crack path in three-dimensional solids

This paper aims to contribute to the three-dimensional generalization of numerical prediction of crack propagation through the formulation of finite elements with embedded discontinuities. The analysis of crack propagation in two-dimensional problems yields lines of discontinuity that can be tracked in a relatively simple way through the sequential construction of straight line segments oriented according to the direction of failure within each finite element in the solid. In three-dimensional analysis, the construction of the discontinuity path is more complex because it requires the creation of plane surfaces within each element, which must be continuous between the elements. In the method proposed by Chaves (2003) the crack is determined by solving a problem analogous to the heat conduction problem, established from local failure orientations, based on the stress state of the mechanical problem. To minimize the computational effort, in this paper a new strategy is proposed whereby the analysis for tracking the discontinuity path is restricted to the domain formed by some elements near the crack surface that develops along the loading process. The proposed methodology is validated by performing three-dimensional analyses of basic problems of experimental fractures and comparing their results with those reported in the literature.

Local Injections of Adipose-Derived Mesenchymal Stem Cells Modulate Inflammation and Increase Angiogenesis Ameliorating the Dystrophic Phenotype in Dystrophin-Deficient Skeletal Muscle

The effects of adipose-derived mesenchymal stem cells (ADMSC) transplantation on degeneration, regeneration and skeletal muscle function were investigated in dystrophin-deficient mice (24-week-old). ADMSC transplantation improved muscle strength and, resistance to fatigue. An increase in fiber cross-sectional area and in the number of fibers with centralized nuclei and augment of myogenin content were observed. In ADMSC-treated muscles a decrease in muscle content of TNF-alpha, IL-6 and oxidative stress measured by Amplex(A (R)) reagent were observed. The level of TGF-beta 1 was lowered whereas that of VEGF, IL-10 and IL-4 were increased by ADMSC treatment. An increase in markers of macrophage M1 (CD11 and F4-80) and a decrease in T lymphocyte marker (CD3) and arginase-1 were also observed in ADMSCs-treated dystrophic muscle. No change was observed in iNOS expression. Increased phosphorylation of Akt, p70S6k and 4E-BP1 was found in dystrophic muscles treated with ADMSC. These results suggest that ADMSC transplantation modulates inflammation and improves muscle tissue regeneration, ameliorating the dystrophic phenotype in dystrophin-deficient mice.

A new local variety of Crepidomanes minutum (Hymenophyllaceae) in the Mascarene Archipelago (Indian Ocean) and a new record for Mauritius

Crepidomanes minutum (Hymenophyllaceae) is here identified and recorded from Mauritius for the first time. The Mauritian specimens, in addition to those of La Reunion observed at low to middle elevations, are easily distinguished from populations observed outside the Mascarene Archipelago by their dwarfed size and rarity of the stipe proliferation that usually characterizes this species. We thus describe a new variety in this species for the Mascarene Islands.

Recoupled separated-local-field experiments and applications to study intermediate-regime molecular motions

A specific separated-local-field NMR experiment, dubbed Dipolar-Chemical-Shift Correlation (DIPSHIFT) is frequently used to study molecular motions by probing reorientations through the changes in XH dipolar coupling and T-2. In systems where the coupling is weak or the reorientation angle is small, a recoupled variant of the DIPSHIFT experiment is applied, where the effective dipolar coupling is amplified by a REDOR-like pi-pulse train. However, a previously described constant-time variant of this experiment is not sensitive to the motion-induced T-2 effect, which precludes the observation of motions over a large range of rates ranging from hundreds of Hz to around a MHz. We present a DIPSHIFT implementation which amplifies the dipolar couplings and is still sensitive to T-2 effects. Spin dynamics simulations, analytical calculations and experiments demonstrate the sensitivity of the technique to molecular motions, and suggest the best experimental conditions to avoid imperfections. Furthermore, an in-depth theoretical analysis of the interplay of REDOR-like recoupling and proton decoupling based on Average-Hamiltonian Theory was performed, which allowed explaining the origin of many artifacts found in literature data. (C) 2012 Elsevier Inc. All rights reserved.