993 resultados para Hay, John, 1838-1905.


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(Original loaned to library for scanning)

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Background To date, no genome-wide association study (GWAS) has considered the combined phenotype of asthma with hay fever. Previous analyses of family data from the Tasmanian Longitudinal Health Study provide evidence that this phenotype has a stronger genetic cause than asthma without hay fever. Objective We sought to perform a GWAS of asthma with hay fever to identify variants associated with having both diseases. Methods We performed a meta-analysis of GWASs comparing persons with both physician-diagnosed asthma and hay fever (n = 6,685) with persons with neither disease (n = 14,091). Results At genome-wide significance, we identified 11 independent variants associated with the risk of having asthma with hay fever, including 2 associations reaching this level of significance with allergic disease for the first time: ZBTB10 (rs7009110; odds ratio [OR], 1.14; P = 4 × 10−9) and CLEC16A (rs62026376; OR, 1.17; P = 1 × 10−8). The rs62026376:C allele associated with increased asthma with hay fever risk has been found to be associated also with decreased expression of the nearby DEXI gene in monocytes. The 11 variants were associated with the risk of asthma and hay fever separately, but the estimated associations with the individual phenotypes were weaker than with the combined asthma with hay fever phenotype. A variant near LRRC32 was a stronger risk factor for hay fever than for asthma, whereas the reverse was observed for variants in/near GSDMA and TSLP. Single nucleotide polymorphisms with suggestive evidence for association with asthma with hay fever risk included rs41295115 near IL2RA (OR, 1.28; P = 5 × 10−7) and rs76043829 in TNS1 (OR, 1.23; P = 2 × 10−6). Conclusion By focusing on the combined phenotype of asthma with hay fever, variants associated with the risk of allergic disease can be identified with greater efficiency.

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The collection consists of 25 letters written by Benjamin between 1838 and 1881 on a variety of subjects, four Confederate notes and two bonds bearing his picture, miscellaneous items about Benjamin (1893-1942), nine issues of the Congressional globe with speeches by Benjamin, as well as separate copies of his printed speeches, and a photostatic copy of the "Diary of Events" (400 pp.) kept by Benjamin, the original of which is in the Library of Congress (1862-1864).

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Contains Board of Directors minutes (1903, 1907), Executive Committee minutes (1907), Removal Committee minutes (1903-1917), Annual Reports (1910, 1913), Monthly Reports (1901-1919), Monthly Bulletins (1914-1915), studies of those removed, Bressler's "The Removal Work, Including Galveston," and several papers relating to the IRO and immigration. Financial papers include a budget (1914), comparative per capita cost figures (1909-1922), audits (1915-1918), receipts and expenditures (1918-1922), investment records, bank balances (1907-1922), removal work cash book (1904-1911), office expenses cash account (1903-1906), and the financial records of other agencies working with the IRO (1906). Includes also removal case records of first the Jewish Agricultural Society (1899-1900), and then of the IRO (1901-1922) when it took over its work, family reunion case records (1901-1904), and the follow-up records of persons removed to various cities (1903-1914). Contains also the correspondence of traveling agents' contacts throughout the U.S. from 1905-1914, among them Stanley Bero, Henry P. Goldstein, Philip Seman, and Morris D. Waldman.

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United Empire Loyalist is an honour given to American Loyalists who came to British North America and the British Colonies to show their loyalty to King George III after the British defeat in the American Revolution. The Loyalists settled in Quebec, Ontario, Nova Scotia and modern day New Brunswick. The Colonel John Butler (Niagara) Branch (formerly the St. Catharines and District Branch) has origins which date as far back as 1898. A branch was organized in Virgil by Captain John D. Servos, but was unsuccessful. In 1905 there was another attempt to form a branch, but the war of 1914-1918 resulted in this branch becoming inactive. In 1914, an Act of Parliament incorporated the United Empire Loyalists’ Association of Canada. The St. Catharines and District Branch was formed in 1921. This branch remained active, and in 1992 they changed their name to The Colonel John Butler (Niagara) Branch. The Loyalists also have a strong focus on genealogy. All descendants are eligible to use UE (which stands for Unity of the Empire) after their names. source: http://www.coljohnbutleruel.com

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Demostrar la vinculación entre la educación y la democracia dentro del amplio pensamiento de John Dewey. Expone brevemente unas notas biográficas de John Dewey y explica las líneas directrices de su pensamiento filosófico-educativo del que procede su concepción democrática de la educación. 1) En educación Dewey distingue dos sentidos, uno amplio, como conjunto de procesos mediante los cuales un grupo transmite a sus miembros más pequeños aquellos ideales que aseguran la supervivencia del grupo. Y otro restringido, en el que separa dos aspectos, el psicológico y el social. El material del que ha de partir la educación son los instintos y las capacidades. La interpretación posterior de ellas sólo será posible cuando se tenga un amplio conocimiento de las condiciones sociales del individuo. 2) La educación olvidará toda pretendida finalidad trascendente, para poseer una finalidad inmanente, ya que la educación como tal, no posee un fin fuera de sí misma, fuera del preparar al hombre para la vida misma. Es decir, para poder aplicar sus capacidades en los distintos momentos de la vida. Una educación que se limite a preparar al hombre para un momento determinado, para un tiempo concreto, quedará rápidamente desfasada debido a la vertiginosa rapidez de desarrollo a nivel mundial. 3) Para Dewey, la educación presenta tres grandes características, que son, activa, científica y social. Con todo lo que estos tres términos significan en el pensamiento deweyano. 4) El hombre como ser social por naturaleza, necesita para desarrollarse como tal hombre, vivir asociado con sus semejantes. Esta necesidad no debe adquirir formas más o menos defectuosas de asociación, sino que ha de inclinarse por aquellas que presente mayor índice de cooperación e integración entre sus miembros, es decir, por la democracia. 5) Una democracia bien entendida, no simplemente como forma de gobierno basada en el sufragio universal, ni como libertad exterior plena de los individuos que la componen. La democracia, en el pensamiento de Dewey, es algo más, es esencialmente una cosmovisión, una forma detetrminada de concebir la vida y el mundo que implican toda una filosofía. 6) Hay que señalar el carácter dinámico de la democracia, al mismo tiempo que se la considera no como algo innato sino adquirido, desempeñando un importante papel para la libertad del hombre. 7) Fundamentada sólidamente la democracia en las capacidades de la naturaleza humana, ha de ser considerada como ideal moral a conseguir, difícil pero no utópico. Basta para ello hacer un estudio del recorrido histórico del hombre. Puesto que lo social y lo moral coinciden en Dewey, y la democracia es el ideal social también será el ideal moral. Democracia y educación han de estar íntimamente relacionadas, ya que ninguna de ellas puede llevarse a cabo plenamente si no es con la colaboración de la otra. La democracia sin la educación es insostenible y la educación sin la democracia mera coacción desde el exterior.

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