Human alveolar bone cell proliferation, expression of osteoblastic phenotype, and matrix mineralization on porous titanium produced by powder metallurgy

Objective: This study aimed at investigating the influence of the porous titanium (Ti) structure on the osteogenic cell behaviour. Materials and methods: Porous Ti discs were fabricated by the powder metallurgy process with the pore size typically between 50 and 400 mm and a porosity of 60%. Osteogenic cells obtained from human alveolar bone were cultured until subconfluence and subcultured on dense Ti (control) and porous Ti for periods of up to 17 days. Results: Cultures grown on porous Ti exhibited increased cell proliferation and total protein content, and lower levels of alkaline phosphatase (ALP) activity than on dense Ti. In general, gene expression of osteoblastic markers-runt-related transcription factor 2, collagen type I, alkaline phosphatase, bone morphogenetic protein-7, and osteocalcin was lower at day 7 and higher at day 17 in cultures grown on porous Ti compared with dense Ti, a finding consistent with the enhanced growth rate for such cultures. The amount of mineralized matrix was greater on porous Ti compared with the dense one. Conclusion: These results indicate that the porous Ti is an appropriate substrate for osteogenic cell adhesion, proliferation, and production of a mineralized matrix. Because of the three-dimensional environment it provides, porous Ti should be considered an advantageous substrate for promoting desirable implant surface-bone interactions.

Persistent Impairment of Testicular Histology and Sperm Motility in Adult Rats Treated with Cisplatin at Peri-Puberty

Cisplatin is one of the most widely used and effective chemotherapeutic agents for the treatment of several human malignancies. This study evaluated the effects of peri-pubertal cisplatin administration on several reproductive end-points and the reversibility of these effects in adulthood. Peri-pubertal Wistar male rats (45 days old) were divided into two groups: control (saline 0.9%) and cisplatin (1 mg/kg/day, 5 days/week, for 3 weeks, i.p.). The study was conducted in two steps and evaluations were performed at ages of 66 (post-pubertal age) and 140 (adult age) days on: (i) organ weights, serum gonadotropins and testosterone levels, sperm counts, motility and morphology, testicular histomorphometry, spermatogenesis kinetics, Sertoli cell number and in situ detection of apoptotic germ cells and (ii) sexual behaviour, fertility and intratesticular testosterone. At the end of cisplatin therapy, rats showed reductions in sperm production and reserves, sperm with progressive movement, tubular diameter, intratesticular testosterone and fertility potential, but increased numbers of TUNEL-positive seminiferous tubules, immotile sperm and pre-implantation losses compared with control. Moreover, cisplatin-treated post-pubertal rats displayed impaired testicular histopathology and sexual behaviour. Serum gonadotropins and testosterone levels, sperm morphology, spermatogenesis kinetics and Sertoli cell number were comparable between experimental groups at both ages. Alterations found in post-puberty were recovered at adulthood, except for sperm motility and damage to testicular histology. The persistence of these cisplatin effects, despite the unaltered fertility after natural mating in rats, may have implications for reproductive function of young boys undergoing cancer therapy, given the lower reproductive efficiency in human beings compared with rats.

Beyond methodological nationalism: The contribution of Robert E. Park to the history of intercultural communication

The legacy of nineteenth century social theory followed a ���nationalist��� model of society, assuming that analysis of social realities depends upon national boundaries, taking the nation-state as the primary unit of analysis, and developing the concept of methodological nationalism. This perspective regarded the nation-state as the natural - and even necessary - form of society in modernity. Thus, the constitution of large cities, at the end of the 19th century, through the intense flows of immigrants coming from diverse political and linguistic communities posed an enormous challenge to all social research. One of the most significant studies responding to this set of issues was The Immigrant Press and its Control, by Robert E. Park, one of the most prominent American sociologists of the first half of the 20th century. The Immigrant Press and its Control was part of a larger project entitled Americanization Studies: The Acculturation of Immigrant Group into American Society, funded by the Carnagie Corporation following World War I, taking as its goal to study the so-called ���Americanization methods��� during the 1920s. This paper revisits that particular work by Park to reveal how his detailed analysis of the role of the immigrant press overcame the limitations of methodological nationalism. By granting importance to language as a tool uniting each community and by showing how the strength of foreign languages expressed itself through the immigrant press, Park demonstrated that the latter produces a more ambivalent phenomenon than simply the assimilation of immigrants. On the one hand, the immigrant press served as a connecting force, driven by the desire to preserve the mother tongue and culture while at the same time awakening national sentiments that had, until then, remained diffuse. Yet, on the other hand, it facilitated the adjustment of immigrants to the American context. As a result, Park���s work contributes to our understanding of a particular liminal moment inherent within many intercultural contexts, the space between emigrant identity (emphasizing the country of origin) and immigrant identity (emphasizing the newly adopted country). His focus on the role played by media in the socialization of immigrant groups presaged later work on this subject by communication scholars. Focusing attention on Park���s research leads to other studies of the immigrant experience from the same period (e.g., Thomas & Znaniecki, The Polish Peasant in Europe and America), and also to insights on multi-presence and interculturality as significant but often overlooked phenomena in the study of immigrant socialization.

Revestimento de pisos em madeira para interiores

Disserta����o para a obten����o do grau de Mestre em Engenharia Civil

Cidadania p��s-nacional

In the midst of changes of the world political order fostered mainly by the very debated phenomenon of globalization, the nation-state is confronted with new paradigms regarding their identification with society. Citizenship, as was defined up to the latter decades of the last century, rooted in nationalist ideals that tend to condition it full exercise on exclusionary policies oriented criteria, is not consistent with the human needs of present days. One can observe, mainly in Europe with the establishment of European citizenship, certain propensity towards a relative detachment between nationality and citizenship. It is expected with the present research to expose some of the arguments invoked by those who defend the possibility of a post-national conception of citizenship, i.e., decoupled from the concept of nationality and national boundaries, in order to develop a grounding for a necessary re-articulation of this institute. This assumption is based mainly on the movement of universal human rights and the revaluation of human dignity, especially through participatory policies on citizenship and respect for ethnic and cultural diversity.

Discursos para a Independ��ncia: a Esc��cia e o Referendo de 2014

Disserta����o de mestrado em Ci��ncia Pol��tica

The Peace Processes in the Basque Country and Northern Ireland (1994-2006): a Comparative Approach

The peace process in Northern Ireland demonstrates that new sovereignty formulas need to be explored in order to meet the demands of the populations and territories in conflict. The profound transformation of the classic symbolic elements of the nation-state within the context of the European Union has greatly contributed to the prospects for a resolution of this old conflict. Today���s discussions are focused on the search for instruments of shared sovereignty that are adapted to a complex and plural social reality. This new approach for finding a solution to the Irish conflict is particularly relevant to the Basque debate about formulating creative and modern solutions to similar conflicts over identity and sovereignty. The notion of shared sovereignty implemented in Northern Ireland ���a formula for complex interdependent relations��� is of significant relevance to the broader international community and is likely to become an increasingly potent and transcendent model for conflict resolution and peace building.

White matter maturation reshapes structural connectivity in the late developing human brain.

From toddler to late teenager, the macroscopic pattern of axonal projections in the human brain remains largely unchanged while undergoing dramatic functional modifications that lead to network refinement. These functional modifications are mediated by increasing myelination and changes in axonal diameter and synaptic density, as well as changes in neurochemical mediators. Here we explore the contribution of white matter maturation to the development of connectivity between ages 2 and 18 y using high b-value diffusion MRI tractography and connectivity analysis. We measured changes in connection efficacy as the inverse of the average diffusivity along a fiber tract. We observed significant refinement in specific metrics of network topology, including a significant increase in node strength and efficiency along with a decrease in clustering. Major structural modules and hubs were in place by 2 y of age, and they continued to strengthen their profile during subsequent development. Recording resting-state functional MRI from a subset of subjects, we confirmed a positive correlation between structural and functional connectivity, and in addition observed that this relationship strengthened with age. Continuously increasing integration and decreasing segregation of structural connectivity with age suggests that network refinement mediated by white matter maturation promotes increased global efficiency. In addition, the strengthening of the correlation between structural and functional connectivity with age suggests that white matter connectivity in combination with other factors, such as differential modulation of axonal diameter and myelin thickness, that are partially captured by inverse average diffusivity, play an increasingly important role in creating brain-wide coherence and synchrony.

La naci��n de "los otros". Afrodescendientes porte��os y la construcci��n de la naci��n argentina a fines del siglo XIX

Investigaci��n producida a partir de una estancia en Buenos Aires en septiembre del 2007. Los procesos de consolidaci��n de las naciones-estado llevan consigo una serie de pol��ticas y pr��cticas que se focalizan en la construcci��n del "pueblo". Particularmente, la construcci��n del estado nacional argentino en el siglo XIX implic�� la definici��n -por parte de los grupos de poder- de un pueblo que cumpliera con las expectativas que se esperaban de una joven naci��n que se encaminaba hacia la civilizaci��n y el progreso, es decir, lo que en esa ��poca se correspond��a con un imaginario de pueblo blanco y europeo. As��, se propiciaron pol��ticas de erosi��n de quienes habitaban en el territorio nacional pero que no cumpl��an con aquellos mandatos, promoviendo su ���invisibilizaci��n���. Nosotros trabajamos una de estas comunidades erosionadas de la memoria y de la historia nacional argentina, la comunidad de afrodescendientes de Buenos Aires. El objeto de la investigaci��n que se est�� llevando a cabo es justamente el an��lisis de la poblaci��n afroargentina de Buenos Aires en las ��ltimas d��cadas del siglo XIX, un momento en que su presencia e historia estaban siendo negadas de los discursos y de las pr��cticas. Esta investigaci��n de corte hist��rico-antropol��gico necesita para su consecuci��n de un trabajo exhaustivo de archivos, objetivo principal de la beca de investigaci��n fuera de Catalu��a. Lo que se intent�� en el viaje fue encontrar y rescatar fuentes que permitieran entrever las din��micas de esta comunidad, sus formas de resistir y/o de negociar un estado nacional cada vez m��s fuerte y que sentaba las bases de lo que deb��a ser el ���pueblo argentino���.

Regulatory federalism in network industries

Report for the scientific sojourn at the UC Berkeley, USA, from march until july 2008. This document starts by surveying the literature on economic federalism and relating it to network industries. The insights and some new developments (which focus on the role of interjurisdictional externalities, multiple objectives and investment incentives) are used to analyze regulatory arrangements in telecommunications and energy in the EU and the US. In the long history of vertically integrated monopolies in telecommunications and energy, there was a historical trend to move regulation up in the vertical structure of government, at least form the local level to the state or nation-state level. This move alleviated the pressure on regulators to renege on the commitment not to expropriate sunk investments, although it did not eliminate the practice of taxation by regulation that was the result of multiple interest group action. Although central or federal policy making is more focused and especialized and makes it difficult for more interest groups to organize, it is not clear that under all conditions central powers will not be associated with underinvestment. When technology makes the introduction of competition in some segments possible, the possibilities for organizing the institutional architechture of regulation expand. The central level may focus on structural regulation and the location of behavioral regulation of the remaining monopolists may be resolved in a cooperative way or concentrated at the level where the relevant spillovers are internalized.

Which European Public Sphere? Normative Standards and Empirical Insights from Multilingual Switzerland

Since the beginning of the 1990s, the EU has been increasingly criticised for its democratic deficit, which is intrinsically linked to the absence of a public sphere at the European level. Whereas scholars consider the emergence of such a public sphere as a necessary requirement for the democratisation of the EU, they disagree on the conceptualisation and normative requirements for a meaningful public sphere at the European level. This article takes an empirical perspective and draws on the nation-state context of multilingual Switzerland to get insights into what a European public sphere might realistically look like. Based on a content analysis of the leading quality paper from each German- and French-speaking Switzerland by means of political claims analysis, it shows that three of the most often cited criteria for a European public sphere - horizontal openness and interconnectedness, shared meaning structures, and inclusiveness - are hardly met in the Swiss context. On this basis, it concludes that the normative barrier for finding a European public sphere might be unrealistically high and should be reconsidered.

Devenir charr��a dans l'Uruguay de l'apr��s dictature Entre m��moires fragment��es et �� sens du collectif ��. Une ethnographie audiovisuelle en collaboration.

Dans cette recherche, je me suis int��ress��e �� la gen��se des rapports sociaux construisant un collectif, dans l'articulation ��tre nomm�� et se nommer. En Uruguay, pays construit sur un imaginaire social dit "sans indiens", mon travail a consist�� �� essayer de comprendre les conditions historiques, sociales et politiques d'��mergence de collectifs de personnes r��clamant l'appartenance �� une identit�� autochtone pr��cise, l'identit�� charr��a. J'ai d��montr�� qu'il s'agit d'un processus en cours, individuel et collectif, qui a des temporalit��s diverses, qui a n��anmoins ��merg�� depuis une vingtaine d'ann��es, dans le contexte de la post-dictature et celui g��opolitique de l'autochtonie, dans une articulation local/global. L'analyse d��voile que l'identit�� charr��a est l'enjeu du rapport social qui est la lutte politique contre l'exclusion. Cette identit�� accompagne l'��tat-nation depuis sa fondation. Figure duelle, cette identit�� contient les traces des violences internes dans un continuum de m��moires fragment��es et entrelac��es. Elle est aussi promesse de devenir en tant que mod��le identitaire parvenu �� l'autonomie et conservant le �� sens du collectif ��. Anthropologue engag��e, me situant dans une perspective d��coloniale, j'ai propos�� aux personnes avec qui j'ai effectu�� cette recherche, d'��laborer une ethnographie collaborative, la cam��ra et les films se situant au coeur du terrain, compris comme espace relationnel de construction d'une connaissance partag��e. -- My research is based on the genesis of social relations which build up a collective, structured on being named and be named. My work in Uruguay, country built on a social construct called "without Indians", was to try to understand the historical, social and political conditions of emerging collectives. These claim the belonging of a precise indigenous identity, the charrua identity. I showed that the current process, which is individual and collective, with different temporalities, emerged twenty years ago, in the post-dictatorship context as well as the geopolitical context of indigeneity, in a local/global structure. The analysis reveals that the charrua identity is the stake of the social relation which is political fight against exclusion. This identity accompanies the nation state since its foundation. Dategory dual, this identity keeps the traces of the internal in the continuum of the fragmented and intertwined memories. This is also the becoming promise of an identity model, which reaches autonomy and keeps the "sense of collective". As an involved anthropologist, I worked from a decolonization point of view. I suggested that the people who went through the research with me, should work out a collaborative ethnography, the video camera and the movies being set in the middle of the fieldwork. This one is conceived as a relational space of construction of a shared knowledge.

2000 Consolidated Plan, November 1999

Report produced by Community Development, part of Iowa Economic Development

The Nationalism of stateless nations and Europe. The Catalan case

This paper analyzes how the ideas and concepts of Europe have developed in Catalonia, under the conditions of a decentralizing ���nation-state��� (Spain) on one hand, and the European integration process on the other. It analyzes the programmes, manifestations of political leaders, and political actions of the Catalan political parties, specially the nationalists, from the setting up of the Spanish state of autonomies (1977-1982) until today. The paper tries to show how, in multilevel governance, holistic and enthusiastic visions of an economically and political integrating Europe as a ���natural ally��� of a Catalan nationalism were partially replaced by more pragmatic and even more critical assessments.

Intertwined cultural demands of immigrants and minority nations

Since at least the last two decades of the 20th century, the normative debate on multiculturalism has been one-dimensional. It has deployed arguments related to cultural demands either linked to feminism and sub-cultural identities, immigration or national minorities. Little attention has been given to the relations between these dimensions, and how they effect each other in putting forward demands to the nation-state. The purpose of this article is to analyse the interaction between cultural demands of immigrants and minority nations. The basic objective of this paper is to give an overview of different reflections coming from three basic contributors: J. Carens, W. Kymlicka and R. Baub��ck.