Standardized evaluation of algorithms for computer-aided diagnosis of dementia based on structural MRI: The CADDementia challenge

Algorithms for computer-aided diagnosis of dementia based on structural MRI have demonstrated high performance in the literature, but are difficult to compare as different data sets and methodology were used for evaluation. In addition, it is unclear how the algorithms would perform on previously unseen data, and thus, how they would perform in clinical practice when there is no real opportunity to adapt the algorithm to the data at hand. To address these comparability, generalizability and clinical applicability issues, we organized a grand challenge that aimed to objectively compare algorithms based on a clinically representative multi-center data set. Using clinical practice as the starting point, the goal was to reproduce the clinical diagnosis. Therefore, we evaluated algorithms for multi-class classification of three diagnostic groups: patients with probable Alzheimer's disease, patients with mild cognitive impairment and healthy controls. The diagnosis based on clinical criteria was used as reference standard, as it was the best available reference despite its known limitations. For evaluation, a previously unseen test set was used consisting of 354 T1-weighted MRI scans with the diagnoses blinded. Fifteen research teams participated with a total of 29 algorithms. The algorithms were trained on a small training set (n = 30) and optionally on data from other sources (e.g., the Alzheimer's Disease Neuroimaging Initiative, the Australian Imaging Biomarkers and Lifestyle flagship study of aging). The best performing algorithm yielded an accuracy of 63.0% and an area under the receiver-operating-characteristic curve (AUC) of 78.8%. In general, the best performances were achieved using feature extraction based on voxel-based morphometry or a combination of features that included volume, cortical thickness, shape and intensity. The challenge is open for new submissions via the web-based framework: http://caddementia.grand-challenge.org.

A blog says I am here! : Encouraging reflection on performance-making and drama practice through blogs

This chapter considers the use of social software, in particular the blog, emerging from youth web-culture as a space for groups and individuals to reflect upon performance-making processes. lt focuses on the Drama Australia VINE project, launched at the beginning of 2006 through to its conclusion at the end of2007. The VINE project brought together groups of drama students within schools, universities and the broader community to make group performances based on a common theme. Using a multi-user blogging environment, vineblogs net, groups or individuals maintained blogs of their performance-making processes. This allowed the work to l¡e shared within the VINE project community and potentially with a worldwide audience. A case study was set up involving one class of students and their teachers who were involved in the VINE project and participants were asked to reflect and comment upon the performance-making and blogging experience. The chapter considers the challenge that we face as educators to find appropriate avenues to engage young people in reflection. It considers the ways in which students engage with technology that are ofter different from their teachers. The chapter goes on to discuss how blogs can contribute to the creation of a sense of individual or group identity and recognition. It asks, 'how do blogs encourage reflection upon performance-making processes and facilitate the creating of connections and the building of community between drama students and teachers across a range of settings?' Finally the chapter describes what we've learned about blogs in drama and considers where we go from here'

Learning in imbalanced relational data

Traditional learning techniques learn from flat data files with the assumption that each class has a similar number of examples. However, the majority of real-world data are stored as relational systems with imbalanced data distribution, where one class of data is over-represented as compared with other classes. We propose to extend a relational learning technique called Probabilistic Relational Models (PRMs) to deal with the imbalanced class problem. We address learning from imbalanced relational data using an ensemble of PRMs and propose a new model: the PRMs-IM. We show the performance of PRMs-IM on a real university relational database to identify students at risk.

Towards discovery of influence and personality traits through social link prediction

Estimation of a person’s influence and personality traits from social media data has many applications. We use social linkage criteria, such as number of followers and friends, as proxies to form corpora, from popular blogging site Livejournal, for examining two two-class classification problems: influential vs. non-influential, and extraversion vs. introversion. Classification is performed using automatically-derived psycholinguistic and mood-based features of a user’s textual messages. We experiment with three sub-corpora of 10000 users each, and present the most effective predictors for each category. The best classification result, at 80%, is achieved using psycholinguistic features; e.g., influentials are found to use more complex language, than non-influentials, and use more leisure-related terms.

Detection of cross-channel anomalies from multiple data channels

We identify and formulate a novel problem: crosschannel anomaly detection from multiple data channels. Cross channel anomalies are common amongst the individual channel anomalies, and are often portent of significant events. Using spectral approaches, we propose a two-stage detection method: anomaly detection at a single-channel level, followed by the detection of cross-channel anomalies from the amalgamation of single channel anomalies. Our mathematical analysis shows that our method is likely to reduce the false alarm rate. We demonstrate our method in two applications: document understanding with multiple text corpora, and detection of repeated anomalies in video surveillance. The experimental results consistently demonstrate the superior performance of our method compared with related state-of-art methods, including the one-class SVM and principal component pursuit. In addition, our framework can be deployed in a decentralized manner, lending itself for large scale data stream analysis.

Challenging the traditional sequence of teaching introductory calculus

Despite considerable research with students of calculus, rate, and hence derivative, remain difficult concepts to teach and learn. The demonstrated lack of conceptual understanding of introductory calculus limits its usefulness in related areas. Since rate is such a troublesome concept, this study piloted reversing the usual presentation of introductory calculus to begin with area and integration, rather than rate and derivative. Two classes of first-year university students taking introductory calculus were selected to pilot the effect of changing the sequence; one class was a control group and the other class followed the reversed sequence. Advances in technology, especially computer algebra systems (CASs) may facilitate new ways of studying mathematics. In this study, handheld CASs were used to support students’ thinking as they grappled with the concepts of introductory calculus. The use of CASs enabled consideration of symbolic patterns and numerical integration leading to a deeper conceptual understanding of integration. The easy access to the multiple representations of functions provided by CASs facilitated an exploration of rate where each representation highlighted different aspects of rate resulting in deeper conceptual understanding of differentiation.

Control of crystallization in supramolecular soft materials engineering

As one class of the most important supramolecular functional materials, gels formed by low molecular weight gelators (LMWGs) have many important applications. The key important parameters affecting the in-use performance of a gel are determined by the hierarchical fiber network structures. Fiber networks consisting of weakly interacting multiple domains are commonly observed in gels formed by LMWGs. The rheological properties, particularly the elasticity, of a gel with such a fiber network are weak due to the weak interactions between the individual domains. As achieving desirable rheological properties of such a gel is practically relevant, in this work, we demonstrate the engineering of gels with such a type of fiber network by controlling crystallization of the gelator. Two example gels formed by a glutamic acid derivative in a non-ionic surfactant Tween 80 and in propylene glycol were engineered by controlling the thermodynamic driving force for crystallization. For a fixed gelator concentration, the thermodynamic driving force was manipulated by controlling the temperature for fiber crystallization. It was observed that there exists an optimal temperature at which a gel with maximal elasticity can be fabricated. This will hopefully provide guidelines for producing high performance soft materials by engineering their fiber network structures.

Using second life to teach about marketing in second life

There are compelling reasons for educators to consider incorporating virtual worlds (VWs) in their marketing curriculum. That said, the ways in which VWs can be implemented into the teaching curriculum are many and varied. This article reports on two studies in which notionally similar graduate classes are taught about marketing in Second Life (SL). The degree of student and instructor immersion is intentionally varied: One class is taught entirely in SL, by a technically expert instructor, while novice/intermediate instructors teach the second class in an interactive tutorial setting. Taken together, these studies offer marketing educators insights into developing “full” and “lite” approaches to teaching in SL, thereby lowering the barrier to uptake of the technology by catering to a broader spectrum of both instructor and student competencies, interests, and abilities.

PTEX is an essential nexus for protein export in malaria parasites

During the blood stages of malaria, several hundred parasite-encoded proteins are exported beyond the double-membrane barrier that separates the parasite from the host cell cytosol. These proteins have a variety of roles that are essential to virulence or parasite growth. There is keen interest in understanding how proteins are exported and whether common machineries are involved in trafficking the different classes of exported proteins. One potential trafficking machine is a protein complex known as the Plasmodium translocon of exported proteins (PTEX). Although PTEX has been linked to the export of one class of exported proteins, there has been no direct evidence for its role and scope in protein translocation. Here we show, through the generation of two parasite lines defective for essential PTEX components (HSP101 or PTEX150), and analysis of a line lacking the non-essential component TRX2 (ref. 12), greatly reduced trafficking of all classes of exported proteins beyond the double membrane barrier enveloping the parasite. This includes proteins containing the PEXEL motif (RxLxE/Q/D) and PEXEL-negative exported proteins (PNEPs). Moreover, the export of proteins destined for expression on the infected erythrocyte surface, including the major virulence factor PfEMP1 in Plasmodium falciparum, was significantly reduced in PTEX knockdown parasites. PTEX function was also essential for blood-stage growth, because even a modest knockdown of PTEX components had a strong effect on the parasite's capacity to complete the erythrocytic cycle both in vitro and in vivo. Hence, as the only known nexus for protein export in Plasmodium parasites, and an essential enzymic machine, PTEX is a prime drug target.

Essays on corporate restructuring

Esta tese tem por objetivo examinar as características do processo de decisão em que credores optam pela recuperação judicial ou liquidação da empresa em dificuldade financeira. O trabalho está dividido em quatro capítulos. No segundo capítulo, apresenta-se, de forma sistematizada, referencial teórico e evidências empíricas para apontar resultados importantes sobre estudos desenvolvidos nas áreas de recuperação de empresas e falência. O capítulo também apresenta três estudos de caso com o propósito de mostrar a complexidade de cada caso no que diz respeito à concentração de recursos, conflito de interesse entre as classes de credores e a decisão final sobre a aprovação ou rejeição do plano de recuperação judicial. No terceiro capítulo, analisam-se os determinantes do atraso pertinente à votação do plano de recuperação judicial. O trabalho propõe um estudo empírico dos atrasos entre 2005 e 2014. Os resultados sugerem que: (i) maior concentração da dívida entre as classes de credores possui relação com atrasos menores; (ii) maior quantidade de bancos para votar o plano de recuperação judicial possui relação com maiores atrasos; (iii) o atraso médio na votação diminui quando apenas uma classe de credores participa da votação do plano; (iv) credores trabalhistas e com garantia real atrasam a votação quando o valor dos ativos para garantir a dívida em caso de liquidação é maior; (v) o atraso médio na votação é maior em casos de pior desempenho do setor de atuação do devedor, sendo solicitado pelas classes quirografária e com garantia real; e (vi) a proposta de venda de ativos é o principal tópico discutido nas reuniões de votação do plano nos casos em que o atraso na votação é maior. Por fim, no quarto capítulo, apresenta-se evidência sobre a votação dos credores e a probabilidade de aprovação do plano de recuperação judicial. Os resultados sugerem que: (i) credores trabalhistas estão propensos a aprovar o plano de recuperação mesmo quando o plano é rejeitado pelas demais classes; (ii) planos com propostas de pagamento mais heterogêneas para as três classes de credores possuem menor chance de serem aceitos; (iii) a chance de aprovação do plano diminui nos casos em que mais credores quirografários participam da recuperação; e (iv) planos com proposta de venda de ativos possuem maior chance de serem aprovados. Finalmente, maior concentração da dívida na classe com garantia real diminui a chance de aprovação do plano, e o contrário ocorre na classe quirografária.

A sala de aula em cena: uma pesquisa em ensino do teatro a partir da experiência docente

At first moment we present a reflection about the history of theater and later a contextualization of didactic movements oriented to scenic arts. Through at the constant dialogue with authors of areas involving education, theatre, corporeality and music was possible analyzing, develop and criticize a education work under my responsibility involving fourteen classes. At the second moment will occur a critical self about the quality of theater classes his contents and methodologies. The technique will be at side of the emotion and together develop skills aimed at tracing paths for theater developed at a classroom of a especific private school in Natal-RN. At the third moment one class is chosen for analyze of the academic research and many experiments happen after this decision, initiated and sensitized through of the music with a significant look at the corporeality and prioritizing the theater as content in ninth grade - elementary school two. At the conclusion is possible see that learning is mutual and the theater can become life routine as well as the arts in general and when all arts will be regularized into the national educational system for public and private schools we will have more susceptible humans and more intellectual capacity

Trabalhadores por conta própria: O trabalho dos vendedores ambulantes da passarela do Natal shopping e do Via Direta

This study aid to understand the work conditions of street vendors located on the sidewalks of two malls in Brazil Northeast Natal / RN - Both malls Natal Shopping and Via Direta, to analyze their inclusion in the informal economy and to study the supposed autonomy provided by work as self-employment in its both aspects economic and social analyzing the importance on the condition of "masters of their own business" has for the street vendors, as an alternative to not submission to the figure of the boss, that represents the exploitation of one class over another. The theoretical and methodological aspects that support this study was aimed in discussion on the restructuring of production, considering its effects on the world of work, pointing to unemployment as one of the potencies element of excluded processes that exciting workers to engage in the informal market. Informality is presented as a survival strategy and as integrating part of the reproduction of capital. This research was conducted under a critical perspective, whish has been utilized quantitative and qualitative analyses. The results of this study format questions that provided during the research process the socio-economic characterization of workers, main cause of this study, and how street vendors expres their status of workers as self-employed for their work, and the perception that they have on their form of inclusion in the informal market.

The 5S rDNA family evolves through concerted and birth-and-death evolution in fish genomes: an example from freshwater stingrays

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Viés Analítico em Estudos Tafonômicos com Macroinvertebrados: Implicações (Paleo)Ambientais e (Paleo)Ecológicas

A review of recent literature shows that most taphonomic studies of Holocene and fossil macrovertebrates are not methodologically standardized. Hence, results from distinct studies are not comparable, even among researches sharing virtually identical goals, targeting the same biological group of similar age and depositional environment. The effects of the shell size in the taphonomic analysis are still poorly understood. In order to study this issue, the taphonomic signatures (articulation, valve type, fragmentation, abrasion, corrosion, edge modification, color alteration, bioerosion and encrustation) of brachiopod shells (Bouchardia rosea (Mawe)), from Ubatuba Bay in the northern coast of São Paulo State, were investigated according to the sieve sizes. In the study area, 14 collecting stations were sampled via Van Veen grab sampler, along a bathymetric gradient, ranging from 0 to 35 m of depth. Bulk samples were sieved through 8 mm, 6 mm, and 2 mm mesh sizes, yielding a total of 5.204 shells. The results indicate that, when taphonomic signatures were independently analyzed per size classes (8 mm, 6 mm, and 2 mm), the taphonomic signatures are recorded in a complex and random way. Additionally, cluster analysis showed that the similarity among the clusters vary according to the considered sieve size. Thus, the sieve size plays an important role in the distribution of taphonomic signatures in shells of distinct sizes. These results suggest that the concentration of the taphonomic analysis on one class (e.g., the largest sieve size, 8 mm) is not always the best method. Rather, the total data (all sieves included) seems more accurate in recording the whole spectrum of taphonomic processes recorded in shells of a given assemblage.

O pro-álcool e algumas relações CTS concebidas por alunos de 6ª série do ensino fundamental

A crescente degradação do meio ambiente e o reconhecimento, por parte da sociedade contemporânea, da existência de problemas considerados críticos, acentuadamente a questão energética, intensifica a preocupação em incorporar nas atividades de ensino aspectos da relação do ser humano com o ambiente. A necessidade de abordar, durante atividades de ensino de ciências, questões relacionadas com a dimensão valorativa e aspectos da relação entre ciência, tecnologia e sociedade passa a ser reconhecida tanto por educadores de maneira geral quanto por especialistas da área, de maneira particular. O movimento Ciência, Tecnologia e Sociedade (CTS) como um conjunto de propostas para o ensino de ciências é uma conseqüência concreta desta tendência. No caso do Brasil são poucas as pesquisas em ensino de ciências que exploram essa possibilidade e são poucas as experiências em termos de trabalhos em sala de aula que abordam esta questão. Este trabalho, realizado entre maio e novembro de 1996, sistematiza os dados coletados em uma classe de 6ª série do ensino fundamental que teve como tema de estudos o Projeto Pro-Álcool. Foi planejado e desenvolvido um conjunto de atividades, utilizando-se de um número bastante diversificado de procedimentos didáticos. Os resultados de pesquisa indicam que, um trabalho que ofereça aos alunos oportunidades de discussões e reflexões, a partir de procedimentos e material didático diversificado e rico em termos de solicitações e propostas aos alunos, pode promover a incorporação, em sala de aula, de diferentes dimensões relacionadas com a ciência, tecnologia, sociedade e ambiente.