Petrophysical investigations on sediment core CRP-2A from the Ross Sea, Antarctica

A suite of petropysical measurements - velocity versus pressure, bulk density, porosity, matrix density, and magnetic susceptibility -was undertaken on 63 core plugs from CRP-2A. These data are used to calibrate neutron, resistivity, and magnetic susceptibility well logs. Agreement between core-plug magnetic susceptibility measurements and both well-log and whole-core data is excellent. Comparison of core-plug bulk densities with continious well-log density records shows very good agreement. Core-plug measurements of matrix density permit conversion of the well-log and whole-core density records to porosity. Sands and muds exhibit similar downhole compaction patterns, and both patterns are consistent with 250 ± 150 m of exhumation. Pervasive cementation, particularly in the lower half of the core, has affected many CRP-2A petrophysical parameters: (1) fractional porosities are reduced by about 0.05 - 0.10 in the lower part of the hole; (2) velocity and porosity rebound are much smaller than is usually observed for unconsolidated sediments with burial depths similar to CRP-2A; (3) velocities are unusually insensitive to pressure, suggesting that any exhumation-induced microcracks have been scaled subsequently; (4) the velocity/porosity relationship lacks the characteristic signature of exhumation-induced microcracks; (5) the velocity/porosity relationship changes with depth, indicating downhole increase in consolidation; (6) Vp/Vs ratios of the highest-porosity sediments are unusually low, implying enhancement of framework stiffness.

Investigation of microfossils on sediment core CRP-2 from the Ross Sea, Antarctica

Marine diatoms are the primary biostratigraphical and paleoenvironmental tool for interpreting the upper Palaeogene and lower Neogene strata recovered during the second drilling season of the Cape Roberts Project at site CRP-2 in the western Ross Sea, Antarctica. Silicoflagellates, ebridians, and a chrysophyte cyst provide supporting biostratigraphical information. More than 100 dominantly planktic diatom taxa are recognised. Of these, more than 30 are treated informally, pending SEM examination and formal description. Many other taxa are noted only to generic level. Lower Oligocene (c. 31 Ma) through lower Miocene (c. 18.5 Ma) diatoms occur from 28 mbsf down to 565 mbsf. Below this level, to the bottom of the hole at 624.15 mbsf, diatom assemblages are poorly-preserved and many samples are barren. A biostratigraphic zonal framework, consisting of ten diatom zones, is proposed for the Antarctic continental shelf. Ages inferred from the diatom biostratigraphy correspond well with geochronological data from argon dating of volcanic materials and strontium dating of calcareous macrofossils, as well as nannofossil biochronological datums. The biochronostratigraphical record from CRP-2/2A provides an important record of diatom events and mid-Cenozoic environmental changes in the Antarctic neritic zone.

Investigation of Miocene foraminifera in sediment core CRP-1 from the Ross Sea, Antarctica

A faunal comprising 18 foraminiferal taxa wa recovered from a suite of 52 core samples from lower Miocene sandstone, claystone and diamictite in the CRP-1 drillhole, Cape Roberts, Antarctica. The fauna is characterised by low foraminiferal abundance and diversity, the absence of planktics, and typically, the presence of Cribroelphidium sp. and/or Melonis spp. These factors indicate deposition in an inner shelf or nearshore environment. Many of the foraminifers found in CRP-1 also occure in the upper Oligocene-Miocene sequences in CIROS-1 and DSDP-270, but the fauna provides no precise indication of age. Typical and distinctive species from CRP-1 are illustrated with SEM photomicrographs.

Centennial-scale evolution of Dansgaard-Oeschger events in sediment core MD95-2006

There is much uncertainty surrounding the mechanisms that forced the abrupt climate fluctuations found in many palaeoclimate records during Marine Isotope Stage (MIS)-3. One of the processes thought to be involved in these events is the Atlantic Meridional Overturning Circulation (MOC), which exhibited large changes in its dominant mode throughout the last glacial period. Giant piston core MD95-2006 from the northeast Atlantic Ocean records a suite of palaeoceanographic proxies related to the activity of both surface and deep water masses through a period of MIS-3 when abrupt climate fluctuations were extremely pronounced. A two-stage progression of surface water warming during interstadial warm events is proposed, with initial warming related to the northward advection of a thin warm surface layer within the North Atlantic Current, which only extended into deeper surface layers as the interstadial progressed. Benthic foraminifera isotope data also show millennial-scale oscillations but of a different structure to the abrupt surface water changes. These changes are argued to partly be related to the influence of low-salinity deepwater brines. The influence of deepwater brines over the site of MD95-2006 reached a maximum at times of rapid warming of surface waters. This observation supports the suggestion that brine formation may have helped to destabilize the accumulation of warm, saline surface waters at low latitudes, helping to force the MOC into a warm mode of operation. The contribution of deepwater brines relative to other mechanisms proposed to alter the state of the MOC needs to be examined further in future studies.

Organic and inorganic geochemical measurements of sediment core GeoB7702-3

It has long been known that extreme changes in North African hydroclimate occurred during the late Pleistocene yet many discrepancies exist between sites regarding the timing, duration and abruptness of events such as Heinrich Stadial (HS) 1 and the African Humid Period (AHP). The hydroclimate history of the Nile River is of particular interest due to its lengthy human occupation history yet there are presently few continuous archives from the Nile River corridor, and pre-Holocene studies are rare. Here we present new organic and inorganic geochemical records of Nile Basin hydroclimate from an eastern Mediterranean (EM) Sea sediment core spanning the past 28 ka BP. Our multi-proxy records reflect the fluctuating inputs of Blue Nile versus White Nile material to the EM Sea in response to gradual changes in local insolation and also capture abrupt hydroclimate events driven by remote climate forcings, such as HS1. We find strong evidence for extreme aridity within the Nile Basin evolving in two distinct phases during HS1, from 17.5 to 16 ka BP and from 16 to 14.5 ka BP, whereas peak wet conditions during the AHP are observed from 9 to 7 ka BP. We find that zonal movements of the Congo Air Boundary (CAB), and associated shifts in the dominant moisture source (Atlantic versus Indian Ocean moisture) to the Nile Basin, likely contributed to abrupt hydroclimate variability in northern East Africa during HS1 and the AHP as well as to non-linear behavior of hydroclimate proxies. We note that different proxies show variable gradual and abrupt responses to individual hydroclimate events, and thus might have different inherent sensitivities, which may be a factor contributing to the controversy surrounding the abruptness of past events such as the AHP. During the Late Pleistocene the Nile Basin experienced extreme hydroclimate fluctuations, which presumably impacted Paleolithic cultures residing along the Nile corridor.

West nile virus core protein: Tetramer structure and ribbon formation

We have determined the crystal structure of the core (C) protein from the Kunjin subtype of West Nile virus (WNV), closely related to the NY99 strain of WNV, currently a major health threat in the U.S. WNV is a member of the Flaviviridae family of enveloped RNA viruses that contains many important human pathogens. The C protein is associated with the RNA genome and forms the internal core which is surrounded by the envelope in the virion. The C protein structure contains four a. helices and forms dimers that are organized into tetramers. The tetramers form extended filamentous ribbons resembling the stacked alpha helices seen in HEAT protein structures.

Development of lipid-core-peptide (LCP) based vaccines for the prevention of the group A streptococcal (GAS) infection

Traditional vaccines consisting of whole attenuated micro-organisms. or microbial components administered with adjuvant, have been demonstrated as one of the most cost-effective and successful public health interventions. Their use in large scale immunisation programs has lead to the eradication of smallpox, reduced morbidity and mortality from many once common diseases, and reduced strain on health services. However, problems associated with these vaccines including risk of infection. adverse effects, and the requirement for refrigerated transport and storage have led to the investigation of alternative vaccine technologies. Peptide vaccines, consisting of either whole proteins or individual peptide epitopes, have attracted much interest, as they may be synthesised to high purity and induce highly specific immune responses. However, problems including difficulties stimulating long lasting immunity. and population MHC diversity necessitating multiepitopic vaccines and/or HLA tissue typing of patients complicate their development. Furthermore, toxic adjuvants are necessary to render them immunogenic. and as such non-toxic human-compatible adjuvants need to be developed. Lipidation has been demonstrated as a human compatible adjuvant for peptide vaccines. The lipid-core-peptide (LCP) system. incorporating lipid adjuvant, carrier, and peptide epitopes, exhibits promise as a lipid-based peptide vaccine adjuvant. The studies reviewed herein investigate the use of the LCP system for developing vaccines to protect against group A streptococcal (GAS) infection. The studies demonstrate that LCP-based GAS vaccines are capable of inducing high-titres of antigen specific IgG antibodies. Furthermore. mice immunised with an LCP-based GAS vaccine were protected against challenge with 8830 strain GAS.

Increased adjuvant activity of minimal CD8 T cell peptides incorporated into lipid-core-peptides

A problem facing the use of subunit peptide and protein vaccines is their inability to stimulate protective immune responses. Many different approaches have been utilized to overcome this inefficient immune activation. The approach we have taken is to modify the vaccine antigen so that it now has adjuvant properties. To do this, multiple copies of minimal CD8 T cell epitopes were attached to a poly lysine lipid core. These constructs are known as lipid-core-peptides (LCP). The research presented here examines the adjuvant activity of LCP. Using mouse models, we were able to show that LCP were indeed able to activate antigen-presenting cells in vitro and to activate cytotoxic T-cell responses in vivo. More importantly, LCP were able to stimulate the development of a protective antitumour immune response.

Synthesis and immunological evaluation of M protein targeted tetra-valent and tri-valent group A streptococcal vaccine candidates based on the lipid-core peptide system

Group A streptococcus (GAS) is responsible for causing many clinical complications including the relatively benign streptococcal pharyngitis and impetigo. However. if left untreated. these conditions may lead to more severe diseases such as rheumatic fever (RF) and rheumatic heart disease (RHD). These diseases exhibit high morbidity and mortality, Particularly in developing countries and in indigenous populations of affluent countries. Only ever occur following GAS infection, a vaccine offers Promise for their Prevention. As stich, we have investigated the Use of the lipid-core peptide (LCP) system for the development of multi-valent Prophylactic GAS vaccines. The current study has investigated the capacity of this system to adjuvant LIP to four different GAS peptide epitopes. Presented are the synthesis and immunological assessment of tetra-valent and tri-valent GAS LCP systems. We demonstrated their capacity to elicit systemic IgG antibody responses in B10.BR mice to all GAS peptide epitopes. The data also showed that the LCP systems Were self-adjuvanting. These findings are particularly encouraging for the development of multi-valent LCP-based GAS vaccines.

Why is Werner Sombart not part of the core of classical sociologists? From fame to (near) oblivion:From Fame to (Near) Oblivion

The life and work of Werner Sombart poses an intellectual puzzle in the genealogy of modern social theorists. During his lifetime, Sombart was probably the most influential and prominent social scientist in Germany as well as in many other countries. Today he is among the least known social scientists. Why did he lose his status as one of the most brilliant and influential scholars and intellectuals of the 20th century? Why is his work almost forgotten today? While Weber's thesis about the influence of Protestantism on the development of capitalism is widely known, even beyond sociological circles, few sociologists today know that Sombart had an alternative explanation. An obvious explanation for Sombart's fall from grace is his embrace of Nazism. As Heidegger provides a counter-example, Sombart's fate requires a more complex explanation. In addition, we explore the different reception of his work in economic and sociological circles as compared to cultural theory and history. © 2001, SAGE Publications. All rights reserved.

The spectral sensitivity of long period gratings fabricated in elliptical core D-shaped optical fibre

Long period gratings (LPGs) were written into a D-shaped optical fibre that has an elliptical core with a W-shaped refractive index profile and the first detailed investigation of such LPGs is presented. The LPGs’ attenuation bands were found to be sensitive to the polarisation of the interrogating light with a spectral separation of about 15 nm between the two orthogonal polarisation states. A finite element method was successfully used to model many of the behavioural features of the LPGs. In addition, two spectrally overlapping attenuation bands corresponding to orthogonal polarisation states were observed; modelling successfully reproduced this spectral feature. The spectral sensitivity of both orthogonal states was experimentally measured with respect to temperature and bending. These LPG devices produced blue and red wavelength shifts depending upon the orientation of the bend with measured maximum sensitivities of -3.56 and +6.51 nm m, suggesting that this type of fibre LPG may be useful as a shape/bend orientation sensor with reduced errors associated with polarisation dependence. The use of neighbouring bands to discriminate between temperature and bending was also demonstrated, leading to an overall curvature error of ±0.14 m-1 and an overall temperature error of ±0.3 °C with a maximum polarisation dependence error of ±8 × 10-2 m-1 for curvature and ±5 × 10-2 °C for temperature.

The spectral sensitivity of long period gratings fabricated in elliptical core D-shaped optical fibre

Long period gratings (LPGs) were written into a D-shaped optical fibre that has an elliptical core with a W-shaped refractive index profile and the first detailed investigation of such LPGs is presented. The LPGs’ attenuation bands were found to be sensitive to the polarisation of the interrogating light with a spectral separation of about 15 nm between the two orthogonal polarisation states. A finite element method was successfully used to model many of the behavioural features of the LPGs. In addition, two spectrally overlapping attenuation bands corresponding to orthogonal polarisation states were observed; modelling successfully reproduced this spectral feature. The spectral sensitivity of both orthogonal states was experimentally measured with respect to temperature and bending. These LPG devices produced blue and red wavelength shifts depending upon the orientation of the bend with measured maximum sensitivities of -3.56 and +6.51 nm m, suggesting that this type of fibre LPG may be useful as a shape/bend orientation sensor with reduced errors associated with polarisation dependence. The use of neighbouring bands to discriminate between temperature and bending was also demonstrated, leading to an overall curvature error of ±0.14 m-1 and an overall temperature error of ±0.3 °C with a maximum polarisation dependence error of ±8 × 10-2 m-1 for curvature and ±5 × 10-2 °C for temperature.

Synthesis of CuS and CuS/ZnS core/shell nanocrystals for photocatalytic degradation of dyes under visible light

High quality CuS and CuS/ZnS core/shell nanocrystals (NCs) were synthesized in a large quantity using a facile hydrothermal method at low temperatures of 60 C and evaluated in the photodegradation of Rhodamine B (RhB) under visible light irradiation. Synthesis time plays an important role in controlling the morphology, size and photocatalytic activity of both CuS and CuS/ZnS core/shell NCs which evolve from spherical shaped particles to form rods with increasing reaction time, and after 5 h resemble "flower" shaped morphologies in which each "flower" is composed of many NCs. Photocatalytic activity originates from photo-generated holes in the narrow bandgap CuS, with encapsulation by large bandgap ZnS layers used to form the core/shell structure that improves the resistance of CuS towards photocorrosion. Such CuS/ZnS core/shell structures exhibit much higher photocatalytic activity than CuS or ZnS NCs alone under visible light illumination, and is attributed to higher charge separation rates for the photo-generated carriers in the core/shell structure. © 2013 Elsevier B.V.

An Elementary Core Equivalence Theorem in a Countable Economy

We consider an infinite exchange economy with countably many traders, which can be regarded as a natural extension of finite exchange economies to an infinite one. In our countable economy the core defined in the traditional manner would be empty. To avoid this unwanted situation we have to strengthen the notion of “improves upon”. We will achieve this based on the idea that forming coalitions involve costs.

Transcriptional Response of Two Core Photosystem Genes in Symbiodinium spp. Exposed to Thermal Stress

Mutualistic symbioses between scleractinian corals and endosymbiotic dinoflagellates (Symbiodinium spp.) are the foundation of coral reef ecosystems. For many coral-algal symbioses, prolonged episodes of thermal stress damage the symbiont's photosynthetic capability, resulting in its expulsion from the host. Despite the link between photosynthetic competency and symbiont expulsion, little is known about the effect of thermal stress on the expression of photosystem genes in Symbiodinium. This study used real-time PCR to monitor the transcript abundance of two important photosynthetic reaction center genes, psbA(encoding the D1 protein of photosystem II) and psaA (encoding the P700 protein of photosystem I), in four cultured isolates (representing ITS2-types A13, A20, B1, and F2) and two in hospite Symbiodinium spp. within the coral Pocillopora spp. (ITS2-types C1b-c and D1). Both cultured and in hospite Symbiodinium samples were exposed to elevated temperatures (32°C) over a 7-day period and examined for changes in photochemistry and transcript abundance. Symbiodinium A13 and C1b-c (both thermally sensitive) demonstrated significant declines in both psbA and psaA during the thermal stress treatment, whereas the transcript levels of the other Symbiodinium types remained stable. The downregulation of both core photosystem genes could be the result of several different physiological mechanisms, but may ultimately limit repair rates of photosynthetic proteins, rendering some Symbiodinium spp. especially susceptible to thermal stress.