The Drosophila melanogaster Homologue of the Xeroderma Pigmentosum D Gene Product Is Located in Euchromatic Regions and Has a Dynamic Response to UV Light-induced Lesions in Polytene Chromosomes

The XPD/ERCC2/Rad3 gene is required for excision repair of UV-damaged DNA and is an important component of nucleotide excision repair. Mutations in the XPD gene generate the cancer-prone syndrome, xeroderma pigmentosum, Cockayne’s syndrome, and trichothiodystrophy. XPD has a 5′- to 3′-helicase activity and is a component of the TFIIH transcription factor, which is essential for RNA polymerase II elongation. We present here the characterization of the Drosophila melanogaster XPD gene (DmXPD). DmXPD encodes a product that is highly related to its human homologue. The DmXPD protein is ubiquitous during development. In embryos at the syncytial blastoderm stage, DmXPD is cytoplasmic. At the onset of transcription in somatic cells and during gastrulation in germ cells, DmXPD moves to the nuclei. Distribution analysis in polytene chromosomes shows that DmXPD is highly concentrated in the interbands, especially in the highly transcribed regions known as puffs. UV-light irradiation of third-instar larvae induces an increase in the signal intensity and in the number of sites where the DmXPD protein is located in polytene chromosomes, indicating that the DmXPD protein is recruited intensively in the chromosomes as a response to DNA damage. This is the first time that the response to DNA damage by UV-light irradiation can be visualized directly on the chromosomes using one of the TFIIH components.

Nonlinear indicial response of complex nonstationary oscillations as pulmonary hypertension responding to step hypoxia

This paper is devoted to the quantization of the degree of nonlinearity of the relationship between two biological variables when one of the variables is a complex nonstationary oscillatory signal. An example of the situation is the indicial responses of pulmonary blood pressure (P) to step changes of oxygen tension (ΔpO2) in the breathing gas. For a step change of ΔpO2 beginning at time t1, the pulmonary blood pressure is a nonlinear function of time and ΔpO2, which can be written as P(t-t1 | ΔpO2). An effective method does not exist to examine the nonlinear function P(t-t1 | ΔpO2). A systematic approach is proposed here. The definitions of mean trends and oscillations about the means are the keys. With these keys a practical method of calculation is devised. We fit the mean trends of blood pressure with analytic functions of time, whose nonlinearity with respect to the oxygen level is clarified here. The associated oscillations about the mean can be transformed into Hilbert spectrum. An integration of the square of the Hilbert spectrum over frequency yields a measure of oscillatory energy, which is also a function of time, whose mean trends can be expressed by analytic functions. The degree of nonlinearity of the oscillatory energy with respect to the oxygen level also is clarified here. Theoretical extension of the experimental nonlinear indicial functions to arbitrary history of hypoxia is proposed. Application of the results to tissue remodeling and tissue engineering of blood vessels is discussed.

Dynamic response of human and primate head and neck to +Gy impact acceleration. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Dynamic response of finite length MAGLEV vehicles subjected to crosswind gusts. Final report.

Transportation Department, Office of Systems Engineering, Washington, D.C.

A method for predicting the aerodynamic loads and dynamic response of the rotor blades of a tandem-rotor helicopter.

"USAAVLABS technical report 67-38."

Simple and complex models for nonlinear seismic response of reinforced concrete structures /

Mode of access: Internet.

Dynamic response of materials to intense impulsive loading.

Includes bibliographical references.

Dynamic response: Real-time adaptation for music emotion

Music plays an enormous role in today's computer games; it serves to elicit emotion, generate interest and convey important information. Traditional gaming music is fixed at the event level, where tracks loop until a state change is triggered. This behaviour however does not reflect musically the in-game state between these events. We propose a dynamic music environment, where music tracks adjust in real-time to the emotion of the in-game state. We are looking to improve the affective response to symbolic music through the modification of structural and performative characteristics through the application of rule-based techniques. In this paper we undertake a multidiscipline approach, and present a series of primary music-emotion structural rules for implementation. The validity of these rules was tested in small study involving eleven participants, each listening to six permutations from two musical works. Preliminary results indicate that the environment was generally successful in influencing the emotion of the musical works for three of the intended four directions (happier, sadder & content/dreamier). Our secondary aim of establishing that the use of music-emotion rules, sourced predominantly from Western classical music, could be applied with comparable results to modern computer gaming music was also largely successfully.

Dynamic response of spring mounted flexible platforms carring rotating machinery

DUE TO COPYRIGHT RESTRICTIONS ONLY AVAILABLE FOR CONSULTATION AT ASTON UNIVERSITY LIBRARY AND INFORMATION SERVICES WITH PRIOR ARRANGEMENT

Bifurcation and dynamic response analysis of a rotating blade excited by upstream vortices

Acknowledgements The authors acknowledge the projects supported by the National Basic Research Program of China (973 Project)(No. 2015CB057405) and the National Natural Science Foundation of China (No. 11372082) and the State Scholarship Fund of CSC. DW thanks for the hospitality of the University of Aberdeen.

海洋平台张力腿非线性动力响应

采用非线性梁模型,充分考虑张力腿轴向与流向的耦合效应及平台运动对张力腿的作用,运用Galerkin法进行分析求解,研究不同的长径比(L/D)情况下,弯曲刚度和非线性耦合效应的影响,以期得到更适用于实际的张力腿简化模型.

有限位移下张力腿平台的非线性动力响应

与一阶无限小位移情况不同,张力腿平台(TLP)发生有限位移时,所受外力与响应耦合,运动方程也必须在瞬时位置建立.建立了有限位移情况下张力腿平台非线性动力响应分析模型,其中考虑了由六自由度有限位移引起的多种非线性因素,如各自由度之间的耦合、瞬时位置、瞬时湿表面等;还包括自由表面效应、粘性力等因素引起的非线性.推导出张力腿平台六自由度有限运动非线性控制方程.对一个名为“ISSC TLP”的典型张力腿平台进行了数值计算,求得该平台在规则波作用下的六自由度运动响应.用退化到线性范围的解与已有解进行了对比,吻合良好.数值结果表明,综合考虑非线性因素后响应有明显改变