Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

Maija kukkarossa? : talouden valta ja vallaton talous : naistutkimuspäivät 2005

Naistutkimuspäivät, marraskuu 2005, Helsingin kauppakorkeakoulu ja Svenska Handelshögskolan.

Organisaatioiden mykkä alue?

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Kirjallisuusarvostelu

1998 Brock Baseball Team

1998 Brock Badger men's baseball team photo. Front Row (L to R): Bill Gillen, Ryan Villers, Greg Arbour, Mark Cheeseman, Andrew Tinnish, Rick Bottomley, Matt Fletcher, Brad Namtzu, Darryl Presley, Dan Pino, Grant Giffen, Mike Caruso, Mark Reilly Back Row (L to R): Jeff Lounsbury (Head Coach), Jayar Green, Creston Rudolph, Ryan Fisher, Jamie Trull, Stefan Strecker, Andrew Robb, Jeremy Walker, Ryan Johns, Matt Stezycki, Steve Lester, Fabio Del Rio, Jarrod Haase, Jess Dixon, Rick Falconer (Pitching Coach) Absent: Marc Purdy, Ian Bala, Marc LePage (Asst. Coach), Waybe Briggs-Jude (Asst. Coach)

1970-71 Hockey Team

1970-71 Brock Generals Hockey team. The members from left to right - Back row: Tom Kearney (trainer), Joel Finlay, Tony Grey, Gregg Carrigan, Craig Morrison, Pat Moroney, Rick Charron, Jim Swain, Bill Fuller, Barry Hopkins, Mike McNiven, Rick Sullivan, Ed Barszcz, Phil McCann, Randy Oiling (Manager), Al Kellogg (Coach). Front row: Wayne Butt, Ron Powell, Tim Goodman, Pat McCann, Arkell Farr, Dave Perrin, Gregg Law. Missing: Jeff Della Vedova.

Men's Rugby (1981-82)

Back Row: J.B. Owens, Ross Smith (Head Coach), Adam Frost, Derrick Harwood, Dave DeRose, Bill Arniel, Danny Mazor, Alan Ross, Randy McKeller, Pete McDougall, Ray D'Archi, Kelvin Oda, Mark Pelletier, Eric Thompson, Marty Houston, Ken White (Asst. Coach) Front Row: Peter Love, Chris Peskett, Duff Porteous, Bart Ward, Dave Sohmer, Gary Gautier, Ken Murray, Dave Tamowski, Steve Shaughnessy, Jeff Wood Absent: Alfred Esmaily, Luc Gignac, Fred Kovacs, Andrew Norman