A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3.

Deletion of the short arm of human chromosome 1 is the most common cytogenetic abnormality observed in neuroblastoma. To characterize the region of consistent deletion, we performed loss of heterozygosity (LOH) studies on 122 neuroblastoma tumor samples with 30 distal chromosome 1p polymorphisms. LOH was detected in 32 of the 122 tumors (26%). A single region of LOH, marked distally by D1Z2 and proximally by D1S228, was detected in all tumors demonstrating loss. Also, cells from a patient with a constitutional deletion of 1p36, and from a neuroblastoma cell line with a small 1p36 deletion, were analyzed by fluorescence in situ hybridization. Cells from both sources had interstitial deletions of 1p36.2-36.3 which overlapped the consensus region of LOH defined by the tumors. Interstitial deletion in the constitutional case was confirmed by allelic loss studies using the panel of polymorphic markers. Four proposed candidate genes--DAN, ID3 (heir-1), CDC2L1 (p58), and TNFR2--were shown to lie outside of the consensus region of allelic loss, as defined by the above deletions. These results more precisely define the location of a neuroblastoma suppressor gene within 1p36.2-36.3, eliminating 33 centimorgans of proximal 1p36 from consideration. Furthermore, a consensus region of loss, which excludes the four leading candidate genes, was found in all tumors with 1p36 LOH.

O imaginário das ilhas atlânticas no universo medieval islâmico-cristão

O pensamento cultural medieval aparece-nos como herdeiro da Antiguidade Clássica, da sua filosofia, ciência, arte e mitos. Todos estes conceitos traduzem-se com facilidade para as elites intelectuais cristãs e muçulmanas, que os conservam e integram em elementos da sua própria cultura. A ideia do mar, em especial o mar dito ‘aberto’ como o Oceano Atlântico, é marcada pelo maravilhoso. Em plena Idade Média o Oceano Atlântico surge como território de Caos, envolto em mistério. O Oceano Atlântico é local das mais variadas manifestações do fantástico. Desta forma, as ilhas atlânticas, contidas neste vasto oceano, são elas próprias impregnadas de um carácter maravilhoso. Tentaremos, ao longo desta dissertação de mestrado, abordar a questão das ilhas atlânticas e das suas características a nível de imaginário. Este exercício será feito, sempre que possível, fazendo o cruzamento de fontes de origem islâmica e de origem cristã. Desta maneira, surgirá uma imagem comum em relação ao imaginário do Oceano Atlântico e, em especial, das ilhas neste contidas. O objetivo principal deste trabalho é verdadeiramente demonstrar pontos de aproximação entre relatos e mapas, de origem cristã e islâmica, ligados a ilhas fantásticas e, ao mesmo tempo, reais. Veremos que as duas categorias, do real e do imaginário, sobrepõem-se diversas vezes, sendo que não se conseguem muitas vezes distinguir a nível das fontes. Desta forma, relatos de navegações atlânticas como a de São Brandão (de origem celto-cristã) ou a dos Aventureiros de Lisboa (originária no al-Andalus,) são reveladoras das atitudes e ideias na Idade Média em relação ao Atlântico e às suas ilhas.

General principles proposed for staff management /

Letter from Carl M. White, and letter from the comittee precede statement of principles, dated December 24, 1941.

Inventory of building and related needs as requested by colleges, schools, and departments of the University of Illinois, Urbana and Chicago Illinois.

Mode of access: Internet.

The history and chronicles of Scotland:

Bellenden's translation was first published in 1536.

The Holy Bible : containing the Old and New Testaments/

Mode of access: Internet.

De plica Polonica tractatus medico-physicus, cum remediorum methodo noviter elucidatus ... Accedunt experta de oedem affectu ex historia morborum Vratislaviensum /

Mode of access: Internet.

Memorial for Archibald Douglas of Douglas, esq; and for Margaret, dutchess of Douglas, and Charles, duke of Queensberry and Dover, his curators, defenders;

Concerning the claim of Archibald Douglas as heir of tailzie to his uncle, Archibald, duke of Douglas.

[Selected works].

[v. 1]. The quiet husband. The secret foe (1845). The squire (1845). Who shall be heir?. -- [v. 2]. The merchant's daughter. The grandfather (1844). Nan Darrell. Kate Walsingham. The heiress (1845). -- [v. 3]. the prince and the pedler (1845). The fright. The expectant (1845). Ellen Wareham.

The dramatic works and poems of James Shirley, now first collected : with notes by the late William Gifford, esq., and additional notes, and some account of Shirley and his writings /

v. 1. Some account of Shirley and his writings. Commendatory verses on Shirley. Love tricks, or, The school of complement. The maid's revenge. The brothers. The witty fair one. The wedding.--v. 2. The grateful servant. The traitor. Love's cruelty. Love in a maze. The bird in a cage. Hyde park.--v. 3. The ball. The young admiral. The gamester. The example. The opportunity. The coronation.--v. 4. The lady of pleasure. The royal master. The duke's mistress. The doubtful heir. St. Patrick for Ireland. The constant maid. The humorous courtier.--v. 5. The gentleman of Venice. The politician. The imposture. The cardinal. The sisters. The court secret.--v. 6. Honoria and Mammon. Chabot, admiral of France. The Arcadia. The triumph of peace. A contention for honour and riches. The triumph of beauty. Cupid and death. The contention of Ajax and Ulysses for the armour of Achilles. Poems.

Historical law-tracts.

"The discourses relate, each of them, to subjects common to the law of England and of Scotland."--Pref.

Constance Latimer, or, The blind girl : with other tales /

"Published for the benefit of the New-York institution for the instruction of the blind."

Harper's novels.

Title taken from the binding.

A noble lord /

Sequel to the lost heir.

The complete writings of Charles Reade.

"This copy is number 93 of the Author's Illustrated Library Edition of the Complete Writings of Charles Reade newly collected and to be done in seventeen volumes which will include a collection of Readiana. Only one thousand copies will be printed."