Kurt Sprengel's Handbuch der pathologie.

v.1: Ullgemeine pathologie -- v.2: Fieber. Entzündungen -- v.3.

Kurt, der schwarze bastard, auf seinen reisen in unbekannte länder. Mit einem titelkupfer.

Mode of access: Internet.

Vademecum histórico y bibliográfico, de la anatomía, fisiología, higiene, terapéutica y materia médica, cirugía, medicina, medicina legal y obstrecticia (sic), formado con presencia de las tablas sinópticas de los doctores Choulant, Kurt Sprengel, Black, Victor Broussais, Montffalcon, Decembiers y otros historiadores, y añadido hasta nuestros dias /

Mode of access: Internet.

Kurt Sprengels Geschichte der botanik.

A revised German edition of the author's Historia rei herbariae, Amsterdam, 1807-1808.

Richard Kurt.

Mode of access: Internet.

Radio - Staff - Elwood Ryan, Kurt Schmeissen, Louis Cohen, and Lillian Dixon

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Radio - Staff - Elwood Ryan, Kurt Schmeissen, Louis Cohen, and Lillian Dixon

2 of 2

"Warum bleiben wir eigentlich nicht immer hier?" Schweden als Projektionsraum für deutsche Sehnsüchte in Kurt Tucholskys 'Schloss Gripsholm' und seinen beiden Verfilmungen

Aus deutscher Perspektive hat die Darstellung von Skandinavien als nördlicher, liminaler Raum, der paradoxerweise zugleich so eng mit der eigenen nationalen Identität verknüpft erscheint, dass man für Verhältnis der Staaten seit dem 19. Jahrhundert eine Form des kulturellen Kolonialismus gelten machen kann, eine lange Tradition. Diese Einstellung setzt sich in den modernen deutschen Darstellungen vom Norden fort, unter denen Kurt Tucholskys außerordentlich populäre „Sommergeschichte“ Schloß Gripsholm, deren Beliebtheit sich auch an der Existenz zweier erfolgreicher Verfilmungen ablesen lässt, eine zentrale und wegweisende Position einnimmt. Sowohl im Roman als auch in den beiden Adaptionen erscheint Schweden als utopischer Gegenentwurf, als eine liberale und moderne alternative Heimat, die zunächst Fluchtmöglichkeiten aus dem Deutschland der 1920er, 1930er und 1960er zu bieten scheint. Weit entfernt davon ein realistisches Bild von Skandinavien entwerfen zu wollen, überbieten sich besonders die beiden Filmversionen gegenseitig in stark ästhetisierenden Entwürfen eines mit nord-romantischen Zügen versehenen „Anti-Deutschland“, an denen sich die sozio-politischen Diskurse der Zeit ablesen lassen. Dieser Aufsatz beleuchtet die Funktionalisierung des Skandinavienbildes als Imaginations- und Reflexionsraum für deutsche Wünsche und Sehnsüchte und analysiert neben der zentralen Bedeutung der räumlichen Dimension auch die Alltagsmythologischen Aspekte der Schwedendarstellung in allen drei Werken.

Cheaper Faster Drug Development Validated By The Repositioning Of Drugs Against Neglected Tropical Diseases.

There is an urgent need to make drug discovery cheaper and faster. This will enable the development of treatments for diseases currently neglected for economic reasons, such as tropical and orphan diseases, and generally increase the supply of new drugs. Here, we report the Robot Scientist 'Eve' designed to make drug discovery more economical. A Robot Scientist is a laboratory automation system that uses artificial intelligence (AI) techniques to discover scientific knowledge through cycles of experimentation. Eve integrates and automates library-screening, hit-confirmation, and lead generation through cycles of quantitative structure activity relationship learning and testing. Using econometric modelling we demonstrate that the use of AI to select compounds economically outperforms standard drug screening. For further efficiency Eve uses a standardized form of assay to compute Boolean functions of compound properties. These assays can be quickly and cheaply engineered using synthetic biology, enabling more targets to be assayed for a given budget. Eve has repositioned several drugs against specific targets in parasites that cause tropical diseases. One validated discovery is that the anti-cancer compound TNP-470 is a potent inhibitor of dihydrofolate reductase from the malaria-causing parasite Plasmodium vivax.

Em jogo a relação entre pesquisador e clube : futebol e processos grupais

Universidade Estadual de Campinas . Faculdade de Educação Física

On-line identification of minor flavones from sugarcane juice by LC/UV/MS and post-column derivatization

This work describes the on-line characterization of minor flavones from sugarcane (Saccharum officinarum) juice by high-performance liquid chromatography coupled to diode array UV detection and mass spectrometry (LC/UV/MS) using atmospheric pressure chemical ionization-collision-induced dissociation (APCI-CID-MS/MS) and post-column derivatization using UV shift reagents. HPLC-UV analysis with shift reagents provided information about the substitution pattern in the flavonoid skeleton and, combined with MS data, these techniques allowed for the on-line identification of five "garapa" flavones: luteolin-8-C-glucosyl-7-O-glucuronide; tricin-7-O-neohesperoside-4'-O-rhamnoside; tricin-7-O-methylglucuronate-4'-O-rhamnoside; tricin-7-O-methylglucuronide; swertisin, while four other compounds were partially identified as glycosylflavones. Only swertisin (7-O-methylapigenin-6-C-glucoside) was reported previously in sugarcane molasses.

Growth Response of Various Perennial Grasses to Increasing Salinity

Although the effect of salinity on plant growth has been the focus of a substantive research effort, much of this research has failed to adequately separate the various growth limiting aspects of salinity; thus the results are confounded by multiple factors. Eight perennial grass species were grown in a sand culture system dominated by NaCl (electrical conductivities (ECs) between 1.4 and 38 dS m 1), with sufficient Ca added to each treatment to ensure that Na-induced Ca deficiency did not reduce growth. Of the eight perennial grass species examined, Chloris gayana cv. Pioneer (Rhodes grass) was the most salt tolerant species, whilst in comparison, Chrysopogon zizanioides cv. Monto (vetiver) was of only moderate tolerance. However, observed salinity tolerances tended to be lower than those expected from published values based on the threshold salinity model (bent stick model). This discrepancy may be due in part to differences in the evapotranspirational demand between studies; an increase in demand accelerating the accumulation of Na in the shoots and hence decreasing apparent salinity tolerance. It was also observed that the use of a non-saline growth period to allow seed germination and establishment results in the overestimation of vegetative salinity tolerance if not taken into consideration. This is particularly true for species of low salt tolerance due to their comparatively rapid growth in the non-saline medium compared to that at full salinity.

An "openable," high-strength gradient set for orthopedic MRI

A novel three-axis gradient set and RF resonator for orthopedic MRT has been designed and constructed. The set is openable and may be wrapped around injured joints. The design methodology used was the minimization of magnetic field spherical harmonics by simulated annealing. Splitting of the longitudinal coil presents the major design challenge to a fully openable gradient set and in order to efficiently design such coils, we have developed a new fast algorithm for determining the magnetic field spherical harmonics generated by an are of multiturn wire. The algorithm allows a realistic impression of the effect of split longitudinal designs. A prototype set was constructed based on the new designs and tested in a 2-T clinical research system. The set generated 12 mT/m/A with a linear region of 12 cm and a switching time of 100 mu s, conforming closely with theoretical predictions. Preliminary images from the set are presented. (C) 1999 Academic Press.

The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA.CER) trial: study design and rationale

Background The protease-activated receptor 1 (PAR-1), the main platelet receptor for thrombin, represents a novel target for treatment of arterial thrombosis, and SCH 530348 is an orally active, selective, competitive PAR-1 antagonist. We designed TRA.CER to evaluate the efficacy and safety of SCH 530348 compared with placebo in addition to standard of care in patients with non-ST-segment elevation (NSTE) acute coronary syndromes (ACS) and high-risk features. Trial design TRA.CER is a prospective, randomized, double-blind, multicenter, phase III trial with an original estimated sample size of 10,000 subjects. Our primary objective is to demonstrate that SCH 530348 in addition to standard of care will reduce the incidence of the composite of cardiovascular death, myocardial infarction (MI), stroke, recurrent ischemia with rehospitalization, and urgent coronary revascularization compared with standard of care alone. Our key secondary objective is to determine whether SCH 530348 will reduce the composite of cardiovascular death, MI, or stroke compared with standard of care alone. Secondary objectives related to safety are the composite of moderate and severe GUSTO bleeding and clinically significant TIMI bleeding. The trial will continue until a predetermined minimum number of centrally adjudicated primary and key secondary end point events have occurred and all subjects have participated in the study for at least I year. The TRA.CER trial is part of the large phase III SCH 530348 development program that includes a concomitant evaluation in secondary prevention. Conclusion TRA.CER will define efficacy and safety of the novel platelet PAR-1 inhibitor SCH 530348 in the treatment of high-risk patients with NSTE ACS in the setting of current treatment strategies. (Am Heart J 2009; 158:327-34.)