Cognición no social y neuroimagen en TEA sin discapacidad intelectual

La presente tesis doctoral está constituida por tres estudios independientes pero relacionados entre sí: 1) Estimation of the intelligence quotient using Wechsler intelligence scales in children and adolescents with Asperger syndrome (SA), 2) Executive function is affected in autism spectrum disorder, but does not correlate with intelligence, y 3) Reduced gyrification is related to reduced interhemispheric connectivity in autism spectrum disorders. El objetivo general es estudiar las alteraciones cognitivas en niños y adolescentes con un Trastorno del Espectro Autista (TEA) sin discapacidad intelectual (SDI) asociada, particularmente en cuanto a sus aspectos en funcionamiento general (puntuaciones en escala de inteligencia Wechsler) y funciones ejecutivas, y estudiar la girificación y conectividad en el córtex prefrontal teniendo en cuenta su relación con las funciones ejecutivas. Como objetivos específicos: i) Medir los perfiles de inteligencia en niños y adolescentes con SA; ii) Evaluar la validez de cinco formas abreviadas de las escalas Wechsler de inteligencia en niños y adolescentes con SA, frente a la versión completa, teniendo en cuenta los criterios propuestos por Resnick & Entin, (1971); iii) Evaluar las funciones ejecutivas en una muestra homogénea de niños y adolescentes con TEA-SDI y comparar sus puntuaciones con las obtenidas por un grupo de niños y adolescentes sanos pareados por edad, años de educación, sexo, estatus socioeconómico y cociente intelectual (CI); iv) Evaluar si los déficits en funciones ejecutivas correlacionan con déficits en inteligencia general; v) Evaluar si los déficits en funcionamiento ejecutivo en los niños y adolescentes con TEA-SDI correlacionan con su nivel de funcionamiento o con la gravedad de los síntomas que presentan; vi) Estudiar la relación entre girificación y conectividad de la sustancia blanca, prestando especial atención a los cambios relacionados con la edad en una muestra de pacientes con TEA de alto funcionamiento; vii) Estudiar la girificación y conectividad en el córtex prefrontal teniendo en cuenta su relación con las funciones ejecutivas; y viii) Replicar los resultados obtenidos en nuestra muestra con los datos procedentes de una base independiente de niños y adolescentes con autismo de alto funcionamiento (Autism Brain Imaging Data Exchange, ABIDE)...

Análise de grandezas cinemáticas e dinâmicas inerentes à hemiparesia através da descoberta de conhecimento em bases de dados

Em virtude de uma elevada expectativa de vida mundial, faz-se crescente a probabilidade de ocorrer acidentes naturais e traumas físicos no cotidiano, o que ocasiona um aumento na demanda por reabilitação. A terapia física, sob o paradigma da reabilitação robótica com serious games, oferece maior motivação e engajamento do paciente ao tratamento, cujo emprego foi recomendado pela American Heart Association (AHA), apontando a mais alta avaliação (Level A) para pacientes internados e ambulatoriais. No entanto, o potencial de análise dos dados coletados pelos dispositivos robóticos envolvidos é pouco explorado, deixando de extrair informações que podem ser de grande valia para os tratamentos. O foco deste trabalho consiste na aplicação de técnicas para descoberta de conhecimento, classificando o desempenho de pacientes diagnosticados com hemiparesia crônica. Os pacientes foram inseridos em um ambiente de reabilitação robótica, fazendo uso do InMotion ARM, um dispositivo robótico para reabilitação de membros superiores e coleta dos dados de desempenho. Foi aplicado sobre os dados um roteiro para descoberta de conhecimento em bases de dados, desempenhando pré-processamento, transformação (extração de características) e então a mineração de dados a partir de algoritmos de aprendizado de máquina. A estratégia do presente trabalho culminou em uma classificação de padrões com a capacidade de distinguir lados hemiparéticos sob uma precisão de 94%, havendo oito atributos alimentando a entrada do mecanismo obtido. Interpretando esta coleção de atributos, foi observado que dados de força são mais significativos, os quais abrangem metade da composição de uma amostra.

Novo procedimento para a realização de análise capwap no ensaio de carregamento dinâmico em estacas pré-moldadas.

Desde a década de 1980 diversos autores apresentaram correlações entre provas de carga estática e ensaios de carregamento dinâmico em estacas. Para uma boa correlação é fundamental que os testes sejam bem executados e que atinjam a ruptura segundo algum critério, como o de Davisson, por exemplo, além de levar em conta o intervalo de tempo entre a execução da prova de carga estática e do ensaio dinâmico, face ao efeito \"set up\". Após a realização do ensaio dinâmico realiza-se a análise CAPWAP que permite a determinação da distribuição do atrito lateral em profundidade, a carga de ponta e outros parâmetros dos solos tais como quakes e damping. A análise CAPWAP é realizada por tentativas através do procedimento \"signal matching\", isto é, o melhor ajuste entre os sinais de força medido pelos sensores e o calculado. É relativamente fácil mostrar que a mesma solução pode ser obtida através de dados de entrada diferentes. Isso significa que apesar de apresentarem cargas mobilizadas próximas o formato da curva da simulação de prova de carga estática, obtida pelo CAPWAP, assim como a distribuição do atrito lateral, podem ser diferentes, mesmo que as análises apresentem \"match quality\" (MQWU) satisfatórios. Uma forma de corrigir o formato da curva simulada do CAPWAP, assim como a distribuição do atrito lateral, é através da comparação com provas de carga estática (PCE). A sobreposição das duas curvas, a simulada e a \"real\", permite a determinação do quake do fuste através do trecho inicial da curva carga-recalque da prova de carga estática, que por sua vez permite uma melhor definição da distribuição do atrito lateral e da reação de ponta. Neste contexto surge o conceito de \"match quality de recalques\" (MQR). Quando a PCE não está disponível, propõe-se efetuar um carregamento estático utilizando o peso próprio do martelo do bate-estaca (CEPM). Mostra-se, através de dois casos de obra, em que estavam disponíveis ensaios de carregamento dinâmico e PCEs, que esse procedimento permite obter uma melhor solução do ponto de vista físico, isto é consistente com as características do subsolo e com a curva carga-recalque da PCE, e não apenas matemático, através da avaliação do \"match quality\" (MQWU).

Le role des politiques monétaires et la convergence macroeconomique sur le développement des systèmes financiers dans les pays du sud de la Méditerranée. = The role of monetary policies and macroeconomic convergence in the development of financial systems in south Mediterranean countries. MEDPRO Technical Report No. 12/April 2012

This MEDPRO Technical Report shows that the monetary and exchange rate policies conducted by central banks in the South Mediterranean region display apparent homogeneity in their operational frameworks, albeit with some specificities and differing degrees of advancement. While central banks state that price stability is their ultimate objective, failures to control interest rates as operational objectives of monetary policy result in monetary authorities resorting to quantitative approaches to monetary policy, meaning that monetary aggregates and credit targets are being used as intermediate targets of monetary policy. An econometric exercise limited to Maghreb countries (Algeria, Morocco, and Tunisia) has been conducted to analyse the potential scenarios of convergence and monetary policy coordination. Given the high structural heterogeneity and the slow pace of real convergence due to weak commercial integration in the Maghreb, results nevertheless show alternative dynamics in the integration of effective nominal exchange rates, as well as a complete convergence dynamic in exchange rate policies. Partial convergence of monetary policies regarding the stabilisation of inflation rates remains an open option for a transitional phase where financial integration is low.

Development of an intelligent quality management system using fuzzy association rules

In order to survive in the increasingly customer-oriented marketplace, continuous quality improvement marks the fastest growing quality organization’s success. In recent years, attention has been focused on intelligent systems which have shown great promise in supporting quality control. However, only a small number of the currently used systems are reported to be operating effectively because they are designed to maintain a quality level within the specified process, rather than to focus on cooperation within the production workflow. This paper proposes an intelligent system with a newly designed algorithm and the universal process data exchange standard to overcome the challenges of demanding customers who seek high-quality and low-cost products. The intelligent quality management system is equipped with the ‘‘distributed process mining” feature to provide all levels of employees with the ability to understand the relationships between processes, especially when any aspect of the process is going to degrade or fail. An example of generalized fuzzy association rules are applied in manufacturing sector to demonstrate how the proposed iterative process mining algorithm finds the relationships between distributed process parameters and the presence of quality problems.

Automated mapping of environmental variables from a SEIS or SISE perspective

The INTAMAP FP6 project has developed an interoperable framework for real-time automatic mapping of critical environmental variables by extending spatial statistical methods and employing open, web-based, data exchange protocols and visualisation tools. This paper will give an overview of the underlying problem, of the project, and discuss which problems it has solved and which open problems seem to be most relevant to deal with next. The interpolation problem that INTAMAP solves is the generic problem of spatial interpolation of environmental variables without user interaction, based on measurements of e.g. PM10, rainfall or gamma dose rate, at arbitrary locations or over a regular grid covering the area of interest. It deals with problems of varying spatial resolution of measurements, the interpolation of averages over larger areas, and with providing information on the interpolation error to the end-user. In addition, monitoring network optimisation is addressed in a non-automatic context.

IN VIVO analysis of ocular morphological changes during phakic accommodation

The principal theme of this thesis is the in vivo examination of ocular morphological changes during phakic accommodation, with particular attention paid to the ciliary muscle and crystalline lens. The investigations detailed involved the application of high-resolution imaging techniques to facilitate the acquisition of new data to assist in the clarification of aspects of the accommodative system that were poorly understood. A clinical evaluation of the newly available Grand Seiko Auto Ref/ Keratometer WAM-5500 optometer was undertaken to assess its value in the field of accommodation research. The device was found to be accurate and repeatable compared to subjective refraction, and has the added advantage of allowing dynamic data collection at a frequency of around 5 Hz. All of the subsequent investigations applied the WAM-5500 for determination of refractive error and objective accommodative responses. Anterior segment optical coherence tomography (AS-OCT) based studies examined the morphology and contractile response of youthful and ageing ciliary muscle. Nasal versus temporal asymmetry was identified, with the temporal aspect being both thicker and demonstrating a greater contractile response. The ciliary muscle was longer in terms of both its anterior (r = 0.49, P <0.001) and overall length (r = 0.45, P = 0.02) characteristics, in myopes. The myopic ciliary muscle does not appear to be merely stretched during axial elongation, as no significant relationship between thickness and refractive error was identified. The main contractile responses observed were a thickening of the anterior region and a shortening of the muscle, particularly anteriorly. Similar patterns of response were observed in subjects aged up to 70 years, supporting a lensocentric theory of presbyopia development. Following the discovery of nasal/ temporal asymmetry in ciliary muscle morphology and response, an investigation was conducted to explore whether the regional variations in muscle contractility impacted on lens stability during accommodation. A bespoke programme was developed to analyse AS-OCT images and determine whether lens tilt and decentration varied between the relaxed and accommodated states. No significant accommodative difference in these parameters was identified, implying that any changes in lens stability with accommodation are very slight, as a possible consequence of vitreous support. Novel three-dimensional magnetic resonance imaging (MRI) and analysis techniques were used to investigate changes in lens morphology and ocular conformation during accommodation. An accommodative reduction in lens equatorial diameter provides further evidence to support the Helmholtzian mechanism of accommodation, whilst the observed increase in lens volume challenges the widespread assertion that this structure is incompressible due to its high water content. Wholeeye MRI indicated that the volume of the vitreous chamber remains constant during accommodation. No significant changes in ocular conformation were detected using MRI. The investigations detailed provide further insight into the mechanisms of accommodation and presbyopia, and represent a platform for future work in this field.

UncertWeb processing service:making models easer to access on the web

Models are central tools for modern scientists and decision makers, and there are many existing frameworks to support their creation, execution and composition. Many frameworks are based on proprietary interfaces, and do not lend themselves to the integration of models from diverse disciplines. Web based systems, or systems based on web services, such as Taverna and Kepler, allow composition of models based on standard web service technologies. At the same time the Open Geospatial Consortium has been developing their own service stack, which includes the Web Processing Service, designed to facilitate the executing of geospatial processing - including complex environmental models. The current Open Geospatial Consortium service stack employs Extensible Markup Language as a default data exchange standard, and widely-used encodings such as JavaScript Object Notation can often only be used when incorporated with Extensible Markup Language. Similarly, no successful engagement of the Web Processing Service standard with the well-supported technologies of Simple Object Access Protocol and Web Services Description Language has been seen. In this paper we propose a pure Simple Object Access Protocol/Web Services Description Language processing service which addresses some of the issues with the Web Processing Service specication and brings us closer to achieving a degree of interoperability between geospatial models, and thus realising the vision of a useful 'model web'.

Proceedings of the Spring Servitization Conference (SSC 2013):servitization in the multi-organisation enterprise

The increased data complexity and task interdependency associated with servitization represent significant barriers to its adoption. The outline of a business game is presented which demonstrates the increasing complexity of the management problem when moving through Base, Intermediate and Advanced levels of servitization. Linked data is proposed as an agile set of technologies, based on well established standards, for data exchange both in the game and more generally in supply chains.

Linking design and manufacturing domains via web-based and enterprise integration technologies

The manufacturing industry faces many challenges such as reducing time-to-market and cutting costs. In order to meet these increasing demands, effective methods are need to support the early product development stages by bridging the gap of communicating early design ideas and the evaluation of manufacturing performance. This paper introduces methods of linking design and manufacturing domains using disparate technologies. The combined technologies include knowledge management supporting for product lifecycle management systems, Enterprise Resource Planning (ERP) systems, aggregate process planning systems, workflow management and data exchange formats. A case study has been used to demonstrate the use of these technologies, illustrated by adding manufacturing knowledge to generate alternative early process plan which are in turn used by an ERP system to obtain and optimise a rough-cut capacity plan. Copyright © 2010 Inderscience Enterprises Ltd.

Adaptive Brain-Computer Interface Systems For Communication in People with Severe Neuromuscular Disabilities

Brain-computer interfaces (BCI) have the potential to restore communication or control abilities in individuals with severe neuromuscular limitations, such as those with amyotrophic lateral sclerosis (ALS). The role of a BCI is to extract and decode relevant information that conveys a user's intent directly from brain electro-physiological signals and translate this information into executable commands to control external devices. However, the BCI decision-making process is error-prone due to noisy electro-physiological data, representing the classic problem of efficiently transmitting and receiving information via a noisy communication channel.

This research focuses on P300-based BCIs which rely predominantly on event-related potentials (ERP) that are elicited as a function of a user's uncertainty regarding stimulus events, in either an acoustic or a visual oddball recognition task. The P300-based BCI system enables users to communicate messages from a set of choices by selecting a target character or icon that conveys a desired intent or action. P300-based BCIs have been widely researched as a communication alternative, especially in individuals with ALS who represent a target BCI user population. For the P300-based BCI, repeated data measurements are required to enhance the low signal-to-noise ratio of the elicited ERPs embedded in electroencephalography (EEG) data, in order to improve the accuracy of the target character estimation process. As a result, BCIs have relatively slower speeds when compared to other commercial assistive communication devices, and this limits BCI adoption by their target user population. The goal of this research is to develop algorithms that take into account the physical limitations of the target BCI population to improve the efficiency of ERP-based spellers for real-world communication.

In this work, it is hypothesised that building adaptive capabilities into the BCI framework can potentially give the BCI system the flexibility to improve performance by adjusting system parameters in response to changing user inputs. The research in this work addresses three potential areas for improvement within the P300 speller framework: information optimisation, target character estimation and error correction. The visual interface and its operation control the method by which the ERPs are elicited through the presentation of stimulus events. The parameters of the stimulus presentation paradigm can be modified to modulate and enhance the elicited ERPs. A new stimulus presentation paradigm is developed in order to maximise the information content that is presented to the user by tuning stimulus paradigm parameters to positively affect performance. Internally, the BCI system determines the amount of data to collect and the method by which these data are processed to estimate the user's target character. Algorithms that exploit language information are developed to enhance the target character estimation process and to correct erroneous BCI selections. In addition, a new model-based method to predict BCI performance is developed, an approach which is independent of stimulus presentation paradigm and accounts for dynamic data collection. The studies presented in this work provide evidence that the proposed methods for incorporating adaptive strategies in the three areas have the potential to significantly improve BCI communication rates, and the proposed method for predicting BCI performance provides a reliable means to pre-assess BCI performance without extensive online testing.

RAGE Reusable Game Software Components and Their Integration into Serious Game Engines

This paper presents and validates a methodology for integrating reusable software components in diverse game engines. While conforming to the RAGE com-ponent-based architecture described elsewhere, the paper explains how the interac-tions and data exchange processes between a reusable software component and a game engine should be implemented for procuring seamless integration. To this end, a RAGE-compliant C# software component providing a difficulty adaptation routine was integrated with an exemplary strategic tile-based game “TileZero”. Implementa-tions in MonoGame, Unity and Xamarin, respectively, have demonstrated successful portability of the adaptation component. Also, portability across various delivery platforms (Windows desktop, iOS, Android, Windows Phone) was established. Thereby this study has established the validity of the RAGE architecture and its un-derlying interaction processes for the cross-platform and cross-game engine reuse of software components. The RAGE architecture thereby accommodates the large scale development and application of reusable software components for serious gaming.

Planificação de uma plataforma web de calendarização e divulgação da oferta cultural do município de Angra do Heroísmo

Com o intuito de melhorar a eficiência na gestão e execução de responsabilidades junto dos munícipes, a Câmara Municipal de Angra do Heroísmo (CMAH), localizada na ilha Terceira (Região Autónoma dos Açores), distribui as suas valências por vários departamentos e colaboradores especializados. Apesar desta segmentação existem circunstâncias em que os mesmos trabalham em conjunto e cruzam informações, por exemplo, nos processos de licenciamento. Contudo, esta necessária troca de dados é deficiente quando se calendarizam eventos organizados ou não pela instituição em causa. Consequentemente, esta falha resulta muitas vezes na sobreposição de eventos, algo considerado insustentável numa comunidade relativamente pequena, como é o caso de Angra do Heroísmo (em 2013, contava com 35.109 habitantes). A autarquia pretende solucionar o problema tendo em conta as capacidades proporcionadas pelas plataformas da Web 2.0 que, entre outras, permitem a participação dos utilizadores e a fácil inserção e gestão da informação por pessoas sem conhecimentos técnicos aprofundados. Esta dissertação determina as especificações que devem estar presentes numa plataforma Web de calendarização e divulgação da oferta cultural, ao serviço do Município de Angra do Heroísmo; conceptualiza um protótipo funcional que valida as especificações identificadas e serve de apoio à construção da plataforma final a desenvolver no futuro. Esta investigação tem como fim melhorar o processo de calendarização e divulgação de eventos da oferta cultural do concelho angrense. Esta finalidade implicou a necessidade de conhecer aprofundadamente o funcionamento da instituição, identificando e distinguindo o papel dos vários intervenientes e processos, pelo que parte da investigação decorreu na Câmara Municipal de Angra do Heroísmo. Entre os vários desafios desta pesquisa destacam-se a recolha e compreensão de informação sobre o processo em estudo e o planeamento de um sistema digital intuitivo, que respeite as estruturas de decisão e o sistema hierárquico da autarquia e que detenha o grau de rigor exigido nas organizações governativas.

Orthogonal persistence in Java supported by aspect- oriented programming and reflection

The persistence concern implemented as an aspect has been studied since the appearance of the Aspect-Oriented paradigm. Frequently, persistence is given as an example that can be aspectized, but until today no real world solution has applied that paradigm. Such solution should be able to enhance the programmer productivity and make the application less prone to errors. To test the viability of that concept, in a previous study we developed a prototype that implements Orthogonal Persistence as an aspect. This first version of the prototype was already fully functional with all Java types including arrays. In this work the results of our new research to overcome some limitations that we have identified on the data type abstraction and transparency in the prototype are presented. One of our goals was to avoid the Java standard idiom for genericity, based on casts, type tests and subtyping. Moreover, we also find the need to introduce some dynamic data type abilities. We consider that the Reflection is the solution to those issues. To achieve that, we have extended our prototype with a new static weaver that preprocesses the application source code in order to introduce changes to the normal behavior of the Java compiler with a new generated reflective code.