Impact of Syncope on Quality of Life: Validation of a Measure in Patients Undergoing Tilt Testing

INTRODUCTION AND OBJECTIVES: Recurrent syncope has a significant impact on quality of life. The development of measurement scales to assess this impact that are easy to use in clinical settings is crucial. The objective of the present study is a preliminary validation of the Impact of Syncope on Quality of Life questionnaire for the Portuguese population. METHODS: The instrument underwent a process of translation, validation, analysis of cultural appropriateness and cognitive debriefing. A population of 39 patients with a history of recurrent syncope (>1 year) who underwent tilt testing, aged 52.1 ± 16.4 years (21-83), 43.5% male, most in active employment (n=18) or retired (n=13), constituted a convenience sample. The resulting Portuguese version is similar to the original, with 12 items in a single aggregate score, and underwent statistical validation, with assessment of reliability, validity and stability over time. RESULTS: With regard to reliability, the internal consistency of the scale is 0.9. Assessment of convergent and discriminant validity showed statistically significant results (p<0.01). Regarding stability over time, a test-retest of this instrument at six months after tilt testing with 22 patients of the sample who had not undergone any clinical intervention found no statistically significant changes in quality of life. CONCLUSIONS: The results indicate that this instrument is of value for assessing quality of life in patients with recurrent syncope in Portugal.

MET: a promising anticancer therapeutic target.

The MET pathway is dysregulated in many human cancers and promotes tumour growth, invasion and dissemination. Abnormalities in MET signalling have been reported to correlate with poor clinical outcomes and drug resistance in patients with cancer. Thus, MET has emerged as an attractive target for cancer therapy. Several MET inhibitors have been introduced into the clinic, and are currently in all phases of clinical trials. In general, initial results from these studies indicate only a modest benefit in unselected populations. In this Review, we discuss current challenges in developing MET inhibitors--including identification of predictive biomarkers--as well as the most-efficient ways to combine these drugs with other targeted agents or with classic chemotherapy or radiotherapy.

RECUEIL DES ŒUVRES POÉTIQUES de Jehan Molinet. Ms. in-fol. sur papier de 201 f., demi-rel. v. f, tr. r. (Rel. du XVIIIe siècle.)

Complainte (La) de Grece

Paris, le Sacré-Cœur : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58391

(Arrêt de parlement qui condamne Jean Massard de La Cressonnière, curé de Ville-sur-Arce à faire amende honorable au bailliage de Bar-sur-Seine, à 3 ans de bannissement du ressort et à 100 livres d'amende, 10 livres d'aumône et mille livres de dommages et interêts.)

[Acte. 1752-06-17. Paris]

(Arrêt de parlement qui déclare la contumace bien instruite contre le sieur Laugier de Beaurecueil, curé de la paroisse de Sainte-Marguerite de Paris et le nommé Filz, porte-Dieu, et bannit à perpétuité hors du royaume ledit Laugier de Beaurecueil.)

[Acte. 1755-03-08. Paris]

(Arrêt du parlement touchant un scandale arrivé dans l'église des religieux Carmes de Nantes, à l'occasion d'un service que l'Université de la même ville faisait célébrer, le 14 janvier, pour le feu curé de Thouarré.)

[Acte. 1756-01-19. Rennes]

Arrêts du grand conseil des 2 décembre 1698 et 23 janvier 1699, en faveur des officiers commensaux de feue Madame la Dauphine, pour le rang et préséance, l'eau bénite et autres droits honorifiques de l'église, contre Me Laurens Garnier de la Courdubois, procureur du roi en l'élection d'Eu, Me Laurens Lenclos, curé de la paroisse de la Sainte-Trinité de ladite ville, et Laur. Gourdin, son bedeau

[Acte. 1698-12-02. Paris]

Arrêt du grand conseil pour la dîme des Sainfoins et Bourgognes, tant dans les enclos que hors d'iceux. (Entre les religieuses des Filles-Dieu de Paris, et Jean-François-de-Sales Charmolue, curé de Houilles.)

[Acte. 1707-09-28. Paris]