Photonic crystal fiber Bragg grating based sensors:opportunities for applications in healthcare

We review the state-of-the-art in photonic crystal fiber (PCF) and microstructured polymer optical fiber (mPOF) based mechanical sensing. We first introduce how the unique properties of PCF can benefit Bragg grating based temperature insensitive pressure and transverse load sensing. Then we describe how the latest developments in mPOF Bragg grating technology can enhance optical fiber pressure sensing. Finally we explain how the integration of specialty fiber sensor technology with bio-compatible polymer based micro-technology provides great opportunities for fiber sensors in the field of healthcare.

Low-cost fully integrated fiber Bragg grating interrogation system

Fiber Bragg gratings can be used for monitoring different parameters in a wide variety of materials and constructions. The interrogation of fiber Bragg gratings traditionally consists of an expensive and spacious peak tracking or spectrum analyzing unit which needs to be deployed outside the monitored structure. We present a dynamic low-cost interrogation system for fiber Bragg gratings which can be integrated with the fiber itself, limiting the fragile optical in- and outcoupling interfaces and providing a compact, unobtrusive driving and read-out unit. The reported system is based on an embedded Vertical Cavity Surface Emitting Laser (VCSEL) which is tuned dynamically at 1 kHz and an embedded photodiode. Fiber coupling is provided through a dedicated 45° micromirror yielding a 90° in-the-plane coupling and limiting the total thickness of the fiber coupled optoelectronic package to 550 µm. The red-shift of the VCSEL wavelength is providing a full reconstruction of the spectrum with a range of 2.5 nm. A few-mode fiber with fiber Bragg gratings at 850 nm is used to prove the feasibility of this low-cost and ultra-compact interrogation approach.

Processing of highly porous titanium parts by metal injection moulding in combination with innovative plasma treatment

A combinação da Moldagem por Injeção de pós Metálicos (Metal Injection Moulding MIM) e o Método do Retentor Espacial (Space Holder Method - SHM) é uma técnica promissora para fabricação de peças porosas de titânio com porosidade bem definida como implantes biomédicos, uma vez que permite um alto grau de automatização e redução dos custos de produção em larga escala quando comparado a técnica tradicional (SHM e usinagem a verde). Contudo a aplicação desta técnica é limitada pelo fato que há o fechamento parcial da porosidade na superfície das amostras, levando ao deterioramento da fixação do implante ao osso. E além disso, até o presente momento não foi possível atingir condições de processamento estáveis quando a quantidade de retentor espacial excede 50 vol. %. Entretanto, a literatura descreve que a melhor faixa de porosidade para implantes de titânio para coluna vertebral está entre 60 - 65 vol. %. Portanto, no presente estudo, duas abordagens foram conduzidas visando a produção de amostras altamente porosas através da combinação de MIM e SHM com o valor constante de retentor espacial de 70 vol. % e uma porosidade aberta na superfície. Na primeira abordagem, a quantidade ótima de retentor espacial foi investigada, para tal foram melhorados a homogeneização do feedstock e os parâmetros de processo com o propósito de permitir a injeção do feedstock. Na segunda abordagem, tratamento por plasma foi aplicado nas amostras antes da etapa final de sinterização. Ambas rotas resultaram na melhoria da estabilidade dimensional das amostras durante a extração térmica do ligante e sinterização, permitindo a sinterização de amostras de titânio altamente porosas sem deformação da estrutura.

(Table S1) Age determination of Atlantic Ocean sediment cores

Well-dated benthic foraminifer oxygen isotopic records (d18O) from different water depths and locations within the Atlantic Ocean exhibit distinct patterns and significant differences in timing over the last deglaciation. This has two implications: on the one hand, it confirms that benthic d18O cannot be used as a global correlation tool with millennial-scale precision, but on the other hand, the combination of benthic isotopic records with independent dating provides a wealth of information on past circulation changes. Comparing new South Atlantic benthic isotopic data with published benthic isotopic records, we show that (1) circulation changes first affected benthic d18O in the 1000-2200 m range, with marked decreases in benthic d18O taking place at ~17.5 cal. kyr B.P. (ka) due to the southward propagation of brine waters generated in the Nordic Seas during Heinrich Stadial 1 (HS1) cold period; (2) the arrival of d18O-depleted deglacial meltwater took place later at deeper North Atlantic sites; (3) hydrographic changes recorded in North Atlantic cores below 3000 m during HS1 do not correspond to simple alternations between northern- and southern-sourced water but likely reflect instead the incursion of brine-generated deep water of northern as well as southern origin; and (4) South Atlantic waters at ~44°S and ~3800 m depth remained isolated from better-ventilated northern-sourced water masses until after the resumption of North Atlantic Deep Water (NADW) formation at the onset of the Bølling-Allerod, which led to the propagation of NADW into the South Atlantic.

Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years : 7-year follow-up of the phase 3, double-blind, randomised controlled VIVIANE study

Acknowledgments The VIVIANE study was funded and coordinated by GlaxoSmithKline Biologicals SA, which also covered all costs associated with development and publication of this report. We thank all study participants and their families. We gratefully acknowledge the work of the central and local study coordinators, and staff members of the sites who participated in this study. Writing support services were provided by Mary Greenacre (An Sgriobhadair, Isle of Barra, UK), on behalf of GSK Vaccines; editing and publication coordination services were provided by Jérôme Leemans (Keyrus Biopharma, Lasne, Belgium), Stéphanie Delval (XPE Pharma and Science, Wavre, Belgium), and Matthieu Depuydt (Business Decision Life Sciences, Brussels, Belgium), on behalf of GSK Vaccines

Partisan Dealignment in Germany: A rejoinder to Russell Dalton

The work of Russell Dalton has undoubtedly played a seminal role in the study of the relation between political sophistication and partisan dealignment. We furthermore acknowledge the presence of a consensus on the occurrence of lower levels of partisanship in Germany. Using panel data as well as pooled cross-sectional observations, however, it is clear that generational replacement is not the sole driving force of partisan dealignment, but that period effects should also be taken into account. While on an aggregate level rising levels of political sophistication have occurred simultaneously with decreasing partisanship, individual level analysis suggests clearly that the least sophisticated are most likely to feel alienated from the party system. We close with some very specific suggestion on how to address the democratic consequences of declining levels of partisanship.

Age, Period and Cohort effects in the Decline of Party Identification in Germany

Party identification traditionally is seen as an important linkage mechanism, connecting voters to the party system. Previous analyses have suggested that the level of party identity is in decline in Germany, and in this article, we first expand previous observations with more recent data. These suggest that the erosion of party identity continues up to the present time. An age-period-cohort analysis of the panel data of the SOEP panel suggests that period effects are significantly negative. Furthermore, it can be observed that throughout the 1992-2009 observation period, education level and political interest have become more important determinants of party identity. Contrary to some of the literature, therefore, it can be shown that the loss of party identity is concentrated among groups with lower levels of political sophistication, indicating that the socio-economic profile of the group with a sense of party identification has become more distinct compared to the population as a whole. In the discussion, we investigate the theoretical and democratic consequences of this trend.

Optical fiber sensors embedded in flexible polymer foils

In traditional electrical sensing applications, multiplexing and interconnecting the different sensing elements is a major challenge. Recently, many optical alternatives have been investigated including optical fiber sensors of which the sensing elements consist of fiber Bragg gratings. Different sensing points can be integrated in one optical fiber solving the interconnection problem and avoiding any electromagnetical interference (EMI). Many new sensing applications also require flexible or stretchable sensing foils which can be attached to or wrapped around irregularly shaped objects such as robot fingers and car bumpers or which can even be applied in biomedical applications where a sensor is fixed on a human body. The use of these optical sensors however always implies the use of a light-source, detectors and electronic circuitry to be coupled and integrated with these sensors. The coupling of these fibers with these light sources and detectors is a critical packaging problem and as it is well-known the costs for packaging, especially with optoelectronic components and fiber alignment issues are huge. The end goal of this embedded sensor is to create a flexible optical sensor integrated with (opto)electronic modules and control circuitry. To obtain this flexibility, one can embed the optical sensors and the driving optoelectronics in a stretchable polymer host material. In this article different embedding techniques for optical fiber sensors are described and characterized. Initial tests based on standard manufacturing processes such as molding and laser structuring are reported as well as a more advanced embedding technique based on soft lithography processing.

(Table 3) Description of petrographic profiles in Mittelholstein, Germany

In der vorliegenden Arbeit wird nach morphologischen und sedimentpetrographischen Methoden die Entwässerung der würmzeitlichen Eisrandlagen Mittelholsteins untersucht. Das Untersuchungsgebiet liegt im Mittelteil des nördlichen Holsteins. Im Norden und Osten schließt es etwa mit den Orten Gr. Vollstedt-Blumenthal-Stolpe-Tensfeld, im Süden mit dem Tal der Tensfelder und Oster- bzw. Bram-Au, während es im Westen durch die Höhen der Riß-Moränen zwischen Kellinghusen und Brammer abgegrenzt wird. Morphologisch zeigt sich eine Dreiteilung: im Norden und Osten die würmzeitliche Jungmoräne, im Westen und Süden die rißzeitliche Altmoräne, zwischen beiden die Sander- und Abflussebenen der Würm-Vereisung.

Market reforms and privatisation in the English National Health Service

The article examines developments in the marketisation and privatisation of the English National Health Service, primarily since 1997. It explores the use of competition and contracting out in ancillary services and the levering into public services of private finance for capital developments through the Private Finance Initiative. A substantial part of the article examines the repeated restructuring of the health service as a market in clinical services, initially as an internal market but subsequently as a market increasing opened up to private sector involvement. Some of the implications of market processes for NHS staff and for increased privatisation are discussed. The article examines one episode of popular resistance to these developments, namely the movement of opposition to the 2011 health and social care legislative proposals. The article concludes with a discussion of the implications of these system reforms for the founding principles of the NHS and the sustainability of the service.

Receptive Vocabulary of CLIL and Non-CLIL Primary and Secondary School Learners

CLIL instruction has been reported to be beneficial for foreign language vocabulary learning since CLIL students show higher vocabulary profiles than students of their same age in traditional EFL contexts. However, to our knowledge, the receptive vocabulary knowledge of CLIL and non-CLIL learners at the end of primary and secondary education has not been examined yet. Hence, this study aims at comparing the receptive vocabulary size 79 CLIL primary learners with the receptive vocabulary knowledge of 331 non-CLIL learners at the end of primary and secondary school. Sex-based differences were also analysed. The 2k Vocabulary Levels Test (VLT) was used for the purposes of the study. Results revealed that learners’ receptive vocabulary sizes lie within the most frequent 1000 words, non-CLIL secondary school students throw better results than primary students but the differences between the secondary group and the CLIL group are not statistically significant. As for sex-based differences, we found no significant differences among the groups. These findings led us to believe that the CLIL approach offers a benefit for vocabulary acquisition since CLIL learners have been exposed to the foreign language for a shorter period of time and the results are quite similar to their non-CLIL secondary school partners.

Vampyyrin varjossa. Pelon elementit elokuvassa Nosferatu – Eine Symphonie des Grauens.

Tutkielman aiheena on vuonna 1922 tehty saksalainen ekspressionistinen elokuva Nosferatu – Eine Symphonie des Grauens. Elokuva on ensimmäinen virallinen sovitus irlantilaisen kirjailija Bram Stokerin Draculasta (1897). Tutkielmassa tarkastellaan, minkälaisia pelon elementtejä elokuva välittää katsojilleen. Tämän lisäksi tutkielmassa on kehitelty lähiluvun tutkimusmetodia hyödyntäen rakennetaulukkoa, jolla elokuvasta ilmeneviä pelon elementtejä analysoidaan. Rakennetaulukon muodostuksessa on erityisesti hyödynnetty saksalaisen elokuvatutkija Siegfried Kracauerin kahta teosta: Caligarista Hitleriin (1947) sekä Propaganda ja kansallissosialistinen elokuva (1942). Tutkimuksessa on Kracauerin oppeja noudattaen laadittu jokaiselle analysoitavalle kohtaukselle oma rakennetaulukkonsa, johon on yksityiskohtaisesti purettu kohtausten visuaalinen sisältö, vuorosanat ja musiikki. Analysoitava aineisto koostuu kuudesta elokuvan kohtauksesta. Valituissa kohtauksissa keskeisessä roolissa ovat elokuvan päähenkilöt: vampyyrikreivi Orlok, asianajaja Hutter ja tämän vaimo Ellen. Keskeisenä tutkimuskirjallisuutena on käytetty elokuvatutkimuksesta, vampyyripopulaarikulttuurista, pelon kulttuurista sekä saksalaisesta 1900–1930-lukujen yhteiskunnasta kertovia teoksia. Tutkimuskirjallisuudella avataan Nosferatu – Eine Symphonie des Grauens -elokuvan historiallista sekä kulttuurista kontekstia. Kirjallisuuden lisäksi tutkimuksessa on käytetty kommenttiraitoja, joita Nosferatu – Eine Symphonie des Grauens -elokuvaan on tehty. Taustatutkimuksessa on myös käytetty elokuvasta kertovia dokumentteja. Tutkimustuloksissa päädytään siihen, että ensisijaisesti Nosferatu – Eine Symphonie des Grauens välittää katsojilleen kuoleman pelkoon liitettäviä elementtejä. Pelon elementtejä välitetään monipuolisesti elokuvassa kuten hahmojen olemuksen ja dialogin, miljöön, kamerakuvan luomien näkökulmien ja musiikin keinoin. Käytetty lähiluvun tutkimusmetodi ja rakennetaulukko ovat toimivia elokuvan kohtausten analyyseissä, mutta vaativat vielä jatko-tutkimuksia, mikäli niitä halutaan yrittää soveltaa muussa kuin ekspressionistisen elokuva-aineiston tarkastelussa.

Political participation in Australia : contingency in the behaviour and attitudes of citizens

Nonparametric tests of collectively rational consumption behavior: an integer programming procedure

We present an IP-based nonparametric (revealed preference) testing procedure for rational consumption behavior in terms of general collective models, which include consumption externalities and public consumption. An empirical application to data drawn from the Russia Longitudinal Monitoring Survey (RLMS) demonstrates the practical usefulness of the procedure. Finally, we present extensions of the testing procedure to evaluate the goodness-of-…t of the collective model subject to testing, and to quantify and improve the power of the corresponding collective rationality tests.