Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus.

Leishmaniaparasites cause a broad range of disease, with cutaneous afflictions being, by far, the most prevalent. Variations in disease severity and symptomatic spectrum are mostly associated to parasite species. One risk factor for the severity and emergence of leishmaniasis is immunosuppression, usually arising by coinfection of the patient with human immunodeficiency virus (HIV). Interestingly, several species ofLeishmaniahave been shown to bear an endogenous cytoplasmic dsRNA virus (LRV) of theTotiviridaefamily, and recently we correlated the presence of LRV1 withinLeishmaniaparasites to an exacerbation murine leishmaniasis and with an elevated frequency of drug treatment failures in humans. This raises the possibility of further exacerbation of leishmaniasis in the presence of both viruses, and here we report a case of cutaneous leishmaniasis caused byLeishmania braziliensisbearing LRV1 with aggressive pathogenesis in an HIV patient. LRV1 was isolated and partially sequenced from skin and nasal lesions. Genetic identity of both sequences reinforced the assumption that nasal parasites originate from primary skin lesions. Surprisingly, combined antiretroviral therapy did not impact the devolution ofLeishmaniainfection. TheLeishmaniainfection was successfully treated through administration of liposomal amphotericin B.

Lithology and measurement of largest grains in ODP Hole 152-918D (Table 1)

Shipboard analysis of the 1183-m sedimentary section recovered at Site 918 in the Irminger Basin during Ocean Drilling Program Leg 152 revealed material of glacial origin (diamictons, ice-rafted debris (IRD) and dropstones) as deep as 543 m below sea floor (bsf). The sediment containing the deepest dropstone was biostratigraphically dated shipboard as approximately 7 Ma, pushing back the date for the onset of glaciation on southern Greenland by 5 Ma. Thin layers of fine sand were found as much as 60 m deeper in the core, raising the possibility of an even earlier date for glaciation. To determine the sedimentary history of these deeper sand layers, the surface textures on quartz grains from eleven cores bracketing the interval of interest were analyzed by scanning electron microscope. The results suggest that the grains in the 60-m interval below the deepest dropstone have a glacial history. At that level, an 11 -Ma Sr-isotope date was obtained from planktonic foraminifers. This late Miocene timing is supported biostratigraphically by both nannofossil and foraminifer assemblages, indicating a new minimum age for the onset of glaciation on southern Greenland and in the North Atlantic.

La navidad en las montañas; a Spanish American story

Mode of access: Internet.

Florinda, or The Moors in Spain; a new grand opera in four acts.

Words in Italian and English.

Cy commence le livre nom[m]e la discipline damour divine.

"Written by an anonymous Celestine monk in the 1470s at Notre Dame D'Ambert near Orleans ... an interesting example of devotional literature in the vernacular written by the Celestines for women. The complicated story behind this text (which survives in only two manuscripts), however, is even more interesting, since its source is the Miroir des simples âmes (Mirror of Simple Souls) by the mystical writer, Marguerite Porete, who was burnt at the stake as a relapsed heretic in Paris in 1310"--Textmanuscripts.com

The Boston Handel and Haydn Society collection of church music : being a selection of the most approved psalm and hymn tunes, anthems, sentences, chants, &c. : together with many beautiful extracts from the works of Haydn, Mozart, Beethoven, and other eminent composers, harmonized for three and four voices, with a figured base for the organ and piano forte /

Mode of access: Internet.

Les sérénades. pour baryton ou contralto /

For voice and piano.

Evaluation of environmental control technologies for magnetic fields /

August 1978.

Memoirs and correspondence of Field-Marshal Viscount Combermere, G. C. B., etc., from his family papers.

Mode of access: Internet.

Descriptive catalogue of the original charters, royal grants, and donations ...

Mode of access: Internet.

Historia General de los hechos de los castellanos en las Islas i tierra firme del mar oceano /

Mode of access: Internet.

The Odeon :

Mode of access: Internet.

Hand book to the antiquities of Athens,

Mode of access: Internet.

Letters of Queen Henrietta Maria, including her private correspondence with Charles the First.

Mode of access: Internet.

Report on Egypt and Candia : addressed to the Right Hon. Lord Viscount Palmerston, Her Majesty's principal secretary of state for foreign affairs, &c. &c. &c. /

Includes index.