Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus.
Data(s) |
06/04/2016
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Resumo |
Leishmaniaparasites cause a broad range of disease, with cutaneous afflictions being, by far, the most prevalent. Variations in disease severity and symptomatic spectrum are mostly associated to parasite species. One risk factor for the severity and emergence of leishmaniasis is immunosuppression, usually arising by coinfection of the patient with human immunodeficiency virus (HIV). Interestingly, several species ofLeishmaniahave been shown to bear an endogenous cytoplasmic dsRNA virus (LRV) of theTotiviridaefamily, and recently we correlated the presence of LRV1 withinLeishmaniaparasites to an exacerbation murine leishmaniasis and with an elevated frequency of drug treatment failures in humans. This raises the possibility of further exacerbation of leishmaniasis in the presence of both viruses, and here we report a case of cutaneous leishmaniasis caused byLeishmania braziliensisbearing LRV1 with aggressive pathogenesis in an HIV patient. LRV1 was isolated and partially sequenced from skin and nasal lesions. Genetic identity of both sequences reinforced the assumption that nasal parasites originate from primary skin lesions. Surprisingly, combined antiretroviral therapy did not impact the devolution ofLeishmaniainfection. TheLeishmaniainfection was successfully treated through administration of liposomal amphotericin B. |
Formato |
application/pdf |
Identificador |
http://boris.unibe.ch/82128/1/840.full.pdf Parmentier, Laurent Philippe Simon; Cusini, Alexia; Müller, Norbert; Zangger, Haroun; Hartley, Mary-Anne; Desponds, Chantal; Castiglioni, Patrik; Dubach, Patrick; Ronet, Catherine; Beverley, Stephen M; Fasel, Nicolas (2016). Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus. The American Journal of Tropical Medicine and Hygiene, 94(4), pp. 840-843. American Society of Tropical Medicine and Hygiene 10.4269/ajtmh.15-0803 <http://dx.doi.org/10.4269/ajtmh.15-0803> doi:10.7892/boris.82128 info:doi:10.4269/ajtmh.15-0803 info:pmid:26834198 urn:issn:0002-9637 |
Idioma(s) |
eng |
Publicador |
American Society of Tropical Medicine and Hygiene |
Relação |
http://boris.unibe.ch/82128/ |
Direitos |
info:eu-repo/semantics/openAccess |
Fonte |
Parmentier, Laurent Philippe Simon; Cusini, Alexia; Müller, Norbert; Zangger, Haroun; Hartley, Mary-Anne; Desponds, Chantal; Castiglioni, Patrik; Dubach, Patrick; Ronet, Catherine; Beverley, Stephen M; Fasel, Nicolas (2016). Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus. The American Journal of Tropical Medicine and Hygiene, 94(4), pp. 840-843. American Society of Tropical Medicine and Hygiene 10.4269/ajtmh.15-0803 <http://dx.doi.org/10.4269/ajtmh.15-0803> |
Palavras-Chave | #610 Medicine & health #630 Agriculture |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |