El sistema financiero para la vivienda y la producción de vivienda para el sector informal

Analiza los resultados alcanzados por el Gobierno Federal en su política nacional de habitación mediante la creación del Sistema Financiero de la Habitación y del Banco Nacional de la Habitación, así como aquellos objetivos sociales que se trazó inicialmente y que no logró sostener.

Evolução recente dos mercados de crédito e de títulos no Brasil e sua atuação no financiamento dos macro-setores indústria, comércio e serviços (1996-2007): uma interpretação pós-keynesiana

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Os agentes estatais na produção do espaço urbano em cidades do interior paulista: Marília, Presidente, Araçatuba e São José do Rio Preto

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Direcionamento de crédito: uma análise sobre os efeitos da atuação do BNDES durante a crise do Subprime

This essay treats the government acting on the National Financial System (SFN) through the policy of directing credit, a common practice within industrialization attempts. In Brazil this policy occurred mainly through the principal instrument of the government on the financial system, the National Bank of Economic and Social Development (BNDES). It will be explained BNDES’ position within public finances and its ability to mobilize or act as an intermediary for mobilizing resources for the economy. Will also be addressed the countercyclical characteristics of BNDES’ disbursements in the Brazilian economy using as a backdrop the financial crisis that erupted in the overthrow of the mortgages in the USA, also known as the subprime crisis. Finally we will present the main ideas behind the criticism and praise that this model with strong state presence in the financial system suffers

As políticas de crédito do BNDES e suas consequências no desenvolvimento territorial do estado de São Paulo (2006 - 2010)

Based on investment strategies, the history of the BNDES and the economic policy current between the years 2006 and 2010, this paper presents an analysis of the support given by the Bank in the state of São Paulo, trying to see how these influenced the territorial structure and development of this state in the period

A problemática trazida pelos bancos de perfis genéticos criminais no Brasil

Pós-graduação em Direito - FCHS

Distribuição dos desembolsos do BNDES no setor sucroenergético no Brasil

The organization and dynamics of the energetic-sugarcane sector in Brazil have suffered the impacts of the “deregulation” process that took place in the 1990s, since when it is no longer monitored by the State. In this scenario, the agribusiness enterprises, in order to survive, act over production, marketing and management of their activities, among others areas, demanding financial investments. The credit lines offered by BNDES (National Bank for Economic and Social Development) are one of the factors that enable the implementation of these actions. In this context, the aim of this study is to assess the connections between BNDES's outlays for the sugarcane sector in Brazil from 2001 to 2008, and the activities of this sector, according to the federation unity and the region in the country. The work is based on: i) literature review and ii) secondary selected data collection aimed at the composition of data series. The organization and analysis of data indicates that the largest amount of money is destined to the south-central region, specifically the state of São Paulo. This is the only state that receives almost all types of financings, an equivalent to 68% of the receptions in the period. The concentration of BNDES's outlays in the south-central region may be linked to the dominance of the sector in this region, either in terms of harvested area, amount of production, employment contracts or number of enterprises.

Os financiamentos do BNDES às usinas sucroalcooleiras paulistas: potencialidades da ampliação da desigualdade regional no Brasil

The present work focuses on addressing the financing made by BNDES to sucroalcooleiras plants located in the State of São Paulo in Brazil. The study points out the Bank loans at São Paulo due to accumulation of plants technical objects that BNDES loans provide the State, with the installation of new equipment, machinery and services in canavieiros enterprises for electric power generation. Sucroalcooleiras plants are getting financing from BNDES to expand and diversify power generation in the country, mainly in São Paulo, because residential and industrial consumption of electricity grows annually. The offer of new financing to sucroalcooleiras plants for energy production Sao Paulo electric provides continued technical density in São Paulo and the expansion of regional inequality in the country. Therefore, the present study highlights for the period 2008 to 2013 the BNDES financing for are sucroalcooleiras plants in order to highlight the consolidation of technical objects in the State and show that the funding will help in the expansion of regional disparity

Differential expression of CD90 and CD14 stem cell markers in malignant breast cancer cell lines

The recently emerged concept of cancer stem cell (CSC) has led to a new hypothesis on the basis for tumor progression. Basically, the CSC theory hypothesizes the presence of a hierarchically organized and relatively rare cell population, which is responsible for tumor initiation, self-renewal, and maintenance, in addition to accumulation of mutation and resistance to chemotherapy. CSCs have recently been described in breast cancer. Different genetic markers have been used to isolate breast CSCs, none of which have been correlated with the tumorigenicity or metastatic potential of the cells, limiting their precise characterization and clinical application in the development of therapeutic protocols. Here, we sought for subpopulations of CSCs by analyzing 10 judiciously chosen stem cell markers in a normal breast cell line (MCF10-A) and in four human breast cancer cell lines (MCF-7, MDA-MB-231, MDA-MB-435, and Hs578-T) displaying different degrees of metastatic and invasiveness potential. We were able to identify two markers, which are differentially expressed in nontumorigenic versus tumor cells. The CD90 marker was highly expressed in the malignant cell lines. Interestingly, the CD14 molecule displayed higher expression levels in the nontumorigenic cell line. Therefore, we demonstrated that these two markers, which are more commonly used to isolate and characterize stem cells, are differentially expressed in breast tumor cells, when compared with nontumorigenic breast cells. (C) 2012 International Society for Advancement of Cytometry

TGF-beta 1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1/2 in highly invasive breast cancer cells

Background: Metastasis is the main factor responsible for death in breast cancer patients. Matrix metalloproteinases (MMPs) and their inhibitors, known as tissue inhibitors of MMPs (TIMPs), and the membrane-associated MMP inhibitor (RECK), are essential for the metastatic process. We have previously shown a positive correlation between MMPs and their inhibitors expression during breast cancer progression; however, the molecular mechanisms underlying this coordinate regulation remain unknown. In this report, we investigated whether TGF-beta 1 could be a common regulator for MMPs, TIMPs and RECK in human breast cancer cell models. Methods: The mRNA expression levels of TGF-beta isoforms and their receptors were analyzed by qRT-PCR in a panel of five human breast cancer cell lines displaying different degrees of invasiveness and metastatic potential. The highly invasive MDA-MB-231 cell line was treated with different concentrations of recombinant TGF-beta 1 and also with pharmacological inhibitors of p38 MAPK and ERK1/2. The migratory and invasive potential of these treated cells were examined in vitro by transwell assays. Results: In general, TGF-beta 2, T beta RI and T beta RII are over-expressed in more aggressive cells, except for T beta RI, which was also highly expressed in ZR-75-1 cells. In addition, TGF-beta 1-treated MDA-MB-231 cells presented significantly increased mRNA expression of MMP-2, MMP-9, MMP-14, TIMP-2 and RECK. TGF-beta 1 also increased TIMP-2, MMP-2 and MMP-9 protein levels but downregulated RECK expression. Furthermore, we analyzed the involvement of p38 MAPK and ERK1/2, representing two well established Smad-independent pathways, in the proposed mechanism. Inhibition of p38MAPK blocked TGF-beta 1-increased mRNA expression of all MMPs and MMP inhibitors analyzed, and prevented TGF-beta 1 upregulation of TIMP-2 and MMP-2 proteins. Moreover, ERK1/2 inhibition increased RECK and prevented the TGF-beta 1 induction of pro-MMP-9 and TIMP-2 proteins. TGF-beta 1-enhanced migration and invasion capacities were blocked by p38MAPK, ERK1/2 and MMP inhibitors. Conclusion: Altogether, our results support that TGF-beta 1 modulates the mRNA and protein levels of MMPs (MMP-2 and MMP-9) as much as their inhibitors (TIMP-2 and RECK). Therefore, this cytokine plays a crucial role in breast cancer progression by modulating key elements of ECM homeostasis control. Thus, although the complexity of this signaling network, TGF-beta 1 still remains a promising target for breast cancer treatment.

TGF-β1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1/2 in highly invasive breast cancer cells

Abstract Background Metastasis is the main factor responsible for death in breast cancer patients. Matrix metalloproteinases (MMPs) and their inhibitors, known as tissue inhibitors of MMPs (TIMPs), and the membrane-associated MMP inhibitor (RECK), are essential for the metastatic process. We have previously shown a positive correlation between MMPs and their inhibitors expression during breast cancer progression; however, the molecular mechanisms underlying this coordinate regulation remain unknown. In this report, we investigated whether TGF-β1 could be a common regulator for MMPs, TIMPs and RECK in human breast cancer cell models. Methods The mRNA expression levels of TGF-β isoforms and their receptors were analyzed by qRT-PCR in a panel of five human breast cancer cell lines displaying different degrees of invasiveness and metastatic potential. The highly invasive MDA-MB-231 cell line was treated with different concentrations of recombinant TGF-β1 and also with pharmacological inhibitors of p38 MAPK and ERK1/2. The migratory and invasive potential of these treated cells were examined in vitro by transwell assays. Results In general, TGF-β2, TβRI and TβRII are over-expressed in more aggressive cells, except for TβRI, which was also highly expressed in ZR-75-1 cells. In addition, TGF-β1-treated MDA-MB-231 cells presented significantly increased mRNA expression of MMP-2, MMP-9, MMP-14, TIMP-2 and RECK. TGF-β1 also increased TIMP-2, MMP-2 and MMP-9 protein levels but downregulated RECK expression. Furthermore, we analyzed the involvement of p38 MAPK and ERK1/2, representing two well established Smad-independent pathways, in the proposed mechanism. Inhibition of p38MAPK blocked TGF-β1-increased mRNA expression of all MMPs and MMP inhibitors analyzed, and prevented TGF-β1 upregulation of TIMP-2 and MMP-2 proteins. Moreover, ERK1/2 inhibition increased RECK and prevented the TGF-β1 induction of pro-MMP-9 and TIMP-2 proteins. TGF-β1-enhanced migration and invasion capacities were blocked by p38MAPK, ERK1/2 and MMP inhibitors. Conclusion Altogether, our results support that TGF-β1 modulates the mRNA and protein levels of MMPs (MMP-2 and MMP-9) as much as their inhibitors (TIMP-2 and RECK). Therefore, this cytokine plays a crucial role in breast cancer progression by modulating key elements of ECM homeostasis control. Thus, although the complexity of this signaling network, TGF-β1 still remains a promising target for breast cancer treatment.

A arquitetura habitacional social brasileira: propostas assertivas e inovações no âmbito dos institutos de previdência estatais do Século XX

No Brasil, a repetição descomedida de tipologias, partidos arquitetônicos e urbanísticos nos conjuntos residenciais sociais tomou vulto a partir da segunda metade da década de 1960, no âmbito do recém-criado Banco Nacional de Habitação (BNH). A produção desse órgão, até a década de 1980, é marcada pela disseminação do modelo da casa unifamiliar isolada no lote, com cobertura em duas águas, e pela perpetuação dos blocos com quatro pavimentos assentados diretamente no solo, com programas e plantas padrões implantadas sem levar em consideração os aspectos físico-climáticos e culturais locais. Essas unidades foram situadas em grandes conjuntos sem infraestrutura e/ou equipamentos coletivos, localizados, na maior parte das vezes, nas periferias das cidades. Porém, num momento anterior, mais precisamente entre as décadas de 1930 e 1960, os debates sobre a temática da moradia econômica e/ou mínima renderam ao país uma gama de propostas inovadoras, com destaque para as formulações e modelos pensados e concebidos pelos institutos de previdência, em especial, pelas Caixas e Institutos de Aposentadoria e Pensões (CAPs/IAPs). Nesse contexto, o presente artigo se propõe a apresentar as principais diretrizes que regeram as ações imobiliárias dos mencionadas instituições previdenciárias estatais no Brasil, bem como identificar e analisar algumas das inovações pensadas e concretizadas nesse sentido, muitas das quais foram relegadas a partir de 1964. Para tanto, tirar-se-á partido, sobremaneira, de dados primários relacionados à estruturação e à evolução dos regimentos e regulamentos das ações dos supracitados órgãos no campo da moradia, encontrados essencialmente nos arquivos jurídicos do país, bem como de pesquisa documental específica nos processos de financiamentos imobiliários concedidos aos trabalhadores urbanos brasileiros, ao longo das quatro décadas de atuação das CAPs e dos IAPs. O estudo destas vertentes, contextualizando-as no cenário das mudanças contemporâneas, conforma um esforço de compreensão da história da moradia social no Brasil, como também, das políticas públicas habitacionais no país.

Alemán Buba: Dinero para jóvenes, A/Z

[ES] Estudio divulgativo del Bundesk Bank (BUBA. Glosario de términos económicos elaborado por el Banco Nacional Alemán, parcialmente traducido al español por el autor. Incluye términos que comienzan por la letra A