Blind reconiliation

Information reconciliation is a crucial procedure in the classical post-processing of quantum key distribution (QKD). Poor reconciliation e?ciency, revealing more information than strictly needed, may compromise the maximum attainable distance, while poor performance of the algorithm limits the practical throughput in a QKD device. Historically, reconciliation has been mainly done using close to minimal information disclosure but heavily interactive procedures, like Cascade, or using less e?cient but also less interactive ?just one message is exchanged? procedures, like the ones based in low-density parity-check (LDPC) codes. The price to pay in the LDPC case is that good e?ciency is only attained for very long codes and in a very narrow range centered around the quantum bit error rate (QBER) that the code was designed to reconcile, thus forcing to have several codes if a broad range of QBER needs to be catered for. Real world implementations of these methods are thus very demanding, either on computational or communication resources or both, to the extent that the last generation of GHz clocked QKD systems are ?nding a bottleneck in the classical part. In order to produce compact, high performance and reliable QKD systems it would be highly desirable to remove these problems. Here we analyse the use of short-length LDPC codes in the information reconciliation context using a low interactivity, blind, protocol that avoids an a priori error rate estimation. We demonstrate that 2×103 bits length LDPC codes are suitable for blind reconciliation. Such codes are of high interest in practice, since they can be used for hardware implementations with very high throughput.

Optimal fits of diffusion constants from single-time data points of Brownian trajectories

Experimental methods based on single particle tracking (SPT) are being increasingly employed in the physical and biological sciences, where nanoscale objects are visualized with high temporal and spatial resolution. SPT can probe interactions between a particle and its environment but the price to be paid is the absence of ensemble averaging and a consequent lack of statistics. Here we address the benchmark question of how to accurately extract the diffusion constant of one single Brownian trajectory. We analyze a class of estimators based on weighted functionals of the square displacement. For a certain choice of the weight function these functionals provide the true ensemble averaged diffusion coefficient, with a precision that increases with the trajectory resolution.

Progress on the development of a technology for silicon purification

The polysilicon market is experiencing tremendous changes due to the strong demand from Photovoltaics (PV), which has by far surpassed the demand from Microelectronics. The need of solar silicon has induced a large increase in capacity, which has now given a scenario of oversupply, reducing the polysilicon price to levels that put a strong pressure on the cost structure of the producers. The paper reports on the R&D efforts carried out in the field of solar silicon purification via the chlorosilane route by a private-public consortium that is building a pilot plant of 50-100 tonnes/year, that will synthesize trichlorosilane, purify it and deposit ultrapure silicon in an industrial-size Siemens type reactor. It has also capabilities for ingot growth and material characterization. A couple of examples of the progress so far are given, the first one related to the recycling scheme of chlorinated compounds, and the second to the minimization of radiation losses in the CVD deposition process, which account for a relevant part of the total energy consumption. In summary, the paper gives details on the technology being developed in our pilot plant, which offers a unique platform for field-testing of innovative approaches that can lead to a cost reduction of solar silicon produced via the chlorosilane route.

Towards an optimal implementation of cascade

The aim of this contribution is to study the modifications of Cascade, comparing them with the original protocol on the grounds of a full set of parameters, so that the effect of these modifications can be fairly assessed. A number of simulations were performed to study not only the efficiency but also other characteristics of the protocol that are important for its practical application, such as the number of communications and the failure probability. Note that, although it is generally believed that the only price to pay for an improved efficiency is an increased interactivity, when looking at all the significant magnitudes a different view emerges, showing that, for instance, the failure probability eliminate some the supposed advantages of these improvements.

Métodos eficientes para criptografia baseada em reticulados.

Reticulados têm sido aplicados de diferentes maneiras em criptografia. Inicialmente utilizados para a destruição de criptossistemas, eles foram posteriormente aplicados na construção de novos esquemas, incluindo criptossistemas assimétricos, esquemas de assinatura cega e os primeiros métodos para encriptação completamente homomórfica. Contudo, seu desempenho ainda é proibitivamente lenta em muitos casos. Neste trabalho, expandimos técnicas originalmente desenvolvidas para encriptação homomórfica, tornando-as mais genéricas e aplicando-as no esquema GGH-YK-M, um esquema de encriptação de chave pública, e no esquema LMSV, a única construção homomórfica que não sucumbiu a ataques de recuperação de chaves IND-CCA1 até o momento. Em nossos testes, reduzimos o tamanho das chaves do GGH-YK-M em uma ordem de complexidade, especificamente, de O(n2 lg n) para O(n lg n), onde n é um parâmetro público do esquema. A nova técnica também atinge processamento mais rápido em todas as operações envolvidas em um criptossistema assimétrico, isto é, geração de chaves, encriptação e decriptação. A melhora mais significativa é na geração de chaves, que se torna mais de 3 ordens de magnitude mais rápida que resultados anteriores, enquanto a encriptação se torna por volta de 2 ordens de magnitude mais rápida. Para decriptação, nossa implementação é dez vezes mais rápida que a literatura. Também mostramos que é possível aumentar a segurança do esquema LMSV contra os ataques quânticos de recuperação de chaves recentemente publicados pela agência britânica GCHQ. Isso é feito através da adoção de reticulados não-ciclotômicos baseados em anéis polinomiais irredutíveis quase-circulantes. Em nossa implementação, o desempenho da encriptação é virtualmente idêntico, e a decriptação torna-se ligeiramente inferior, um pequeno preço a se pagar pelo aumento de segurança. A geração de chaves, porém, é muito mais lenta, devido à necessidade de se utilizar um método mais genérico e caro. A existência de métodos dedicados altamente eficientes para a geração de chaves nesta variante mais segura do LMSV permanece como um problema em aberto.

Whole life performance bid evaluation in the Korean public sector

Korea has increasingly adopted design-build for public construction projects in the last few years. There is a much greater awareness of the need to change a system based on ‘Value for Money’ which is high on the government's agenda. A whole life performance bid evaluation model is proposed to aid decision makers in the selection of a design-builder. This is based on the integration of a framework using an analytic hierarchy process as the bid awarding system is being changed from one based on lowest price, to one based on best value over the life-cycle. Key criteria like whole life cost, service life planning and design quality are important through the key stages of evaluation process. The model uses a systematic and holistic approach which enables a public sector to make better decisions in design-builder selection, which will deliver whole life benefits, based on long term cost-effectiveness and whole life.

A design and implementation methodology for high variety electronics assembly systems

Small indigenous manufacturers of electronic equipment are coming under increasingly severe pressure to adopt a strong defensive position against large multinational and Far Eastern companies. A common response to this threat has been for these firms to adopt a 'market driven' business strategy based on quality and customer service, rather than a 'technology led' strategy which uses technical specification and price to compete. To successfully implement this type of strategy there is a need for production systems to be redesigned to suit the new demands of marketing. Increased range and fast response require economy of scope rather t ban economy or scale while the organisation's culture must promote quality and process consciousness. This paper describes the 'Modular Assembly Cascade' concept which addresses these needs by applying the principles of flexible manufacturing (FMS) and just in time (,JlT) to electronics assembly. A methodology for executing the concept is also outlined. This is called DRAMA (Design Houtirw !'or· Adopting Modular Assembly).

Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma.

The ability to rearrange the germ-line DNA to generate antibody diversity is an essential prerequisite for the production of a functional repertoire. While this is essential to prevent infections, it also represents the "Achilles heel" of the B-cell lineage, occasionally leading to malignant transformation of these cells by translocation of protooncogenes into the immunoglobulin (Ig) loci. However, in evolutionary terms this is a small price to pay for a functional immune system. The study of the configuration and rearrangements of the Ig gene loci has contributed extensively to our understanding of the natural history of development of myeloma. In addition to this, the analysis of Ig gene rearrangements in B-cell neoplasms provides information about the clonal origin of the disease, prognosis, as well as providing a clinical useful tool for clonality detection and minimal residual disease monitoring. Herein, we review the data currently available on both Ig gene rearrangements and protein patterns seen in myeloma with the aim of illustrating how this knowledge has contributed to our understanding of the pathobiology of myeloma.

Cabazitaxel for Hormone-Relapsed Metastatic Prostate Cancer Previously Treated With a Docetaxel-Containing Regimen: An Evidence Review Group Perspective of a NICE Single Technology Appraisal

As part of its single technology appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited the company that manufactures cabazitaxel (Jevtana(®), Sanofi, UK) to submit evidence for the clinical and cost effectiveness of cabazitaxel for treatment of patients with metastatic hormone-relapsed prostate cancer (mHRPC) previously treated with a docetaxel-containing regimen. The School of Health and Related Research Technology Appraisal Group at the University of Sheffield was commissioned to act as the independent Evidence Review Group (ERG). The ERG produced a critical review of the evidence for the clinical and cost effectiveness of the technology based upon the company's submission to NICE. Clinical evidence for cabazitaxel was derived from a multinational randomised open-label phase III trial (TROPIC) of cabazitaxel plus prednisone or prednisolone compared with mitoxantrone plus prednisone or prednisolone, which was assumed to represent best supportive care. The NICE final scope identified a further three comparators: abiraterone in combination with prednisone or prednisolone; enzalutamide; and radium-223 dichloride for the subgroup of people with bone metastasis only (no visceral metastasis). The company did not consider radium-223 dichloride to be a relevant comparator. Neither abiraterone nor enzalutamide has been directly compared in a trial with cabazitaxel. Instead, clinical evidence was synthesised within a network meta-analysis (NMA). Results from TROPIC showed that cabazitaxel was associated with a statistically significant improvement in both overall survival and progression-free survival compared with mitoxantrone. Results from a random-effects NMA, as conducted by the company and updated by the ERG, indicated that there was no statistically significant difference between the three active treatments for both overall survival and progression-free survival. Utility data were not collected as part of the TROPIC trial, and were instead taken from the company's UK early access programme. Evidence on resource use came from the TROPIC trial, supplemented by both expert clinical opinion and a UK clinical audit. List prices were used for mitoxantrone, abiraterone and enzalutamide as directed by NICE, although commercial in-confidence patient-access schemes (PASs) are in place for abiraterone and enzalutamide. The confidential PAS was used for cabazitaxel. Sequential use of the advanced hormonal therapies (abiraterone and enzalutamide) does not usually occur in clinical practice in the UK. Hence, cabazitaxel could be used within two pathways of care: either when an advanced hormonal therapy was used pre-docetaxel, or when one was used post-docetaxel. The company believed that the former pathway was more likely to represent standard National Health Service (NHS) practice, and so their main comparison was between cabazitaxel and mitoxantrone, with effectiveness data from the TROPIC trial. Results of the company's updated cost-effectiveness analysis estimated a probabilistic incremental cost-effectiveness ratio (ICER) of £45,982 per quality-adjusted life-year (QALY) gained, which the committee considered to be the most plausible value for this comparison. Cabazitaxel was estimated to be both cheaper and more effective than abiraterone. Cabazitaxel was estimated to be cheaper but less effective than enzalutamide, resulting in an ICER of £212,038 per QALY gained for enzalutamide compared with cabazitaxel. The ERG noted that radium-223 is a valid comparator (for the indicated sub-group), and that it may be used in either of the two care pathways. Hence, its exclusion leads to uncertainty in the cost-effectiveness results. In addition, the company assumed that there would be no drug wastage when cabazitaxel was used, with cost-effectiveness results being sensitive to this assumption: modelling drug wastage increased the ICER comparing cabazitaxel with mitoxantrone to over £55,000 per QALY gained. The ERG updated the company's NMA and used a random effects model to perform a fully incremental analysis between cabazitaxel, abiraterone, enzalutamide and best supportive care using PASs for abiraterone and enzalutamide. Results showed that both cabazitaxel and abiraterone were extendedly dominated by the combination of best supportive care and enzalutamide. Preliminary guidance from the committee, which included wastage of cabazitaxel, did not recommend its use. In response, the company provided both a further discount to the confidential PAS for cabazitaxel and confirmation from NHS England that it is appropriate to supply and purchase cabazitaxel in pre-prepared intravenous-infusion bags, which would remove the cost of drug wastage. As a result, the committee recommended use of cabazitaxel as a treatment option in people with an Eastern Cooperative Oncology Group performance status of 0 or 1 whose disease had progressed during or after treatment with at least 225 mg/m(2) of docetaxel, as long as it was provided at the discount agreed in the PAS and purchased in either pre-prepared intravenous-infusion bags or in vials at a reduced price to reflect the average per-patient drug wastage.

How do Small Players Deduce Beliefs about Uncertainty? A Look at Texas Shale Oil Investments

Thesis (Ph.D.)--University of Washington, 2016-08

Una estrategia de inversión basada en múltiplos que bate los retornos del MILA

El presente trabajo plantea la hipótesis de que se puede emplear una estrategia basada en múltiplos para obtener retornos superiores a los del mercado integrado latinoamericano (MILA), lo cual sugeriría que no se cumple a cabalidad la forma semifuerte de eficiencia de mercado, según la cual no se puede batir al mercado de manera sistemática a partir del uso de información pública. Para ello, se desarrolló una estrategia de inversión para inversionistas no sofisticados, basada en tres ratios financieros (PER, Price to Book Value y grado de apalancamiento), que busca obtener retornos superiores al índice MILA; asimismo, se llevaron a cabo pruebas estadísticas para probar si los excesos de retorno obtenidos son significativos y sugieren la existencia de ineficiencia en el MILA. Mediante dicho análisis, se concluyó que, a partir del uso oportuno de la información financiera que publican las empresas, se diseñaron algunas estrategias de inversión basadas en múltiplos que batieron al índice S&P MILA Andean 40, incluso luego de realizar el ajuste por nivel de riesgo. A diferencia de los trabajos anteriores, en la presente investigación, se planteó un punto de vista diferente para analizar los resultados obtenidos por la estrategia de inversión, dado que se compara el rendimiento acumulado obtenido, pero, además, se ha analizado estadísticamente la existencia de un alpha significativo. En este proceso, se realizó una regresión de mínimos cuadrados ordinarios a fin de verificar estadísticamente la existencia de un alpha positivo y no se pudo concluir que este sea significativo. En línea con los trabajos revisados, se pudo apreciar que el PER serviría como un predictor de retornos acumulados superiores a los de mercado; sin embargo, los resultados obtenidos no han sido concluyentes en términos estadísticos. Con estos resultados, no se puede rechazar la hipótesis semifuerte de los mercados eficientes. No obstante, existirían ventanas de tiempo que podrían ser aprovechadas para obtener rendimientos superiores al mercado.

MICROSCALE DIELECTRIC ANTI-REFLECTION COATINGS FOR PHOTOVOLTAICS

In order to power our planet for the next century, clean energy technologies need to be developed and deployed. Photovoltaic solar cells, which convert sunlight into electricity, are a clear option; however, they currently supply 0.1% of the US electricity due to the relatively high cost per Watt of generation. Thus, our goal is to create more power from a photovoltaic device, while simultaneously reducing its price. To accomplish this goal, we are creating new high efficiency anti-reflection coatings that allow more of the incident sunlight to be converted to electricity, using simple and inexpensive coating techniques that enable reduced manufacturing costs. Traditional anti-reflection coatings (consisting of thin layers of non-absorbing materials) rely on the destructive interference of the reflected light, causing more light to enter the device and subsequently get absorbed. While these coatings are used on nearly all commercial cells, they are wavelength dependent and are deposited using expensive processes that require elevated temperatures, which increase production cost and can be detrimental to some temperature sensitive solar cell materials. We are developing two new classes of anti-reflection coatings (ARCs) based on textured dielectric materials: (i) a transparent, flexible paper technology that relies on optical scattering and reduced refractive index contrast between the air and semiconductor and (ii) silicon dioxide (SiO2) nanosphere arrays that rely on collective optical resonances. Both techniques improve solar cell absorption and ultimately yield high efficiency, low cost devices. For the transparent paper-based ARCs, we have recently shown that they improve solar cell efficiencies for all angles of incident illumination reducing the need for costly tracking of the sun’s position. For a GaAs solar cell, we achieved a 24% improvement in the power conversion efficiency using this simple coating. Because the transparent paper is made from an earth abundant material (wood pulp) using an easy, inexpensive and scalable process, this type of ARC is an excellent candidate for future solar technologies. The coatings based on arrays of dielectric nanospheres also show excellent potential for inexpensive, high efficiency solar cells. The fabrication process is based on a Meyer rod rolling technique, which can be performed at room-temperature and applied to mass production, yielding a scalable and inexpensive manufacturing process. The deposited monolayer of SiO2 nanospheres, having a diameter of 500 nm on a bare Si wafer, leads to a significant increase in light absorption and a higher expected current density based on initial simulations, on the order of 15-20%. With application on a Si solar cell containing a traditional anti-reflection coating (Si3N4 thin-film), an additional increase in the spectral current density is observed, 5% beyond what a typical commercial device would achieve. Due to the coupling between the spheres originated from Whispering Gallery Modes (WGMs) inside each nanosphere, the incident light is strongly coupled into the high-index absorbing material, leading to increased light absorption. Furthermore, the SiO2 nanospheres scatter and diffract light in such a way that both the optical and electrical properties of the device have little dependence on incident angle, eliminating the need for solar tracking. Because the layer can be made with an easy, inexpensive, and scalable process, this anti-reflection coating is also an excellent candidate for replacing conventional technologies relying on complicated and expensive processes.

Avaliação fiscal vs valores de mercado de imóveis em dação em pagamento (segmento habitacional)

Mestrado em Gestão e Avaliação Imobiliária

Determinación de los costos de operación del sistema de transporte urbano en buses para el año 2015

El presente trabajo tiene como propósito realizar un estudio de todos los costos de operación en que incurre el sector de transporte urbano en la ciudad de Cuenca para prestar su servicio, mediante la aplicación del sistema de costeo estándar, con el fin de determinar una tarifa que sirva como guía o base para la fijación del precio que los usuarios deberían pagar por la utilización del transporte. Se está generando la problemática de incrementar los pasajes de $0,25 centavos a $0,41 centavos debido a que los propietarios del transporte no están de acuerdo con la tarifa vigente. Por lo que es necesario efectuar un análisis apropiado para determinar el precio que debe pagar la población por el uso del transporte urbano; aplicando técnicas y conocimientos propios de la contabilidad de costos. Para llevar a cabo el estudio de los costos operativos se considera un muestreo estratificado de todas las compañías de transporte urbano con el fin de efectuar encuestas a los transportistas; además, obtener información proporcionada por la Cámara de Transporte de Cuenca, Consorcio SIR y las compañías de transporte, identificando costos variables, fijos, de capital, kilómetros recorridos, número de usuarios que utilizan este servicio y número de vueltas.

A internacionalização de empresas portuguesas para Cabo Verde : investimento directo e as estratégias competitivas

A presente investigação procura estudar a internacionalização das empresas portuguesas para Cabo Verde, através de investimento direto, e as estratégias competitivas que elas adotaram. Na sequência da revisão da literatura, a fim de obter respostas para a pergunta de pesquisa, analisamos a internacionalização das empresas portuguesas, a sua evolução, o investimento português no estrangeiro, e a evolução dos fluxos do Investimento Direto Estrangeiro (IDE) em Cabo Verde, a partir de dados estatísticos recolhidos na literatura publicada. De seguida foram recolhidos dados primários, através da aplicação de dois questionários direcionados para o mercado cabo-verdiano (clientes) e empresas portuguesas que investiram em Cabo Verde. A amostra é constituída por 157 clientes, 77 do sexo feminino e 80 do sexo masculino, e a outra amostra é constituída por 10 empresas portuguesas que investiram em Cabo Verde através de Investimento Direto. Os resultados do presente estudo mostram que a estratégia de adaptação não contribuiu significativamente para melhorar a opinião do mercado cabo-verdiano sobre as marcas portuguesas e que, as empresas adaptaram naquele mercado principalmente as variáveis distribuição e preço. As empresas portuguesas podem seguir estratégias de padronização do produto e da promoção/comunicação, precisando apenas adaptar o preço aos diferentes fatores de custo e a distribuição à natureza insular do mercado. Concluímos que, de uma forma geral, a proximidade cultural, geográfica e histórica entre os dois países é responsável pela não necessidade da estratégia de adaptação por parte das empresas portuguesas quando internacionalizam para Cabo Verde. /ABSTRACT: The present investigation aims to study the internationalization of portuguese companies to Cape Verde, through direct investment, and their competitive strategies. Following the literature review, in order to answer the research question, the internationalization of Portuguese companies was analyzed, as was the Portuguese investment abroad, and the evolution of Foreign Direct Investment (FDI) flows in Cape Verde, with statistical data collected from the literature. Primary data was collected through the use of two questionnaires directed to the Cape Verdean market (customers) and to the Portuguese companies that have invested in Cape Verde. The sample consists of 157 customers, 77 females and 80 males, and the other sample consists of 10 Portuguese companies that have invested in Cape Verde through Direct Investment. The results of this study show that the adaptation strategy did not help improve Cape Verdean market's opinion about the Portuguese brands, and those, companies adapted primarily the distribution and price variables. The Portuguese companies can follow standardization strategies of the product and the promotion I communication, just needing to adjust the price to the various cost factors and the distribution to the insular nature of the market. We conclude that, in general, the cultural, historic and geographical proximity and the close relationship between the two countries lessens the necessity of adaptation strategy by the Portuguese companies when they internationalize to Cape Verde.