1960-1980. Het gouden tijdperk van de openbare werken. 1960-1980. L'âge d'or des travaux public

info:eu-repo/semantics/published

12C2H2-Ar van der Waals complex

New theoretical and experimental results on the acetylene-Ar van der Waals complex are presented and the literature is reviewed. New ab initio calculations at the MP2 level were performed using large basis sets with diffuse functions and taking into account the basis set superposition error. It was found that the structure of acetylene is not significantly altered by the complexation and that its vibrational frequencies are only slightly lowered. Finally, it was observed that the calculated properties of the complex (structure, vibrational spectrum, bond dissociation energy) are not sensitive to the structure imposed on acetylene. Experimentally, acetylene-Ar was produced in a supersonic expansion under experimental conditions corresponding to 9 K rotational temperature. Thanks to the performances of CW-CRDS detection, the Ka = 0 ← 1, 1 ← 0, and 2 ← 1 sub- bands of the v1 + v3 band could be recorded and resolved and most of their lines assigned. Upper-state rotational constants were fitted, however not including the upper Ka = 2 state, which shows K-doubling the opposite of the expected. The Lorentzian width of most line profiles sets the mean lifetime to some 7.5 ns. Local perturbations affecting line positions and/or line widths are demonstrated. Additional series of lines tentatively attributed to acetylene-Ar are discussed.© 2009 American Chemical Society.

FANTASIO: a versatile experimental set-up to investigate jet-cooled molecules

The design of a new apparatus, named FANTASIO, for studying jet-cooled molecules is described. It includes, around the same supersonic expansion cell, a high resolution Fourier transform spectrometer with single or multipass optics, a tunable diode laser spectrometer with optional cavity ring-down facilities, and a quadrupole mass spectrometer. Performance and operational procedures are illustrated.

Accurate ground-state potential energy surfaces of the C2H2–Kr and C2H2–Xe van der Waals complexes

Accurate ab initio intermolecular potential energy surfaces (IPES) have been obtained for the first time for the ground electronic state of the C 2H2-Kr and C2H2-Xe van der Waals complexes. Extensive tests, including complete basis set and all-electron scalar relativistic results, support their calculation at the CCSD(T) level of theory, using small-core relativistic pseudopotentials for the rare-gas atoms and aug-cc-pVQZ basis sets extended with a set of 3s3p2d1f1g mid-bond functions. All results are corrected for the basis set superposition error. The importance of the scalar relativistic and rare-gas outer-core (n.1)d correlation effects is investigated. The calculated IPES, adjusted to analytical functions, are characterized by global minima corresponding to skew T-shaped geometries, in which the Jacobi vector positioning the rare-gas atom with respect to the center of mass of the C2H2 moiety corresponds to distances of 4.064 and 4.229Å, and angles of 65.22° and 68.67° for C 2H2-Kr and C2H2-Xe, respectively. The interaction energy of both complexes is estimated to be -151.88 (1.817 kJ mol-1) and -182.76 cm-1 (2.186 kJ mol-1), respectively. The evolution of the topology of the IPES as a function of the rare-gas atom, from He to Xe, is also discussed. © 2012 Taylor and Francis.

Cross-sectional study of 168 patients with hepatorenal tyrosinaemia and implications for clinical practice

Background: Hepatorenal tyrosinaemia (Tyr 1) is a rare inborn error of tyrosine metabolism. Without treatment, patients are at high risk of developing acute liver failure, renal dysfunction and in the long run hepatocellular carcinoma. The aim of our study was to collect cross-sectional data. Methods. Via questionnaires we collected retrospective data of 168 patients with Tyr 1 from 21 centres (Europe, Turkey and Israel) about diagnosis, treatment, monitoring and outcome. In a subsequent consensus workshop, we discussed data and clinical implications. Results: Early treatment by NTBC accompanied by diet is essential to prevent serious complications such as liver failure, hepatocellular carcinoma and renal disease. As patients may remain initially asymptomatic or develop uncharacteristic clinical symptoms in the first months of life newborn mass screening using succinylacetone (SA) as a screening parameter in dried blood is mandatory for early diagnosis. NTBC-treatment has to be combined with natural protein restriction supplemented with essential amino acids. NTBC dosage should be reduced to the minimal dose allowing metabolic control, once daily dosing may be an option in older children and adults in order to increase compliance. Metabolic control is judged by SA (below detection limit) in dried blood or urine, plasma tyrosine (<400 μM) and NTBC-levels in the therapeutic range (20-40 μM). Side effects of NTBC are mild and often transient. Indications for liver transplantation are hepatocellular carcinoma or failure to respond to NTBC. Follow-up procedures should include liver and kidney function tests, tumor markers and imaging, ophthalmological examination, blood count, psychomotor and intelligence testing as well as therapeutic monitoring (SA, tyrosine, NTBC in blood). Conclusion: Based on the data from 21 centres treating 168 patients we were able to characterize current practice and clinical experience in Tyr 1. This information could form the basis for clinical practice recommendations, however further prospective data are required to underpin some of the recommendations.

Modulation of the complement system in monocytes contributes to tuberculosis-associated immune reconstitution inflammatory syndrome.

Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a common complication in HIV-TB co-infected patients receiving combined antiretroviral therapy (cART). This study investigated a putative contribution of monocytes to the development of TB-IRIS.

The role of monocytes in the development of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome

info:eu-repo/semantics/published

La elipse como lugar geométrico a través de la geometría del doblado de papel en el contexto de Van Hiele

El presente artículo es un producto derivado de la investigación: “La elipse como lugar geométrico a través de la geometría del doblado de papel en el contexto de Van Hiele”, en la que se analizó el proceso de comprensión del concepto de elipse como lugar geométrico, de cinco estudiantes del grado décimo de una Institución Educativa de la ciudad de Medellín. El estudio de casos cualitativo permitió el establecimiento de los descriptores de los niveles de razonamiento de Van Hiele que caracterizaron dicho proceso de comprensión y a su vez, iluminaron la creación de un guion de entrevista de carácter socrático, que se convirtió en una experiencia de aprendizaje para los estudiantes en tanto que les permitió avanzar en su nivel de razonamiento.

Fases de aprendizaje en el contexto de van Hiele para el concepto de continuidad local

El presente reporte articula el modelo educativo de van Hiele en su aspecto prescriptivo con la enseñanza de uno de los conceptos fundamentales del Análisis Matemático, continuidad local, a través de la implementación y el desarrollo de un Módulo de Aprendizaje que permite procesos de razonamiento en los estudiantes con el fin de promoverlos de un Nivel II a un Nivel III, el módulo es construido en correspondencia con los descriptores de fases para de dar cuenta de las estructuras mentales elaboradas. Posteriormente, en el análisis de cada uno de los tres casos, se describe en categorías en correspondencia los descriptores y donde se hace explícito como razonan los estudiantes en su paso del Nivel II al Nivel III respecto al concepto de continuidad local.

Determinación de niveles Van Hiele en alumnos de primer año medio sobre la transformación isométrica de simetría

Este artículo presenta los resultados de una investigación realizada en alumnos de primer año medio del Liceo Eleuterio Ramírez de Osorno. El objetivo de dicha investigación era conocer el desarrollo del pensamiento geométrico en el tema de transformaciones isométricas según la Teoría de Van Hiele. La metodología de investigación es cualitativa, específicamente mediante estudio de casos. La recolección de datos se realizó mediante un seguimiento en el desarrollo de las actividades planteadas, observación de participantes y entrevistas. Como resultado se obtuvo que los alumnos mayoritariamente exhiben características del nivel 1 de reconocimiento para la isometría de simetría.

Aspectos comparativos en la extensión del modelo de Van Hiele al concepto de aproximación local

En el contexto del modelo de Van Hiele, se ha llevado a cabo un estudio comparativo de dos colecciones de descriptores para el mismo concepto: El de aproximación local en su manifestación de la recta tangente a la gráfica de una curva en un punto. A partir de las visualizaciones que se obtienen de los mecanismos llamados "haz de secantes" y del "zoom", se concluye que, en efecto, el nivel de razonamiento es independiente de la forma de abordar el concepto, de ese mecanismo particular usado para acercarse al mismo.

Twentieth Century Society Spring lecture series: second lives for Twentieth Century masterpieces

The Twentieth Century Society’s Spring lecture series (six in total) looks at the restoration and refurbishment of key C20 buildings in Britain and the US. Buildings covered: BBC Broadcasting House in London (G Val Meyer 1930-32, MacCormac Jamieson Prichard 2000-09). Speaker: Mark Hines (Mark Hines Architects), was the project architect and is the author of The Story of Broadcasting House: Home of the BBC. 5 February 2009. Crown Hall, Chicago (Mies van der Rohe 1952), the Art and Architecture Building, Yale University, New Haven (Paul Rudolf 1961-63) and the former Wills head office in Bristol (SOM with YRM 1970-75). Speaker: Patrick Bellew (Atelier 10 Engineers), 12 February 2009. Center for British Art, Yale University, New Haven (Louis Kahn 1969-77). Speaker: Peter Inskip (Inskip and Jenkins Architects), 17 February 2009. Brunswick Centre London (Patrick Hodgkinson 1967-72; Levitt Bernstein with Patrick Hodgkinson 2006). Speaker: Stuart Tappin (Stand Consulting Engineers Ltd), 26 February 2009. De La Warr Pavilion, Bexhill-on-Sea (Mendelsohn and Chermayeff 1934-5, John McAslan and Partners 2000-05). Speaker: Mark Cannata (HOK Architects), 5 March 2009. Finsbury Health Centre London (Lubetkin & Tecton 1938, first phase of conservation work Avanti Architects 1995.). Speaker: John Allan of Avanti Architects, 12 March 2009.

Observatie van voorlichtingslessen seksuele diversiteit in het Voortgezet Onderwijs: een pilot onderzoek

Mooij, T., & Fettelaar, D. (2013). Observatie van voorlichtingslessen seksuele diversiteit in het Voortgezet Onderwijs: Een pilot onderzoek. Tijdschrift voor Orthopedagogiek, 52(6), 282-298.

Faciliteren van sociaal leren in de lerarenopleiding

De laatste decennia is er in onderwijspraktijk en onderwijsonderzoek veel aandacht voor sociaal leren van (aanstaande) leraren als een stimulans voor hun professionele ontwikkeling. Bij het nastreven van innovatie in dergelijke lerarengroepen, blijkt faciliteren van belang. In deze studie is onderzocht op welke wijze lerarengroepen gefaciliteerd kunnen worden ter optimalisatie van de professionele ontwikkeling van de groepsleden. Hiervoor is gebruik gemaakt van een eerder ontwikkeld theoretisch kader met 4 dimensies en 11 indicatoren van sociaal leren. Het onderzoek is uitgevoerd in een lerarenopleiding primair onderwijs (pabo) waar groepen van pabodocenten, pabostudenten en leerkrachten primair onderwijs zijn gevolgd gedurende twee jaren in een enkelvoudige en meervoudige casestudie. Data zijn verzameld in de vorm van video/audio-opnames van de werkbijeenkomsten, het beantwoorden van reflectieve vragen, het volgen van de digitale leeromgeving en het uitvoeren van retrospectieve interviews. Op basis van kwalitatieve analyses is op diverse momenten samen met de groepsleden bekeken hoe de sociale configuratie eruit zag, of dit passend was bij de groepsdoelen en welke vervolgstappen wenselijk waren. De in deze studie ontwikkelde interviewleidraad blijkt een bruikbaar kwalitatief instrument in dit faciliteringsproces.