An integrated model of adoption and development of e-commerce in companies

Since the mid-1990s researchers have sought to understand why some firms embark on e-commerceoperations on the Internet while others prefer to wait and see how events unfold. We still have todetermine which variables contribute to explaining the extent to which firms use e-commerce, giventhat to date the literature has not yet offered conclusive evidence on this question. The current workaims to provide an integrated vision of the set of factors influencing the e-commerce adoptionprocess. We use a sample of 2,038 firms of all types that trade their products either with otherorganizations or with end-consumers.

Mitotic regulation by Polo-like kinase 1 and the Chromosomal Passenger Complex

During mitosis, the duplicated genome must be accurately divided between two daughter cells. Polo-like kinase 1 (Plk1) and Aurora B kinase, together with its binding partners Incenp, Survivin and Borealin (chromosomal passenger complex, CPC), have key roles in coordinating mitotic events. The accuracy of cell division is safeguarded by a signaling cascade termed the mitotic spindle checkpoint (SC), which ensures that chromosomes are not physically separated before correct bipolar attachments have been formed between kinetochores and spindle microtubules (MT). An inhibitory “wait anaphase” signal, which delays chromosome separation (anaphase onset), is created at individual kinetochores and broadcasted throughout the cell in response to lack of kinetochore-microtubule (kMT) attachment or proper interkinetochore tension. It is believed that the fast turnover of SC molecules at kinetochores contributes to the cell’s ability to produce this signal and enables rapid responses to changing cellular conditions. Kinetochores that lack MT attachment and tension express a certain phosphoepitope called the 3F3/2 phosphoepitope, which has been linked to SC signaling. In the experimental part, we investigated the regulation of the 3F3/2 phosphoepitope, analyzed whether CPC molecules turn over at centromeres, and dissected the mitotic roles of the CPC using a microinjection technique that allowed precise temporal control over its function. We found that the kinetochore 3F3/2 phosphoepitope is created by Plk1, and that CPC proteins exhibit constant exchange at centromeres. Moreover, we found that CPC function is necessary in the regulation of chromatid movements and spindle morphology in anaphase. In summary, we identified new functions of key mitotic regulators Plk1 and CPC, and provided insighs into the coordination of mitotic events.

An overview of the proposal for a new Package Travel Directive

After an endless wait, a proposal for a new Package Travel Directive repealing Directive 90/314/EEC1 was presented on 9 July 2013 (hereafter, the Proposal).This article is aimed at providing an overall view of the Proposal. I will address the following issues: The concept of traveller; online package holidays and assisted travel arrangements; information requirements; a new particular right of withdrawal for package travel; other changes to the contract before the start of the package; performance of the Package; and insolvency protection. Some early concluding remarks are made as to when a future Package Travel Directive might take place at some future date

Epävarmuuden mallintaminen investointilaskelmissa ja irtautumispäätöksen ajoittaminen: Case Paroc

Tässä diplomityössä on tutkittu epävarmuuden mallintamista investointilaskelmissa. Kirjallisuuden perusteella luotiin prosessimalli, jolla voidaan strukturoidusti tehdä yritysinvestointi- tai yritysirtaantumispäätös. Malli koostuu neljästä päävaiheesta, mutta pääpainopiste mallissa on laskentamenetelmissä. Luotua prosessimallia sekä erityisesti laskentamenetelmiä on sovellettu yritysesimerkin avulla. Epävarmuuden mallintamisongelmaa on käsitelty sekä perinteisten klassillisten investointiteorioiden että reaalioptioajatteluun pohjautuvien menetelmien avulla. Reaalioptioteoriaan perustuvien menetelmien avulla voidaan ottaa huomioon tulevat epävarmuudet ja päätöksentekomahdollisuudet. Perinteisten reaalioptioteorioiden käytännön elämän vastaisten taustaoletuksien vuoksi tutkittiin erityisesti uusimpia malleja. Diplomityössä yritysesimerkiksi valittiin Paroc Group, jonka yritysjärjestelytilannetta tutkittiin sen nykyisen omistajan eli pankin näkökulmasta. Diplomityön yhtenä keskeisenä tavoitteena oli selvittää, että kannattaako pankin myydä yhtiö tämän hetkisellä markkinahinnalla vai odottaa parempaa myyntiajankohtaa.

Marketing plan for a new service concept: case Taksipalvelu MPS Oy

Markkinointisuunnitelmatutkimukset koostuvat pääosin tuotantoalalle tai suurille yrityksille tehdyistä markkinointisuunitelmista. Vaikuttaa siltä, että pienet yritykset tekevät suunnitelmansa ilman nimenomaisesti heille suunniteltua mallia, jos tekevät suunnitelmaa ollenkaan. Kuten sanottu, sovellukset palveluyrityksille ja pk-yrityksille puuttuvat markkinointisuunnitelmiin kohdistuvasta tutkimuksesta, mikä lisää tämän tutkimuksen arvoa keskittyen juuri kyseisiin markkinointisuunnitelman osa-alueisiin. Tutkimusta sovelletaan uuteen palvelukonseptiin, jota case-yritys Taksipalvelu MPS Oy on lanseeraamassa. Palvelu on kohdistettu venäläisille matkailijoille sekä Lappeenrannan alueella eläville venäläisille, ja se perustuu ennen kaikkea korkeaan laatuun. Tutkimus on tärkeä, sillä taksiala on hyvin säännelty, mutta säännöstelyn piirissä on todennäköisesti paljon potentiaalia palveluiden differentaatioon. Segmentointi ja palveluiden kohdistus tiettyihin asiakasryhmiin on taksialalla myös hyvin minimaalista. Tutkimalla kohdistetun palvelun kysyntää ja arvoa saadaan selville olisiko tällainen toiminta kannattavaa vai ei. Venäläisten asiakkaiden määrä on kasvanut Lappeenrannan alueella paljon, minkä potentiaalia ei ole ehkä vielä täysin hyödynnetty. Tutkimuksen tarkoituksena on luoda hyödyllinen markkinointisuunnitelma case-yritykselle kiinnittäen erityisesti huomiota toimialaan ja kohdeasiakasryhmään. Tarkoituksena on antaa suuntaviivoja kuinka lähestyä kohdeasiakkaita ja kuinka markkinoida palvelua oikein. Tavoitteena on myös selvittää onko valitulla asiakassegmentillä kysyntää vai tulisiko kohdistaminen tehdä toisia määritteitä käyttäen.

Anomalia anatômica da veia porta: uma causa rara de impossibilidade de doação do lobo direito em transplante hepático intervivos

Living related liver transplantation is being increasingly used for patients that can not wait for a cadaveric organ. We describe a case of a right lobe donor who had a type III portal vein anomaly. On this anomaly the portal vein gives branches first to the right posterior vein and then to the right anterior vein and the left portal vein. The recipient had portal vein thrombosis that was recognized only during the surgery. The Doppler examination performed before the operation did not detect this thrombosis. The transplant was not accomplished. Anatomical anomaly of the portal vein may be a rare cause impossibility to organ donation in living related liver transplantation.

Analyzing the Effects of the New Renewable Energy Policy in Russia on Investments into Wind, Solar and Small Hydro Power

This thesis presents an analysis of recently enacted Russian renewable energy policy based on capacity mechanism. Considering its novelty and poor coverage by academic literature, the aim of the thesis is to analyze capacity mechanism influence on investors’ decision-making process. The current research introduces a number of approaches to investment analysis. Firstly, classical financial model was built with Microsoft Excel® and crisp efficiency indicators such as net present value were determined. Secondly, sensitivity analysis was performed to understand different factors influence on project profitability. Thirdly, Datar-Mathews method was applied that by means of Monte Carlo simulation realized with Matlab Simulink®, disclosed all possible outcomes of investment project and enabled real option thinking. Fourthly, previous analysis was duplicated by fuzzy pay-off method with Microsoft Excel®. Finally, decision-making process under capacity mechanism was illustrated with decision tree. Capacity remuneration paid within 15 years is calculated individually for each RE project as variable annuity that guarantees a particular return on investment adjusted on changes in national interest rates. Analysis results indicate that capacity mechanism creates a real option to invest in renewable energy project by ensuring project profitability regardless of market conditions if project-internal factors are managed properly. The latter includes keeping capital expenditures within set limits, production performance higher than 75% of target indicators, and fulfilling localization requirement, implying producing equipment and services within the country. Occurrence of real option shapes decision-making process in the following way. Initially, investor should define appropriate location for a planned power plant where high production performance can be achieved, and lock in this location in case of competition. After, investor should wait until capital cost limit and localization requirement can be met, after that decision to invest can be made without any risk to project profitability. With respect to technology kind, investment into solar PV power plant is more attractive than into wind or small hydro power, since it has higher weighted net present value and lower standard deviation. However, it does not change decision-making strategy that remains the same for each technology type. Fuzzy pay-method proved its ability to disclose the same patterns of information as Monte Carlo simulation. Being effective in investment analysis under uncertainty and easy in use, it can be recommended as sufficient analytical tool to investors and researchers. Apart from described results, this thesis contributes to the academic literature by detailed description of capacity price calculation for renewable energy that was not available in English before. With respect to methodology novelty, such advanced approaches as Datar-Mathews method and fuzzy pay-off method are applied on the top of investment profitability model that incorporates capacity remuneration calculation as well. Comparison of effects of two different RE supporting schemes, namely Russian capacity mechanism and feed-in premium, contributes to policy comparative studies and exhibits useful inferences for researchers and policymakers. Limitations of this research are simplification of assumptions to country-average level that restricts our ability to analyze renewable energy investment region wise and existing limitation of the studying policy to the wholesale power market that leaves retail markets and remote areas without our attention, taking away medium and small investment into renewable energy from the research focus. Elimination of these limitations would allow creating the full picture of Russian renewable energy investment profile.

The control of deliberate waiting strategies in a stop-signal task

To inhibit an ongoing flow of thoughts or actions has been largely considered to be a crucial executive function, and the stop-signal paradigm makes inhibitory control measurable. Stop-signal tasks usually combine two concurrent tasks, i.e., manual responses to a primary task (go-task) are occasionally countermanded by a stimulus which signals participants to inhibit their response in that trial (stop-task). Participants are always instructed not to wait for the stop-signal, since waiting strategies cause the response times to be unstable, invalidating the data. The aim of the present study was to experimentally control the strategies of waiting deliberately for the stop-signal in a stop-task by means of an algorithm that measured the variation in the reaction times to go-stimuli on-line, and displayed a warning legend urging participants to be faster when their reaction times were more than two standard deviations of the mean. Thirty-four university students performed a stop-task with go- and stop-stimuli, both of which were delivered in the visual modality and were lateralized within the visual field. The participants were divided into two groups (group A, without the algorithm, vs group B, with the algorithm). Group B exhibited lower variability of reaction times to go-stimuli, whereas no significant between-group differences were found in any of the measures of inhibitory control, showing that the algorithm succeeded in controlling the deliberate waiting strategies. Differences between deliberate and unintentional waiting strategies, and anxiety as a probable factor responsible for individual differences in deliberate waiting behavior, are discussed.

Cell therapy in dilated cardiomyopathy: from animal models to clinical trials

Dilated cardiomyopathy can be the end-stage form and common denominator of several cardiac disorders of known cause, such as hypertensive, ischemic, diabetic and Chagasic diseases. However, some individuals have clinical findings, such as an increase in ventricular chamber size and impaired contractility (classical manifestations of dilated cardiomyopathy) even in the absence of a diagnosed primary disease. In these patients, dilated cardiomyopathy is classified as idiopathic since its etiology is obscure. Nevertheless, regardless of all of the advances in medical, pharmacological and surgical procedures, the fate of patients with dilated cardiomyopathy (of idiopathic or of any other known cause) is linked to arrhythmic episodes, severe congestive heart failure and an increased risk of sudden cardiac death. In this review, we will summarize present data on the use of cell therapies in animal models of dilated cardiomyopathies and will discuss the few clinical trials that have been published so far involving patients affected by this disease. The animal models discussed here include those in which the cardiomyopathy is produced by genetic manipulation and those in which disease is induced by chemical or infectious agents. The specific model used clearly creates restrictions to translation of the proposed cell therapy to clinical practice, insofar as most of the clinical trials performed to date with cell therapy have used autologous cells. Thus, translation of genetic models of dilated cardiomyopathy may have to wait until the use of allogeneic cells becomes more widespread in clinical trials of cell therapies for cardiac diseases.

Pienten ja keskisuurten yritysten kasvun mahdollistavat ja kasvua rajoittavat tekijät

Viimeaikaisen talouden yleisen heikon tilanteen johdosta päättäjät ympäri Eurooppaa ovat kääntyneet pienten ja keskisuurten yritysten (pk-yritys) puoleen työllisyyden parantamiseksi. Pk-yritysten edustaessa yli 99% Suomen yrityskannasta, ovat ne erittäin tärkeässä asemassa työllisyystilanteen lisäksi myös maamme talouden kannalta, ja pk-yrityksille onkin asetettu kasvupaineita viimeaikaisten kasvuyritysten menestystarinoiden innoittamana. Tässä tutkimuksessa pääasiallisena tavoitteena on tutkia pk-yritysten kasvuun liittyviä tekijöitä kasvun mahdollistavien sekä kasvua rajoittavien tekijöiden kannalta. Pääasiallisen tavoitteen ohella on tutkittu myös pk-yritysten tekemiä konkreettisia toimia kasvua mahdollistavien tekijöiden vahvistamiseksi, sekä kasvua rajoittavien tekijöiden murtamiseksi. Tutkimus etenee siten, että ensin käydään läpi pk-yritysten kasvuun liittyviä yleisiä asioita, jonka jälkeen siirrytään kasvun mahdollistaviin ja sitä rajoittaviin tekijöihin. Tutkimus on toteutettu laadullisena tutkimuksena eli se on kvalitatiivinen tutkimus. Tutkimuksen empiirinen aineisto koostuu neljän pk-yrityksen teemahaastatteluista, sekä kyselylomakkeesta, joissa kartoitettiin pk-yritysten omistaja-johtajien mielipiteitä yritysten kasvun mahdollistavista ja sitä rajoittavista tekijöistä. Teemahaastattelujen haastattelurunko on rakennettu pk-yritysten kasvua käsittelevien artikkelien ja niissä ilmenneiden kasvuun liittyvien havaintojen pohjalta. Tutkimuksen perusteella pk-yritysten omistaja-johtajat ovat sitä mieltä, että Suomen veropoliittiset, sekä työlainsäädännölliset ratkaisut rajoittavat yritysten kasvua, eivätkä kannusta yrittäjyyteen. Tämän lisäksi kasvua rajoittavat omistaja-johtajien tavoitteet yritystoimintaan liittyen, sekä pätevän työvoiman rekrytointiin liittyvät ongelmat. Kasvun mahdollistavien tekijöiden osalta omistaja-johtajat pitivät tärkeinä yritystoimintaa tukevien järjestelmien merkitystä, yrityksen tunnetuksi tekemistä, yrityksen ja sen sidosryhmien välisten suhteiden kehittämistä ja yhteistyötä sekä yritystoiminnan laadun kehittämistä ja valvontaa. Tutkimuksessa ilmeni myös pk-yritysten pystyvän murtamaan aikaisemmissa tutkimuksissa ilmenneitä kasvua rajoittavia tekijöitä tehokkaasti, saavan aikaan kasvua niiden olemassaolosta huolimatta.

The effects of a general excercise program on task self-efficacy and social physique anxiety in older adults

Older adults represent the most sedentary segment of the adult population, and thus it is critical to investigate factors that influence exercise behaviour for this age group. The purpose of this study was to examine the influence of a general exercise program, incorporating cardiovascular, strength, flexibility, and balance components, on task selfefficacy and SPA in older adult men and women. Participants (n=114, Mage = 67 years) were recruited from the Niagara region and randomly assigned to a 12-week supervised exercise program or a wait-list control. Task self-efficacy and SPA measures were taken at baseline and program end. The present study found that task self-efficacy was a significant predictor of leisure time physical activity for older adults. In addition, change in task self-efficacy was a significant predictor of change in SPA. The findings of this study suggest that sources of task self-efficacy should be considered for exercise interventions targeting older adults.

Dr. Stuart D. Scott Papers, 1837-2010 (non-inclusive)

Dr. Stuart D. Scott has written extensively in the fields of prehistory and history. As an archaeologist, he has traveled to some of the most significant sites in the world, including Pompeii, Stonehenge, the Valley of the Kings, Egypt’s pyramids and the Taj Mahal. He spent nine months excavating with the Tikal Project in Guatemala before returning to the University of Arizona where he received a Ph.D. in 1963. He excavated in New Zealand as a Fulbright scholar in 1963-1964. In the fall of 1964, Dr. Scott started a long career in the Anthropology Department of the State University of New York. He taught graduate and undergraduate archaeology courses and continued his archaeological and historical research. In 1979, Scott established the Old Fort Niagara Archaeology in Progress Project at Old Fort Niagara in Youngstown, New York. For many years, he became involved with historical archaeology in western New York. It was during this work that he became interested in the Upper Canada Rebellion of 1837-1838 and its aftermath. Dr. Scott and his wife, Patricia Kay Scott, would use Christmas breaks, summer vacations, and sabbatical years to travel. They were repeatedly lured back to the South Pacific, conducting research in New Zealand, Australia and many of the Micronesian and Polynesian islands. To tell the whole story of the Rebellion and the prison exiles, they traveled extensively in Canada, the United States, England and Tasmania to collect archival research and to experience the scenes of this remarkable narrative. In 2004, Dr. Scott published To the Outskirts of Habitable Creation: Americans and Canadians Transported to Tasmania in the 1840s, which told the story of the men captured, tried, convicted, and exiled as a result of the Rebellion, also called the Patriot War. Other contributions include: • A collaboration with Dr. Charles Cazeau on the book Exploring the Unknown, Great Mysteries Reexamined published by Plenum Press in 1979 • The Patriot Game: New Yorkers and the Canadian Rebellion of 1837-1838, which appeared in New York History, Vol. 68, No.3. 1987 • A Frontier Spirit: The Life of James Gemmell published in Australiasian Canadian Studies, Vol. 25, No. 2 2007 • To the Outskirts of Habitable Creation which appeared in the Friends of the National Archives, Vol. 20, No. 1 2009 • Numerous academic journal publications • Service on conference panels • Various research papers and proposals Before retiring in 1997 and while still a resident of Buffalo, N.Y., Dr. Scott spent considerable time with Brock University President Emeritus James A. Gibson and History Professor Colin Duquemin. The three shared a love of Rebellion history. It was largely because of this connection that Brock University was chosen as the recipient of Dr. Scott’s research materials.

Letter - E.C. Schmon to Arthur A. Schmon, 15 February 1918

This letter discusses the long wait between correspondence due to the mail delivery. She also discusses the weeks plans. This letter is labelled 57th.

Letter - E.C. Schmon to Arthur A. Schmon, 21 & 22 January 1920

The letter discusses the upcoming eye operation for Mrs. Reynolds (E.C. Schmon's mother). The second letter mentions her sister is ill and needs tending to while her mother is not able to wait on her. The letter is labelled number 105.

Letter - E.C. Schmon to Arthur A. Schmon, Tuesday P.M.

The letter reads:"Daddy dearie I have been so blue and homesick to-day that I could have cried my eyes out. Oh! Sweetheart, will the time ever come for that ice breaker to go down? I love you so and miss you so that dearie me if I don't see you soon, I'll die. Please keep reminding Mr. Grogan to let me know when that boat goes, for if I should miss it, I would be distincted. And if you should hear of it's sailing, dear, you let me know, too. The way I talk anyone might think that I am having a very unpleasant visit. On the contrary, I am enjoying my little sojourn here very much. I am with the family most of the time and they are all perfectly wonderful to me. They can't do enough for me. Shower me with love all the time, but with it all there is that big, big desire to be with my Dadd. I want to be where my heart is - in Shelter Bay. I can hardly wait to hear about the house. Have they started the plastering yet? I forgot to tell you that I cannot find out whether or not that linoleum can be bought in Canada. I shall keep on making inquiries, tho, dear, and hope to hear something about it soon. Well Daddy my own, bye-bye for another time. Al the love in the world your little Bubbles."