TASKGURU

La revoluci��n del internet ha llevado a muchos cambios. Con el paso del tiempo, dependemos menos de los papeles y m��s de los archivos digitales. Los niveles de informaci��n han incrementado exponencialmente y la interconectividad que han brindado servicios como redes sociales se encuentra en niveles jam��s pensados hace media d��cada. Sin embargo, el mercado laboral tradicional ha visto pocos cambios; a pesar de que han surgido numerosas ocupaciones y desaparecido puestos del mismo modo, la gran mayor��a de personas se ven obligadas a buscar el sustento propio y de sus familias dedic��ndole una cantidad considerable de tiempo a su trabajo y dejando de lado muchos otros asuntos pertinentes al hogar, a los negocios e incluso asuntos personales. El sistema de adquisici��n de servicios se encuentra completamente estancado. En Colombia, seg��n cifras de 2011 del Departamento Administrativo Nacional de Estadistica (DANE), existen m��s de 10 millones de viviendas y m��s de 500.000 establecimientos de comercio, que por lo menos una vez por a��o tienen un reparo para hacer, por esta raz��n, se genera una amplia demanda en la prestaci��n de este tipo de servicios. Miles de personas contin��an sin encontrar servicios espec��ficos a sus necesidades en el momento adecuado, incluso cuando existe dinero destinado hacia los mismos, en gran parte debido a los esquemas tradicionales y la inhabilidad de conectar necesidades con servicios. Este emprendimiento busca cambiar ese esquema tradicional de las p��ginas amarillas, los clasificados y otras fuentes que se han quedado en el siglo XX como medio publicitario de trabajos realizados por independientes en temas relacionados con el hogar u oficina y abrir camino hacia una nueva forma de encontrar un apareamiento en tiempo real y enfocado en los consumidores, creando una sitio web y posteriormente aplicaciones m��viles, en la que cada cliente puede comparar los precios estandarizados de cada servicio del hogar, pagar electr��nicamente lo pactado y dejar calificaciones del servicio posteriormente; cambiando el estilo de negociaci��n de modo m��s formal y bajo un esquema que logre acuerdos mutuamente beneficiales. En el corto plazo, se busca que las personas puedan considerar alternativas a los esquemas existentes para dar a satisfacer sus necesidades. En el mediano y largo plazo el objetivo del 4 proyecto es romper los paradigmas en los mismos que se han mantenido desde tanto tiempo y revolucionar su funcionamiento conforme a las herramientas existentes en la actualidad. El siguiente proyecto tiene como propuesta proveer una soluci��n completa para los hogares y establecimientos comerciales en t��rminos de adquisici��n de servicios prestados por personas independientes y con poca o nula regulaci��n en el mercado actual. Es una propuesta que permite cambiar la log��stica y el modelo de negociaci��n de mediante una herramienta virtual que adicionalmente brinde una respuesta m��s r��pida y facilidad de uso.

Pulsioximetr��a de pacientes en hemodi��lisis, de la unidad de terapia renal ��� fundaci��n cardioinfantil, an��lisis para establecer recomendaciones

Introducci��n. En Colombia, el 80% de los pacientes con enfermedad renal cr��nica en hemodi��lisis tienen f��stula arteriovenosa perif��rica (FAV) que asegura el flujo de sangre durante la hemodi��lisis (1), la variabilidad en el flujo de sangre en el brazo de la FAV hacia la parte distal, puede afectar la lectura de la oximetr��a de pulso (SpO2) (2), llevando a la toma de decisiones equivocadas por el personal de salud. El objetivo de este estudio es aclarar si existe diferencia entre la SpO2 del brazo de la FAV y el brazo contralateral. Materiales y m��todos. Se realiz�� un estudio de correlaci��n entre los valores de SpO2 del brazo con FAV contra el brazo sin FAV, de 40 pacientes que asistieron a hemodi��lisis. La recolecci��n de los datos se llev�� a cabo, con un formato que incluy�� el resultado de la pulsioximetria y variables asociadas, antes, durante y despu��s de la hemodi��lisis. Se compar�� la mediana de los deltas de las diferencias con pruebas estad��sticas T Student ��� Mann Whitney, aceptando un valor significativo de p < 0,05. Resultados. No se encontraron diferencias estad��sticamente significativas de la SpO2 entre el brazo con FAV y el brazo sin FAV, antes, durante y despu��s de la di��lisis, sin embargo si se apreci�� una correlaci��n positiva estad��sticamente significativa. Conclusiones. Se encontr�� correlaci��n positiva estad��sticamente significativa, donde no hubo diferencias en el resultado la pulsioximetr��a entre el brazo con FAV y brazo sin FAV, por lo tanto es v��lido tomar la pulsioximetr��a en cualquiera de los brazos.

Dynamically Adapting BDI Agent Architectures based on High-level User Specifications

Users are facing an increasing challenge of managing information and being available anytime anywhere, as the web exponentially grows. As a consequence, assisting them in their routine tasks has become a relevant issue to be addressed. In this paper, we introduce a software framework that supports the development of Personal Assistance Software (PAS). It relies on the idea of exposing a high level user model in order to increase user trust in the task delegation process as well as empowering them to manage it. The framework provides a synchronization mechanism that is responsible for dynamically adapting an underlying BDI agent-based running implementation in order to keep this high-level view of user customizations consistent with it.

Atitudes relativas a meios de comunica����o: um estudo explorat��rio sobre o Wap

The new economy stimulated by the bigger Internet participation as an interaction mean between people and business has been changing the companies�� management routine. Nowadays, Internet access goes through telephones, in the houses and offices, or through nets of the Intranet kind, with the users in their working settings. The Internet personal access added, with mobility, surely will bring changes to our contacting form to the outside world as well as it will create a possibility of giving the customers a bigger variety of products and services. The present study aims are: (i) to verify the customers behaviours related to this new media, presented in the mobiles digital screens; (ii) to explore some of their main features, and (iii) to compare them with the other media features, as the radio and the TV ones. The applied research methodology was the data collecting through phone interviews. To obtain a Confidence Interval of 95%, 470 WAP, Internet, radio and TV current users�� answers were gotten. To compare the media, the Fishbein multi-attributes model was used what possibilities to form comparative scores of the attributes built for the research. To mark the discussion concerning the public behaviour related to the differentiated use of the mentioned media out, the study produced uses the McLuhan theoretical reference (1969), specially concerning to his theoretical building, denominated hot and cold means. But this referential theoretic mark could not be supported by the accomplished quantitative study result. The comparison of built attribute scores averages has differentiated the hot media WAP, like radio, as well as the cold media one, like TV. This way, showing that the access new technology appearance, WAP, not only enlarges the Internet use, but also appoints to a new theoretic classification possibility to this new media. The accomplished quantitative research revealed that, through the user point of view, the ��Contents�� category is considered as one of the most important WAP aspects. The TV and the radio received significantly lower grades in this subject. The public considers that is important that the WAP information is ��trustworthy��, ��easy�� to find, ��available��, ��sufficient�� and that attends the ��urgency�� expected by the user. It was observed that the WAP score ��emotion�� is inferior to the radio and TV and superior to the Internet ones. But, the differences found are not significant. Considering the low score of importance given to the attributes group ��emotion��, is not recommended the WAP use as media when the emotional users aspects are wanted to be reached.

On the dynamic behaviour of the "click" mechanism in dipteran flight

In this paper, the dynamic behaviour of the "click" mechanism is analysed. A more accurate model is used than in the past, in which the limits of movement due to the geometry of the flight mechanism are imposed. Moreover, the effects of different damping models are investigated. In previous work, the damping model was assumed to be of the linear viscous type for simplicity, but it is likely that the damping due to drag forces is nonlinear. Accordingly, a model of damping in which the damping force is proportional to the square of the velocity is used, and the results are compared with the simpler model of linear viscous damping. Because of the complexity of the model an analytical approach is not possible so the problem has been cast in terms of non-dimensional variables and solved numerically. The peak kinetic energy of the wing root per energy input in one cycle is chosen to study the effectiveness of the "click" mechanism compared with a linear resonant mechanism. It is shown that, the "click" mechanism has distinct advantages when it is driven below its resonant frequency. When the damping is quadratic, there are some further advantages compared to when the damping is linear and viscous, provided that the amplitude of the excitation force is large enough to avoid the erratic behaviour of the mechanism that occurs for small forces. (C) 2011 Elsevier Ltd. All rights reserved.

Electrochromic Switching Mechanism of Iron Hexacyanoferrates Molecular Compounds: The Role of Fe2+(CN)(6) Vacancies

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

Advanced ceramics: Evaluation of the mechanism of stock removal and ground surface quality

The aim of this work is to evaluate the mechanism of stock removal and the ground surface quality of advanced ceramics machined by a surface grinding process using diamond grinding wheels. The analysis of the grinding performance was done regarding the cutting surface wear behavior of the grinding wheel for ceramic workpieces. The ground surface was evaluated using Scanning Electron Microscopy (SEM). As a result it can be said that the mechanism of material removal in the grinding of ceramic is largely one of brittle fracture. The increase of the hmax can reduce the tangential force required by the process. Although, it results in an increase in the surface damage, reducing the mechanical properties of the ground component.

Mechanism of colonization in the Mediterranean-sea. Asperarca nodulosa: morphological and genetic analysis

Il mar Mediterraneo �� un bacino acquifero peculiare per la recente colonizzazione di specie aliene, per l���evento geologico legato alla Crisi di salinit�� del Messiniano e per l���ampio range di salinit��. L���individuazione dei meccanismi di colonizzazione si �� incentrata sullo studio morfologico, istologico e molecolare delle specie Asperarca nodulosa ed Anadara demiri (Arcidae-Bivalvia-Mollusca). La ricerca si �� basata sulla caratterizzazione morfologica, con utilizzo del microscopio elettronico a scansione, al fine di individuare il tipo di sviluppo larvale. Successivamente i dati rilevati al S.E.M. sono stati supportati dall���indagine istologica che ha evidenziato la presenza di gonadi a sessi distinti e la non incubazione larvale. L���ulteriore analisi filogenetica ha permesso di evidenziare la netta suddivisione tra le tre popolazioni studiate, indagine effettuata tramite marcatori arbitrari (RAPDs) e nucleari specifici (ITS). I risultati ottenuti trovano supporto da quanto noto su base morfologica. I dati, nel complesso, mostrano una perdita delle capacit�� di diffusione della specie tramite sviluppo larvale plantotrofico a favore di quello lecitotrofico o diretto; tale tesi �� ulteriormente supportata dai dati molecolari che mostrano una netta separazione delle popolazioni prese in esame ed un conseguente isolamento tra individui appartenenti a zone di profondit�� del Mediterraneo (sub-bacini abissali). La ricerca ha, inoltre,esaminato i meccanismi di introduzione attuali nel bacino acquifero che �� soggetto ad una nuova invasione da parte specie aliene dovuta all���apertura del canale di Suez. L���analisi si �� focalizzata sullo studio per l��� individuazione dell���origine della specie aliena A. demiri , di presunta derivazione Indo-Pacifica, ma rivelatasi, nei dati preliminari, di origine Atlantica.

Mechanism of resistance to tyrosine kinase inhibitors in philadelphia-positive acute lymphblastic leukaemia (all): from genetic alterations to impaired RNA editing

The Ph chromosome is the most frequent cytogenetic aberration associated with adult ALL and it represents the single most significant adverse prognostic marker. Despite imatinib has led to significant improvements in the treatment of patients with Ph+ ALL, in the majority of cases resistance developed quickly and disease progressed. Some mechanisms of resistance have been widely described but the full knowledge of contributing factors, driving both the disease and resistance, remains to be defined. The observation of rapid development of lymphoblastic leukemia in mice expressing altered Ikaros (Ik) isoforms represented the background of this study. Ikaros is a zinc finger transcription factor required for normal hemopoietic differentiation and proliferation, particularly in the lymphoid lineages. By means of alternative splicing, Ikaros encodes several proteins that differ in their abilities to bind to a consensus DNA-binding site. Shorter, DNA nonbinding isoforms exert a dominant negative effect, inhibiting the ability of longer heterodimer partners to bind DNA. The differential expression pattern of Ik isoforms in Ph+ ALL patients was analyzed in order to determine if molecular abnormalities involving the Ik gene could associate with resistance to imatinib and dasatinib. Bone marrow and peripheral blood samples from 46 adult patients (median age 55 yrs, 18-76) with Ph+ ALL at diagnosis and during treatment with imatinib (16 pts) or dasatinib (30 pts) were collected. We set up a fast, high-throughput method based on capillary electrophoresis technology to detect and quantify splice variants. 41% Ph+ ALL patients expressed high levels of the non DNA-binding dominant negative Ik6 isoform lacking critical N-terminal zinc-fingers which display abnormal subcellular compartmentalization pattern. Nuclear extracts from patients expressed Ik6 failed to bind DNA in mobility shift assay using a DNA probe containing an Ikaros-specific DNA binding sequence. In 59% Ph+ ALL patients there was the coexistence in the same PCR sample and at the same time of many splice variants corresponded to Ik1, Ik2, Ik4, Ik4A, Ik5A, Ik6, Ik6 and Ik8 isoforms. In these patients aberrant full-length Ikaros isoforms in Ph+ ALL characterized by a 60-bp insertion immediately downstream of exon 3 and a recurring 30-bp in-frame deletion at the end of exon 7 involving most frequently the Ik2, Ik4 isoforms were also identified. Both the insertion and deletion were due to the selection of alternative splice donor and acceptor sites. The molecular monitoring of minimal residual disease showed for the first time in vivo that the Ik6 expression strongly correlated with the BCR-ABL transcript levels suggesting that this alteration could depend on the Bcr-Abl activity. Patient-derived leukaemia cells expressed dominant-negative Ik6 at diagnosis and at the time of relapse, but never during remission. In order to mechanistically demonstrated whether in vitro the overexpression of Ik6 impairs the response to tyrosine kinase inhibitors (TKIs) and contributes to resistance, an imatinib-sensitive Ik6-negative Ph+ ALL cell line (SUP-B15) was transfected with the complete Ik6 DNA coding sequence. The expression of Ik6 strongly increased proliferation and inhibited apoptosis in TKI sensitive cells establishing a previously unknown link between specific molecular defects that involve the Ikaros gene and the resistance to TKIs in Ph+ ALL patients. Amplification and genomic sequence analysis of the exon splice junction regions showed the presence of 2 single nucleotide polymorphisms (SNPs): rs10251980 [A/G] in the exon2/3 splice junction and of rs10262731 [A/G] in the exon 7/8 splice junction in 50% and 36% of patients, respectively. A variant of the rs11329346 [-/C], in 16% of patients was also found. Other two different single nucleotide substitutions not recognized as SNP were observed. Some mutations were predicted by computational analyses (RESCUE approach) to alter cis-splicing elements. In conclusion, these findings demonstrated that the post-transcriptional regulation of alternative splicing of Ikaros gene is defective in the majority of Ph+ ALL patients treated with TKIs. The overexpression of Ik6 blocking B-cell differentiation could contribute to resistance opening a time frame, during which leukaemia cells acquire secondary transforming events that confer definitive resistance to imatinib and dasatinib.

Chinese Internet language: A sociolinguistic analysis of adaptations of the Chinese writing system

This paper examines the adaptations of the writing system in Internet language in mainland China from a sociolinguistic perspective. A comparison is also made of the adaptations in mainland China with those that Su (2003) found in Taiwan. In Computer-Mediated Communication (CMC), writing systems are often adapted to compensate for their inherent inadequacies (such as difficulty in input). Su (2003) investigates the creative uses of the writing system on the electronic bulletin boards (BBS) of two college student organizations in Taipei, Taiwan, and identifies four popular and creative uses of the Chinese writing system: stylized English, stylized Taiwanese-accented Mandarin, stylized Taiwanese, and the recycling of a transliteration alphabet used in elementary education. According to Coupland (2001; cited in Su 2003), stylization is ���the knowing deployment of culturally familiar styles and identities that are marked as deviating from those predictably associated with the current speaking context���. Within this framework and drawing on the data in previous publications on Internet language and online sources, this study identifies five types of adaptations in mainland China���s Internet language: stylized Mandarin (e.g., ������ pi��opi��o for ������ ���beautiful���), stylized dialect-accented Mandarin (e.g., ������ hu��ch��ng for ������ ���very much���), stylized English (e.g., ��������� y��m��ier for ���email���), stylized initials (e.g., bt ������ bi��nt��i for ���abnormal���; pk, short form for ���player kill���), and stylized numbers (e.g., 9494 ji��shi ji��shi ������������ ���that is it���). The Internet community is composed of highly mobile individuals and thus forms a weak-tie social network. According to Milroy and Milroy (1992), a social network with weak ties is often where language innovation takes place. Adaptations of the Chinese writing system in Internet language provide interesting evidence for the innovations within a weak-tie social network. Our comparison of adaptations in mainland China and Taiwan shows that, in maximizing the effectiveness and functionality of their communication, participants of Internet communication are confronted with different language resources and situations, including differences in Romanization systems, English proficiency level, and attitudes towards English usage. As argued by Milroy and Milroy (1992), a weak-tie social network model can bridge the social class and social network. In the Internet community, the degree of diversity of the stylized linguistic varieties indexes the virtual and/or social status of its participants: the more diversified one���s Internet language is, the higher is his/her virtual and/or social status.

Keep at bay! - Abnormal personal space regulation as marker of paranoia in schizophrenia.

BACKGROUND During threat, interpersonal distance is deliberately increased. Personal space regulation is related to amygdala function and altered in schizophrenia, but it remains unknown whether it is particularly associated with paranoid threat. METHODS We compared performance in two tests on personal space between 64��patients with schizophrenia spectrum disorders and 24��matched controls. Patients were stratified in those with paranoid threat, neutral affect or paranoid experience of power. In the stop-distance paradigm, participants indicated the minimum tolerable interpersonal distance. In the fixed-distance paradigm, they indicated the level of comfort at fixed interpersonal distances. RESULTS Paranoid threat increased interpersonal distance two-fold in the stop-distance paradigm, and reduced comfort ratings in the fixed-distance paradigm. In contrast, patients experiencing paranoid power had high comfort ratings at any distance. Patients with neutral affect did not differ from controls in the stop-distance paradigm. Differences between groups remained when controlling for gender and positive symptom severity. Among schizophrenia patients, the stop-distance paradigm detected paranoid threat with 93% sensitivity and 83% specificity. CONCLUSIONS Personal space regulation is not generally altered in schizophrenia. However, state paranoid experience has distinct contributions to personal space regulation. Subjects experiencing current paranoid threat share increased safety-seeking behavior.

Monitorizaci��n de sistemas en alta disponibilidad

El objetivo del proyecto es implantar un sistema de monitorizaci��n, con la peculiaridad de encontrarse en alta disponibilidad, esto es, que el servicio (la monitorizaci��n de una infraestructura) se preste forma continua y no se vea interrumpido. Dado que el prop��sito del sistema es monitorizar activamente una infraestructura, ha sido necesario desplegar una infraestructura, adem��s del sistema de monitorizaci��n. La infraestructura en cuesti��n est�� compuesta por un servidor de documentaci��n, un servidor de base de datos, un servidor de aplicaciones y un servidor web. El sistema de monitorizaci��n se ha desplegado en la misma red de ��rea local de esta infraestructura y monitoriza que los servicios prestados por los componentes de esta infraestructura se encuentren operativos y funcionando adecuadamente. As�� pues, se tendr��a un sistema de monitorizaci��n local funcional. No obstante, el proyecto plantea un sistema escalable, que est�� preparado para el crecimiento de la infraestructura y contin��e siendo eficiente. Para ello, sistema de monitorizaci��n se encuentre dividido por dos componentes: ��� Sonda delegada: monitoriza localmente los activos de la infraestructura a monitorizar, es el escenario anteriormente descrito. ��� Sonda maestra: recibe los resultados de la monitorizaci��n realizada, este sistema puede estar desplegado en otra red distinta a la sonda delegada. Este enfoque no solo es escalable, sino tambi��n es fiel a la realidad, pues puede darse el caso de que las sondas pertenezcan a distintas infraestructuras e inclusive, distintas organizaciones, y se comuniquen a trav��s de internet, mediante un mecanismo confiable a ser posible. El proyecto plantea que ambas sondas se encuentren en alta disponibilidad (en adelante HA, referente a high availability), y que cada sonda est�� compuesta por dos equipos (nodos, en adelante). Como se analizar�� en posteriores cap��tulos, existen diversas configuraciones que permiten implantar un sistema en HA, la configuraci��n escogida para el proyecto es Activo ��� Pasivo(los detalles de esta configuraci��n tambi��n se explican en posteriores cap��tulos). Para finalizar, se estudiara la posibilidad de ofrecer respuestas activas en ciertas situaciones y configuraciones adicionales sobre el sistema de monitorizaci��n base. Por otro lado, para la implantaci��n del proyecto se ha usado software de c��digo abierto para la virtualizaci��n de la infraestructura (Virtual Box y GNS3), los sistemas operativos base (Linux), el sistema de monitorizaci��n(Nagios Core) as�� como el software que implementa la HA (corosync y pacemaker).---ABSTRACT---The aim of the Project is to implement a monitoring system, with the peculiarity of being deployed in high availability, what it is that the service (monitoring infrastructure) is provided continuously and not interrupted. As the purpose of the system is monitoring infrastructure actively, an infrastructure has been deployed, and also the monitoring system. The infrastructure monitored is composed of a documentation server, a server database, an application server and a Web server. The monitoring system has been also deployed on the same LAN of this infrastructure and monitors the services provided by the components of this infrastructure are operational and working as expected. This is a local monitoring system functional. However, the project also proposes a scalable system that is ready for growth of infrastructure and efficient. This is the reason of divide the system in two components: ��� Slave Component: monitors locally the infrastructure assets to be monitored, this is the scenario described above. ��� Master Component: get the results from the monitoring, provided by the Slave Component. This system can be deployed in a different network than the slave component. This approach is not only scalable but also a real scenario, as may be the case that the Components belongs to different infrastructures and even, different organizations, also this components can communicate over the Internet, through a reliable mechanism if possible. The project proposes that both Components are deployed in high availability (HA onwards concerning high availability), each Component is composed of two servers (nodes, hereafter). As will be discussed in later chapters, there are several settings available to deploy a system in HA, the configuration chosen for the project is Active - Passive (details of this configuration are also explained in later chapters). Finally the possibility of offering active responses in certain situations and additional settings on the monitoring system will be discussed. On the other hand, for the implementation of the project, open source software has been used, for virtualization infrastructure (Virtual Box and GNS3), code-based operating systems (Linux), the monitoring system (Nagios core), as well as the software that implements the HA (corosync and pacemaker).

Optimizing communication by compression for Multi-GPU Scalable Breadth-First Searches

Debido al creciente aumento del tama��o de los datos en muchos de los actuales sistemas de informaci��n, muchos de los algoritmos de recorrido de estas estructuras pierden rendimento para realizar b��squedas en estos. Debido a que la representacion de estos datos en muchos casos se realiza mediante estructuras nodo-vertice (Grafos), en el a��o 2009 se cre�� el reto Graph500. Con anterioridad, otros retos como Top500 serv��an para medir el rendimiento en base a la capacidad de c��lculo de los sistemas, mediante tests LINPACK. En caso de Graph500 la medicion se realiza mediante la ejecuci��n de un algoritmo de recorrido en anchura de grafos (BFS en ingl��s) aplicada a Grafos. El algoritmo BFS es uno de los pilares de otros muchos algoritmos utilizados en grafos como SSSP, shortest path o Betweeness centrality. Una mejora en este ayudar��a a la mejora de los otros que lo utilizan. Analisis del Problema El algoritmos BFS utilizado en los sistemas de computaci��n de alto rendimiento (HPC en ingles) es usualmente una version para sistemas distribuidos del algoritmo secuencial original. En esta versi��n distribuida se inicia la ejecuci��n realizando un particionado del grafo y posteriormente cada uno de los procesadores distribuidos computar�� una parte y distribuir�� sus resultados a los dem��s sistemas. Debido a que la diferencia de velocidad entre el procesamiento en cada uno de estos nodos y la transfencia de datos por la red de interconexi��n es muy alta (estando en desventaja la red de interconexion) han sido bastantes las aproximaciones tomadas para reducir la perdida de rendimiento al realizar transferencias. Respecto al particionado inicial del grafo, el enfoque tradicional (llamado 1D-partitioned graph en ingles) consiste en asignar a cada nodo unos vertices fijos que ��l procesar��. Para disminuir el tr��fico de datos se propuso otro particionado (2D) en el cual la distribuci��n se haci�� en base a las aristas del grafo, en vez de a los vertices. Este particionado reduc��a el trafico en la red en una proporcion O(NxM) a O(log(N)). Si bien han habido otros enfoques para reducir la transferecnia como: reordemaniento inicial de los vertices para a��adir localidad en los nodos, o particionados din��micos, el enfoque que se va a proponer en este trabajo va a consistir en aplicar t��cnicas recientes de compression de grandes sistemas de datos como Bases de datos de alto volume o motores de b��squeda en internet para comprimir los datos de las transferencias entre nodos.---ABSTRACT---The Breadth First Search (BFS) algorithm is the foundation and building block of many higher graph-based operations such as spanning trees, shortest paths and betweenness centrality. The importance of this algorithm increases each day due to it is a key requirement for many data structures which are becoming popular nowadays. These data structures turn out to be internally graph structures. When the BFS algorithm is parallelized and the data is distributed into several processors, some research shows a performance limitation introduced by the interconnection network [31]. Hence, improvements on the area of communications may benefit the global performance in this key algorithm. In this work it is presented an alternative compression mechanism. It differs with current existing methods in that it is aware of characteristics of the data which may benefit the compression. Apart from this, we will perform a other test to see how this algorithm (in a dis- tributed scenario) benefits from traditional instruction-based optimizations. Last, we will review the current supercomputing techniques and the related work being done in the area.

A general genetic approach in Escherichia coli for determining the mechanism(s) of action of tumoricidal agents: application to DMP 840, a tumoricidal agent.

We describe here a simple and easily manipulatable Escherichia coli-based genetic system that permits us to identify bacterial gene products that modulate the sensitivity of bacteria to tumoricidal agents, such as DMP 840, a bisnaphthalimide drug. To the extent that the action of these agents is conserved, these studies may expand our understanding agents is conserved, these studies may expand our understanding of how the agents work in mammalian cells. The approach briefly is to use a library of E. coli genes that are overexpressed in a high copy number vector to select bacterial clones that are resistant to the cytotoxic effects of drugs. AtolC bacterial mutant is used to maximize permeability of cells to hydrophobic organic molecules. By using DMP 840 to model the system, we have identified two genes, designated mdaA and mdaB, that impart resistance to DMP 840 when they are expressed at elevated levels. mdaB maps to E. coli map coordinate 66, is located between the parE and parC genes, and encodes a protein of 22 kDa. mdaA maps to E. coli map coordinate 18, is located adjacent to the glutaredoxin (grx) gene, and encodes a protein of 24 kDa. Specific and regulatable overproduction of both of these proteins correlates with DMP 840 resistance. Overproduction of the MdaB protein also imparts resistance to two mammalian topoisomerase inhibitors, Adriamycin and etoposide. In contrast, overproduction of the MdaA protein produces resistance only to Adriamycin. Based on its drug-resistance properties and its location between genes that encode the two subunits of the bacterial topoisomerase IV, we suggest that mdaB acts by modulating topoisomerase IV activity. The location of the mdaA gene adjacent to grx suggests it acts by a drug detoxification mechanism.