Efectividad de la vacuna acelular antipertussis en adolescentes: una revisión sistemática

La incidencia de la tosferina ha mostrado un incremento en los últimos años; afectando predominantemente a los niños menores de 1 año, adolescentes y adultos. En el 2005 el Comité Asesor de Prácticas en Inmunización (ACIP) recomendó administrar una dosis de refuerzo de la vacuna acelular antipertussis a los adolescentes. Esta estrategia ha sido adoptada por distintos países. Sin embargo hasta el momento no existe una revisión sistemática que evalúe la efectividad de esta medida de prevención primaria. Métodos: Revisión sistemática de la literatura de artículos acerca de la efectividad de la vacuna acelular antipertussis como dosis de refuerzo en adolescentes. Resultados: La búsqueda inicial arrojó un total de 121 resultados, de los cuales solo 4 cumplieron los criterios de selección. Se evaluó en éstos, la inmunogenicidad generada contra tétanos y difteria por la vacuna Tdap vs Td con resultados significativos y similares. Además se documentó la respuesta inmunológica protectora generada por la Tdap contra tosferina. En cuanto a la reactogenicidad, en general fue baja. Discusión: La vacuna Tdap genera inmunogenicidad similar a la Td contra tétanos y difteria. Además proporciona adecuada protección contra la tosferina como dosis de refuerzo en los adolescentes. Conclusión: La evidencia disponible sugiere que se puede recomendar la vacuna Tdap como dosis de refuerzo en adolescentes entre los 10 y los 18 años de edad por su baja reactogenicidad y adecuada inmunogenicidad contra tétanos, difteria y B. Pertussis.

¿Pluralismo o colonialidad médica? Un estudio alrededor del cáncer en diferentes sistemas médicos colombianos

En esta investigación se realiza un análisis del tipo de relaciones que se establecen entre la medicina alopática y la medicina indígena yagecera en el escenario urbano de Bogotá. Para ello, toma distancia de los estudios ya realizados sobre este tema en el campo de la antropología a partir de dos aspectos: en primer lugar, busca acercarse a esta relación a partir de las trayectorias profesionales de un conjunto de médicos (tanto indígenas como alopáticos); en segundo lugar, se aproxima a estas relaciones a partir de una enfermedad particular: el cáncer.

Problemas y consecuencias del resurgir del pragmatismo norteamericano: 1952-1976

Revisión crítica de la ‘versión heredada’ sobre el resurgir del pragmatismo norteamericano. Aquí sostengo que ésta es una narrativa sobre la historia de la filosofía que puede ser usada para “reivindicar” la continuidad o para “añorar” la pérdida de esa tradición. Presento tres argumentos a favor de mi tesis sobre la versión heredada: i) es insuficiente para explicar el surgimiento del pragmatismo; ii) es un tipo de narrativa que hace plausible una imagen de la filosofía; iii) impide apreciar que la formación del canon obedece a los propósitos de los seguidores del movimiento.

Estudio de caso : vida empresarial / epidemiología empresarial. Caso de estudio - el éxito de el Pomar

Durante los años 1998 y 2002 El Pomar atravesó por una fuerte crisis económica caracterizada por una disminución de las ventas y falta de liquidez que conllevó a graves problemas con los proveedores. Igualmente, había deficiencia en la dirección del área administrativa y financiera generando debilidades frente a la competencia, pues carecían de controles en los procesos internos. Desde el año 2001 hasta el año 2003, las ventas de la empresa habían disminuido en un 65%, lo que ocasionó el cierre de 4 comercializadoras que tenían y el incumplimiento de sus obligaciones fiscales, financieras y con sus proveedores. Dada esta situación se le aconseja a la Junta Directiva tramitar un acuerdo de restructuración bajo la Ley 550 de 1999 con el fin de pagar a sus acreedores. Este acuerdo fue formalizado con los proveedores el 8 de noviembre de 2003 en donde todas las partes quedaron de acuerdo luego que la Superintendencia de Sociedades diera el aval para ejecutarlo. Para el año 2010 la empresa logró superar esta etapa, luego de que la administración se enfocó en reconquistar el mercado perdido, se vendió la empresa a accionistas colombianos para adquirir capital y se realizó de alianzas estratégicas con otras empresas. El presente trabajo tiene como tema central discutir el caso empresarial de cómo El Pomar logró resurgir de su crisis. De este modo, es cómo se establecerán los parámetros que determinarán el desarrollo del trabajo, tales como: perdurabilidad empresarial, ley 550 de 1999, resurgimiento y estrategia.

La influencia del resurgimiento religioso en el papel social de la mujer musulmana en Turquía (2007-2011)

El presente estudio de caso tiene como objetivo explicar la influencia del resurgimiento religioso en el papel social de la mujer, en el Estado de Turquía, dentro del periodo tiempo comprendido entre el año 2007 al 2011. Este proceso se ha podido evidenciar a través del islam político y las demandas culturales, en este sentido, se tendrá en cuenta el Partido de la Justicia y el Desarrollo para describir la situación de la mujer musulmana a partir del feminismo islámico; de esta manera se podrá entender su participación en el ámbito público y privado. El análisis de fuentes primarias y secundarias será el método principal para la recolección de información, de igual forma se desarrollarán entrevistas, lo que permitirá un acercamiento con las mujeres y su estilo de vida, a partir de sus prácticas religiosas. El resultado de esta investigación demostrará que el resurgimiento religioso le ha permitido a la mujer musulmana identificarse con su religión en el escenario público y tener mayor relevancia en las diferentes áreas del Estado.

Vuelta de tuerca: insurgencia política y epistémica de los movimientos sociales en Bolivia (Tema Central)

El artículo tiene el propósito de reflexionar sobre el (re)surgimiento de la acción colectiva en forma de (nuevos) movimientos sociales en Bolivia, más allá de su posición contestaria a los modelos hegemónicos en boga. Estos movimientos no solo se convirtieron en sujetos políticos-ideológicos con capacidad de generar propuestas alternativas a los modelos hegemónicos, sino con la capacidad epistémica de cuestionar los supuestos básicos del orden hegemónico.

Historia marxista latinoamericana: nacimiento, caída y resurrección (Traducción)

Este ensayo analiza el nacimiento y la caída de la historia marxista latinoamericana a lo largo del siglo XX. Se examinan dos casos representativos durante el resurgimiento de la misma en los últimos diez años: uno de ellos en Argentina y el otro en México. Casos similares se han dado en otros países de la región, pero el argentino y mexicano ilustran dos maneras opuestas de abordar el renacer de la historia marxista

Carbohydrate-based therapeutics

In recent years there has been a resurgence of interest in the biological roles of carbohydrates and as a result it is now known that carbohydrates are involved in a vast array of disease processes. This review summarises progress in the development of carbohydrate-based therapeutics that involve: inhibition of carbohydrate-lectin interactions; immunisation, using monoclonal antibodies for carbohydrate antigens; inhibition of enzymes that synthesise disease-associated carbohydrates; replacement of carbohydrate-processing enzymes; targeting of drugs to specific disease cells via carbohydrate-lectin interactions; carbohydrate based anti-thrombotic agents.

The Kurdish conflict: international humanitarian law and post-conflict mechanisms

This book is highly topical considering the recent resurgence of violence by the PKK, the incursions into Northern Iraq by the Turkish army and security forces and Turkey’s EU accession negotiations. Turkey has become an increasingly important player in Middle Eastern geopolitics. More than two decades of serious conflict in Turkey are proving to be a barrier to improved relations between Turkey and the EU. This book is the first study to address fully the legal and political dimensions of the conflict, and their impact on mechanisms for conflict resolution in the region, offering a scholarly exploration of a debate that is often politically and emotionally highly charged. Kerim Yildiz and Susan Breau look at the practical application of the law of armed conflicts to the ongoing situation in Turkey and Northern Iraq. The application of the law in this region also means addressing larger questions in international law, global politics and conflict resolution. Examples include belligerency in international law, whether the ‘war on terror’ has resulted in changes to the law of armed conflict and terrorism and conflict resolution. The Kurdish Conflict explores the practical possibilities of conflict resolution in the region, examining the political dynamics of the region, and suggesting where lessons can be drawn from other peace processes, such as in Northern Ireland. This book will be of great value to policy-makers, regional experts, and others interested in international humanitarian law and conflict resolution.

Soft money : private foundations of party politics

In the area of campaign financing in federal elections, one of the most controversial issues is that of soft money. Soft money refers to those funds raised by the national party organizations for use on various grassroots and party-building activities. but which are not subject to the restraints of federal campaign finance law. Critics contend that these party-building activitie, such as generic television advertising, voter registration and get-out-the vote drives, provide ancillary benefits to federal candidates and should, therefore, be subject to federal contribution and expenditure limits. Critics further argue that because these funds are not subject to federal law and do benefit federal candidates, the national parties raise monies in amounts and from sources, such as corporations and unions, that are prohibited under federal law. Efforts to gain a better understanding of soft money have been hampered by a lack of data, as the national parties were not required to disclose their soft money receipts and transactions until 1991. The purpose of this study is to analyze data recently made available in an attempt to add the import of empirical evidence to the debate over soft money. The nature, size and timing of soft money contributions are investigated and national party soft money disbursements are examined. The findings suggest that any attempts to reform the soft money system must first consider its compensatory benefits. Most prominently, this includes the extent to which soft money has promoted the resurgence of the national party organizations in the context of election politics.

Contratos relacionais na indústria aeronáutica brasileira : um estudo empírico do modelo de parcerias de risco da Embraer

O presente trabalho é um estudo empírico das práticas contratuais adotadas pela EMBRAER posteriormente ao seu processo de privatização em 1994, e do arranjo contratual empregado para viabilizar a realização dos projetos de aeronaves responsáveis pelo ressurgimento da empresa ao final da década 1990. Aspecto fundamental da engenharia contratual empreendida foi a formação das chamadas Parcerias de Risco entre a Embraer e um grupo selecionado de fornecedores-chave visando o co-desenvolvimento das aeronaves. A análise das informações obtidas na pesquisa aponta a importância epistemológica de se utilizar novos instrumentos de análise que permitam compreender melhor as práticas contratuais empregadas e seu papel no desenvolvimento. Assim, utilizamos a teoria relacional dos contratos como lente teórica para analisar o modelo de parcerias de risco e, por meio dela, investigar qual o papel exercido pelos elementos relacionais no sucesso dos programas ERJ 145 e EMBRAER 170/190. A hipótese central que norteia o trabalho é a de que, no inovador arranjo contratual que envolveu a Embraer, fornecedores estrangeiros e o BNDES, a relação contratual foi construída por meio de mecanismos promissórios e não-promissórios de projeção de trocas, e os padrões de normatividade estabelecidos entre as partes transcenderam o contrato escrito. A contribuição da teoria relacional dos contratos para a análise de tais práticas possui duplo caráter. A primeiro contribuição é eminentemente descritiva, ao fornecer um instrumental teórico mais abrangente e poderoso para compreender a real dinâmica das práticas contratuais em análise. A segunda contribuição, de natureza normativa, consiste em explicitar aspectos relacionais que compõem, juntamente com os elementos promissórios, uma certa normatividade interna ao contrato que informa a conduta dos agentes ao longo da relação. Nos programas ERJ 145 e EMBRAER 170/90, procuramos demonstrar como a formulação de um arranjo contratual mais relacional em substituição ao tradicional conjunto de relações contratuais de fornecimento descontínuas, foi fundamental para o sucesso dos projetos e até mesmo para a sua própria viabilização. Nesse sentido, a teoria relacional dos contratos fornece categorias de análise que não apenas oferecem um ferramental teórico mais adequado para descrever relações como a do caso em estudo, mas também fornece, por meio de uma descrição mais rica e abrangente, lições sobre como desenhar contratos. Isto é importante para demonstrar como a problemática das dimensões implícitas do contratos transcende o campo da teoria contratual e da justiça contratual e apresenta-se de grande relevância para a agenda de pesquisa em Direito e Desenvolvimento.

Oil price shocks and policy implications the emergence of U.S. tight oil production: a case study

How have shocks to supply and demand affected global oil prices; and what are key policy implications following the resurgence of oil production in the United States? Highlights: − The recent collapse in global oil prices was dominated by oversupply. − The future of tight oil in the United States is vulnerable to obstacles beyond oil prices. − Opinions on tight oil from the Top 25 think tank organizations are considered. Global oil prices have fallen more than fifty percent since mid-2014. While price corrections in the global oil markets resulted from multiple factors over the past twelve months, surging tight oil production from the United States was a key driver. Tight oil is considered an unconventional or transitional oil source due to its location in oil-bearing shale instead of conventional oil reservoirs. These qualities make tight oil production fundamentally different from regular crude, posing unique challenges. This case study examines these challenges and explores how shocks to supply and demand affect global oil prices while identifying important policy considerations. Analysis of existing evidence is supported by expert opinions from more than one hundred scholars from top-tier think tank organizations. Finally, implications for United States tight oil production as well as global ramifications of a new low price environment are explored.

A Hora e o Nevoeiro: discurso épico, vontade de potência e mal-estar da modernidade no poema Mensagem de Fernando Pessoa

Considering articles written for Fernando Pessoa in 1912 about The new Portuguese poetry , where he already proclaimed the appearance of the Super-Camões, poet that would be able to revolutionize Portuguese literature e, concomitantly, to make resurging from rubble the Portuguese nation; we understand that, decades before the writing of Message, the poet was already armed with a Will of Power , expression of Friedrich Nietzsche that incorporate the idea of resurgence to the man like creator of news values. Fernando Pessoa believed to make his poetical word, the epic, restoring word of the ideas of Messianism and Fifth Empire as the pushing force of the new Portuguese largeness. However, we look for to investigate the conditions of Malaise that surround the universe of the poem and that restrict its capacity of action on the reality in its return, a time that the space destined in modernity to the poet and to his poetry hindered him of a devoted and positive action, We select therefore theorist like Sigmund Freud e Walter Benjamin

Culicídeos vetores em uma unidade de conservação da caatinga na região do seridó no Rio Grande do Norte aspectos da transmissão de doenças

The scarcity of occurrence records of culicid species, transmitting insects of etiologic agents for arboviruses, protozoan diseases and philarioses, and lack of information about their interactions with the forest environment make the Caatinga one of the most unknown biomes in Brazil. The aim of this study was to identify culicid species in a conservation unit located in a preserved area of the Caatinga and the possible associations with local abiotic factors, as well as characterize the natural and artificial ecotopes present in the Caatinga of Rio Grande do Norte state. The Ecological Station of Serido (ESEC-Seridó) is a Caatinga Conservation Unit located in a rural area of Rio Grande do Norte. The hot and dry climate of the Caatinga, along with a short rainy season, favor the adaptation and resistance of plants, resulting in completely distinct landscapes over the course of the year. The study took place over the course of one year, with monthly collections between 10h-12h, 14h-16h and 18h-20h. Adult mosquitoes were collected in a forest area using a manual suction trap with human bait as attractant at the three times and a Shannon trap for night collections. During the rainy season ovitraps were randomly distributed at different sites. The different capture sites were observed and photographed. Immature and adult insects captured were taken to the laboratory for identification. Of the 5081 insects collected in human-bait and Shannon traps, 75% were Mansonia wilsoni. In addition, Aedeomyia, Aedes, Anopheles, Coquillettidia, Culex, Haemagogus, Mansonia and Psorophora were identified. Of the 92 Haemagogus eggs found, 71 were collected on the banks of a reservoir. Mosquito larvae were found and photographed in an artificial breeding site of a neighboring rural area. Humidity had the greatest influence on culicid density in the Caatinga. Rain was important in the appearance of Haemagogus, Anopheles, Aedes and Psorophora. Temperature had a negative influence on Anopheles triannulatus. The occurence of important vector species of diseases in a little known preserved area of the Caatinga as well as environmental and sociocultural questions are factors that favor the emergence of transmitting insects, making these areas potential subject to the resurgence of diseases

Structure of shikimate kinase from Mycobacterium tuberculosis reveals the binding of shikimic acid

Tuberculosis made a resurgence in the mid-1980s and now kills approximately 3 million people a year. The re-emergence of tuberculosis as a public health threat, the high susceptibility of HIV-infected persons and the proliferation of multi-drug-resistant strains have created a need to develop new drugs. Shikimate kinase and other enzymes in the shikimate pathway are attractive targets for development of non-toxic antimicrobial agents, herbicides and anti-parasitic drugs, because the pathway is essential in these species whereas it is absent from mammals. The crystal structure of shikimate kinase from Mycobacterium tuberculosis (MtSK) complexed with MgADP and shikimic acid ( shikimate) has been determined at 2.3 Angstrom resolution, clearly revealing the amino-acid residues involved in shikimate binding. This is the first three-dimensional structure of shikimate kinase complexed with shikimate. In MtSK, the Glu61 residue that is strictly conserved in shikimate kinases forms a hydrogen bond and salt bridge with Arg58 and assists in positioning the guanidinium group of Arg58 for shikimate binding. The carboxyl group of shikimate interacts with Arg58, Gly81 and Arg136 and the hydroxyl groups interact with Asp34 and Gly80. The crystal structure of MtSK-MgADP-shikimate will provide crucial information for the elucidation of the mechanism of the shikimate kinase-catalyzed reaction and for the development of a new generation of drugs against tuberculosis.