Iowa Department of Administrative Services Agency Performance Plan

Agency Performance Plan

Department of Administrative Services, Information Technology Enterprise, A Review of Selected Service Contracts, April 1, 1998 - June 30, 2003

Other Audit Reports - Special Report

A Review of the State's Leased Space and the Leasing Process, General Services Enterprise of the Department of Administrative Services, July 1, 1998 through June 30, 2003

Other Audit Reports - State Leasing

Report of Recommendations to the Iowa Department of Administrative Services, June 30, 2004

State Audit Reports

Report of Recommendations to the Iowa Department of Administrative Services on the Review of General and Application Controls over the HRIS and Payroll Systems, May 10, 2004 through June 4, 2004

State Audit Reports

Iowa Department of Administrative Services Agency Performance Plan, FY 2004

Agency Performance Plan

Report of Recommendations to the Iowa Department of Administrative Services, June 30, 2005

State Audit Reports

Efficiency of recombinant human TNF in human cancer therapy.

Recombinant human tumour necrosis factor (TNF) has a selective effect on angiogenic vessels in tumours. Given that it induces vasoplegia, its clinical use has been limited to administration through isolated limb perfusion (ILP) for regionally advanced melanomas and soft tissue sarcomas of the limbs. When combined with the alkylating agent melphalan, a single ILP produces a very high objective response rate. In melanoma, the complete response (CR) rate is around 80% and the overall objective response rate greater than 90%. In soft tissue sarcomas that are inextirpable, ILP is a neoadjuvant treatment resulting in limb salvage in 80% of the cases. The CR rate averages 20% and the objective response rate is around 80%. The mode of action of TNF-based ILP involves two distinct and successive effects on the tumour-associated vasculature: first, an increase in endothelium permeability leading to improved chemotherapy penetration within the tumour tissue, and second, a selective killing of angiogenic endothelial cells resulting in tumour vessel destruction. The mechanism whereby these events occur involves rapid (of the order of minutes) perturbation of cell-cell adhesive junctions and inhibition of alphavbeta3 integrin signalling in tumour-associated vessels, followed by massive death of endothelial cells and tumour vascular collapse 24 hours later. New, promising approaches for the systemic use of TNF in cancer therapy include TNF targeting by means of single chain antibodies or endothelial cell ligands, or combined administration with drugs perturbing integrin-dependent signalling and sensitizing angiogenic endothelial cells to TNF-induced death.

Iowa Department of Administrative Services Agency Performance Plan, FY 2007

Agency Performance Plan

Report on the Strategic Sourcing Initiative implemented by the Department of Administrative Services (DAS)

Report on the Strategic Sourcing Initiative implemented by the Department of Administrative Services (DAS)

Annual Report for the Iowa Department of Administrative Services, Fiscal Year 2008

Annual Report for the Iowa Department of Administrative Services, Fiscal Years 2004-2006

Report on the Iowa Department of Administrative Services for the year ended June 30, 2006

Report on the Iowa Department of Administrative Services for the year ended June 30, 2006