Performance of polymeric reinforcements in vehicle structures submitted to frontal impact

Preformed structural reinforcements have shown good performance in crash tests, where the great advantage is their weight. These reinforcements are designed with the aim of increasing the rigidity of regions with large deformations, thus stabilising sections of the vehicle that work as load path during impact. The objective of this work is to show the application of structural reinforcements made of polymeric material PA66 in the field of vehicle safety, through finite element simulations. Simulations of frontal impact at 50 km/h and in ODB (offset deformable barrier) at 57 km/h configurations (standards such as ECE R-94 and ECE R-12) were performed in the software LS-DYNA R (R) and MADYMO (R). The simulations showed that the use of polymeric reinforcements leads to a 70% reduction in A-pillar intrusion, a 65% reduction in the displacement of the steering column and a 59% reduction in the deformation in the region of the occupant legs and feet. The level of occupant injuries was analysed by MADYMO (R) software, and a reduction of 23.5% in the chest compression and 80% in the tibia compression were verified. According to the standard, such conditions lead to an improvement in the occupant safety in a vehicle collision event.

Angiogenesis and angioregression gene expression analyses in swine corpus luteum

The corpus luteum (CL) lifespan is characterized by a rapid growth, differentiation and controlled regression of the luteal tissue, accompanied by an intense angiogenesis and angioregression. Indeed, the CL is one of the most highly vascularised tissue in the body with a proliferation rate of the endothelial cells 4- to 20-fold more intense than in some of the most malignant human tumours. This angiogenic process should be rigorously controlled to allow the repeated opportunities of fertilization. After a first period of rapid growth, the tissue becomes stably organized and prepares itself to switch to the phenotype required for its next apoptotic regression. In pregnant swine, the lifespan of the CLs must be extended to support embryonic and foetal development and vascularisation is necessary for the maintenance of luteal function. Among the molecules involved in the angiogenesis, Vascular Endothelial Growth Factor (VEGF) is the main regulator, promoting endothelial cells proliferation, differentiation and survival as well as vascular permeability and vessel lumen formation. During vascular invasion and apoptosis process, the remodelling of the extracellular matrix is essential for the correct evolution of the CL, particularly by the action of specific class of proteolytic enzymes known as matrix metalloproteinases (MMPs). Another important factor that plays a role in the processes of angiogenesis and angioregression during the CL formation and luteolysis is the isopeptide Endothelin-1 (ET-1), which is well-known to be a potent vasoconstrictor and mitogen for endothelial cells. The goal of the present thesis was to study the role and regulation of vascularisation in an adult vascular bed. For this purpose, using a precisely controlled in vivo model of swine CL development and regression, we determined the levels of expression of the members of VEGF system (VEGF total and specific isoforms; VEGF receptor-1, VEGFR-1; VEGF receptor-2, VEGFR-2) and ET- 1 system (ET-1; endothelin converting enzyme-1, ECE-1; endothelin receptor type A, ET-A) as well as the activity of the Ca++/Mg++-dependent endonucleases and gelatinases (MMP-2 and MMP-9). Three experiments were conducted to reach such objectives in CLs isolated from ovaries of cyclic, pregnant or fasted gilts. In the Experiment I, we evaluated the influence of acute fasting on VEGF production and VEGF, VEGFR-2, ET-1, ECE-1 and ET-A mRNA expressions in CLs collected on day 6 after ovulation (midluteal phase). The results indicated a down-regulation of VEGF, VEGFR-2, ET-1 and ECE-1 mRNA expression, although no change was observed for VEGF protein. Furthermore, we observed that fasting stimulated steroidogenesis by luteal cells. On the basis of the main effects of VEGF (stimulation of vessel growth and endothelial permeability) and ET-1 (stimulation of endothelial cell proliferation and vasoconstriction, as well as VEGF stimulation), we concluded that feed restriction possibly inhibited luteal vessel development. This could be, at least in part, compensated by a decrease of vasal tone due to a diminution of ET-1, thus ensuring an adequate blood flow and the production of steroids by the luteal cells. In the Experiment II, we investigated the relationship between VEGF, gelatinases and Ca++/Mg++-dependent endonucleases activities with the functional CL stage throughout the oestrous cycle and at pregnancy. The results demonstrated differential patterns of expression of those molecules in correspondence to the different phases of the oestrous cycle. Immediately after ovulation, VEGF mRNA/protein levels and MMP-9 activity are maximal. On days 5–14 after ovulation, VEGF expression and MMP-2 and -9 activities are at basal levels, while Ca++/Mg++-dependent endonuclease levels increased significantly in relation to day 1. Only at luteolysis (day 17), Ca++/Mg++-dependent endonuclease and MMP-2 spontaneous activity increased significantly. At pregnancy, high levels of MMP-9 and VEGF were observed. These results suggested that during the very early luteal phase, high MMPs activities coupled with high VEGF levels drive the tissue to an angiogenic phenotype, allowing CL growth under LH (Luteinising Hormone) stimulus, while during the late luteal phase, low VEGF and elevate MMPs levels may play a role in the apoptotic tissue and extracellular matrix remodelling during structural luteolysis. In the Experiment III, we described the expression patterns of all distinct VEGF isoforms throughout the oestrous cycle. Furthermore, the mRNA expression and protein levels of both VEGF receptors were also evaluated. Four novel VEGF isoforms (VEGF144, VEGF147, VEGF182, and VEGF164b) were found for the first time in swine and the seven identified isoforms presented four different patterns of expression. All isoforms showed their highest mRNA levels in newly formed CLs (day 1), followed by a decrease during mid-late luteal phase (days 10–17), except for VEGF182, VEGF188 and VEGF144 that showed a differential regulation during late luteal phase (day 14) or at luteolysis (day 17). VEGF protein levels paralleled the most expressed and secreted VEGF120 and VEGF164 isoforms. The VEGF receptors mRNAs showed a different pattern of expression in relation to their ligands, increasing between day 1 and 3 and gradually decreasing during the mid-late luteal phase. The differential regulation of some VEGF isoforms principally during the late luteal phase and luteolysis suggested a specific role of VEGF during tissue remodelling process that occurs either for CL maintenance in case of pregnancy or for noncapillary vessel development essential for tissue removal during structural luteolysis. In summary, our findings allow us to determine relationships among factors involved in the angiogenesis and angioregression mechanisms that take place during the formation and regression of the CL. Thus, CL provides a very interesting model for studying such factors in different fields of the basic research.

Monitoring Complex Processes to Verify System Conformance: A Declarative Rule-Based Framework

Over the last 60 years, computers and software have favoured incredible advancements in every field. Nowadays, however, these systems are so complicated that it is difficult – if not challenging – to understand whether they meet some requirement or are able to show some desired behaviour or property. This dissertation introduces a Just-In-Time (JIT) a posteriori approach to perform the conformance check to identify any deviation from the desired behaviour as soon as possible, and possibly apply some corrections. The declarative framework that implements our approach – entirely developed on the promising open source forward-chaining Production Rule System (PRS) named Drools – consists of three components: 1. a monitoring module based on a novel, efficient implementation of Event Calculus (EC), 2. a general purpose hybrid reasoning module (the first of its genre) merging temporal, semantic, fuzzy and rule-based reasoning, 3. a logic formalism based on the concept of expectations introducing Event-Condition-Expectation rules (ECE-rules) to assess the global conformance of a system. The framework is also accompanied by an optional module that provides Probabilistic Inductive Logic Programming (PILP). By shifting the conformance check from after execution to just in time, this approach combines the advantages of many a posteriori and a priori methods proposed in literature. Quite remarkably, if the corrective actions are explicitly given, the reactive nature of this methodology allows to reconcile any deviations from the desired behaviour as soon as it is detected. In conclusion, the proposed methodology brings some advancements to solve the problem of the conformance checking, helping to fill the gap between humans and the increasingly complex technology.

Un ambiente integrato basato sul calcolo degli eventi per il riconoscimento di pose mediante kinect

In questo lavoro di tesi si è sviluppato un sistema di supporto al fisioterapista per la definizione degli esercizi da far eseguire al paziente che consenta di automatizzare il controllo della corretta esecuzione degli esercizi stessi da parte del paziente. Si è realizzato un linguaggio per codificare gli esercizi ed un editor per poterli esprimere, attraverso il linguaggio, da parte dello specialista. E' stato realizzato un motore che riesca a valutare in modo automatico se il paziente sta eseguendo correttamente gli esercizi proposti, confrontando le pose riconosciute utilizzando il sensore Microsoft Kinect con le pose degli esercizi definiti attraverso l'editor. Il filo conduttore per la realizzazione del linguaggio e del motore è stata la teoria del Calcolo degli Eventi, estesa con il concetto di aspettativa.

Quantitative analysis of extracapsular extension of metastatic lymph nodes and its significance in radiotherapy planning in head and neck squamous cell carcinoma

We performed a histopathologic analysis to assess the extent of the extracapsular extension (ECE) beyond the capsule of metastatic lymph nodes (LN) in head and neck cancer to determine appropriate clinical target volume (CTV) expansions.

Incidence of small lymph node metastases with evidence of extracapsular extension: clinical implications in patients with head and neck squamous cell carcinoma

Small lymph nodes (LN) show evidence of extracapsular extension (ECE) in a significant number of patients. This study was performed to determine the impact of ECE in LN 7 mm as compared with ECE in larger LN.

Estimates of Use of Research-Based Instructional Strategies in Core Electrical or Computer Engineering Courses

Many research-based instruction strategies (RBISs) have been developed; their superior efficacy with respect to student learning has been demonstrated in many studies. Collecting and interpreting evidence about: 1) the extent to which electrical and computer engineering (ECE) faculty members are using RBISs in core, required engineering science courses, and 2) concerns that they express about using them, are important aspects of understanding how engineering education is evolving. The authors surveyed ECE faculty members, asking about their awareness and use of selected RBISs. The survey also asked what concerns ECE faculty members had about using RBISs. Respondent data showed that awareness of RBISs was very high, but estimates of use of RBISs, based on survey data, varied from 10% to 70%, depending on characteristics of the strategy. The most significant concern was the amount of class time that using an RBIS might take; efforts to increase use of RBISs must address this.

Outcome and patterns of failure after postoperative intensity modulated radiotherapy for locally advanced or high-risk oral cavity squamous cell carcinoma

Background To determine the outcome and patterns of failure in oral cavity cancer (OCC) patients after postoperative intensity modulated radiotherapy (IMRT) with concomitant systemic therapy. Methods All patients with locally advanced (AJCC stage III/IV) or high-risk OCC (AJCC stage II) who underwent postoperative IMRT at our institution between December 2006 and July 2010 were retrospectively analyzed. The primary endpoint was locoregional recurrence-free survival (LRRFS). Secondary endpoints included distant metastasis-free survival (DMFS), overall survival (OS), acute and late toxicities. Results Overall 53 patients were analyzed. Twenty-three patients (43%) underwent concomitant chemotherapy with cisplatin, two patients with carboplatin (4%) and four patients were treated with the monoclonal antibody cetuximab (8%). At a median follow-up of 2.3 (range, 1.1–4.6) years the 3-year LRRFS, DMFS and OS estimates were 79%, 90%, and 73% respectively. Twelve patients experienced a locoregional recurrence. Eight patients, 5 of which had both a flap reconstruction and extracapsular extension (ECE), showed an unusual multifocal pattern of recurrence. Ten locoregional recurrences occurred marginally or outside of the high-risk target volumes. Acute toxicity grades of 2 (27%) and 3 (66%) and late toxicity grades of 2 (34%) and 3 (11%) were observed. Conclusion LRRFS after postoperative IMRT is satisfying and toxicity is acceptable. The majority of locoregional recurrences occurred marginally or outside of the high-risk target volumes. Improvement of high-risk target volume definition especially in patients with flap reconstruction and ECE might transfer into better locoregional control.

Paracellin-1 gene mutation with multiple congenital abnormalities

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis is an autosomal recessive renal tubular disorder characterized by renal magnesium wasting, hypercalciuria, advanced nephrocalcinosis and progressive renal failure. Mutations in the paracellin-1 (CLDN16) gene have been defined as the underlying genetic defect. The tubular disorders and progression in renal failure are usually resistant to magnesium substitution and hydrochlorothiazide therapy, but hypomagnesemia may improve with advanced renal insufficiency. We present a patient with a homozygous truncating CLDN16 gene mutation (W237X) who had early onset of renal insufficiency despite early diagnosis at 2 months. He also had additional abnormalities including horseshoe kidney, neonatal teeth, atypical face, cardiac abnormalities including coarctation of the aorta associated with atrial and ventricular septal defects, umbilical hernia and hypertrichosis. To the best of our knowledge, this is the youngest case diagnosed as familial hypomagnesemia with hypercalciuria and nephrocalcinosis and the first case having such additional congenital abnormalities independent of the disease itself.

Upregulation of endothelin converting enzyme-1 in host liver during chronic cardiac allograft rejection

Endothelin regulates cytokine expression in vitro and in vivo. This study investigated the effects of chronic allograft rejection on hepatic endothelin-converting enzyme-1 (ECE-1) gene expression and endothelin-1 (ET-1) plasma clearance. Using the Lewis-F344 minor histocompatibility mismatch model of heterotopic cardiac transplantation, hepatic ECE-1 gene expression was measured by real-time polymerase chain reaction and host plasma clearance of ET-1 was measured 8 weeks after transplantation in the absence of immunosuppression. In animals undergoing allograft rejection, hepatic ECE-1 gene expression increased 2-fold (P < 0.05), whereas no effect of rejection on ET-1 clearance from plasma was observed. In summary, upregulation of ECE-1 gene expression occurs in the liver of the host during chronic allograft rejection. Because the liver represents both a key organ for cytokine production and for endothelin metabolism, increased hepatic ECE-1-mediated ET-1 synthesis may contribute to host responses and cytokine production during allograft rejection.

Educación en contexto de encierro

Las diferentes problemáticas que acaecen a nuestro país, como la pobreza estructural y la nueva, el desempleo, los avances tecnológicos, la crisis y la coyuntura, son condicionantes en el elevado índice de violencia y delincuencia que van afectando de forma integral el desarrollo del sistema educativo. La educación en contexto de encierro (ECE), permite exponer los hechos carcelarios y previos como fruto de una relación económica y social, producto de un régimen de acumulación colapsado, que postula un ciclo educativo gradual y en parte obligatorio, a la vez que excluye a quienes lo integran. Desde la génesis del capitalismo, pobreza y delito formaron parte de la misma ecuación, tal como los campesinos se vieron impulsados al trabajo en la fábrica o a la vagabundez, castigados por la transformación del modelo que los convirtió en “delincuentes" desde los inicios de la primera Revolución Industrial. Ante la perturbación de las desigualdades que se manifiestan en todos los aspectos de la vida social, se hace pertinente cuestionar a la Justicia y al Derecho, como una estructura de poder que defiende los derechos ciudadanos, pero que a la vez se impone a los sectores vulnerables como instrumento de dominación, donde el régimen legal es tan solo el orden y la regulación de esta forma de control social, garantizado a través de:  Medios represivos para el control compulsivo y violento de la mayoría de la población, como lo son los cuerpos de seguridad, las fuerzas armadas, el aparato judicial y las cárceles.  Medios simbólicos, reconocidos en el resto de las instituciones de administración y gestión del Estado, escuelas y universidades, partidos, iglesias, que actúan como dispositivos necesarios para reforzar ese control social. Dentro de este análisis crítico de una situación que reproduce las condiciones actuales de dominación, induciendo a los sectores opuestos a la sumisión, adaptación o resignación, se tratará de distinguir una beta que impulse a la reflexión actualizada de las condiciones de dominación, y a una visión esperanzada y movilizadora que permita activar a los sectores potenciales de transformación, en un esfuerzo mancomunado a partir del conocimiento y la acción. Es por eso que se plantea la necesidad de intercambiar diferentes teorías, que mediante la adaptación de sus elementos a la problemática, hagan posible abordarla en su complejidad, desde un enfoque ecléctico, expuesto a esclarecer la temática, como así también a generar nuevos interrogantes.

Explicit expressions for solar panel equivalent circuit parameters based on analytical formulation and the Lambert W - Function

Due to the high dependence of photovoltaic energy efficiency on environmental conditions (temperature, irradiation...), it is quite important to perform some analysis focusing on the characteristics of photovoltaic devices in order to optimize energy production, even for small-scale users. The use of equivalent circuits is the preferred option to analyze solar cells/panels performance. However, the aforementioned small-scale users rarely have the equipment or expertise to perform large testing/calculation campaigns, the only information available for them being the manufacturer datasheet. The solution to this problem is the development of new and simple methods to define equivalent circuits able to reproduce the behavior of the panel for any working condition, from a very small amount of information. In the present work a direct and completely explicit method to extract solar cell parameters from the manufacturer datasheet is presented and tested. This method is based on analytical formulation which includes the use of the Lambert W-function to turn the series resistor equation explicit. The presented method is used to analyze the performance (i.e., the I - V curve) of a commercial solar panel at different levels of irradiation and temperature. The analysis performed is based only on the information included in the manufacturer's datasheet.

Competencia emocional y percepción de toma de decisiones en jugadores de voleibol

El propósito de este estudio fue analizar las relaciones existentes entre la dimensión percibida de la toma de decisiones y la competencia emocional de jugadores de voleibol de diferentes niveles de pericia. Para llevar a cabo esta investigación se emplearon el Cuestionario de Estilos de Toma de Decisión en el deporte (CETD) (Ruiz, Graupera y Sánchez, 2000) para evaluar la dimensión percibida de la toma de decisiones y La Escala de Competencia Emocional en el Deporte (ECE-D) (Arruza, Arribas, González, Balagué, Romero y Ruiz, 2005). Participaron un total de 122 jugadores de voleibol de ambos sexos (76 mujeres y 46 hombres) y niveles de pericia (local y autonómico, nacional e internacional). Los resultados obtenidos mostraron diferencias significativas en función del nivel de pericia en la competencia decisional y la competencia emocional. No ocurrió lo mismo en función del sexo. En cuanto a las relaciones existentes entre las variables de ambos cuestionarios, destacamos las existentes entre la Competencia Decisional Percibida y el Reconocimiento Emocional (r=.311) y entre esta última y la Ansiedad y el Agobio al Decidir (r=.-405).

State of the Art and Future Trends in Grid Codes Applicable to Isolated Electrical Systems

Electrical power systems are changing their traditional structure, which was based on a little number of large generating power plants placed at great distances from loads by new models that tend to split the big production nodes in many smaller ones. The set of small groups which are located close to consumers and provide safe and quality energy is called distributed generation (DG). The proximity of the sources to the loads reduces losses associated with transportation and increases overall system efficiency. DG also favors the inclusion of renewable energy sources in isolated electrical systems or remote microgrids, because they can be installed where the natural resource is located. In both cases, as weak grids unable to get help from other nearby networks, it is essential to ensure appropriate behavior of DG sources to guarantee power system safety and stability. The grid codes sets out the technical requirements to be fulfilled for the sources connected in these electrical networks. In technical literature it is rather easy to find and compare grid codes for interconnected electrical systems. However, the existing literature is incomplete and sparse regarding isolated electrical systems and this happens due to the difficulties inherent in the pursuit of codes. Some countries have developed their own legislation only for their island territory (as Spain or France), others apply the same set of rules as in mainland, another group of island countries have elaborated a complete grid code for all generating sources and some others lack specific regulation. This paper aims to make a complete review of the state of the art in grid codes applicable to isolated systems, setting the comparison between them and defining the guidelines predictably followed by the upcoming regulations in these particular systems.

Modelización del efecto de la pendiente de la vía sobre el consumo de vehículos turismo

El presente trabajo tiene por objetivo generar una metodología validada que permita predecir el consumo de vehículos turismo circulando en cualquier tramo de vía a partir del perfil orográfico y del diagrama velocidad-tiempo. Para la generación de la metodología, se ha realizado un modelo de simulación con el programa ADVISOR que permite calcular el consumo de combustible para un determinado recorrido en el que se tiene en cuenta el perfil orográfico. Este modelo fue validado con datos reales medidos con equipos on-board y se usó para calcular el consumo de combustible diferencial debido al efecto de la pendiente de la vía, al poderse simular con y sin pendiente. Se realizaron múltiples simulaciones de recorridos con velocidad máxima variable con el fin de obtener un número significativo de datos. Con los resultados de las diferentes simulaciones, se realizó un estudio estadístico, para determinar las variables influyentes y se generó una función estadística (Ecuación de Consumo Estimado – ECE) que permite calcular el consumo de combustible debido a la pendiente de la vía, conociendo el consumo del vehículo en carretera llana (sin pendiente). Esta función estadística generada (ECE), se validó con datos reales medidos en tráfico real. Con el fin de darle generalidad y aplicabilidad a la función generada, y teniendo en cuenta que el consumo de combustible en carretera llana no está siempre disponible, se ha calculado el consumo de combustible sin pendiente utilizando la metodología Copert 4, metodología oficial desarrollada por la Agencia de Medio Ambiente de Europa (EEA) para la estimación de emisiones y consumo de combustible que está basada en datos experimentales pero que no tiene en cuenta la pendiente de la vía. La Ecuación de Consumo Estimado (ECE) aplicada a los consumos calculados por la metodología Copert 4, se valida también usando datos reales medidos en tráfico real y se comprueba que esta función se ajusta considerablemente bien a la realidad, con un error en el consumo acumulado frente al del ensayo real de un 1% y una correlación con el consumo instantáneo del ensayo real de 0,93. Se concluye, que la Función de Consumo Estimado (ECE), permite predecir el efecto de la pendiente sobre el consumo de combustible de un vehículo turismo en tráfico real con un error menor del 1%. Abstract This projects aims to develop a validated methodology that enables to predict cars consumption while circulating at any kind of road section based on its orographic outline and the speed-time diagram. In order to develop this methodology, a simulation model has been performed with the programme ADVISOR, that allows fuel consumption calculation for an specific route in which the orographic outline is considered. This model was validated by real data measured with an on-board equipment and it was used to calculate the differential fuel consumption caused by the effect of the slope on the road, as it was possible to simulate with or without slope. Many simulations were run with routes with variable maximum speed, aiming to obtain a significant amount of data. An statistical study was carried out with the results of those simulations with the purpose to determine the influential variables and an statistical function ( Estimated Consumption Equation – ECE) that enables fuel consumption calculation due to the road’s slope when the consumption of a vehicle on horizontal road (without any slope) is known. This statistical function (ECE) was validated by real data measured in real traffic conditions. With the purpose to generalise the function and increase its applicability, considering that the consumption of a vehicle on horizontal road is not always available, the nonslope fuel consumption has been calculated through Copert 4 methodology, which is the official methodology developed by the European Environmental Agency (EEA) for emissions and fuel consumption calculation based on experimental data, but without taking into consideration the road’s slope. The Estimated Consumption Equation (ECE) applied to the consumption calculated through Copert 4 methodology is also validated using real data measured in real traffic conditions. It was verified that this function considerably adjusts to reality, with an error on the accumulated consumption compared to the real test of 1% and a correlation with the real test immediate fuel consumption of 0,93. It is concluded that the Estimated Consumption Equation (ECE) enables to predict the effect of the slope on the fuel consumption of a car in real traffic conditions with an error less than 1%.