Outcome and patterns of failure after postoperative intensity modulated radiotherapy for locally advanced or high-risk oral cavity squamous cell carcinoma


Autoria(s): Geretschläger, Andreas; Bojaxhiu, Beat; Crowe, Susanne; Arnold, Andreas; Manser, Peter; Hallermann, Wock; Aebersold, Daniel M.; Ghadjar, Pirus
Data(s)

2012

Resumo

Background To determine the outcome and patterns of failure in oral cavity cancer (OCC) patients after postoperative intensity modulated radiotherapy (IMRT) with concomitant systemic therapy. Methods All patients with locally advanced (AJCC stage III/IV) or high-risk OCC (AJCC stage II) who underwent postoperative IMRT at our institution between December 2006 and July 2010 were retrospectively analyzed. The primary endpoint was locoregional recurrence-free survival (LRRFS). Secondary endpoints included distant metastasis-free survival (DMFS), overall survival (OS), acute and late toxicities. Results Overall 53 patients were analyzed. Twenty-three patients (43%) underwent concomitant chemotherapy with cisplatin, two patients with carboplatin (4%) and four patients were treated with the monoclonal antibody cetuximab (8%). At a median follow-up of 2.3 (range, 1.1–4.6) years the 3-year LRRFS, DMFS and OS estimates were 79%, 90%, and 73% respectively. Twelve patients experienced a locoregional recurrence. Eight patients, 5 of which had both a flap reconstruction and extracapsular extension (ECE), showed an unusual multifocal pattern of recurrence. Ten locoregional recurrences occurred marginally or outside of the high-risk target volumes. Acute toxicity grades of 2 (27%) and 3 (66%) and late toxicity grades of 2 (34%) and 3 (11%) were observed. Conclusion LRRFS after postoperative IMRT is satisfying and toxicity is acceptable. The majority of locoregional recurrences occurred marginally or outside of the high-risk target volumes. Improvement of high-risk target volume definition especially in patients with flap reconstruction and ECE might transfer into better locoregional control.

Formato

application/pdf

Identificador

http://boris.unibe.ch/14123/1/1748-717X-7-175.pdf

Geretschläger, Andreas; Bojaxhiu, Beat; Crowe, Susanne; Arnold, Andreas; Manser, Peter; Hallermann, Wock; Aebersold, Daniel M.; Ghadjar, Pirus (2012). Outcome and patterns of failure after postoperative intensity modulated radiotherapy for locally advanced or high-risk oral cavity squamous cell carcinoma. Radiation oncology, 7, p. 175. London: BioMed Central 10.1186/1748-717X-7-175 <http://dx.doi.org/10.1186/1748-717X-7-175>

doi:10.7892/boris.14123

info:doi:10.1186/1748-717X-7-175

info:pmid:23088283

urn:issn:1748-717X

Idioma(s)

eng

Publicador

BioMed Central

Relação

http://boris.unibe.ch/14123/

Direitos

info:eu-repo/semantics/openAccess

Fonte

Geretschläger, Andreas; Bojaxhiu, Beat; Crowe, Susanne; Arnold, Andreas; Manser, Peter; Hallermann, Wock; Aebersold, Daniel M.; Ghadjar, Pirus (2012). Outcome and patterns of failure after postoperative intensity modulated radiotherapy for locally advanced or high-risk oral cavity squamous cell carcinoma. Radiation oncology, 7, p. 175. London: BioMed Central 10.1186/1748-717X-7-175 <http://dx.doi.org/10.1186/1748-717X-7-175>

Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed