991 resultados para Bacille de Koch


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Signatur des Originals: S 36/G04151

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En este comunicado se describen las fallas conceptuales y metodológicas graves que invalidan algunas de sus conclusiones concernientes al aborto y a la mortalidad materna del estudio de Koch y otros. Por lo cuál no altera el acervo de evidencia existente sobre el impacto de las restricciones al aborto sobre la mortalidad materna. En particular, dado que las leyes de aborto en Chile ya eran altamente restrictivas antes de 1989, el estudio no demuestra que el restringir significativamente las leyes de aborto no produzca un impacto negativo en la salud de las mujeres.

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Bacille Calmette-Guérin (BCG) is a live, attenuated strain of Mycobacterium bovis used widely for tuberculosis prophylaxis and bladder cancer immunotherapy, although it has limitations in both contexts. To investigate whether BCG's immunostimulatory properties could be modified, and to gain insight into the interaction between mycobacteria and their hosts, we constructed recombinant BCG strains that secrete functional murine cytokines and studied their properties in mouse models of experimental infection. Cell-mediated immune responses to mycobacterial antigen (purified protein derivative) were assayed using splenocytes from mice inoculated with various BCG recombinants. Antigen-specific proliferation and cytokine release were found to be substantially greater with splenocytes derived from mice injected with cytokine-secreting BCG than with splenocytes from mice injected with BCG lacking cytokines. The most profound effects were induced by BCG secreting interleukin 2, interferon gamma, or granulocyte-macrophage colony-stimulating factor. Thus, cytokine-secreting BCG can enhance immune responses to mycobacterial antigens and may be improved reagents for tuberculosis prophylaxis and cancer immunotherapy.

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"Meiji 32-nen... shuppan ontodokezumi"--Colophon.

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"New series" vol. II, no. 3.

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Mode of access: Internet.

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Mode of access: Internet.

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