Species-specific metastasis of human tumor cells in the severe combined immunodeficiency mouse engrafted with human tissue.

We have attempted to model human metastatic disease by implanting human target organs into the immunodeficient C.B-17 scid/scid (severe combined immunodeficiency; SCID) mouse, creating SCID-hu mice. Preferential metastasis to implants of human fetal lung and human fetal bone marrow occurred after i.v. injection of human small cell lung cancer (SCLC) cells into SCID-hu mice; the homologous mouse organs were spared. Clinically more aggressive variant SCLC cells metastasized more efficiently to human fetal lung implants than did cells from classic SCLC. Metastasis of variant SCLC to human fetal bone marrow was enhanced in SCID-hu mice exposed to gamma-irradiation or to interleukin 1 alpha. These data indicate that the SCID-hu mice may provide a model in which to study species- and tissue-specific steps of the human metastatic process.

1996 University of Michigan Baseball Team

Back Row: (17) Manager Andy Galbreath, Manager Jeff Olsen, Groundskeeper Erich Keil, Andy Hood, Quinn DeMarrais, Alex Wozniak, Mike Seestedt, Brian Bush, Brian Kalczynski, Ryan Kelley, Pete Martay, Luke Bonner, Bobby Scales, Jason Alcaraz, Mario Garza Jr., Dan Murphy, Student Trainer Jon Nichols.

Middle Row: Assistant SID Jim Schneider, Mike Cervenak, John Papp, Bryan Besco, Derek Besco, Chuck Taylor, Tyler Steketee, J.J. Putz, Brian Steinbach, Mike Hribernik, Brian Berryman, Chris Hesse, Matt Herr, Brad Scheiner, Mick Kalahar, Trainer Rex Thompson.

Front Row: (13) Kirk Beermann, Marlon Wright, Mike Muir, John Arvai, Assistant Coach Tom Dodge, Assistant Coach Chris Harrison, Head Coach Geoff Zahn, Assistant Coach Ace Adams, Matt Hyde, Mark Temple, Matt Fleury, Kelly Dransfeldt, Mike Haskell.

Caregivers of the frail elderly : a national profile /

Item 491-B-17

Four months a prisoner of war in 1945 /

Contains the memoirs of Lt. Jack A. Simon who served as a B-17 navigator in the U.S. Army Air Force during WWII. Simon flew twenty seven missions over Germany before his plane was shot down near Derben. His internment ended when American troops liberated Simon's prisoner of war camp in Spring 1945.

Dynamics of pulsed flow in an elastic tube

Internal haemorrhage, often leading to cardio-vascular arrest happens to be one of the prime sources of high fatality rates in mammals. We propose a simplistic model of fluid flow in our attempt to specify the location of the haemorrhagic spot, which, if located accurately, could possibly be operated leading to an instant cure. The model we employ for the purpose is basically fluid mechanical in origin and consists of a viscous fluid, pumped by a periodic force and flowing through an elastic tube. The analogy is with that of blood, pumped from the heart and flowing through an artery or vein. Our results, aided by graphical illustrations, match reasonably well with experimental observations.

Global compilation of benthic data sets I

Approaches to quantify the organic carbon accumulation on a global scale generally do not consider the small-scale variability of sedimentary and oceanographic boundary conditions along continental margins. In this study, we present a new approach to regionalize the total organic carbon (TOC) content in surface sediments (<5 cm sediment depth). It is based on a compilation of more than 5500 single measurements from various sources. Global TOC distribution was determined by the application of a combined qualitative and quantitative-geostatistical method. Overall, 33 benthic TOC-based provinces were defined and used to process the global distribution pattern of the TOC content in surface sediments in a 1°x1° grid resolution. Regional dependencies of data points within each single province are expressed by modeled semi-variograms. Measured and estimated TOC values show good correlation, emphasizing the reasonable applicability of the method. The accumulation of organic carbon in marine surface sediments is a key parameter in the control of mineralization processes and the material exchange between the sediment and the ocean water. Our approach will help to improve global budgets of nutrient and carbon cycles.

Organic carbon accumulation in the South Atlantic Ocean

A compilation of 1118 surface sediment samples from the South Atlantic was used to map modern seafloor distribution of organic carbon content in this ocean basin. Using new data on Holocene sedimentation rates, we estimated the annual organic carbon accumulation in the pelagic realm (>3000 m water depth) to be approximately 1.8*10**12 g C/year. In the sediments underlying the divergence zone in the Eastern Equatorial Atlantic (EEA), only small amounts of organic carbon accumulate in spite of the high surface water productivity observed in that area. This implies that in the Eastern Equatorial Atlantic, organic carbon accumulation is strongly reduced by efficient degradation of organic matter prior to its burial. During the Last Glacial Maximum (LGM), accumulation of organic carbon was higher than during the mid-Holocene along the continental margins of Africa and South America (Brazil) as well as in the equatorial region. In the Eastern Equatorial Atlantic in particular, large relative differences between LGM and mid-Holocene accumulation rates are found. This is probably to a great extent due to better preservation of organic matter related to changes in bottom water circulation and not just a result of strongly enhanced export productivity during the glacial period. On average, a two- to three-fold increase in organic carbon accumulation during the LGM compared to mid-Holocene conditions can be deduced from our cores. However, for the deep-sea sediments this cannot be solely attributed to a glacial productivity increase, as changes in South Atlantic deep-water circulation seem to result in better organic carbon preservation during the LGM.

Estudio sobre la viabilidad de la implementación del jurado de conciencia en el ordenamiento colombiano

El objeto del presente trabajo final de grado es analizar la viabilidad de la implementación de la figura del jurado de conciencia en el sistema penal colombiano, que fue suprimida mediante el Decreto 1861 de 1989. A su vez, hacer un análisis de derecho comparado con el fin de determinar los aspectos positivos y negativos de la implementación de los jurados en otros sistemas jurídicos. El resultado del análisis propuesto pretende determinar si es procedente la implementación de los jurados de conciencia en Colombia.

Total synthesis of substituted (±)-6,6-dimethyl-B-norestra-1,3,5(10)-trien-17?-ols and their 9?-isomers

Total syntheses of (±)-1,4-dimethoxy-6,6-dimethyl-B-norestra-1,3,5(10)-trien-17?-ol(11a), (±)-2,3-dimethoxy-6,6-dimethyl-B-norestra-1,3,5(10)-trien-17?-ol (11b), and (±)-3-methoxy-6,6-dimethyl-B-norestra-1,3,5(10)trien-17?-ol (11c), have been carried out starting from 4,7-dimethoxy-3,3-dimethylindan-1-one (1), 5,6-dimethoxy-3,3-dimethylindan-1-one (2), and 4?-methoxy-3-methylbut-2-enophenone (4), respectively. Generally, it is found that the intermediate 6,6-dimethyl-B-norestra-1,3,5(10),8-tetraen-17?-ols (10), on lithium�liquid ammonia reduction, yield a mixture of 8?,9?- and 8?,9?-trienols, (11) and (12) respectively, in the ratio 1 : 1. This is due to the comparable stabilities of these two isomers. However, the reduction carried out in presence of aniline affords a higher percentage of the 8?,9?-trienol (11). The assignment of configurations is made by chemical and 1H n.m.r. analysis. Catalytic hydrogenation of the tetraenols (10) is shown to proceed via initial isomerisation to the corresponding 6,6-dimethyl-B-norestra-1,3,5(10),9(11)-tetraen-17?-ols (26), followed by hydrogenation from the ?-side to give, exclusively, the 8?,9?-trienols (12).

Annual report 1992 - North Pacific Marine Science Organization (PICES). First meeting, Victoria, B.C., Canada, October 12-17, 1992

Document has 52 pages.

~(17)B的晕结构特征

实验利用束流衰减法测量了43.7AMeV丰中子核17B与C靶反应的总截面σR=(1724±93)mb.用零程Glauber计算,假定17B具有核芯15B和两个价中子结构,输入GG和GO密度分布,计算的激发函数曲线与该实验数据很好符合,输入描述稳定核双参数Fermi密度分布,不能得到与实验数据符合的结果,表明17B是核芯15B+2n的假定是合理的.并且中子密度分布表现较大空间扩展-晕结构特征.

丰中子奇异核~(17)B的实验研究

在兰州重离子加速器国家实验室(HIRFL)放射性次级束流线(RIBLL)上,用束流透射法测量了丰中子奇异核17B与C靶反应的总截面.假定17B具有15B(核芯)+2n结构,采用Gauss+HO形式的密度分布和零力程Glauber模型进行计算的结果可以很好地拟合实验数据,并得出17B的密度分布有一个很大的弥散,表明17B是双中子晕核.

Letter - Frederic Nicholls (Canadian General Electric) to W.B. Rankine, 17 December 1897

A letter from 2nd Vice President and General Manager of Canadian General Electric Company, Frederic Nicholls to W. B. Rankine regarding a bid for contract. The letter mentions that the bid for two alternating generators for the Canadian side of Niagara Falls was won by Westinghouse Eletric and Manufacturing Co. Nicholls also mentions that there will be other opportunites to win contracts as more machines are required. Nicholls also implies that Westinghouse may have bid under cost in an effort to secure the first of many contracts with the Canadian Niagara Power Company.