378 resultados para Affection


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研究胶州湾浮游植物的物种组成与时空分布的特点,对于了解该湾生态系统的现状与历史变化趋势以及生态系统对自然条件变化和人类干扰的响应具有重要意义。 本文根据2004年每月一次采集的浮游植物样品,分析了胶州湾浮游植物的物种组成和优势种的时空分布情况。调查发现浮游植物共142种,分属于6门53属,其中硅藻门40属113种,占总物种数的79.6%;甲藻门10属24种,占总物种数的16.9%;其它为金藻门1属2种,裸藻1属1种,绿藻1属2种。浮游植物丰度周年波动范围为11.12-14602.39×104cells/m3,全年平均为1857.55×104cells/m3。全年丰度最高的藻为环纹劳德藻(Lauderia annulata),出现在2月份,而全年的丰度最高值也出现在2月份。在胶州湾中,硅藻所占比例最大,平均为97.44%,最高为99.95%,最低为82.55%。浮游植物的丰度的周年变化:有两个高峰,分别出现在2月份和10月份,是典型的温带海域双高峰的分布形式。 胶州湾浮游植物的优势种分析,采用Kikvidze等(2002)提出的确定优势种数量的计算方法,再依据各物种的优势度排序最终确定优势种。其中在多样性最低的6月和10月,优势种数目均为1种,分别为丹麦细柱藻(Leptocylindrus danicus)和中肋骨条藻(Skeletonema costatum)。而在多样性指数较低的1月、2月,优势种数目分别为2和3;而在物种多样性比较高的5月、7月、11月,由于分布相对比较分散,所以优势种数量较多。这说明这个方法可以较好地完成对胶州湾浮游植物群落分析时确定优势种的目标。优势种出现频率较多的种类为中肋骨条藻(1、3、4、5、8、10、11、12月)、洛氏角毛藻(Chaetoceros lorenzianus)(7、8、9、11、12月)、尖刺拟菱形藻(Pseudonitzschia pungens)(2、3、5、7月)、加拉星杆藻(Asteronella kariana)(1、2、3、5月)、密联角毛藻(Chaetoceros densus)(5、11、12月)、扭鞘藻(Streptothece thamesis)(7、8、9月)、夜光藻(Noctiluca scintillancs)(4、5、7月)、奇异菱形藻(Nitzschia paradoxa)(5、11、12月),对这些种的时空分布进行了分析。 对2004年胶州湾的浮游植物数据进行分层聚类分析后,发现可以将胶州湾划分为三个海区:湾南与湾外海区、湾中西部海区、湾东海区。

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温度跃层是反映海洋温度场的重要物理特性指标,对水下通讯、潜艇活动及渔业养殖、捕捞等有重要影响。本文利用中国科学院海洋研究所“中国海洋科学数据库”在中国近海及西北太平洋(110ºE-140ºE,10ºN-40ºN)的多年历史资料(1930-2002年,510143站次),基于一种改进的温跃层判定方法,分析了该海域温跃层特征量的时空分布状况。同时利用Princeton Ocean Model(POM),对中国近海,特别是东南沿海的水文结构进行了模拟,研究了海洋水文环境对逆温跃层的影响。最后根据历史海温观测资料,利用EOF分解统计技术,提出了一种适于我国近海及毗邻海域,基于现场有限层实测海温数据,快速重构海洋水温垂直结构的统计预报方法,以达到对现场温跃层的快速估计。 历史资料分析结果表明,受太阳辐射和风应力的影响,20°N以北研究海域,温跃层季节变化明显,夏季温跃层最浅、最强,冬季相反,温跃层厚度的相位明显滞后于其他变量,其在春季最薄、秋季最厚。12月份到翌年3月份,渤、黄及东海西岸,呈无跃层结构,西北太平洋部分海域从1月到3月份,也基本无跃层结构。在黄海西和东岸以及台湾海峡附近的浅滩海域,由于风力搅拌和潮混合作用,温跃层出现概率常年较低。夏季,海水层化现象在近海陆架海域得到了加强,陆架海域温跃层强度季节性变化幅度(0.31°C/m)明显大于深水区(约0.05°C/m),而前者温跃层深度和厚度的季节性变化幅度小于后者。20°N以南研究海域,温跃层季节变化不明显。逆温跃层主要出现在冬、春季节(10月-翌年5月)。受长江冲淡水和台湾暖流的影响,东南沿海区域逆温跃层持续时间最长,出现概率最大,而在山东半岛北及东沿岸、朝鲜半岛西及北岸,逆温跃层消长过程似乎和黄海暖流有关。多温跃层结构常年出现于北赤道流及对马暖流区。在黑潮入侵黄、东、南海的区域,多温跃层呈现明显不同的季节变化。在黄海中部,春季多温跃层发生概率高于夏季和秋季,在东海西部,多跃层主要出现在夏季,在南海北部,冬季和春季多温跃层发生概率大于夏季和秋季。这些变化可能主要受海表面温度变化和风力驱动的表层流的影响。 利用Princeton Ocean Model(POM),对中国东南沿海逆温跃层结构进行了模拟,模拟结果显示,长江冲淡水的季节性变化以及夏季转向与实际结果符合较好,基本再现了渤、黄、东海海域主要的环流、温盐场以及逆温跃层的分布特征和季节变化。通过数值实验发现,若无长江、黄河淡水输入,则在整个研究海域基本无逆温跃层出现,因此陆源淡水可能是河口附近逆温跃层出现的基本因素之一。长江以及暖流(黑潮和台湾暖流)流量的增加,均可在不同程度上使逆温跃层出现概率及强度、深度和厚度增加,且暖流的影响更加明显。长江对东南沿海逆温跃层的出现,特别是秋季到冬季初期,有明显的影响,使长江口海域逆温跃层位置偏向东南。暖流对于中国东南沿海的逆温跃层结构,特别是初春时期,有较大影响,使长江口海域的逆温跃层位置向东北偏移。 通过对温跃层长期变化分析得出,黄海冷水团区域,夏季温跃层强度存在3.8年左右的年际变化及18.9年左右的年代际变化,此变化可能主要表现为对当年夏季和前冬东亚地区大气气温的热力响应。东海冷涡区域,夏季温跃层强度存在3.7年的年际变化,在El Nino年为正的强度异常,其可能主要受局地气旋式大气环流变异所影响。谱分析同时表明,该海域夏季温跃层强度还存在33.2年的年代际变化,上世纪70年代中期,温跃层强度由弱转强,而此变化可能与黑潮流量的年代际变化有关。 海洋水温垂直结构的统计预报结果显示,EOF分解的前四个主分量即能够解释原空间点温度距平总方差的95%以上,以海洋表层附近观测资料求解的特征系数推断温度垂直结构分布的结果最稳定。利用东海陆架区、南海深水区和台湾周边海域三个不同区域的实测CTD样本廓线资料,对重构模型的检验结果表明,重构与实测廓线的相关程度超过95%的置信水平。三个区重构与实测温度廓线值的平均误差分别为0.69℃,0.52℃,1.18℃,平均重构廓线误差小于平均气候偏差,统计模式可以很好的估算温度廓线垂直结构。东海陆架海区温度垂直重构廓线与CTD观测廓线获得的温跃层结果对比表明,重构温跃层上界、下界深度和强度的平均绝对误差分别为1.51m、1.36m和0.17℃/m,它们的平均相对误差分别为24.7%、8.9%和22.6%,虽然温跃层深度和强度的平均相对误差较大,但其绝对误差量值较小。而在南海海区,模型重构温跃层上界、下界和强度的平均绝对预报误差分别为4.1m、27.7m和0.007℃/m,它们的平均相对误差分别为16.1%、16.8%和9.5%,重构温跃层各特征值的平均相对误差都在20%以内。虽然南海区温跃层下界深度平均绝对预报误差较大,但相对于温跃层下界深度的空间尺度变化而言(平均温跃层下界深度为168m),平均相对误差仅为16.8%。因此说模型重构的温度廓线可以达到对我国陆架海域、深水区温跃层的较好估算。 基于对历史水文温度廓线观测资料的分析及自主温跃层统计预报模型,研制了实时可利用微机简单、快捷地进行温跃层估算及查询的可视化系统,这是迄今进行大范围海域温跃层统计与实时预报研究的较系统成果。

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基于国际水协会IWA发布的国际评价基准Benchmark,建立了与污水处理厂实际特性相近的标准仿真平台。对污水处理传统A2/O工艺做了合理改进,在不影响出水水质的情况下,取消内回流。应用该平台分别对晴天、雨天与暴雨三种天气的工艺过程模拟,验证了工艺改进的合理性。仿真结果表明,与传统A2/O工艺相比,出水指标差别不大,但污泥泵能耗降低约50%。

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柔性是柔性制造系统(FMS)的一个基本优点,但这一基本优点却往往被人们所忽视,许多现在运行的FMS不是缺乏柔性,就是没能充分利用可获得的柔性来提高生产效率柔性制造系统的负荷分配和路径规划问题正是这种柔性的一个主要方面.然而,路径规划决策却往往被忽视.其中一个主要原因就是人们仍不能从传统的生产管理概念中解放出来.本文在明确概念区分的基础上,提出了一种柔性制造系统的负荷分配和路径规划的线性规划模型,其主要特点是将负荷分配和路径规划问题有机地结合起来,并通过仿真实验验证并分析了此方法对FMS性能上的影响。

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This paper is an important part of the national "863" topic :"Reservoir dynamic model, the development environment and the forecast of remaining oil". In this paper, multi-theory, method and technology are synthesized, and sufficiently use the computer method. We use unifies of qualitative and quota, unifies of macroscopic and microscopic, unifies of dynamic and quiescent description of reservoir, unifies of comprehensive research about reservoir and physical mathematical simulation, unifies of three-dimensional and four-dimensional description of reservoir to research the reservoir of channel sand in Gudao oilfield. and we do some research about the last 10 years of the more than 30 year high pressure water injection and polymer water flooding development, dynamic changes and geologic hazard of reservoir fluid field. It discloses the distribution, genesis and controlling factors. The main innovation achievement and the understanding are: we built-up the framework of the strata and structure, and found genetic type, spatial distribution and aeolotropism of the upper Guantao member. We form the macroscopic and microscopic reservoir model of dynamic evolution, disclose the character, distribution of the macroscopic and microscopic parameter,and the relationship with remaining oil. Next we built-up the model about hydrosialite, and find the styles, group of styles, formation mechanism and controlling factors of the reservoir, disclose the affection of the hydrosialite to remaining oil, pollution of the production environment of oilfield and geologic hazard. The geologic hazards are classified to 8 styles first time, and we disclose the character, distribution law, formation mechanism and controlling factors of the geologic hazard. We built-up the model of the distribution of remaining oil in different periods of Gudao oilfield, and disclose the macroscopic and microscopic formation mechanism of remaining oil in different periods, forecast the distribution of the mobile remaining oil, and find that the main cause of the dynamic evolution of all the sub-models of reservoir fluid field is the geologic process of the reservoir development hydrodynamic force. We develop the reservoir fluid field, research of environment disaster and the description about the support theory, method and technology. The use of this theory in Gudao oilfield has obtained very good economic efficiency, and deepened and develops development geology about the continental facies fault-trough basin, and theory of geologic hazard.

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In the intermediary and later stage of oil field development, remaining oil disperses fiercely, the contradiction in the layer has become the main problem and the distribution of remaining oil is transforming to the difference of single sand-body. So, the fine description research of reservoir is becoming a tendency and the methods of remaining oil research need new developments. In the research of “The Single-sand-body Architectural Element and Potentiality Analysis Research of Meandering River, GuDao Oil Field”, the research principle is analytical hierarchy process and schema prescription what are reservoir fine description methods under the condition of dense well pattern. The knowledge of regional sedimentary system and sedimentary facies is the foundation of this research. According to the 3D distribution model of the microfacies sand-body of fluvial facies, stratigraphic unit classification & coenocorrelation of 154 wells are completed in the research of meandering river sand-body in Ng3-4. In this research, the 3D distribution of microfacies sand-body in the main layers are settled. The architectural element model of Ng4 point bar is analysed using the drill core and FMI data. According to the overgrow model of point bar, the surfaces of lateral accretion is traced and the architectural element model of point bar is settled. In the research, the control of micro-facies sand-body of meandering river to the distribution of remaining oil is analysed and the potential area is proposed. All these will play an important role in the development of GuDao oil field. In this research, abundant of logging data, drill core data and production performance data are used to analyse the contributing factor of single sand-body in the Ng3-4 meandering river. Using the technology of geological modeling, all that are researched including the 3D distribution scales of meandering river point bar, the control affection of inner lateral accretion layer to the distribution of oil & gas and remaining. Then, the way of remaining oil development in the sand-body of meandering river is improved. The innovation of the research technology includes (1) the presentation of the conception and research methods of micro-facies sand-body (2) enriching the content of reservoir architectural element research and (3) to renew the research method of remaining oil analysis. The research has practiced with obvious effect.(1)It is deepened into understand the river facies reservoir construction of Gudao oil field, By Building the reservoir construction and studying the effect of diffent deposit or geological interface to fluid partition and to the distribution of the remaining oil, we improved the understanding to the distribution of the remaining oil;(2)By building the distribution mod of the remaining oil in the reservoir construction and making the remaining oil description detailed,the development direction of old oil field is more clear;(3)Expanded the application scales of the horizontal well and enhanced the application effects of the horizontal well technique , we designed and drilled 23 ports horizontal wells in all , the cumulative hydrocarbon production is 10.6*104 t;(4) According to the findings of the internal building structure in reservoir of the fluvial facies in the region of interest, and uniting the injection/production corresponding states、the producing history and the dynamic monitoring documents of the oil/water wells in the flooding units , we researched the residual oil distribution in the point bar , and found the distribution regular patterns of the remaining oil, and comprehended the distribution of the remaining oil . In base of that , we proceeded the optimizing designs of the oil well potentialities , and advanced the effect of the treatment potentials . It is proved that , it was very important that internal building structure research of the single sand body of reservoir for guiding the high efficiency potentialities of the remaining oil in the high water cut stage .

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The main research area of this thesis is the Western Depression in the Liaohe Basin. Based on the drilling core observation and mud logging data, the features of the mantle–derived fluids and their effects on oil/gas generation in the Western Depression of the Liaohe Basin,was studied with comprehensive methods of volcanic petrology, sediment petrology, fluid geochemistry, sedimentlogy, and structural geology, and use of polarized light microscope, fluorescence microscope, electron microscope, fluid and melt inclusion test, and isotopic test of nature gas etc. The observation of drill cores in study area and other studies reveal that the main passageway of the volcanic eruption in the Cenozoic was the Xibaqian-Gaosheng fault, and the volcanic rocks of each stage were distributed around it. Mantle-derived fluid which affected on oil/gas generation formed later than the volcanic spew and those fluids entered into the depression through the Taian-Dawa fault and the Central fault. The volatile fraction analysis of the melt inclusion reveals the presence of two kinds of mantle fluids; they are hydrogen-rich fluid and carbon dioxide-rich fluid. These the two kinds of fluids were mainly distributed in olivine and pyroxene respectively. The hydrothermal veins development have multiple stages, from high temperature quartz vein to low temperature calcite vein and analcime vein, in which the fluid inclusion extremity component are methane and carbon dioxide, which indicate that when mantle-derived fluids ascended and entered into the basin, most of these fluids interacted with the organic matter in the basin even though some of these entered into atmosphere. The present isotopic test of the nature gas reveals the high 3He/4He value between the region of the Taian-Dawa fault and the Central fault, which also imply the feature of origin in mantle. This phenomenon indicates that the Mesozoic basement faults and the main Cenozoic faults had connected crust and the mantle during the basin evolution, so the mantle derived fluids could enter the basin along those faults. The main source rocks of the ES3 and ES4 members of the Shahejie Formation began to expel hydrocarbon at the end period of the ES1 member of the Shahejie Formation, and reached its peak during the period of the Dongying Formation deposition. During these periods, the mantle derived-fluids entered the basin constantly along the main faults, and supplied lots of hydrogen for hydrocarbon generation. Though the volcanic rocks and the mantle-derived fluids in the Eastern Depression were more developed than in the Western Depression, the source rocks and the deep fluids were not interacted better than the Western Depression because of the affection of structural evolution. In the Eocene, the Eastern Depression did not deposit the ES4 member of the Shahejie Formation, furthermore, the mantle-fluid formed in the Fangshengpao stage escaped to the atmosphere, which confined the later stage hydrocarbon generation capability.

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The transportation and deposition of eolian materials of Chinese loess is correlated and effected by the monsoon from the mid-high latitude. Therefore study of the winter monsoon evolution can help us to understand the dynamic mechanism to climate changes in the east-Asian areas. The anisotropy of magnetic susceptibility (AMS) measurements have been carried out on the samples from the last 250ka wind -blown loess-paleosol sequences at Baicaoyuan and Luochuan. And the main conclusions are following:The magnetic foliation is almost horizontal of the two sections. AMS canthus be represented by an oblate ellipsoid with average K3 perpendicular to thebedding plane and Ki within the bedding plane. It has also shown that the ^-factor isless than 0.5 of the majority of samples. So the two sections are normal magneticfabric for sediments.The degree of anisotropy always shows a strong correlation with the foliationrather than with lineation, therefore the anisotropy is controlled by the foliation.Furthermore the foliation is nearly less than 1.02 and shows the typical wind-blownsediments anisotropy.The intensity of winter monsoon, grain size of the eolian inputs, the foliationand the degree of anisotropy are somewhat inter-related. Generally, the higherintensity of the winter monsoon will carry coarser-grained eolian material, therebyresulting in a larger foliation during deposition. Also the post-depositional compactioncontributes to the anisotropy.The AMS features between loess and paleosol are somewhat different. Wefound that the F, P values of paleosol are lower than that of its parent loess respectively. Moreover, the difference does also exists between the two sections. The anisotropy of Baicaoyuan is more significant than Luochuan section, which maybe related with the location and the intensity of the post-deposition reworks.5. We note that the declination of the long axis is NWW in Baicaoyuan section and the observed NWW direction of the winter monsoon winds based on AMS is consistent with the view that the winter monsoons prevail along the NW-SE direction. But at the Luochuan section, because of the strong affection of the post-deposition reworks, the direction of the long axis is nearly random in the foliation and hardly recognizes the paleowind direction since the last two interglacials.Correlation between the two loess-paleosol sequences implies that it is available in arid or semi-arid areas to take AMS to recognize the paleowind directions on the Loess Plateau.

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Coronary heart disease (CHD)is a common cardiovascular disease in the elderly, is also a typical psychosomatic disease. Personality factors are very important in many psychological factors impacting on the prognosis of patients with CHD. The most influential personality factors to CHD are Type A and Type D personality. The previous research has shown that although Type A personality increased the prevalence of CHD, it cannot predict the development and prognosis after diagnosis. In contradict, Type D personality can predict prognosis. There is still no clinic-based or theory-based answer to the question: Why Type A personality cannot predict the outcome while Type D personality could predict the prognosis independently. The current research conducted a systematic investigation to the above question, which included one comparison study between CHD patients and control group, and four studies on reaction experiment and answered the question: why Type A personality cannot predict whereas Type D personality could effectively predict prognosis of CHD. The findings of the current research were: Type A and Type D personality influence CHD prognosis through different psychological mechanisms: both dimensions of Type D personality have direct influence on social support, whereas neither dimensions of Type A personality related to social support, directly of indirectly. Negative affection component of Type D personality significantly related to anxiety and depression, Social repression significantly related to anxiety but not depression. Both dimensions of Type A personality significantly related to anxiety but not depression. Neither under rest or diaphragmatic breathing conditions, Type A personality had no significant influence on vestibular autonomic reaction among healthy young males. Neither Type A nor Type D personality had significant influence on vestibular autonomic reaction among old CHD patients under rest condition. Type D personality predicted lower sympathetic excitation under rest condition, and lower cardiac vagal tone under diaphragmatic breathing condition among healthy young males. When actively reacted to stimuli (math calculation) under rest condition, Type A personality increased sympathetic excitation among healthy young males. When actively reacted to stimuli (math calculation) under diaphragmatic breathing condition, Type A personality increased cardiac vagal tone among the same group of subjects. When actively reacted to stimuli under neither condition, Type D personality showed no significant influence on vestibular autonomic reaction among young males. When passively reacted to stimuli under neither condition, Type A personality showed no significant influence on vestibular autonomic reaction among young males. When passively stimulated followed rest, Type D personality increased sympathetic excitation and decreased cardiac vagal tone among young males. When passively stimulated followed diaphragmatic breathing, Typed showed no significant influence on vestibular autonomic reaction among young males. The above results indicated that Type A and Type D personalities had different psychological mechanisms to the outcome of CHD treatment: neither dimensions of Type A personality had direct or indirect effects on social support; both dimensions of Type D personality had direct and indirect effects on social support. Negative affection component of Type D personality significantly related to anxiety and depression, Social repression significantly related to anxiety but not depression. Both dimensions of Type A personality significantly related to anxiety but not depression. Social support positively related to the outcome after CHD treatment. The biological mechanisms of Type A and Type B personality to CHD prognosis differed in the following ways: Type A personality increased sympathetic excitation when actively stimulated, but had no influence when passively stimulated among young male subjects. When passively stimulated after rest, Type D personality predicted high sympathetic excitation and low cardiac vagal tone among young males, but not vestibular autonomic reaction among young males. Key words: Type A personality, Type D personality, Coronary Heart Disease (CHD), Prognosis, Psychobiological Mechanisms

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In Kermer, Driver-Linn, Wilson and Gilbert’s (2006) study on affective forecast, they found that people have a tendency to overestimate affective reactions in gains and losses, and people expect losses to have greater hedonic impact than gains of equal magnitude. Because of thus affective forecasting error, people prefer to irrationally avoid losses. Loss aversion is then seen as both a wealth-maximizing error and an affect-maximizing error. The present study examined the relationships among affective forecast, affective experience and loss aversion, and tested Kermer et al.’s (2006) conclusion that people’s loss aversion is an affective forecasting error. In experiment 1, we examined the relationship between affective forecast and loss aversion. Kermer et al.’s (2006) hypothesized that when people expect losses to have greater hedonic impact than gains, they will accept the gambling task, and when people expect gains to have greater hedonic impact than losses, they will refuse the gambling task. We found that (1) individuals with lower loss aversion had a greater tendency to accept a gambling task than those with higher loss aversion; (2) individuals with lower loss aversion expected losses and gains to have smaller affective impacts than those with higher loss aversion. Thus, people never exactly calculated their forecasting affective. In experiment 2, we examined the relationship between affective forecast and affective experience. Consistent with Kermer et al.’s (2006) finding, we found that our participants tended to overestimate affective reactions in gains as well as losses. More interestingly, Kermer et al.’s (2006) found that participants’ predictions for a loss were significantly more distant from experienced emotions than were their predictions for a win, we, however, found the opposite —participants’ predictions for a win were significantly more distant from the experienced emotions than were their predictions for a loss. These experiments further validated the relations between affection and decision making, and contributed to our understanding on the affective reactions to future events. Our study imply that it was not the exact calculation of affective forecast on decision outcomes, but rather the magnitude of affection on outcomes, that influenced people’s affective decision making. It indicated that those with lower magnitude of affection would less like to avoid losses, and thus more like to accept a gambling task.

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The recreational lives of teenagers in Ireland has been the subject of much debate in recent years. The subject has received much attention from academics, particularly in the UK and the US. In Ireland there is a dearth of research on, and a poor understanding of teenagers recreational lives. Additionally much of the research from the UK and the US to date has been focused on teenagers’ use of the street for recreation, arguing that teenagers are increasingly pushed out of public space. The research frequently emphasises teenagers’ resistance against adult hegemony. This thesis explores the recreational geographies of teenagers living in two socially and economically distinct neighbourhoods in Cork. It seeks to fill in gaps in knowledge of teenagers recreational lives in Ireland and contribute to geographical wisdom on teenagers’ geographies. Using a mixed method approach and a variety of thinking tools this research shows that teenagers living in Cork are growing up in a revanchist society. The thesis demonstrates how teenagers’ recreational practices are currently being configured in Irish society, unfolding strategies of dominance and affection which construct and regulate the recreational lives of teenagers. The effects of revanchism on teenagers’ experiences of outdoor space for recreation are also pursued. Furthermore the socio-spatial contingencies of teenagers’ recreational lives and revanchism are probed throughout the thesis, but in greater depth in the final chapters. The work also addresses an under-researched aspect of young people’s recreational - relationships with pets. Lastly, the subject of teenagers’ right to urban space is critically analysed.

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In this paper we analyze the representation of the body in blogs by women with breast cancer. Taking into account both texts and images, we study the representation of the body on the basis of the body problems proposed by Frank (1995): control, body-relatedness, other-relatedness and desire. In the blogs studied we find a desiring and dyadic body, which is understood as part of a network of affection and care. The diagnosis of cancer can generate both dissociation, when the body is experienced as a threat, and association, a wish to be connected to it. In relation to control, a clear will of predictability is observed but traces of assumption of contingency also appear.

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Background: The phosphatidylinositol 3-kinase (PI3K)-AKT signal transduction pathway is critical to cell growth and survival. In vitro functional studies indicate that the candidate schizophrenia susceptibility gene DTNBP1 influences AKT signaling to promote neuronal viability. The AKT1 gene has also been implicated in schizophrenia by association studies and decreased protein expression in the brains of schizophrenic patients. 
 Methods: The association of DTNBP1 in the Irish Study of High Density Schizophrenia Families (ISHDSF) prompted our investigation of AKT1 for association with disease in this sample. Eight single nucleotide polymorphisms spanning AKT1 were analyzed for association with schizophrenia across four definitions of affection and according to Operational Criteria Checklist of Psychotic Illness (OPCRIT) symptom scales. We examined expression of AKT1 messenger RNA from postmortem brain tissue of schizophrenic, bipolar, and control individuals. 
 Results: No single marker showed significant association, but the risk haplotype previously found over-transmitted to Caucasian schizophrenic patients was significantly under-transmitted in the ISHDSF (.01 < p < .05), across all OPCRIT symptom dimensions. Exploratory haplotype analysis confirmed association with schizophrenia toward the 5’ end of AKT1 (.008 < p < .049, uncorrected). We found significantly decreased RNA levels in prefrontal cortex of schizophrenic individuals, consistent with reduced AKT1 protein levels reported in schizophrenic brain. 
 Conclusions: The replication of association of AKT1 gene variants in a further Caucasian family sample adds support for involvement of AKT signaling in schizophrenia, perhaps encompassing a broader clinical phenotype that includes mood dysregulation. We show that AKT signaling might be compromised in schizophrenic and bipolar patients via reduced RNA expression of specific AKT isoforms.

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Large samples of multiplex pedigrees will probably be needed to detect susceptibility loci for schizophrenia by linkage analysis. Standardized ascertainment of such pedigrees from culturally and ethnically homogeneous populations may improve the probability of detection and replication of linkage. The Irish Study of High-Density Schizophrenia Families (ISHDSF) was formed from standardized ascertainment of multiplex schizophrenia families in 39 psychiatric facilities covering over 90% of the population in Ireland and Northern Ireland. We here describe a phenotypic sample and a subset thereof, the linkage sample. Individuals were included in the phenotypic sample if adequate diagnostic information, based on personal interview and/or hospital record, was available. Only individuals with available DNA were included in the linkage sample. Inclusion of a pedigree into the phenotypic sample required at least two first, second, or third degree relatives with non-affective psychosis (NAP), one whom had schizophrenia (S) or poor-outcome schizo-affective disorder (PO-SAD). Entry into the linkage sample required DNA samples on at least two individuals with NAP, of whom at least one had S or PO-SAD. Affection was defined by narrow, intermediate, and broad criteria. The phenotypic sample contained 277 pedigrees and 1,770 individuals and the linkage sample 265 pedigrees and 1,408 individuals. Using the intermediate definition of affection, the phenotypic sample contained 837 affected individuals and 526 affected sibling pairs. Parallel figures for the linkage sample were 700 and 420. Individuals with schizophrenia from these multiplex pedigrees resembled epidemiologically sampled cases with respect to age at onset, gender distribution, and most clinical symptoms, although they were more thought-disordered and had a poorer outcome. Power analyses based on the model of linkage heterogeneity indicated that the ISHDSF should be able to detect a major locus that influences susceptibility to schizophrenia in as few as 20% of families. Compared to first-degree relatives of epidemiologically sampled schizophrenic probands, first-degree relatives of schizophrenic members from the ISHDSF had a similar risk for schizotypal personality disorder, affective illness, alcoholism, and anxiety disorder. With sufficient resources, large-scale ascertainment of multiplex schizophrenia pedigrees is feasible, especially in countries with catchmented psychiatric care and stable populations. Although somewhat more severely ill, schizophrenic members of such pedigrees appear to clinically resemble typical schizophrenic patients. Our ascertainment process for multiplex schizophrenia families did not select for excess familial risk for affective illness or alcoholism. With its large sample ascertained in a standardized manner from a relatively homogeneous population, the ISHDSF provides considerable power to detect susceptibility loci for schizophrenia.

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Scholars have devoted much attention to the causes and consequences of Presbyterian emigration from Ulster to the thirteen colonies before 1776. This article moves beyond the eighteenth century to examine the continued religious links between Presbyterians in Ireland and the United States in the nineteenth century. It begins with an examination of the influence of evangelicalism on both sides of the Atlantic and how this promoted unity in denominational identity, missionary activity to convert Catholics, and revivalist religion during the first half of the century. Though Irish Presbyterians had great affection for their American co-religionists, they were not uncritical, and significant tensions did develop over slavery. The article then examines the religious character of Scotch-Irish or Ulster-Scots identity in the late nineteenth century, which was articulated in response to the alleged demoralising influence of large-scale Irish immigration during and after the Famine of the 1840s, the so-called Romanisation of Catholicism, and the threat of Home Rule in Ireland. The importance of identity politics should not obscure religious developments, and the article ends with a consideration of the origins and character of fundamentalism, perhaps one of the most important cultural connections between Protestants in Northern Ireland and the United States in the twentieth century.