Sequence context analysis in the mouse genome: Single nucleotide polymorphisms and CpG island sequences

A genome-wide view of sequence mutability in mice is still limited, although biologists usually assume the same scenario for mice as for humans. In this study, we examined the sequence context in the local environment of 482,528 mouse single nucleotide po

74-fs nanotube-mode-locked fiber laser

We report an erbium-doped, nanotube mode-locked fiber oscillator generating 74 fs pulses with 63 nm spectral width. This all-fiber-based laser is a simple, low-cost source for time-resolved optical spectroscopy, as well as for many applications where high resolution driven by short pulse durations is required. © 2012 American Institute of Physics.

Compressively Strained InGaAs/InGaAsP Quantum Well Distributed Feedback Laser at 1.74μm

The compressively strained InGaAs/InGaAsP quantum well distributed feedback laser with ridge-wave- guide is fabricated at 1.74μm. It is grown by low-pressure metal organic chemical vapor deposition（MOCVD）. A strain buffer layer is used to avoid indium segregation. The threshold current of the device uncoated with length of 300μm is 11.5mA. The maximum output power is 14mW at 100mA. A side mode suppression ratio of 35.5dB is obtained.

胶州湾浮游动物的物种组成与优势种时空分布特征

浮游动物作为海洋食物链中承上启下的一环，其群落结构和动态变化直接影响着海洋生态系统能流、物流的方向和效率。胶州湾作为一个受自然环境和人类活动双重影响的海湾，是研究人为活动对自然生态系统影响的模式港湾。因此，深入研究胶州湾浮游动物的群落特征及时空分布特点对了解该海湾生态系统的现状与历史变化趋势以及生态系统对自然条件变化和人类干扰的响应具有重要意义，也可为其他海区的研究提供参考资料。 本文根据2004年1月－12月用浅水I型和浅水II型浮游生物网在胶州湾每月一次的垂直拖网采集的浮游动物样品，分析了胶州湾浮游动物的物种组成和优势种的时空分布特征。2004年胶州湾浮游动物共74个种，分属于暖温带近岸种和暖温带近海种。浮游动物丰度周年波动范围1006－15571 ind./m3，全年平均5187 ind./m3。在胶州湾体长<1mm的浮游动物丰度和生物量最大。浮游动物的丰度和物种多样性季节变化明显，春夏大（高），秋冬小（低）。多数月份浮游动物丰度在湾内大于湾外。物种多样性在湾北和湾南较低，在湾中心和湾外较高。 胶州湾浮游动物优势种为双刺纺锤水蚤、小拟哲水蚤、太平洋纺锤水蚤、中华哲水蚤、拟长腹剑水蚤、近缘大眼剑水蚤、长尾住囊虫、强壮箭虫、短角长腹剑水蚤、八斑芮氏水母和小介穗水母等。双刺纺锤水蚤全年都是优势种，小拟哲水蚤除了4月其余月份都是优势种。其他优势种季节更替明显，冬、春季（12月、1－5月）优势种为中华哲水蚤、拟长腹剑水蚤、近缘大眼剑水蚤、长尾住囊虫等；夏季（6－8月）太平洋纺锤水蚤代替中华哲水蚤、拟长腹剑水蚤成为优势种；秋季（9－11月）优势种更替频繁，9月为短角长腹剑水蚤和太平洋纺锤水蚤，10月为太平洋纺锤水蚤、拟长腹剑水蚤和长尾住囊虫，11月为拟长腹剑水蚤、长尾住囊虫、近缘大眼剑水蚤和强壮箭虫。 双刺纺锤水蚤与中华哲水蚤在4月达到数量高峰，丰度分别为5604ind./m3和493 ind./m3。长尾住囊虫6月丰度1809 ind./m3为全年最大。小拟哲水蚤、太平洋纺锤水蚤和近缘大眼剑水蚤在7月达到数量高峰，丰度分别为1667 ind./m3、4000 ind./m3、775 ind./m3。短角长腹剑水蚤和强壮箭虫在8月丰度最大，分别为389ind./m3和192 ind./m3。八斑芮氏水母和小介穗水母分别在3、8月大量出现，丰度分别为194 ind./m3、358 ind./m3。拟长腹剑水蚤全年有7、10月两个高峰。双刺纺锤水蚤、小拟哲水蚤、太平洋纺锤水蚤、短角长腹剑水蚤、八斑芮氏水母和小介穗水母主要在湾北密集；中华哲水蚤密集区趋向于湾中心和湾外；近缘大眼剑水蚤、拟长腹剑水蚤、异体住囊虫和强壮箭虫等分布广泛，不同月份密集区不同。 从目前我们所掌握的资料来看，近30年来，胶州湾浮游动物的种类组成和优势种群没有发生大的变化。与70年代相比，2004年的物种数基本不变，但物种组成稍有不同；优势种丰度大大降低。与90年代相比，2004年物种数有所增加，其中水母类增加了15种，八斑芮氏水母成为冬季优势种；浮游动物的丰度和优势种的水平分布格局基本不变。胶州湾浮游动物的生态类型与渤海相似，但与黄海有所差异；胶州湾优势种的丰度大于渤海，且高峰期比渤海提前一个月。

Participacao das cultivares de soja da EMBRAPA na producao de sementes fiscalizadas III. Parana, 1973/74 a 1983/84.

Amostragem e coleta de dados; Resultados; Conclusoes.

74 Front Street (for solo cello)

74 Front Street is intended as a musical response to the work of American sculptor Fred Sandback (1943-2003), in particular his string sculptures which are intentionally uncomplicated, minimal and strikingly beautiful. The relationship between these string works and music is rather distinct; indeed, before formally studying sculpture Sandback made a number of string instruments. He has said that his string works evolved from a desire to rid art of excessive decoration and, while there are instances of activity in 74 Front Street, much of the piece aims to reflect the simplicity of Sandback’s work.

Los diferentes tipos de láser y sus aplicaciones en podología

Los diferentes tipos de láseres, sobre todo el láser de diodo, irrumpen en la terapéutica podológica para proporcionar una alternativa más de tratamiento en muchas patologías que son el día a día de las consultas. El buen manejo y el conocimiento de sus características son requisitos imprescindibles para no tener efectos secundarios indeseados y poder llevar a cabo tratamientos poco dolorosos, minimizando el tiempo total, y muchas veces proporcionando una solución a diversas patologías.

Interobserver agreement of the Gross Motor Function Classification System in an ambulant population of children with cerebral palsy

Gross Motor Function Classification System (GMFCS) level was reported by three independent assessors in a population of children with cerebral palsy (CP) aged between 4 and 18 years (n=184; 112 males, 72 females; mean age 10y 10mo [SD 3y 7mo]). A software algorithm also provided a computed GMFCS level from a regional CP registry. Participants had clinical diagnoses of unilateral (n=94) and bilateral (n=84) spastic CP, ataxia (n=4), dyskinesia (n=1), and hypotonia (n=1), and could walk independently with or without the use of an aid (GMFCS Levels I-IV). Research physiotherapist (n=184) and parent/guardian data (n=178) were collected in a research environment. Data from the child's community physiotherapist (n=143) were obtained by postal questionnaire. Results, using the kappa statistic with linear weighting (?1w), showed good agreement between the parent/guardian and research physiotherapist (?1w=0.75) with more moderate levels of agreement between the clinical physiotherapist and researcher (?1w=0.64) and the clinical physiotherapist and parent/guardian (?1w=0.57). Agreement was consistently better for older children (>2y). This study has shown that agreement with parent report increases with therapists'experience of the GMFCS and knowledge of the child at the time of grading. Substantial agreement between a computed GMFCS and an experienced therapist (?1w=0.74) also demonstrates the potential for extrapolation of GMFCS rating from an existing CP registry, providing the latter has sufficient data on locomotor ability.

The circle in the relationship between space and body. Photo-essay based on Isidro Blasco and the BAPNE method

This article demonstrates a visual study on the educational space in which the teaching of body percussion is carried out in universities. The methodological framework is chosen by the Visual Arts Based Educational Research, using the work of an artist as a conceptual and methodological model. The research remains notable (1) due to the theoretical reference to the BAPNE method, (2) due to the visual reference to the work of Isidro Blasco – especially with the piece “Shanghai Planet 2009” - ;(3) due to the parallelisms established between the object of study in this investigation -the spatial analysis- and the focuses of interest revealed by the art critics in relation to the work of this artist. By means of a visual speech formed with 7 photo-collages the relationship between body and educational space is visualized in the basic disposition of circular learning. The visual constructions by way of photo-collage and their aesthetic charge brings us closer to the intimacy of the educational space, in the style in which it is distributed to the students in the music classroom, the materialization of interpersonal relationships, the occupied and empty volumes.