1000 resultados para cinética de dissipação
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The project aims to develop ceramic compounds with gradients of the mechanical properties, using the molding technique with commercial starches. To understand the process of interaction between starch and ceramic powders, the proposed methodology involves viscometry tests (up to 200 °C). Viscometric assays were carried out with slurries of alumina, titania and aluminum titanate with potato starch, cassava and corn. The specimens were tested for dilatometry, thermomechanical, thermal shock, mechanical and characterization by SEM. The ceramic powders and starches were analyzed using the optical microscope to measure the size of these. It was made of th kinetics of starch gelatinization and titania with the cornstarch in theoptical microscope to observe how the grains of starch behaved in welling
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Pós-graduação em Cirurgia Veterinária - FCAV
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In this work we have developed an apparatus in order to study the capture of asteroids by planets surrounded by a gas envelope during y-by, to do this we have brought an innovation by using a hydrodynamical gas. We began such project by studying particles trajectories with a code based on the analytical gas. After being used to this model we have started a process to elaborate a code which uses the gas in a numerical way. The hydrodynamical gas is described by equations which are not solved analytically. Therefore, it was used an algorithm able to model the gas by keeping all information of the gas in cells. Thus we have made a code to read such cell`s information and then to solve all calculations. Once this process is done, the program inform us all date about the simulated trajectories
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Pós-graduação em Engenharia Mecânica - FEG
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Pós-graduação em Agronomia (Ciência do Solo) - FCAV
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Pós-graduação em Geociências e Meio Ambiente - IGCE
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A atorvastatina, amplamente utilizada no tratamento de dislipidemias, é fármaco inibidor da enzima 3-hidroxi-3-metilglutaril coenzima A redutase (HMG-CoA) redutase que atua na etapa limitante da síntese do colesterol nas células hepáticas. O transporte hepatocelular da atorvastatina é mediado principalmente pelo polipeptídeo transportador de ânions orgânicos (OATP) 1B1, o qual é altamente polimórfico geneticamente e está sujeito a interação com outros fármacos usados na clínica. O presente estudo teve como objetivo revisar a literatura científica baseada em estudos clínicos, in vitro e experimentais a fim de avaliar o impacto de polimorfismos genéticos de OATP1B1 na disposição cinética, eficácia e toxicidade da atorvastatina. Os estudos clínicos demonstram que o polimorfismo c.521T>C, presente nos alelos SLCO1B1 *5 e *15, resulta em alteração funcional da atividade transportadora, sendo que indivíduos homozigotos para o alelo raro C, apresentam maiores concentrações plasmáticas de atorvastatina e seus metabólitos ativos 2-hidroxiatorvastatina e 4- hidroxiatorvastatina. Entretanto, o aumento na concentração plasmática da atorvastatina e seus metabólitos ativos em indivíduos c.521 CC parece não ser acompanhado de redução na concentração dos mesmos no sítio alvo, tendo em vista que não foram encontradas diferenças significativas na redução da LDL-C ou colesterol total quando comparados aos indivíduos homozigotos para o alelo selvagem. O alelo SLCO1B1*15 mostrou-se significativamente associado a miopatia induzida pela atorvastatina, apesar do pequeno número de pacientes investigados. Estudos in vitro em células expressando OATP1B1 são necessários a fim de investigar o impacto do polimorfismo c.521T>C na concentração de atorvastatina nos hepatócitos. Sugere-se ainda que estudos clínicos sejam conduzidos a fim de avaliar se a redução da dose de...
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Pós-graduação em Biotecnologia - IQ
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Pós-graduação em Química - IQ
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Pós-graduação em Química - IQ
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Pós-graduação em Engenharia Civil - FEIS
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Pós-graduação em Ciência dos Materiais - FEIS
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Immediate functioning of osseointegrated implants has been widely employed in edentulous patients due to its safety and high predictability. However, viability and success of immediate-loaded implants is defined by factors such as number of implants, distribution and splinting, as well as reduction of oblique loads and excessive occlusal contacts. The indirect composite resin-modified glass enable building of a highly aesthetic prosthesis, combining satisfactory resistance and better force dissipation on occlusal loading. This article describes a resin composite, mandibular fixed prosthesis on osseointegrated implants in immediate function.
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Osseointegration involves a cascade of biological events, which can be accelerated by modifying the micro and/or nanometric topography of dental implant surfaces. Considering that different treatment types modify the titanium surface giving it a more pronounced rough topography, and physicochemical changes that appear to positively influence the osseointegration process, a literature review was made on the main types of surface treatments and their influence on the biological and cellular aspects of osseointegration, with publications dating from 1969 until the present moment. Although the precise role of the implant surface on the osseointegration of dental implants is not completely clear, the specific effects of implant surface on bone regeneration, initial kinetics, and evolution of mechanical properties have shown to be quite promising. Thus, based on dental implant surface modifications, osseointegration can be defined as a process by which rigid asymptomatic fixation of an alloplastic material can be achieved and kept in close contact with bone tissue, being resistant to early and late functional loads. This process can be modulated by an appropriate treatment of the alloplastic material surface.