Sistema de localização de um veículo autónomo terrestre

Mestrado em Engenharia Electrotécnica e de Computadores.

Studying the development of an online course on Curriculum : implications for the students' workload in light of the Bologna principles

ECER 2014 "The Past, the Present and Future of Educational Research in Europe" will take place at the University of Porto from 1 - 5 September 2014.

Mapping non-suicidal self-injury in adolescence: Development and confirmatory factor analysis of the impulse, self-harm and sucidal ideation questionnaire for adolescents (ISSIQ-A)

Non-suicidal self-injury (NSSI) is the deliberate, self-inflicted destruction of body tissue without suicidal intent and an important clinical phenomenon. Rates of NSSI appear to be disproportionately high in adolescents and young adults, and is a risk factor for suicidal ideation and behavior. The present study reports the psychometric properties of the Impulse, Self-harm and Suicide Ideation Questionnaire for Adolescents (ISSIQ-A), a measure designed to comprehensively assess the impulsivity, NSSI behaviors and suicide ideation. An additional module of this questionnaire assesses the functions of NSSI. Results of Confirmatory Factor Analysis (CFA) of the scale on 1722 youths showed items' suitability and confirmed a model of four different dimensions (Impulse, Self-harm, Risk-behavior and Suicide ideation) with good fit and validity. Further analysis showed that youth׳s engagement in self-harm may exert two different functions: to create or alleviate emotional states, and to influence social relationships. Our findings contribute to research and assessment on non-suicidal self-injury, suggesting that the ISSIQ-A is a valid and reliable measure to assess impulse, self-harm and suicidal thoughts, in adolescence.

Sistema de controlo de um veículo autónomo terrestre

A crescente necessidade imposta pela gama de aplicações existentes, torna o estudo dos veículos autónomos terrestres um objecto de grande interesse na investigação. A utilização de robots móveis autónomos originou quer um incremento de eficiência e eficácia em inúmeras aplicações como permite a intervenção humana em contextos de elevado risco ou inacessibilidade. Aplicações de monitorização e segurança constituem um foco de utilização deste tipo de sistemas quer pela automatização de procedimentos quer pelos ganhos de eficiência (desde a eficiência de soluções multi-veículo à recolha e detecção de informação). Neste contexto, esta dissertação endereça o problema de concepção, o desenvolvimento e a implementação de um veículo autónomo terrestre, com ênfase na perspectiva de controlo. Este projecto surge pois no âmbito do desenvolvimento de um novo veículo terrestre no Laboratório de Sistemas Autónomos (LSA) do Instituto Superior de Engenharia do Porto (ISEP). É efectuado um levantamento de requisitos do sistema tendo por base a caracterização de aplicações de monitorização, transporte e vigilância em cenários exteriores pouco estruturados. Um estado da arte em veículos autónomos terrestres é apresentado bem como conceitos e tecnologias relevantes para o controlo deste tipo de sistemas. O problema de controlo de locomoção é abordado tendo em particular atenção o controlo de motores DC brushless. Apresenta-se o projecto do sistema de controlo do veículo, desde o controlo de tracção e direcção, ao sistema computacional de bordo responsável pelo controlo e supervisão da missão. A solução adoptada para a implementação mecânica da estrutura do veículo consiste numa plataforma de veículo todo terreno (motociclo 4X4) disponível comercialmente. O projecto e implementação do sistema de controlo de direcção para o mesmo é apresentado quer sob o ponto de vista da solução electromecânica, quer pelo subsistema de hardware de controlo embebido e respectivo software. Tendo em vista o controlo de tracção são apresentadas duas soluções. Uma passando pelo estudo e desenvolvimento de um sistema de raiz capaz de controlar motores BLDC de elevada potência, a segunda passando pela utilização de uma solução através de um controlador externo. A gestão energética do sistema é abordada através do projecto e implementação de um sistema de controlo e distribuição de energia específico. A implementação do veículo foi alcançada nas suas vertentes mecânica, de hardware e software, envolvendo a integração dos subsistemas projectados especialmente bem como a implementação do sistema computacional de bordo. São apresentados resultados de validação do controlo de locomoção básico quer em simulação quer descritos os testes e validações efectuados no veículo real. No presente trabalho, são também tiradas algumas conclusões sobre o desenvolvimento do sistema e sua implementação bem como perspectivada a sua evolução futura no contexto de missões coordenadas de múltiplos veículos robóticos.

Development of triplet repeat primed PCR (TP-PCR) technique as a support of molecular test in Machado-Joseph disease

Dissertação de Mestrado, Ciências Biomédicas, 3 de Fevereiro de 2016, Universidade dos Açores.

Development of TNBS-induced colitis: animal model to test new pharmacological approaches

IBD is a gastro-intestinal disorder marked with chronic inflammation of intestinal epithelium, damaging mucosal tissue and manifests into several intestinal and extra-intestinal symptoms. Currently used medical therapy is able to induce and maintain the patient in remission, however no modifies or reverses the underlying pathogenic mechanism. The research of other medical approaches is crucial to the treatment of IBD and, for this, it´s important to use animal models to mimic the characteristics of disease in real life. The aim of the study is to develop an animal model of TNBS-induced colitis to test new pharmacological approaches. TNBS was instilled intracolonic single dose as described by Morris et al. It was administered 2,5% TNBS in 50% ethanol through a catheter carefully inserted into the colon. Mice were kept in a Tredelenburg position to avoid reflux. On day 4 and 7, the animals were sacrificed by cervical dislocation. The induction was confirmed based on clinical symptoms/signs, ALP determination and histopathological analysis. At day 4, TNBS group presented a decreased body weight and an alteration of intestinal motility characterized by diarrhea, severe edema of the anus and moderate morbidity, while in the two control groups weren’t identified any alteration on the clinical symptoms/signs with an increase of the body weight. TNBS group presented the highest concentrations of ALP comparing with control groups. The histopathology analysis revealed severe necrosis of the mucosa with widespread necrosis of the intestinal glands. Severe hemorrhagic and purulent exsudates were observed in the submucosa, muscular and serosa. TNBS group presented clinical symptoms/signs and histopathological features compatible with a correct induction of UC. The peak of manifestations became maximal at day 4 after induction. This study allows concluding that it’s possible to develop a TNBS induced colitis 4 days after instillation.

E-sharing: development and use of learning objects repository

— In the new learning environments, built width digital technologies, the need to promote quality of education resources, commonly known as Learning Objects, which can support formal and informal distance learning, emerge as one of the biggest challenge that educational institutions will have to face. Due to the fact that is expensive, the reuse and sharing became very important issue. This article presents a Learning Object Repository which aims to store, to disseminate and maintain accessible Learning Objects.

Development and validation of a psychometric scale for assessing PA chest image quality: a pilot study

Purpose - To develop and validate a psychometric scale for assessing image quality perception for chest X-ray images. Methods - Bandura's theory was used to guide scale development. A review of the literature was undertaken to identify items/factors which could be used to evaluate image quality using a perceptual approach. A draft scale was then created (22 items) and presented to a focus group (student and qualified radiographers). Within the focus group the draft scale was discussed and modified. A series of seven postero-anterior chest images were generated using a phantom with a range of image qualities. Image quality perception was confirmed for the seven images using signal-to-noise ratio (SNR 17.2–36.5). Participants (student and qualified radiographers and radiology trainees) were then invited to independently score each of the seven images using the draft image quality perception scale. Cronbach alpha was used to test interval reliability. Results - Fifty three participants used the scale to grade image quality perception on each of the seven images. Aggregated mean scale score increased with increasing SNR from 42.1 to 87.7 (r = 0.98, P < 0.001). For each of the 22 individual scale items there was clear differentiation of low, mid and high quality images. A Cronbach alpha coefficient of >0.7 was obtained across each of the seven images. Conclusion - This study represents the first development of a chest image quality perception scale based on Bandura's theory. There was excellent correlation between the image quality perception scores derived using the scale and the SNR. Further research will involve a more detailed item and factor analysis.

Development of electrochemical methods for determination of tramadol - analytical application to pharmaceutical dosage forms

A square-wave voltammetric (SWV) method and a flow injection analysis system with amperometric detection were developed for the determination of tramadol hydrochloride. The SWV method enables the determination of tramadol over the concentration range of 15-75 µM with a detection limit of 2.2 µM. Tramadol could be determined in concentrations between 9 and 50 µM at a sampling rate of 90 h-1, with a detection limit of 1.7 µM using the flow injection system. The electrochemical methods developed were successfully applied to the determination of tramadol in pharmaceutical dosage forms, without any pre-treatment of the samples. Recovery trials were performed to assess the accuracy of the results; the values were between 97 and 102% for both methods.