990 resultados para Superior frontal cortex
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L’Escola Superior Politècnica (ESUP) de la Universitat Pompeu Fabra, amb el suport del Consell Social va iniciar el curs 2009-2010 un Pla de Mentors (EnginyCat) adreçat als estudiants de primer curs dels Graus TIC. Aquesta és una iniciativa del Departament d’Innovació, Universitats i Empreses de la Generalitat de Catalunya i la seva missió és aproximar l’Enginyeria -el coneixement científic i tecnològic- als joves catalans. Els objectius de l’ESUP amb aquest programa són: donar suport motivacional als nouvinguts, orientar-los durant el desenvolupament de tasques acadèmic-formatives iatendre qüestions més quotidianes. Les avaluacions realitzades fins al moment reflecteixen un notable grau de satisfacció dels estudiants.
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La Unidad de Apoyo a la Calidad y la Innovación Docente de la Escuela Superior Politécnica (Universidad Pompeu Fabra) se plantea la necesidad de potenciar experiencias innovadoras que respondan a las necesidades y demandas del profesorado de la Escuela así como a las directrices enmarcadas en el EEES. Es por esto que apostamos por la creación de un espacio Web sobre la USQUID que se fundamente en la idea de favorecer el contacto entre esta Unidad y el personal a quien ofrece sus servicios –fundamentalmente, profesorado de la ESUP-. En esta Web se facilitan recursos e informaciones varias como publicaciones, anuncios de congresos, recursos relacionados con metodologías docentes experimentadas en Ingenierías, etc.en los dos idiomas oficiales de Cataluña y en inglés para responder también al multilinguismo por el que apuesta nuestra universidad así como para potenciar el desarrollo de actividades multilingües en el aula.
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En el marco del Espacio Europeo de Educación Superior 1 se inscriben innumerables acciones que están desarrollando todas las universidades europeas con la intención de llegar al 2010 con un bagaje lo suficientemente importante como para afrontar este cambio con entereza y sobretodo conservando (o incrementando) la calidad de los procesos de enseñanza- aprendizaje que hasta el momento han predominado. Dentro de este amplio proceso de transformación se encuentra el diseño de los nuevos Grados que brinda la oportunidad de replantear los planes de estudios, por tanto, la organización de las asignaturas, estructura de los contenidos, metodologías y sistemas de evaluación. Toda esta reflexión debe girar, a nuestro entender, alrededor de tres núcleos que se encuentran en estado deinterdependencia: los escenarios profesionales, los perfiles profesionales y las competencias que en ellos se inscriben.Para poder plantear los nuevos Grados en coherencia con la era del EEES debe hacerse un análisis minucioso de los perfil profesionales demandados por el mercado de trabajo que, al fin y al cabo será el destino de los profesionales que se forman en nuestras universidades, es por ello, que la tarea de definir el perfil profesional a priori del diseño de los nuevos Grados resulta una máxima para garantizar la calidad de estos. En este trabajo se presenta un ejemplo de metodología a seguir para la definición de un perfil profesional en Educación Superior, concretamente, el del Ingeniero TIC mediante el Análisis Funcional.
Resumo:
En esta comunicación se plasman los resultados obtenidos de la evaluación llevada a cabo respecto la iniciativa tomada por parte del profesorado de la Escuela Superior Politécnica de la Universidad Pompeu Fabra en cuanto a la construcción de una estructura modular sólida y eficaz para la coordinación y gestión de las asignaturas del actual y futuro plan de estudios. Esta nueva estructura de módulos resulta una iniciativa innovadora que, a su vez, potencia y enfatiza la calidad de los estudios. En concreto la comunicación presenta los resultados de la evaluación piloto de uno de los módulos. Estos resultados nos ofrecen información sobre el punto en el que estamos actualmente así como nos orientan hacia nuevasacciones a desarrollar para optimizar la estructura modularsobre la que se basan los nuevos Grados mejorando los procesosque de ella se desprenden.
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En esta comunicación se presenta el proceso completo de diseño del Curso de Introducción a la Universidad (CIU) que se imparte en la Escuela Superior Politécnica de la Universidad Pompeu Fabra para los estudios de Ingeniería de Telecomunicación e Informática.Se muestran también los resultados obtenidos por parte del colectivo discente así como las propuestas de mejora recibidas por el profesorado una vez finalizado el CIU 08-09
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Nesta reflexão, problematizamos a atividade de cuidar e de ensinar a cuidar em enfermagem e, para tanto, vamos tomar por base alguns conceitos sobre a dominação e o poder simbólicos de Pierre Bourdieu. Nosso pressuposto foi pensar a saúde como um constituinte fundamental para a produção da nossa existência sobre a Terra. A educação, neste texto, é abordada, tendo por referência as ideias de Pedro Demo, entendidas como uma construtora de sujeitos políticos e bem mais amplas que o manejo do conhecimento formal. A educação é a base primeira sobre a qual se constrói a autonomia humana e, assim, permite a constante ampliação das oportunidades para o exercício da cidadania, qualificando a nossa existência cotidiana. No contexto acadêmico, no qual se cruzam a saúde, a educação e a enfermagem, o trabalho docente competente, crítico e, sobretudo, reflexivo, pode se tornar uma práxis altamente instituinte.
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The distribution of parvalbumin (PV), calretinin (CR), and calbindin (CB) immunoreactive neurons was studied with the help of an image analysis system (Vidas/Zeiss) in the primary visual area 17 and associative area 18 (Brodmann) of Alzheimer and control brains. In neither of these areas was there a significant difference between Alzheimer and control groups in the mean number of PV, CR, or CB immunoreactive neuronal profiles, counted in a cortical column going from pia to white matter. Significant differences in the mean densities (numbers per square millimeter of cortex) of PV, CR, and CB immunoreactive neuronal profiles were not observed either between groups or areas, but only between superficial, middle, and deep layers within areas 17 and 18. The optical density of the immunoreactive neuropil was also similar in Alzheimer and controls, correlating with the numerical density of immunoreactive profiles in superficial, middle, and deep layers. The frequency distribution of neuronal areas indicated significant differences between PV, CR, and CB immunoreactive neuronal profiles in both areas 17 and 18, with more large PV than CR and CB positive profiles. There were also significantly more small and less large PV and CR immunoreactive neuronal profiles in Alzheimer than in controls. Our data show that, although the brain pathology is moderate to severe, there is no prominent decrease of PV, CR and CB positive neurons in the visual cortex of Alzheimer brains, but only selective changes in neuronal perikarya.
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Descreve-se o processo de expansão do ensino superior em Enfermagem brasileiro, destacando a diversidade e heterogeneidade desse sistema. Observa-se que o ensino nessa área teve um crescimento muito acelerado e desorganizado a partir da década de noventa. Tal crescimento evidenciou a diversidade e heterogeneidade das instituições de ensino, aspectos que repercutem também no perfil do docente, especialmente na titulação e no regime de trabalho, que variam de acordo com sua inserção institucional. Defende-se que esses efeitos irão repercutir, em última instância, na docência e, portanto, na própria formação inicial, na qualificação do profissional de enfermagem e, consequentemente, na assistência de enfermagem oferecida aos usuários dos diferentes serviços de saúde. Conclui-se pela necessidade da identificação do perfil profissional e dos distintos processos de trabalho docente, contextualizado no cenário atual de políticas públicas voltadas para o sistema de ensino superior no Brasil.
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Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the case of (1)H NMR experiments, originate undesired resonances in spectra affecting the quantification. As an alternative, thiopental can be administrated without any solubilizing agents. The aim of the study was to investigate the effect of deep thiopental anesthesia on the neurochemical profile consisting of 19 metabolites and on glucose transport kinetics in vivo in rat cortex compared with alpha-chloralose using localized (1)H NMR spectroscopy. Thiopental was devoid of effects on the neurochemical profile, except for the elevated glucose at a given plasma glucose level resulting from thiopental-induced depression of glucose consumption at isoelectrical condition. Over the entire range of plasma glucose levels, steady-state glucose concentrations were increased on average by 48% +/- 8%, implying that an effect of deep thiopental anesthesia on the transport rate relative to cerebral glucose consumption ratio was increased by 47% +/- 8% compared with light alpha-chloralose-anesthetized rats. We conclude that the thiopental-induced isoelectrical condition in rat cortex significantly affected glucose contents by depressing brain metabolism, which remained substantial at isoelectricity.
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SUMMARY The human auditory cortex, located on the supratemporal plane of the temporal lobe, is divided in a primary auditory area and several non-primary areas surrounding it. These different areas show anatomical and functional differences. Many studies have focussed on auditory areas in non-human primates, using investigation techniques such as electrophysiological recordings, tracing of neural connections, or immunohistochemical and histochemical staining. Some of these studies have suggested parallel and hierarchical organization of the cortical auditory areas as well as subcortical auditory relays. In humans, only few studies have investigated these regions immunohistochemically, but activation and lesion studies speak in favour of parallel and hierarchical organization, very similar to that of non-human primates. Calcium-binding proteins and metabolic markers were used to investigate possible correlates of hierarchical and parallel organization in man. Calcium-binding proteins, parvalbumin, calretinin and calbindin, modulate the concentration of intracellular free calcium ions and were found in distinct subpopulations of GABAergic neurons in non-human primates species. In our study, their distribution showed several differences between auditory areas: the primary auditory area was darkly stained for both parvalbumin and calbindin, and their expression rapidly decreased while moving away from the primary area. This staining pattern suggests a hierarchical organization of the areas, in which the more darkly stained areas could correspond to an earlier integration level and the areas showing light staining may correspond to higher level integration areas. Parallel organization of primary and non-primary auditory areas was suggested by the complementarity, within a given area, between parvalbumin and calbindin expression across layers. To investigate the possible differences in the energetic metabolism of the cortical auditory areas, several metabolic markers were used: cytochrome oxidase and LDH1 were used as oxidative metabolism markers and LDH5 was used as glycolytic metabolism marker. The results obtained show a difference in the expression of enzymes involved in oxidative metabolism between areas. In the primary auditory area the oxidative metabolism markers were maximally expressed in layer IV. In contrast, higher order areas showed maximal staining in supragranular layers. The expression of LDH5 varied in patches, but did not differ between the different hierarchical auditory areas. The distribution of the two LDH enzymes isoforms also provides information about cellular aspects of metabolic organization, since neurons expressed the LDH1 isoform whereas astrocytes express primarily LDH5, but some astrocytes also contained the LDH1 isoform. This cellular distribution pattern supports the hypothesis of the existence of an astrocyte-neuron lactate shuttle, previously suggested in rodent studies, and in particular of lactate transfer from astrocytes, which produce lactate from the glucose obtained from the circulation, to neurons that use lactate as energy substrate. In conclusion, the hypothesis of parallel and hierarchical organization of the auditory areas can be supported by CaBPs, cytochrome oxidase and LDH1 distribution. Moreover, the two LDHs cellular distribution pattern support the hypothesis of an astrocyte-neuron lactate shuttle in human cortex.
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Barrels are discrete cytoarchitectonic neurons cluster located in the layer IV of the somatosensory¦cortex in mice brain. Each barrel is related to a specific whisker located on the mouse snout. The¦whisker-to-barrel pathway is a part of the somatosensory system that is intensively used to explore¦sensory activation induced plasticity in the cerebral cortex.¦Different recording methods exist to explore the cortical response induced by whisker deflection in¦the cortex of anesthetized mice. In this work, we used a method called the Single-Unit Analysis by¦which we recorded the extracellular electric signals of a single barrel neuron using a microelectrode.¦After recording the signal was processed by discriminators to isolate specific neuronal shape (action¦potentials).¦The objective of this thesis was to familiarize with the barrel cortex recording during whisker¦deflection and its theoretical background and to compare two different ways of discriminating and¦sorting cortical signal, the Waveform Window Discriminator (WWD) or the Spike Shape Discriminator (SSD).¦WWD is an electric module allowing the selection of specific electric signal shape. A trigger and a¦window potential level are set manually. During measurements, every time the electric signal passes¦through the two levels a dot is generated on time line. It was the method used in previous¦extracellular recording study in the Département de Biologie Cellulaire et de Morphologie (DBCM) in¦Lausanne.¦SSD is a function provided by the signal analysis software Spike2 (Cambridge Electronic Design). The¦neuronal signal is discriminated by a complex algorithm allowing the creation of specific templates.¦Each of these templates is supposed to correspond to a cell response profile. The templates are saved¦as a number of points (62 in this study) and are set for each new cortical location. During¦measurements, every time the cortical recorded signal corresponds to a defined number of templates¦points (60% in this study) a dot is generated on time line. The advantage of the SSD is that multiple¦templates can be used during a single stimulation, allowing a simultaneous recording of multiple¦signals.¦It exists different ways to represent data after discrimination and sorting. The most commonly used¦in the Single-Unit Analysis of the barrel cortex are the representation of the time between stimulation¦and the first cell response (the latency), the representation of the Response Magnitude (RM) after¦whisker deflection corrected for spontaneous activity and the representation of the time distribution¦of neuronal spikes on time axis after whisker stimulation (Peri-Stimulus Time Histogram, PSTH).¦The results show that the RMs and the latencies in layer IV were significantly different between the¦WWD and the SSD discriminated signal. The temporal distribution of the latencies shows that the¦different values were included between 6 and 60ms with no peak value for SSD while the WWD¦data were all gathered around a peak of 11ms (corresponding to previous studies). The scattered¦distribution of the latencies recorded with the SSD did not correspond to a cell response.¦The SSD appears to be a powerful tool for signal sorting but we do not succeed to use it for the¦Single-Unit Analysis extracellular recordings. Further recordings with different SSD templates settings¦and larger sample size may help to show the utility of this tool in Single-Unit Analysis studies.
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Prioridades de Custo e Financiamento), pretende-se com: a vontade de aplicar os conhecimentos adquiridos ao longo do curso de Gestão e Planeamento da Educação, a vontade de dar um contributo que se julga necessário na identificação das prioridades do país em matéria do Ensino Superior, que contribua para uma eventual necessidade do país em termos de pessoas com maiores competências, de conhecimentos mais sólidos e abrangentes, dispostos a aceitar a mobilidade profissional, para enfrentar a sociedade do futuro de forma eficaz e criativa
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Na perspectiva da economia do conhecimento aquelas regiões que possuem uma universidade tem nela um motor do desenvolvimento. No entanto nem sempre esse motor funciona a contento. As universidades muitas vezes não conseguem compreender a dinâmica social e econômica das regiões em que estão inseridas e os seus usuários não conseguem entender as particularidades da dinâmica acadêmica. Nesse caso as universidades simplesmente estão na região. As universidades que são da região, inversamente, estão mergulhadas na dinâmica das suas sociedades, procurando contribuir para a solução dos seus problemas. Esta comunicação pretende discutir estratégias de superação desse problema tendo em conta: a contribuição das pesquisas para o desenvolvimento; a formação para o mercado de trabalho; a formação cultural. Baseia-se na experiência adquirida com os trabalhos desenvolvidos pela OCDE em especial com a experiência brasileira no estado do Paraná e acredita-se que possam ser aplicáveis em África
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BACKGROUND: For a long time now, glucose has been thought to be the main, if not the sole substrate for brain energy metabolism. Recent data nevertheless suggest that other molecules, such as monocarboxylates (lactate and pyruvate mainly) could be suitable substrates. Although monocarboxylates poorly cross the blood brain barrier (BBB), such substrates could replace glucose if produced locally.The two key enzymatiques systems required for the production of these monocarboxylates are lactate dehydrogenase (LDH; EC1.1.1.27) that catalyses the interconversion of lactate and pyruvate and the pyruvate dehydrogenase complex that irreversibly funnels pyruvate towards the mitochondrial TCA and oxydative phosphorylation. RESULTS: In this article, we show, with monoclonal antibodies applied to post-mortem human brain tissues, that the typically glycolytic isoenzyme of lactate dehydrogenase (LDH-5; also called LDHA or LDHM) is selectively present in astrocytes, and not in neurons, whereas pyruvate dehydrogenase (PDH) is mainly detected in neurons and barely in astrocytes. At the regional level, the distribution of the LDH-5 immunoreactive astrocytes is laminar and corresponds to regions of maximal 2-deoxyglucose uptake in the occipital cortex and hippocampus. In hippocampus, we observed that the distribution of the oxidative enzyme PDH was enriched in the neurons of the stratum pyramidale and stratum granulosum of CA1 through CA4, whereas the glycolytic enzyme LDH-5 was enriched in astrocytes of the stratum moleculare, the alveus and the white matter, revealing not only cellular, but also regional, selective distributions. The fact that LDH-5 immunoreactivity was high in astrocytes and occurred in regions where the highest uptake of 2-deoxyglucose was observed suggests that glucose uptake followed by lactate production may principally occur in these regions. CONCLUSION: These observations reveal a metabolic segregation, not only at the cellular but also at the regional level, that support the notion of metabolic compartmentalization between astrocytes and neurons, whereby lactate produced by astrocytes could be oxidized by neurons.
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A decisão de sair do país para realizar estudos superiores é, no contexto dos novos países africanos, cada vez mais uma decisão individual, e/ou de famílias, dado o enfraquecimento do papel regulador do Estado na situação actual de liberalização económica e consequente crescente “individualização. A partir de uma série de entrevistas a estudantes universitários angolanos, a estudar em Portugal realizadas em Lisboa e no Porto, e a profissionais que estudaram no ensino superior português, em Luanda, procurar-se-á aferir o lugar ocupado pelas “redes sociais” construídas, e mantidas, em torno de relações familiares alargadas, assim como de relações académicas ou outras, e a sua repercussão na consolidação de redes sociais mais amplas (como as que ligam estes formandos ao país de formação, e as que ligam este país ao seu país de origem) com implicações na cooperação entre os dois países e, mais concretamente, no desenvolvimento de Angola.