Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants.

One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are affecting the number of adults with diabetes. We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs-in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue. We used data from 751 studies including 4,372,000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4.3% (95% credible interval 2.4-7.0) in 1980 to 9.0% (7.2-11.1) in 2014 in men, and from 5.0% (2.9-7.9) to 7.9% (6.4-9.7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28.5% due to the rise in prevalence, 39.7% due to population growth and ageing, and 31.8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Polynesia and Micronesia. In 2014, American Samoa had the highest national prevalence of diabetes (>30% in both sexes), with age-standardised adult prevalence also higher than 25% in some other islands in Polynesia and Micronesia. If post-2000 trends continue, the probability of meeting the global target of halting the rise in the prevalence of diabetes by 2025 at the 2010 level worldwide is lower than 1% for men and is 1% for women. Only nine countries for men and 29 countries for women, mostly in western Europe, have a 50% or higher probability of meeting the global target. Since 1980, age-standardised diabetes prevalence in adults has increased, or at best remained unchanged, in every country. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes worldwide. The burden of diabetes, both in terms of prevalence and number of adults affected, has increased faster in low-income and middle-income countries than in high-income countries. Wellcome Trust.

El diario íntimo, Azorín y la nueva novela

Este artículo contempla la relación entre el diario, como género literario, y el comienzo de la nueva novela en José Martínez Ruiz, «Azorín» de una manera semejante al de otros escritores españoles de la generación del '98, como Baroja o Unamuno. Algunas características de su estilo (la intimidad, el uso de la primera persona, el presente perfecto, la sencillez, la sintaxis fragmentaria, etc.) proceden de este estilo. Este artículo, por tanto, estudia las obras de Azorín entre 1897 y 1904, con la intención de ver la presencia del tema autobiográfico en toda su producción de juventud

Jos minä tietäisin kultani mielen

Soitinnus: lauluääni, piano.

Identification and conservation of remnant genetic resources of brown trout in relict populations from Western Mediterranean streams

Brown trout is a cold-adapted freshwater species with restricted distribution to headwater streams in rivers of the South European peninsulas, where populations are highly vulnerable because Mediterranean regions are highly sensitive to the global climatic warming. Moreover, these populations are endangered due to the introgressive hybridization with cultured stocks. Individuals from six remnant populations in Western Mediterranean rivers were sequenced for the complete mitochondrial DNA control region and genotyped for 11 nuclear markers. Three different brown trout lineages were present in the studied region. Significant genetic divergence was observed among locations and a strong effect of genetic drift was suggested. An important stocking impact (close to 25%) was detected in the zone. Significant correlations between mitochondrial-based rates of hatchery introgression and water flow variation suggested a higher impact of stocked females in unstable habitats. In spite of hatchery introgression, all populations remained highly differentiated, suggesting that native genetic resources are still abundant. However, climatic predictions indicated that suitable habitats for the species in these rivers will be reduced and hence trout populations are highly endangered and vulnerable. Thus, management policies should take into account these predictions to design upstream refuge areas to protect remnant native trout in the region

Intraregional trade in South America, 1913-50. Economic linkages before institutional agreements

Dejando de lado NAFTA, la integración comercial en América Latina sigue siendo muy moderada hoy en día, representando alrededor del 20% del comercio total. Lo sorprendente es que estos valores eran más altos en 1945. Esto constituye un hecho paradoxal: la integración comercial alcanzó su récord antes de la firma de acuerdos de integración comercial. En el presente trabajo se estudia el comercio intrarregional a lo largo del período de entreguerras (1913-1950) a través del análisis de cinco casos: Argentina, Bolivia, Brasil, Chile y Peru. El análisis de la integración comercial en este período representa una novedad en la literatura, ya que los trabajos sobre América Latina, específicos de comercio intraregional, se centran en el período a partir de la década de 1960. El documento destaca dos conclusiones principales: a) con la excepción de los períodos de las guerras mundiales, el comercio intraregional ha sido muy modesto desde 1913 hasta la actualidad, b) en general, el comercio intrarregional repitió la especialización del comercio mundial: una alta concentración en productos de bajo valor añadido.

Intraregional trade in South America, 1913-50. Economic linkages before institutional agreements

Dejando de lado NAFTA, la integración comercial en América Latina sigue siendo muy moderada hoy en día, representando alrededor del 20% del comercio total. Lo sorprendente es que estos valores eran más altos en 1945. Esto constituye un hecho paradoxal: la integración comercial alcanzó su récord antes de la firma de acuerdos de integración comercial. En el presente trabajo se estudia el comercio intrarregional a lo largo del período de entreguerras (1913-1950) a través del análisis de cinco casos: Argentina, Bolivia, Brasil, Chile y Peru. El análisis de la integración comercial en este período representa una novedad en la literatura, ya que los trabajos sobre América Latina, específicos de comercio intraregional, se centran en el período a partir de la década de 1960. El documento destaca dos conclusiones principales: a) con la excepción de los períodos de las guerras mundiales, el comercio intraregional ha sido muy modesto desde 1913 hasta la actualidad, b) en general, el comercio intrarregional repitió la especialización del comercio mundial: una alta concentración en productos de bajo valor añadido.

Akateemiset urapolut. Humanistisen, yhteiskuntatieteellisen ja kasvatustieteellisen alan generalistien urapolkujen alkuvaiheet 1980- ja 1990-luvuilla

Academic Career Paths. The early career phases of generalists in the fields of humanities, social science and education in the 1980’s and 1990’s This doctoral thesis analyses how generalist graduates of master’s degree have attached to the labour market in two different time periods, and how their career paths in the first eight years following graduation have shaped up. The thesis also analyses the channels of employment through which the generalists have got employed in their early career path. By generalists I am referring to graduates of studies in academic fields which have not qualified the person in a specific profession but rather offered a more general readiness for working life. I address two groups of generalist master’s degree graduates of The University of Turku; one including graduates of the year 1985 and the other consisting of graduates of 1995. All subjects have graduated in the field of humanities, social studies or education. 71 respondents from the group of 1985 and 80 respondents from the group of 1995 answered a survey, which provided the data for the thesis. I interpret the data through the theoretical approaches of changing working life, model of normal employment, transitional labour markets, linear life path, overlapping life courses, hidden labour market and social capital. The conclusion of the thesis is that societal era is connected with employment and career paths of academic generalists. Between the two groups there were differences especially in attachment to labor market, in forms of employment (permanent full-time job vs. temporary job) and in employment channels. Compared to the situation the 1985 group had been in after their graduation, the 1995 group - after getting their degree - became more often unemployed and/or employed in duties below their level of education. Their mobility was also greater and their contracts were often temporary, whereas the graduates of 1985 had been employed in more permanent positions. I demonstrate that the career paths of generalists can be categorized in five career types: steady state, transitory, linear, unsteady and diverging career. Graduates of 1985 have been treading on more stable paths than the latter group. The channels of employment they used were roughly equally divided between formal (e.g. newspaper advertisement and employment office) and informal (e.g. personal contacts and unprompted search for work) channels, whereas amongst the 1995 group employment happened through more varied channels and mostly through informal channels. Regardless of their year of graduation the generalists’ careers had begun to evolve already while they were still in the university and had started working at the same time. The thesis displays how the model of normal employment has weakened and career paths have become unsteady as a consequence of temporary positions. What is also evident in employment when turning from the 1980’s towards the succeeding decade is the rise of significance of the hidden labour market and social capital.

Kansallisten immateriaalioikeuksien vaikutus lääkekeksintöihin Suomessa ja Ruotsissa 1980-90-luvulla

Pro gradu- tutkielman tarkoituksena oli tutkia lääkkeiden immateriaalioikeudellisia suojamuotoja Suomen ja Ruotsin osalta. Tutkimuksessa pyrittiin selvittämään lääkkeiden kansallisen patenttisuojan, lisäsuojatodistuksen ja dokumentaatiosuojan vaikutusta lääkekeksintöihin 1980–90-luvun Suomessa ja Ruotsissa. Lääkkeiden lisäsuojatodistuksella tarkoitetaan ainoastaan lääkeaineille tarkoitettua erillistä immateriaalioikeudellista lisäsuojamuotoa, joka pidentää suoja-aikaa enimmillään viidellä vuodella. Dokumentaatiosuojalla tarkoitetaan suojamuotoa, joka suojaa lääkkeiden kehittämisessä aikaan saatuja tutkimus- ja turvallisuustuloksia rinnakkaisvalmistajilta tietyn määritellyn ajan. Suomen ja Ruotsin kansallisessa lainsäädännössä oli tarkasteluajanjaksolla olennaisia eroja. Rinnakkaisongelmana tutkittiin innovaatio- ja patenttipolitiikan merkitystä lääkekeksintöjen määrään ja laatuun. Tutkimuskysymyksiä lähestyttiin virallislähteiden ja kirjallisuuden lisäksi myös teemahaastatteluin. Haastateltavat olivat alan asiantuntijoita. Tutkimus oli haasteellinen. Oli palkitsevaa saada asiaa koskeva ”hiljainen tieto” kansiin. Suomen ja Ruotsin poliittinen ja lainsäädännöllinen ilmapiiri poikkesivat toisistaan. Suomessa vallitsi protektionistinen ilmapiiri ja se näkyi politiikassa ja vaikutti lainsäädäntöön. Menetelmäpatentista ei haluttu luopua. Menetelmäpatentti on patentti, joka käsittää ainoastaan lääkeaineen valmistusmenetelmän, eikä lopputuotetta. Suomessa sallittiin lääkeaineiden tuotepatentti vasta 1995. Toisin oli Ruotsissa; siellä poliittinen ilmapiiri ja valtion sekä lääketeollisuuden näkemykset johtivat kehitystä niin, että tuotepatenttikielto poistettiin huomattavasti aiemmin kuin Suomessa. Ruotsi oli kaukonäköisempi myös muiden suojamuotojen kohdalla. Lopputuloksena tästä seurasi se, että Ruotsin lääketeollisuus on menestynyt huomattavasti paremmin kuin Suomen. Lääkekeksintöjä tehtiin enemmän. Ruotsin lääkekeksinnöistä suuri osa oli uusia molekyylejä; Suomen vastaava osuus oli selvästi pienempi. Myös Ruotsin lääkevienti oli ja on huomattavasti suurempaa kuin Suomen.