Renin-Angiotensin System Blockade Associated with Statin Improves Endothelial Function in Diabetics

Abstract Background: Studies suggest that statins have pleiotropic effects, such as reduction in blood pressure, and improvement in endothelial function and vascular stiffness. Objective: To analyze if prior statin use influences the effect of renin-angiotensin-aldosterone system inhibitors on blood pressure, endothelial function, and vascular stiffness. Methods: Patients with diabetes and hypertension with office systolic blood pressure ≥ 130 mmHg and/or diastolic blood pressure ≥ 80 mmHg had their antihypertensive medications replaced by amlodipine during 6 weeks. They were then randomized to either benazepril or losartan for 12 additional weeks while continuing on amlodipine. Blood pressure (assessed with ambulatory blood pressure monitoring), endothelial function (brachial artery flow-mediated dilation), and vascular stiffness (pulse wave velocity) were evaluated before and after the combined treatment. In this study, a post hoc analysis was performed to compare patients who were or were not on statins (SU and NSU groups, respectively). Results: The SU group presented a greater reduction in the 24-hour systolic blood pressure (from 134 to 122 mmHg, p = 0.007), and in the brachial artery flow-mediated dilation (from 6.5 to 10.9%, p = 0.003) when compared with the NSU group (from 137 to 128 mmHg, p = 0.362, and from 7.5 to 8.3%, p = 0.820). There was no statistically significant difference in pulse wave velocity (SU group: from 9.95 to 9.90 m/s, p = 0.650; NSU group: from 10.65 to 11.05 m/s, p = 0.586). Conclusion: Combined use of statins, amlodipine, and renin-angiotensin-aldosterone system inhibitors improves the antihypertensive response and endothelial function in patients with hypertension and diabetes.

Robust acoustic and semantic modeling in a telephone-based spoken dialog system

Magdeburg, Univ., Fak. für Elektrotechnik und Informationstechnik, Diss., 2009

Mortality from Circulatory System Diseases and Malformations in Children in the State of Rio de Janeiro

Abstract Background: The epidemiological profile of mortality in a population is important for the institution of measures to improve health care and reduce mortality Objective: To estimate mortality rates and the proportional mortality from cardiovascular diseases and malformations of the circulatory system in children and adolescents. Methods: This is a descriptive study of mortality from cardiovascular diseases, malformations of the circulatory system, from all causes, ill-defined causes and external causes in children and adolescents in the state of Rio de Janeiro from 1996 to 2012. Populations were obtained from the Brazilian Institute of Geography and Statistics (Instituto Brasileiro de Geografia e Estatística - IBGE) and deaths obtained from the Department of Informatics of the Unified Health System (DATASUS)/Ministry of Health. Results: There were 115,728 deaths from all causes, 69,757 in males. The annual mortality from cardiovascular diseases was 2.7/100,000 in men and 2.6/100,000 in women. The annual mortality from malformations of the circulatory system was 7.5/100,000 in men and 6.6/100,000 in women. Among the specific causes of circulatory diseases, cardiomyopathies had the highest rates of annual proportional mortality, and from malformations of the circulatory system, it occurred due to unspecified malformations of the circulatory system, at all ages and in both genders. Conclusion: Mortality from malformations of the circulatory system was most striking in the first years of life, while cardiovascular diseases were more relevant in adolescents. Low access to prenatal diagnosis or at birth probably prevented the proper treatment of malformations of the circulatory system.

Effekte einer transienten, früh postnatalen Hyperthyreose auf Verhalten und die Expression der Neurotrophine der NGF-Familie im medialen System und Broca Band der Ratte

Magdeburg, Univ., Medizin. Fak., Diss., 2004

Steuerung eines zweibeinigen Schreitroboters mit einem elastischen Sensor-Aktor-System

Magdeburg, Univ., Fak. für Elektrotechnik und Informationstechnik, Diss., 2012

Modeling the AppA/PpsR signal transduction system of rhodobacter sphaeroides

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2012

Polymerabgeleitete Keramiken im System Si-O-C(-N)-Ta

Magdeburg, Univ., Fak. für Maschinenbau, Diss., 2013

In vivo and in vitro studies on the expression and function of TFF peptides in the gastrointestinal tract and the central nervous system

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014

Cross-frequency coupling tracks motor automization and execution in the human motor system

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014

Entwicklung der Nachrüstlösung einer Brandmeldeanlage zur Anbindung und Visualisierung an das KNX System

Diese Arbeit beschreibt die Nachrüstlösung einer Brandmeldeanlage der Firma Notifier zur Anbindung und Visualisierung an das KNX System. Die Anbindung soll ermöglichen, dass Informationen der Brandmeldeanlage in Form von Feuer- und Statusmeldungen an dem KNX-Bus übertragen und visualisiert werden können. Die positiven Effekte, die daraus resultieren, sind zum einen die mögliche Verknüpfung mit anderen Teilnehmern im KNX-System und zum anderen die daraus resultierende Möglichkeit, alle vorhandenen Systeme in einem Gebäude visualisiert darstellen zu können. Nach der Recherche, zu dem von dem Systemen verwendeten Schnittstellen und Kommunikationsmöglichkeiten, wurde die Auswahl der benötigten Bauteile getroffen, um die Anbindung der beiden Systeme zu ermöglichen. Die daraus resultierende Verwendung eines Mikrocontrollers erforderte die Entwicklung und Programmierung dessen Software. Anschließend war es möglich durch hardware- und softwaretechnischen Lösungen eine Anbindung der beiden Systeme zu ermöglichen und das daraus gesteckte Ziel, eine Visualisierung durch Verwendung spezieller Software des KNX, zu erreichen.

The status (quo) of VET in Brazil : an empirical study about its function, meaning and impingements from the perspective of former dual system apprentices

Magdeburg, Univ., Fak. für Humanwiss., Diss., 2015

City Outdoor Lighting System Control. Problems and Prospects

This review describes current problems, trends and prospects of the quasi-automatic light control system. The lighting systems of million cities.

Effekt Cerebrolysins auf die Regenerations- und Degenerationsprozesse im spinalmotorischen System in vitro

Magdeburg, Univ., Med. Fak., Diss., 2015

Verification of system properties of polynomial systems using discrete-time approximations and set-based analysis

Magdeburg, Univ., Fak. für Elektrotechnik und Informationstechnik, Diss., 2015

Biotechnology for the investigation of the monocyte-macrophage-system in microgravity and space

Otto-von-Guericke-Universität Magdeburg, Fakultät für Naturwissenschaften, Univ., Dissertation, 2015