989 resultados para îlot de Langerhans
Establishing intercompany relationships: Motives and methods for successful collaborative engagement
Resumo:
This study explores the early phases of intercompany relationship building, which is a very important topic for purchasing and business development practitioners as well as for companies' upper management. There is a lot ofevidence that a proper engagement with markets increases a company's potential for achieving business success. Taking full advantage of the market possibilities requires, however, a holistic view of managing related decision-making chain. Most literature as well as the business processes of companies are lacking this holism. Typically they observe the process from the perspective of individual stages and thus lead to discontinuity and sub-optimization. This study contains a comprehensive introduction to and evaluation of literature related to various steps of the decision-making process. It is studied from a holistic perspective ofdetermining a company's vertical integration position within its demand/ supplynetwork context; translating the vertical integration objectives to feasible strategies and objectives; and operationalizing the decisions made through engagement with collaborative intercompany relationships. The empirical part of the research has been conducted in two sections. First the phenomenon of intercompany engagement is studied using two complementary case studies. Secondly a survey hasbeen conducted among the purchasing and business development managers of several electronics manufacturing companies, to analyze the processes, decision-makingcriteria and success factors of engagement for collaboration. The aim has been to identify the reasons why companies and their management act the way they do. As a combination of theoretical and empirical research an analysis has been produced of what would be an ideal way of engaging with markets. Based on the respective findings the study concludes by proposing a holistic framework for successful engagement. The evidence presented throughout the study demonstrates clear gaps, discontinuities and limitations in both current research and in practical purchasing decision-making chains. The most significant discontinuity is the identified disconnection between the supplier selection process and related criteria and the relationship success factors.
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Static process simulation has traditionally been used to model complex processes for various purposes. However, the use of static processsimulators for the preparation of holistic examinations aiming at improving profit-making capability requires a lot of work because the production of results requires the assessment of the applicability of detailed data which may be irrelevant to the objective. The relevant data for the total assessment gets buried byirrelevant data. Furthermore, the models do not include an examination of the maintenance or risk management, and economic examination is often an extra property added to them which can be performed with a spreadsheet program. A process model applicable to holistic economic examinations has been developed in this work. The model is based on the life cycle profit philosophy developed by Hagberg and Henriksson in 1996. The construction of the model has utilized life cycle assessment and life cycle costing methodologies with a view to developing, above all, a model which would be applicable to the economic examinations of complete wholes and which would require the need for information focusing on aspects essential to the objectives. Life cycle assessment and costing differ from each other in terms of the modeling principles, but the features of bothmethodologies can be used in the development of economic process modeling. Methods applicable to the modeling of complex processes can be examined from the viewpoint of life cycle methodologies, because they involve the collection and management of large corpuses of information and the production of information for the needs of decision-makers as well. The results of the study shows that on the basis of the principles of life cycle modeling, a process model can be created which may be used to produce holistic efficiency examinations on the profit-making capability of the production line, with fewer resources thanwith traditional methods. The calculations of the model are based to the maximum extent on the information system of the factory, which means that the accuracyof the results can be improved by developing information systems so that they can provide the best information for this kind of examinations.
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The major objective of this thesis is to describe and analyse how a railcarrier is engaged in an intermodal freight transportation network through its role and position. Because of the fact that the role as a conceptualisation has a lot of parallels with the position, both these phenomena are evaluated theoretically and empirically. VR Cargo (a strategical business unitof the Finnish railway company VR Ltd.) was chosen to be the focal firm surrounded by the actors of the focal net. Because of the fact that networks are sets of relationships rather than sets of actors, it is essential to describe the dimensions of the relationships created through the time thus having a past, presentand future. The roles are created during long common history shared by the actors especially when IM networks are considered. The presence of roles is embeddedin the tasks, and the future is anchored to the expectations. Furthermore, in this study role refers to network dynamics, and to incremental and radical changes in the network, in a similar way as position refers to stability and to the influences of bonded structures. The main purpose of the first part of the study was to examine how the two distinctive views that have a dominant position in modern logistics ¿ the network view (particularly IMP-based network approach) and the managerial view (represented by Supply Chain Management) differ, especially when intermodalism is under consideration. In this study intermodalism was defined as a form of interorganisational behaviour characterized by the physical movement of unitized goods with Intermodal Transport Units, using more than one mode as performed by the net of operators. In this particular stage the study relies mainly on theoretical evaluation broadened by some discussions with the practitioners. This is essential, because the continuous dialogue between theory and practice is highly emphasized. Some managerial implications are discussed on the basis of the theoretical examination. A tentative model for empirical analysis in subsequent research is suggested. The empirical investigation, which relies on the interviews among the members in the focal net, shows that the major role of the focal company in the network is the common carrier. This role has some behavioural and functional characteristics, such as an executive's disclosure expressing strategic will attached with stable and predictable managerial and organisational behaviour. Most important is the notion that the focal company is neutral for all the other operators, and willing to enhance and strengthen the collaboration with all the members in the IM network. This also means that all the accounts are aimed at being equal in terms of customer satisfaction. Besides, the adjustments intensify the adopted role. However, the focal company is also obliged tosustain its role as it still has a government-erected right to maintain solely the railway operations on domestic tracks. In addition, the roles of a dominator, principal, partner, subcontractor, and integrator were present appearing either in a dyadic relationship or in net(work) context. In order to reveal differentroles, a dualistic interpretation of the concept of role/position was employed.
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Building and sustaining competitive advantage through the creation of market imperfections is challenging in a constantly changing business environment - particularly since the sources of such advantages are increasingly knowledge-based. Facilitated by improved networks and communication, knowledge spills over to competitors more easily than before,thus creating an appropriability problem: the inability of an innovating firm to utilize its innovations commercially. Consequently, as the importance of intellectual assets increases, their protection also calls for new approaches. Companies have various means of protection at their disposal, and by taking advantage of them they can make intangibles more non-transferable and prevent, or at leastdelay, imitation of their most crucial intellectual assets. However, creating barriers against imitation has another side to it, and the transfer of knowledge in situations requiring knowledge sharing may be unintentionally obstructed. Theaim of this thesis is to increase understanding of how firms can balance knowledge protection and sharing so as to benefit most from their knowledge assets. Thus, knowledge protection is approached through an examination of the appropriability regime of a firm, i.e., the combination of available and effective means ofprotecting innovations, their profitability, and the increased rents due to R&D. A further aim is to provide a broader understanding of the formation and structure of the appropriability regime. The study consists of two parts. The first part introduces the research topic and the overall results of the study, and the second part consists of six complementary research publications covering various appropriability issues. The thesis contributes to the existing literature in several ways. Although there is a wide range of prior research on appropriability issues, a lot of it is restricted either to the study of individual appropriability mechanisms, or to comparing certain features of them. These approaches are combined, and the relevant theoretical concepts are clarified and developed. In addition, the thesis provides empirical evidence of the formation of the appropriability regime, which is consequently presented as an adaptive process. Thus, a framework is provided that better corresponds to the complex reality of the current business environment.
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Aquest treball de final de grau, té com objectiu realitzar un estat de la qüestió sobre tots els estudis i treballs realitzats, al voltant de la figura de l’artista María Gutiérrez Blanchard. D’una banda, s’ha buscat tota la bibliografia existent sobre ella, fent un recompte del total de les obres i comentant els anys de publicació. A més, s’ha analitzat totes les que s’han pogut consultar; presentant les aportacions, coincidències i dissidències que hi ha entre elles. Per una altra banda, i a partir de les informacions llegides en la bibliografia sobre l’artista, s’ha buscat la presència que té aquesta en les publicacions sobre els moviments, escoles o artistes ,amb els que va tenir algun vincle o relació (Escola de París, cubisme, Juan Gris i art i gènere), en els diccionaris i enciclopèdies d’història de l’art i en diferents documents electrònics.. Aquesta comparació de diferents treballs, m’ha donat l’oportunitat de veure les aportacions o punts positius de tots ells, per tal de conèixer a María Gutiérrez Blanchard i la seva obra; però també, m’ha permès ser conscient de les mancances o punts negatius, i així adonar-me que encara queda molta feina per a fer, per tal de conèixer a fons la seva figura. Cal destacar, el punt de vista masclista des del que s’ha analitzat l’obra d’aquesta artista, establint un forta connexió entre la seva obra i la vida personal (malformació física). .Aquest punt de vista ha estat fortament criticat, principalment durant els darrers anys, des de la bibliografia d’art i gènere, especialment per Xon de Ros, que aporta reflexions molt interessants.
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Es sabido que el siglo XIX ha constituido, para Y. Bonnefoy, un mástil fundamental: especialmente los poetas Nerval, Baudelaire, Rimbaud y Mallarmé, a quienes a dedicados numerosos artículos y libros. El objetivo de este artículo es analizar un estudio publicado por Bonnefoy, en 2001 (es decir cuando tiene ya casi ochenta años, al final de una vida plena) y que constituye una síntesis de su reflexión sobre la poesía del siglo XIX. Allí propone o bien una rectificación o bien una reafirmación de lo que, para el poeta de Tours, es lo “esencial” del siglo XIX. Seguidamente se intentará investigarlo.
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El concepto web 2.0 se utiliza para denominar a un conjunto de aplicaciones que están siempre en evolución de acuerdo a los requerimientos que los usuarios van realizando. En la red podemos encontrar muchas herramientas desarrolladas en la línea de la web 2.0: blogs, wikis, herramientas para compartir marcadores, para compartir archivos, etc. Consideramos que el sistema educativo no puede estar al margen de esta evolución tecnológica y necesita adaptarse a todos los niveles. Las universidades también se encuentran en la necesidad de adecuarse a estos nuevos tiempos, y cada vez encontramos más experiencias formativas de trabajo colaborativo en red para favorecer el aprendizaje de los estudiantes. El trabajo que presentamos es un análisis de herramientas web 2.0 y de una recopilación de buenas prácticas docentes universitarias de desarrollo de metodologías colaborativas utilizando las TIC. Además, ofrecemos recomendaciones del uso de estas herramientas en los procesos de enseñanza y aprendizaje universitario.
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Os marmeleiros sempre foram propagados comercialmente através de enraizamento de estacas. Devido à falta de vigor das mudas, principalmente nos primeiros anos após o plantio, uma série de trabalhos foram desenvolvidos no Brasil a fim de viabilizar a utilização do marmeleiro 'Japonês' (Chaenomeles sinensis Koehne) como porta-enxerto para marmelos. Frente à falta de informações, desenvolveu-se este experimento com o objetivo de verificar o desenvolvimento de diferentes cultivares de marmeleiros enxertadas sobre esse porta-enxerto. Os marmeleiros 'Japonês', 'MC', 'Adams', 'Van Deman', 'Provence', 'Cheldow', 'Smyrna', 'Rea's Mamouth', 'De Patras', 'De Vranja', 'Lajeado', 'Champion', 'Mendoza Inta-37', 'Alongado', 'Meech Prolific', 'Bereckzy', 'Alaranjado', 'Kiakami', 'Du Lot', 'Radaelli', 'CTS 207', 'D'Angers', 'Zuquerinetta', 'BA 29', 'Constantinopla', 'Marmelo Pêra', 'Apple', 'Portugal', 'Füller', 'Meliforme' e 'Pineapple' foram enxertados através de garfagem em mudas de 'Japonês', pelo método em fenda cheia. Foram utilizados garfos com três gemas, coletados de plantas-matrizes. As mudas foram mantidas em viveiro, sendo avaliadas, após 60 dias, a porcentagem de garfos brotados. O comprimento e diâmetro médio do enxerto foram avaliados aos 60; 90; 120 e 150 dias após a realização da enxertia. Concluiu-se que os marmeleiros apresentaram boa afinidade com o porta-enxerto 'Japonês'. As cultivares 'Van Deman', 'Japonês', 'Smyrna', 'De Vranja', 'Lajeado', 'Mendoza Inta-37', 'Alongado', 'Meech Prolific', 'Meliforme', 'Cheldow', 'Champion', 'Bereckzy' e 'De Patras' foram as que tiveram o maior vigor na fase de viveiro.
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INTRODUCTION: Dendritic cells (DCs) are the most important antigen-presenting cell population for activating antitumor T-cell responses; therefore, they offer a unique opportunity for specific targeting of tumors. AREAS COVERED: We will discuss the critical factors for the enhancement of DC vaccine efficacy: different DC subsets, types of in vitro DC manufacturing protocol, types of tumor antigen to be loaded and finally different adjuvants for activating them. We will cover potential combinatorial strategies with immunomodulatory therapies: depleting T-regulatory (Treg) cells, blocking VEGF and blocking inhibitory signals. Furthermore, recommendations to incorporate these criteria into DC-based tumor immunotherapy will be suggested. EXPERT OPINION: Monocyte-derived DCs are the most widely used DC subset in the clinic, whereas Langerhans cells and plasmacytoid DCs are two emerging DC subsets that are highly effective in eliciting cytotoxic T lymphocyte responses. Depending on the type of tumor antigens selected for loading DCs, it is important to optimize a protocol that will generate highly potent DCs. The future aim of DC-based immunotherapy is to combine it with one or more immunomodulatory therapies, for example, Treg cell depletion, VEGF blockage and T-cell checkpoint blockage, to elicit the most optimal antitumor immunity to induce long-term remission or even cure cancer patients.
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World Wide Webin suosiolla on ollut merkittävä vaikutus yhteiskuntaan. WWW-sivut ovat helposti saatavilla ja sisällön tekeminen WWW:hen on helppoa. WWW-ympäristölle myös kehitetään paljon sovelluksia. WWW-sovellusten kehittämiselle ominaista on valinnanvapaus ja nopeuden tavoittelu. WWW-sovellusten ohjelmoinnin mahdollistavat useat toisilleen vaihtoehtoiset tekniikat. Ne eroavat toisistaan suoritusnopeudessa, ominaisuuksien määrässä ja joustavuudessa. Ohjelmoinnissa käytetään apuna useita erilaisia menetelmiä. Apumenetelmiä ovat muun muassa työkalut ja valmiiden komponenttien hyödyntäminen. Valmiit komponentit voivat olla joko ilmaisia, avointa lähdekoodia tai maksullisia. Tämän kandidaatintyön aikana valmistui sovellus, joka piirtää tilastotiedoista kaaviokuvia ja näyttää niitä dynaamisella WWW-sivulla. Sovellus pyrittiin toteuttamaan älykkäästi apumenetelmiä sopivasti hyödyntäen. Sovelluksen kehittämisessä käytettiin apuna sekä ohjelmointityökaluja että valmiita komponentteja. Kaaviokuvien tyypin ja ulkoasun haluttiin olevan käyttäjien muokattavissa. Toisaalta sovelluksen haluttiin olevan helposti laajennettavissa. Vaatimuksiin vastattiin tekemällä kaaviokuvien piirrosta osittain tietokannalla ohjelmoitava.
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La indumentària com a objecte d’anàlisi proporciona informacions importants per a l’estudi de la Historia. Amb tot, la indumentaria proporciona també les bases per a fonamentar una línia didáctica eficient basada en la idea que els vestits son elements que mostren sobretot els efectes dels canvis i de les continuitats. La nostra recerca, iniciada al 2006, en el si del grup de recerca consolidat DIDPATRI (Didàctica del patrimoni, noves tecnologies i museografia comprensiva) de la Universitat de Barcelona explota aquesta línia basada en el potencial de la didàctica de la història social i cultural a través de l’objecte indumentari.
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A nutrição mineral da videira constitui-se em importante fator para a qualidade dos vinhos. Devido a isso, avaliou-se o efeito de porta-enxertos no teor de nutrientes em diferentes tecidos da videira 'Cabernet Sauvignon' (Vitis vinifera L.) na Serra Gaúcha. o experimento foi conduzido durante o ciclo vegetativo de 2004/2005, com os porta-enxertos Rupestris du lot, 101-14, 3309, 420A, Kober 5BB, 161-49, So4 e Paulsen 1103, enxertados em 1993 com a cv. 'Cabernet Sauvignon'. o delineamento experimental foi em blocos ao acaso, com oito tratamentos e três repetições, sendo quatro plantas/parcela. Coletaram-se folhas - separando-se os pecíolos dos limbos -, cachos - separando-se as bagas das ráquis - e ramos, os quais foram posteriormente secados em estufa e pesados. Analisaram-se os nutrientes n, P, K, Ca e Mg. os resultados mostram que houve efeito significativo do porta-enxerto nos teores de N, P, K, Ca e Mg no limbo, pecíolo, ráquis e baga da videira 'Cabernet Sauvignon' e que este efeito variou em função do nutriente e do tecido considerado. Entretanto, não houve efeito significativo do porta-enxerto no teor desses nutrientes no ramo da videira. Além disso, a ordem de grandeza do teor dos nutrientes variou em função do tecido avaliado. Assim, os teores de n e de Ca foram maiores no limbo; os de P e K, na ráquis; e o de Mg, no pecíolo.
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Tieto- ja viestintätekniikan kehittyminen on muuttanut työn luonnetta monella tavalla ja työelämän jatkuva muutos ja joustavuuteen pyrkiminen edellyttävät uusien tietojen ja taitojen hankkimista. Verkko-opetus, verkko-opiskelu ja verkko-oppiminen näyttävät tarjoavat uusia ulottuvuuksia henkilöstökoulutukseen. Tämän diplomityön tarkoituksena on tutkia voidaanko digitaalisella osaamisen kehittämisellä tukea yrityksen henkilöstökoulutusta ja henkilöstöä opiskelussa ja oppimisessa? Osaaminen on strateginen kysymys ja sen kehittämisessä pyritään yrityksissä aiempaa pitkäjänteisempään ja kokonaisvaltaisempaan toimintatapaan. Digitaalinen osaamisen kehittäminen oikein toteutettuna näyttää vahvistavan henkilöstön osaamistasoa. Tekniset apuvälineet eivät ehkä koskaan tule korvaamaan kokemusta ja työssä oppimista, silti ne näyttävät helpottavat tiedonkulkua ja ovat apuna osaamisen kehittämisessä. Kuvitelma verkko-opintojen helppoudesta, täysin ajasta ja paikasta riippumattomana, sekä itsenäisestä opiskelusta on harhaa. Verkkokoulutuksen suurena haasteena on sen soveltaminen järkevällä tavalla organisaation toimintakulttuuriin ja toimintatapoihin. Ajanoloon verkko-opiskelu saattaa muuttua osaksi työtä, mutta asenteiden muokkaamisessa on vielä paljon tekemistä. Yritysten johdon tulee näyttää tietä ja toimia esimerkkinä uusien toimintatapojen käyttöönotossa.
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Arkitus on kartongin jatkojalostusmuoto, jonka tehokkuus muodostuu monen tekijän vaikutuksesta. Tämän työn tavoitteena oli parantaa arkitustehokkuutta tutkitussa kahden folioleikkurin arkittamossa tuotannonsuunnittelun ja tuotannonohjauksen kehittämisellä. Kartonkitehtaan sisäisessä jalostusketjussa arkitus on viimeinen vaihe, mikä tekee siitä pitkälti riippuvaisen edeltävistä konevaiheista, eli kartonkikoneista ja PE-päällystyskoneista. Pelkkä arkituksen tuotannonsuunnittelun huomiointi ei siis vielä takaa hyvää lopputulosta arkitustehokkuuden kannalta. Folioarkitustoiminta on hyvin asiakassuuntautunutta. Arkkikoot määräytyvät asiakkaiden omien tarpeiden perusteella, jolloin eri arkkikokojen kokonaismäärä kasvaa huomattavan suureksi. Viime vuosien trendinä on ollut tilauseräkokojen pieneneminen. Näiden tekijöiden yhteisvaikutuksena arkituksen tuotantoprosessille on ominaista erilaisten asetusten aiheuttama katkonaisuus. Lisäksi pelkästään yhden millimetrin muutos arkin leveydessä voi usein vaikuttaa arkitustehokkuuteen hyvinkin merkittävästi. Näistä syistä arkituksen tuotannonsuunnittelun apuvälineeksi tarvitaan tarkkuuteen ja joustavuuteen kykenevää tietojärjestelmää. Tehokkaan tuotannonohjauksen tueksi tarvitaan lisäksi erilaisia leikkuri- ja kartonkilaatukohtaisia raportteja. Työn teoriaosassa käsitellään tarkemmin arkitustoiminnan ominaisuuksia ja sen tehokkuuteen vaikuttavia tekijöitä. Lisäksi käsitellään tuotannonsuunnittelun ja tuotannonohjauksen periaatteita ja toimintoja.