Estatística aplicada a dados ambientais: influência da qualidade d'água da sub-bacia do Lajeado dos Fragosos sobre a população de borrachudos.

2003

Capillary array electrophoresis for the research of asymmetric transformation reaction of L-proline to D-proline

One asymmetric transformation reaction Of L-proline (L-Pro) to D-proline was studied by a home-made capillary array electrophoresis (CAE) for the first time. The aldehyde catalysts and the organic acid solvents for the asymmetric transformation reaction were rapidly screened and the enantiomeric excess values of the asymmetric product Of L-Pro were directly obtained from the electrophoretogram of CAE.

Consórcio organizacional para promoção e apoio a atividades de P&D e transferência de tecnologia agropecuária.

Conceitos, objetivos e beneficiários do consórcio organizacional; Requisitos básicos; Formação do consórcio.

Características agronômicas de bananeira Terra, cv. D'Angola, em consórcio com açaizeiro (Euterpe precatoria Mart.).

O sistema de cultivo em consórcio de fruteiras com outras culturas, sejam anuais, semiperenes ou perenes, constitui uma boa alternativa para propriedades rurais e uma importante forma de recuperação de áreas degradadas. O objetivo deste trabalho foi avaliar o comportamento de bananeira, cv. D'Angola, em monocultivo e consorciada com açaizeiro, Euterpe precatoria, em diferentes espaçamentos, no primeiro ciclo de produção. Para tanto, foi instalado um experimento seguindo um delineamento em blocos casualizados completos com quatro repetições e seis plantas por parcela. Os tratamentos foram: T1 ? bananeira em 3 m x 3 m (1.111 plantas ha-1); T2 ? bananeira em 3 m x 2 m (1.666 plantas ha-1) com açaizeiro em 3 m x 4 m (833 plantas ha-1); T3 ? bananeira em 3 m x 3 m (1.111 plantas ha-1) com açaizeiro em 3 m x 4 m (833 plantas ha-1); T4 ? bananeira em 4 m x 2 m x 2 m (1.666 plantas ha-1) com açaizeiro em 6 m x 3 m (555 plantas ha-1) e T5 ? bananeira em 4 m x 2 m x 2 m (1.666 plantas ha-1) com açaizeiro em 4 m x 2 m x 3 m (1.111 plantas ha-1). O sistema de cultivo da bananeira terra consorciada com açaizeiro em diferentes espaçamentos pode ser considerado como boa alternativa no primeiro ciclo, pois não apresentou interferência nas características de desenvolvimento, de produção e qualidade física dos frutos. Os plantios mais adensados propiciaram maiores produtividades no primeiro ciclo da cultura.

Espaçamentos para bananeira comprida, cv. D'Angola, em consórcio com açaizeiro-solteiro (Euterpe precatoria).

O espaçamento é um dos principais fatores para aumento de produtividade, sem ocasionar perdas de qualidade de frutos da bananeira, e varia em função das condições de clima e solo da região. Quando a bananeira é cultivada em maiores densidades, aproveita-se melhor a área disponível e o uso da mão de obra é otimizado. Na banana-comprida o espaçamento ideal evita a competição por água, luz e nutrientes, sem comprometer os rendimentos potenciais da cultura.

Sopravvenienze e rimedi nel contratto d'appalto: la previsione del cosiddetto obbligo di rinegoziazione

In this thesis I study how the legal system reacts (or ought to react) to unforeseen circumstances that interfere with the functioning of long term contractual relationships. More precisely, I investigate whether mandatory renegotiation would be an appropriate tool to guarantee the flexibility that long-term relationships require. Furthermore, after having analyzed the instruments that our legal system offers to preserve long-term contractual relationships, I explore the solutions adopted by other legal systems. This comparative analysis helps to formulate normative proposals to improve the functioning of our legal system.

Influence of different neuroprotective drugs on dopamine neurotoxicity induced by 3,4-methylenedioxymethamphetamine and MPTP in mice

Introduction: Parkinson‟s disease (PD) is characterized by a chronic progressive loss of nigrostriatal dopaminergic neurons that is associated with chronic neuroinflammation. Current treatments for PD can significantly improve symptoms but do not cure the disease or slow its progression. An approach used in existing therapies is based on the inhibition of monoamine oxidase (MAO), enzyme involved in the metabolic degradation of dopamine. Although, preclinical studies showed that MAO-B inhibitors have neuroprotective activity in cellular and animal models of PD, clinical trials did not completely confirm this result. Therefore a large number of new molecules, with more potent MAO-B inhibitory activity and a possible neuroprotective effect, have been proposed to replace the pre-existing MAO-B inhibitors. The profile of the recent MAO inhibitor, SZV558, appears to be particularly interesting because of its pharmacodynamic, favorable for disease-modifying properties and its irreversible MAO-B enzyme bind. The enhancement of adult neurogenesis could be of great clinical interest in the management of neurodegenerative disorders. In line with this, the metformin, a well-known antidiabetic drug, has recently been proposed to promote neurogenesis and to have a neuroprotective effect on the neurodegenerative processes induced by the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in a mice PD model. Although, PD has multiple origins, one hypothesis is that amphetamine-related drugs may be part of the wide array of factors leading to the dopaminergic neuron degeneration that causes the disease. These hypothesis are supported by different results that showed a persistent, long-term dopaminergic toxicity induced by 3,4-methylenedioxymethamphetamine (MDMA) in mice. Moreover, the MDMA, altering the dopaminergic transmission, may affect neurogenesis and synaptogenesis. On these basis, considering that the young brain is particularly sensitive to drug-induced neurotoxicity, the consumption of MDMA during the adolescence might increase the vulnerability of dopaminergic neurons. However, the use of amphetamine-related drugs by adolescent and young people is often combined with caffeinated energy drinks in order to amplify their stimulant actions. Although caffeine use is safe, the combined treatment of caffeine and MDMA increases not only the DA release but also the microglia and astroglia activation. Aims: During my Ph.D. I studied the influence of neuroprotective drugs, such as MAO inhibitors and metformin, or substances, such as caffeine, on the neurodegenerative effects of two dopaminergic toxins, MDMA and MPTP, in mice. 1. In the first phase of my study, I evaluated the neuroprotective activity of the new MAO-B inhibitor SZV558, compared with well-known rasagiline, in a chronic mouse model of MPTP plus probenecid (MPTPp), which induces a progressive loss of nigrostriatal dopaminergic neurons. 2. Previous results showed that when MDMA is associated with caffeine, a more pronounced degeneration in adolescent compared with adult mice was observed. To better clarify the molecular mechanism at the base of the different neurotoxic effect of this drug association at different ages, I evaluated the neuronal nitric oxide synthase (nNOS) expression, which plays a critical role in the integration of dopaminergic and glutamatergic transmissions, in the CPu of adolescent or adult mice treated with MDMA, alone or in combination with caffeine. 3. Finally, I investigated the neuroprotective effect of metformin against dopaminergic neurotoxicity induced by MDMA in the CPu and SNc of adult mice. Conclusions: These results demonstrated that the dopaminergic neurodegenerative process may be induced or conditioned by environment stressors or substances which influence, through different ways, the development of neurodegenerative mechanisms. In the present study I evaluated the effects of 3 substances, known as potentially neuroprotective, in combination with two different neurotoxins that affect the nigrostriatal dopaminergic system. The SZV558 MAO-B inhibitor and the metformin protected the nigrostriatal pathway, usually affected in PD, by MPTP- and MDMA- induced neurotoxicity, respectively. On the other hand, caffeine, administrated with MDMA, showed a neurotoxic potential depending on the age of consumers, confirming the vulnerability of adolescent brain to consumption of drug and substances that affected the dopaminergic system. In conclusion, the study of neurodegenerative processes may be relevant to understand the human pharmacology, the origin and development of neurodegenerative disease and to predict the neurotoxic effect of drug abuse.

Albucasis, Traitier de Cyrurgie: Edition de la traduction en ancien fran?ais de la Chirurgie d'Abu'l Qasim Halaf Ibn ?Abbas al-Zahrawi du manuscrit BNF, fran?ais 1318.

Trotter, David, Albucasis, Traitier de Cyrurgie: Edition de la traduction en ancien fran?ais de la Chirurgie d'Abu'l Qasim Halaf Ibn ?Abbas al-Zahrawi du manuscrit BNF, fran?ais 1318 (Niemeyer, 2005)

Le Cheval de Mazeppa, un cas d'intertextualit? franco-anglaise

Sibona, Bruno, Le Cheval de Mazeppa, un cas d'intertextualit? franco-anglaise (L'Harmattan, 2006)

Les manuscrits latins de la Chirurgia d'Albucasis et la lexicographie du latin m?di?val

Trotter, David, 'Les manuscrits latins de la Chirurgia d'Albucasis et la lexicographie du latin m?di?val', Archivum Latinitatis Medii Aevi (Bulletin Du Cange) (2001) 59(1) pp.181-202 RAE2008

Anglo-Norman Dictionary: revised edition, A-C : D-E

Rothwell, W., S. Gregory and David Trotter, Anglo-Norman Dictionary: revised edition, A-C; D-E (MHRA, 2005) RAE2008