14-3-3 proteins in apoptosis

The once obscure members of the 14-3-3 protein family play significant roles in the determination of cell fate. By inhibiting the pro-apoptotic BAD (Bcl-2-antagonist of cell death) and the transcription factor FKHRL-1, 14-3-3 displays important anti-apoptotic characteristics. To date, five points of interaction of 14-3-3 with the apoptotic machinery have been identified. How these interactions are regulated still remains a mystery.

Immunoexpression of CD95 in chronic gastritis and gastric mucosa-associated lymphomas

CD95 (Fas/APO-1)-mediated apoptosis plays an important role in immunological regulation and is related to the pathogenesis of autoimmune diseases. Immunoexpression of CD95 has been reported to frequently occur in low grade non-Hodgkin lymphomas, especially of post-germinal center histogenesis, among which those originating in mucosa-associated lymphoid tissue (MALT lymphomas). However, there is no report comparing in situ immunoexpression of this marker in lymphomas and the hyperplastic lymphoid reaction (chronic gastritis) related to Helicobacter pylori infection. The purpose of the present research was to compare the intensity of lymphoid CD95 immunoexpression in 15 cases of H. pylori-related chronic gastritis and 15 gastric MALT lymphomas. CD95 (anti-CD95) was detected by an immunoperoxidase technique in paraffin sections using the catalyzed amplification system. Graduation of reaction intensity (percentage of CD95-positive cells) was semiquantitative, from 1+ to 4+. Nine cases of chronic gastritis were 4+, five 2+ and one 1+. Three lymphomas were 4+, three 3+, four 2+, four 1+, and one was negative. Although 14 of 15 lymphomas were positive for CD95, the intensity of the reaction was significantly weaker compared to that obtained with gastric tissue for patients with gastritis (P = 0.03). The difference in CD95 immunoexpression does not seem to be useful as an isolated criterion in the differential diagnosis between chronic gastritis and MALT lymphomas since there was overlapping of immunostaining patterns. However, it suggests the possibility of a pathogenetic role of this apoptosis-regulating protein in MALT lymphomas.

Meditationes sancti evangelii 14

Invokaatio: Deo duce.

Meditationes sanctarum epistolarum 14

Arkit: A-B4.

Historia Bibliothecae Regiae Academiae Aboensis 14

Invokaatio: D.A.G.

De bibliothecariis Academiae Aboënsis 14

Arkit: 1 arkintunnukseton lehti, S4.

Artificium Delilae mysticum 14

Invokaatio: In nomine Jesu!

De cognitione Dei et Christi usum rationis supponente, locos Joh. XVII:3. & I Cor. II:14. illustratura

Invokaatio: D.D.

Lytrodoxia Jesu 14

Variantti B.

Disquisitiones practicae 14

Nimekettä edeltää hepreankielinen invokaatio.

Chronicon episcoporum Finlandensium 14

Dedikaatio: Ulrica Sevon född Lindeberg [ruots. pr.].

De ammud anan we-esh seu columna nubis et ignis, Israëlitarum duce in deserto, Exod. 14. v. 19. 20

Invokaatio: Be-shem shamajim.

Insecta Fennica enumerans 1:14

Painovuosi nimekkeestä.

In titulos libri 7-14 Corporis juris civilis Romani

Variantti B.

In titulos libri 7-14 Corporis juris civilis Romani

Variantti A.