978 resultados para Vitamin-K-antagonisten


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A qualidade do fruto do abacaxizeiro é influenciada pelos macronutrientes, principalmente N e K. Este trabalho avaliou a influência de doses de N e K2O sobre as características de qualidade físico-químicas e sobre os defeitos externos e internos dos frutos de abacaxizeiro ‘BRS Imperial’. Aplicaram-se quatro doses de N (0; 160; 320; 550 kg ha-1) e quatro de K2O (0; 240;480 e 600 kg ha-1), em delineamento experimental em blocos ao acaso, com cinco repetições, em um fatorial completo 42. As doses de N e K2O influenciaram todas as variáveisfísico-químicasestudadas, exceto a firmeza dos frutos, que apresentaram média de 10,7 kgf. As doses de N reduziram a acidez titulável (AT) e os sólidos solúveis (SS) e aumentaram o pH e o ratio dos frutos, apresentando, na dose de 550 kg ha-1 de N, os valores médios de 0,31%, 17,9 oBrix, 4,02 e 57,7, respectivamente. As doses de K2O aumentaram AT e os SS, e reduziram o ratio dos frutos, apresentando, na dose de 600 kg ha-1 de K2O, os valores médios de 0,41%, 19,4 oBrix e 47,9, respectivamente. O pH respondeu de forma quadrática, com o valor mínimo de 3,95 na dose de 273 kg ha-1 de K2O. As correlações significativas de Pearson indicaram que plantas com maiores teores foliares de N na época da indução floral produziram frutos com menor AT e SS, enquanto aquelas com maiores teores foliares de K apresentaram maior AT e SS nos frutos. Com aplicação de 550 kg ha de-1 N, os frutos apresentaram translucidez entre 50 e 75% sem adubação potássica e de menos de 25% de translucidez na dose de 400 kg ha-1 de K2O.

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RESUMO O abacaxizeiro ‘BRS Imperial’ é cultivar resistente à fusariose, com folhas sem espinhos, e que carece de informações técnicas específicas para o seu manejo. Este trabalho teve como objetivo avaliar o efeito de doses de N e K2O no desenvolvimento vegetativo, na floração e nos atributos de desenvolvimento da folha ‘D’ do ‘BRS Imperial’, buscando estabelecer parâmetros da planta para a indução artificial do florescimento. Em delineamento em blocos ao acaso e cinco repetições, testaram-se quatro doses de N (0; 160; 320; 550 kg ha-1) e quatro doses de K2O (0; 240; 480 e 600 kg ha-1), em esquema fatorial completo 4 x 4. A adubação potássica influenciou de forma positiva na massa fresca e no comprimento da planta, bem como no número de mudas por planta após a colheita dos frutos, enquanto a aplicação de N influenciou na emissão de folhas e na massa fresca de mudas. A adubação nitrogenada diminuiu o percentual de florescimento induzido artificialmente, enquanto a potássica aumentou esse parâmetro. A massa máxima estimada da folha ‘D’ foi de 56 g na dose de 364 kg ha-1 de N e na maior dose de K2O (600 kg ha-1). A massa da folha ‘D’ apresentou a melhor correlação com a massa do fruto, sendo estimada a massa mínima de 44 g para obtenção de frutos de 900 g, massa mínima exigida pelo mercado para comercialização.

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RESUMO O abacaxizeiro ‘BRS Imperial’ é uma cultivar resistente à fusariose, apresenta frutos saborosos, mas ainda é pouco conhecido dos fruticultores. Este trabalho teve como objetivo avaliar o efeito de diferentes doses de N e K nas características químicas do solo, nos teores foliares de nutrientes e nas variáveis de produção de um cultivo de ‘BRS Imperial’. O experimento foi instalado no espaçamento 0,90 x 0,40 x 0,40 m, com quatro doses de N (0; 160; 320 e 550 kg ha-1) e quatro de K2O (0; 240; 480 e 600 kg ha-1), em blocos ao acaso, com cinco repetições, em fatorial completo 4 x 4. Foram realizadas análises químicas das folhas e do solo, e mensuradas as variáveis de produção. O cultivo do abacaxizeiro sem N e K ou apenas com adubação nitrogenada resultaram em menores índices de pH, K+, Ca e 2+Mg2+ no solo, no final do ciclo de cultivo, em relação aos teores iniciais. Mesmo na maior dose de K aplicada, o teor deste nutriente no solo ficou baixo. Os teores foliares de N e K estimados, nas doses máximas testadas, foram 12,8 e 31,8 g kg-1, respectivamente. As variáveis de colheita mostraram significância para as doses de N em todas as avaliações, enquanto as doses de K2O influenciaram apenas na relação comprimento/diâmetro do fruto. Pela análise de regressão, as doses de N mostraram efeito quadrático na massa dos frutos com coroa, a qual se apresentou com 1.086 g na dose máxima física de 365 kg ha-1 e produtividade estimada de 42 t ha-1.

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Tiedon luomiseen ja hyödyntämiseen perustuvassa liiketoiminnassa yrityksen kyky luoda tietoa ja käyttää hallussaan olevaa tietoa muodostaa perustan kilpailukyvylle ja kilpailueduille. Tutkielmassa rakennetaan konstruktiivista tutkimusotetta käyttäen innovaatioiden synnyn johtamiseen soveltuva toimintamalli Teecen tietoprosesseihin, Nonakan tiedonkonversioprosesseihin ja Ståhlen tietoympäristöihin perustuen. Tietoa syntyy esimerkiksi innovaatioissa. Innovaatioiden voidaan katsoa syntyvän vastakkaisten voimien jatkuvassa vuorovaikutuksessa. Tämä innovaatioita tuottava mekanismi rakentuu tietoa lisäävistä ja tietoa järjestävistä prosesseista, joita voidaan kuvata sekä seci-prosessin että kolmitasoisen tietoympäristön avulla. Sisäinen kilpailu ja yhteistyö vaikuttavat tämän mekanismin toimintaan. Yhteistyö lisää tiedon jakamista ja mahdollistaa radikaalien innovaatioiden ja tuoteinnovaatioiden synnyn. Kilpailun lisääminen vähentää keskinäistä tiedon jakamista ja siirtää innovaatioita fokuksen mukaisiin prosessi-innovaatioihin. Kilpailun ja yhteistyön määrään ja keskinäiseen suhteeseen voidaan vaikuttaa kolmitasoisesta tietoympäristömallista johdettujen kolmen erillisen, joskin toisiinsa vaikuttavan, johtamistavoitteen avulla. Mahdollistava johtaminen rakentaa luottamuksen ja yrityksen toiminnan perustaa. Valtuuttava johtaminen houkuttaa yhteistyöhön mahdollistaen tiedon lisääntymisen. Ohjaavan johtamisen prosessit vievät yritystä strategian mukaiseen suuntaan hyödyntäen sisäistä kilpailua.

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Tutkimuksen tavoite oli selvittää sitä ristiriitaa, joka vallitsee kuluttajien ilmoittaman ja todellisen luomutuotteiden ostokäyttäytymisen välillä. Tätä ristiriitaa tutkittiin selvittämällä ostoprosessin eri osia ja niihin vaikuttavia tekijöitä, kuten sitoutumisastetta, arvoja ja asenteita. Tutkimusmenetelmänä käytettiin kyselytutkimusta, jonka aineisto kerättiin kontrolloidulla kyselyllä yhden viikon aikana Lappeenrannan K-citymarketissa.Tulokset osoittivat, että kuluttajat ostavat luomutuotteita, jos ne koetaan omaa itseä hyödyttäviksi, eli tärkeimmät ostamisen syyt olivat hyvä maku, lisäaineettomuus ja terveellisyys. Sen sijaan kollektiivinen etu, kuten ympäristöystävällisyys, ei ollut kovinkaan tärkeä luomunostoperuste. Näyttäisi myös siltä, että ne, jotka arvo- ja ajatusmaailmansa puolesta olisivat potentiaalisia luomutuotteiden kuluttajia, ostavat muita tuotteita tottumuksen perusteella.

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One of the most important reference groups for Mycenaean pottery is the Mycenae/Berbati (MB). In several studies, a second group has been identified (MBKR). The chemical compositions were similar to MB, but with important differences in the Na, K and Rb contents. The present study suggests that these differences are due to selective alteration and contamination processes that are indirectly determined by the original firing temperature. Therefore, groups MB and MBKR should be considered as a single reference group.

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BACKGROUND: Low vitamin D status has been associated with an increased risk of developing type 2 diabetes and insulin resistance (IR), although this has been recently questioned. OBJECTIVE: We examined the association between serum vitamin D metabolites and incident IR. METHODS: This was a prospective, population-based study derived from the CoLaus (Cohorte Lausannoise) study including 3856 participants (aged 51.2 ± 10.4 y; 2217 women) free from diabetes or IR at baseline. IR was defined as a homeostasis model assessment (HOMA) index >2.6. Fasting plasma insulin and glucose were measured at baseline and at follow-up to calculate the HOMA index. The association of vitamin D metabolites with incident IR was analyzed by logistic regression, and the results were expressed for each independent variable as ORs and 95% CIs. RESULTS: During the 5.5-y follow-up, 649 (16.9%) incident cases of IR were identified. Participants who developed IR had lower baseline serum concentrations of 25-hydroxyvitamin D3 [25(OH)D3 (25-hydroxycholecalciferol); 45.9 ± 22.8 vs. 49.9 ± 22.6 nmol/L; P < 0.001], total 25(OH)D3 (25(OH)D3 + epi-25-hydroxyvitamin D3 [3-epi-25(OH)D3]; 49.1 ± 24.3 vs. 53.3 ± 24.1 nmol/L; P < 0.001), and 3-epi-25(OH)D3 (4.2 ± 2.9 vs. 4.3 ± 2.5 nmol/L; P = 0.01) but a higher 3-epi- to total 25(OH)D3 ratio (0.09 ± 0.05 vs. 0.08 ± 0.04; P = 0.007). Multivariable analysis adjusting for month of sampling, age, and sex showed an inverse association between 25(OH)D3 and the likelihood of developing IR [ORs (95% CIs): 0.86 (0.68, 1.09), 0.60 (0.46, 0.78), and 0.57 (0.43, 0.75) for the second, third, and fourth quartiles compared with the first 25(OH)D3 quartile; P-trend < 0.001]. Similar associations were found between total 25(OH)D3 and incident IR. There was no significant association between 3-epi-25(OH)D3 and IR, yet a positive association was observed between the 3-epi- to total 25(OH)D3 ratio and incident IR. Further adjustment for body mass index, sedentary status, and smoking attenuated the association between 25(OH)D3, total 25(OH)D3, and the 3-epi- to total 25(OH)D3 ratio and the likelihood of developing IR. CONCLUSION: In the CoLaus study in healthy adults, the risk of incident IR is not associated with serum concentrations of 25(OH)D3 and total 25(OH)D3.

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Background. We elaborated a model that predicts the centiles of the 25(OH)D distribution taking into account seasonal variation. Methods. Data from two Swiss population-based studies were used to generate (CoLaus) and validate (Bus Santé) the model. Serum 25(OH)D was measured by ultra high pressure LC-MS/MS and immunoassay. Linear regression models on square-root transformed 25(OH)D values were used to predict centiles of the 25(OH)D distribution. Distribution functions of the observations from the replication set predicted with the model were inspected to assess replication. Results. Overall, 4,912 and 2,537 Caucasians were included in original and replication sets, respectively. Mean (SD) 25(OH)D, age, BMI, and % of men were 47.5 (22.1) nmol/L, 49.8 (8.5) years, 25.6 (4.1) kg/m(2), and 49.3% in the original study. The best model included gender, BMI, and sin-cos functions of measurement day. Sex- and BMI-specific 25(OH)D centile curves as a function of measurement date were generated. The model estimates any centile of the 25(OH)D distribution for given values of sex, BMI, and date and the quantile corresponding to a 25(OH)D measurement. Conclusions. We generated and validated centile curves of 25(OH)D in the general adult Caucasian population. These curves can help rank vitamin D centile independently of when 25(OH)D is measured.

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Vitamin D is the main hormone of bone metabolism. However, the ubiquitary nature of vitamin D receptor (VDR) suggests potential for widespread effects, which has led to new research exploring the effects of vitamin D on a variety of tissues, especially in the skeletal muscle. In vitro studies have shown that the active form of vitamin D, calcitriol, acts in myocytes through genomic effects involving VDR activation in the cell nucleus to drive cellular differentiation and proliferation. A putative transmembrane receptor may be responsible for nongenomic effects leading to rapid influx of calcium within muscle cells. Hypovitaminosis D is consistently associated with decrease in muscle function and performance and increase in disability. On the contrary, vitamin D supplementation has been shown to improve muscle strength and gait in different settings, especially in elderly patients. Despite some controversies in the interpretation of meta-analysis, a reduced risk of falls has been attributed to vitamin D supplementation due to direct effects on muscle cells. Finally, a low vitamin D status is consistently associated with the frail phenotype. This is why many authorities recommend vitamin D supplementation in the frail patient.

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Contexte de recherche Mon projet de thèse en médecine concerne l'exploration des facteurs associés à l'excrétion urinaire de calcium durant 24h dans une étude populationnelle suisse. Les données qui ont été utilisées sont issues d'une étude populationnelle connue sous le nom de « Swiss survey on Salt intake », qui a été effectuée entre janvier 2010 et mars 2012 et avait pour but principal d'investiguer la consommation de sel de la population suisse. L'étude a regroupé plusieurs centres d'investigations dans toute la Suisse (11 centres dans 9 cantons), dans trois langues nationales (français, allemand et italien) et concerne des participants âgés de plus de 15 ans. Cette étude avait l'avantage de collecter des données anthropométriques, sanguines, urinaires, de lister les traitements et de poser des questions sur le style de vie (alcool, activité physique, etc.). A notre connaissance, peu d'articles populationnels explorent les facteurs associés à l'excrétion urinaire de calcium durant 24h et notamment l'association de celle-ci avec le calcium corrigé sanguin et la 250H-vitamine D2*3 sanguin chez les hommes et les femmes. Méthodes Après exclusions des données manquantes, 1293 participants sur 1550 ont été retenus pour l'analyse statistique. Celle-ci a été effectuée grâce au logiciel Stata 12. Nous avons utilisé la régression linéaire multiple dont la variable dépendante était l'excrétion urinaire de calcium durant 24h en stratifiant les analyses par sexe (en raison des interactions statistiques significatives entre calcémie et sexe, et entre vitamine D et sexe). Les variables indépendantes comprenaient des variables en lien avec l'excrétion urinaire de calcium (vingt-quatre covariables au total) dont la 250H-vitamine D2+3 (avec la variabilité saisonnière) et la calcémie (calcium sérique corrigé par les protéines). Résultats D'importantes différences entre hommes et femmes ont été observées : une association positive entre l'excrétion urinaire de calcium durant 24h et la calcémie corrigée a été trouvée chez les femmes mais pas chez les hommes. En parallèle, nous relevons une association positive entre l'excrétion urinaire de calcium durant 24h et la 250H-vitamine D2+3 chez les hommes mais pas chez les femmes (liée essentiellement à la présence 250H-vitamine D3 en quantité bien plus importante que la 250H-vitamine D2). Nous soulevons deux hypothèses possibles pour expliquer ces importances différences hommes-femmes. La première hypothèse est l'influence des hormones sexuelles. La seconde hypothèse est la contribution des facteurs diététiques. De nouvelles analyses et de nouvelles études populationnelles sont nécessaires pour confirmer ou infirmer ces hypothèses. Perspectives Une prochaine étape sera d'explorer l'influence de l'excrétion urinaire de sodium, de potassium et d'urée sur les associations observées afin d'étudier une possible influence de l'alimentation sur ces résultats. Une autre étape consistera à doser les hormones sexuelles dans les échantillons de cette étude ou dans ceux d'une autre étude. La prévalence de l'hypercalciurie dans cette étude (9 % chez les hommes et 8.1% chez les femmes) est plus basse que dans d'anciennes études non-populationnelles. Il paraît important de mentionner qu'il existe peu de données sur les normes de calciurie dans la population générale et qu'il n'existe pas de consensus international claire concernant la définition de l'hypercalciurie. Cette prévalence élevée est notamment pertinente dans la cadre des néphrolithiasés, qui sont connues pour être plus fréquentes chez les hommes que chez les femmes. Enjeux Les différences hommes-femmes observées pourraient avoir des implications pour améliorer notre compréhension des mécanismes impliqués dans les lithiases urinaires et dans le risque cardiovasculaire associé ainsi que dans notre compréhension des mécanismes associés à l'ostéoporose.

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The mechanism of generation of atomic Na and K from SiO2 samples has been studied using explicitly correlated wave function and density functional theory cluster calculations. Possible pathways for the photon and electron stimulated desorption of Na and K atoms from silicates are proposed, thus providing new insight on the generation of the tenuous Na and K atmosphere of the Moon.

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Voltage-dependent K+ channels (Kv) are involved in the proliferation and differentiation of mammalian cells, since Kv antagonists impair cell cycle progression. Although myofibers are terminally differentiated, some myoblasts may re-enter the cell cycle and proliferate. Since Kv1.3 and Kv1.5 expression is remodeled during tumorigenesis and is involved in smooth muscle proliferation, the purpose of this study was to analyze the expression of Kv1.3 and Kv1.5 in smooth muscle neoplasms. In the present study, we examined human samples of smooth muscle tumors together with healthy speci­mens. Thus, leiomyoma (LM) and leiomyosarcoma (LMS) tumors were analyzed. Results showed that Kv1.3 was poorly expressed in the healthy muscle and indolent LM specimens, whereas aggressive LMS showed high levels of Kv1.3 expression. Kv1.5 staining was correlated with malignancy. The findings show a remodeling of Kv1.3 and Kv1.5 in human smooth muscle sarcoma. A correlation of Kv1.3 and Kv1.5 expression with tumor aggressiveness was observed. Thus, our results indicate Kv1.5 and Kv1.3 as potential tumorigenic targets for aggressive human LMS.

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Soitinnus: lauluääni, piano.