Painting of fourth, a chromosome-specific protein in Drosophila

Chromosome-specific gene regulation is known thus far only as a mechanism to equalize the transcriptional activity of the single male X chromosome with that of the two female X chromosomes. In Drosophila melanogaster, a complex including the five Male-Specific Lethal (MSL) proteins, “paints” the male X chromosome, mediating its hypertranscription. Here, with the molecular cloning of Painting of fourth (Pof), we describe a previously uncharacterized gene encoding a chromosome-specific protein in Drosophila. Unlike the MSL proteins, POF paints an autosome, the fourth chromosome of Drosophila melanogaster. Chromosome translocation analysis shows that the binding depends on an initiation site in the proximal region of chromosome 4 and spreads in cis to involve the entire chromosome. The spreading depends on sequences or structures specific to chromosome 4 and cannot extend to parts of other chromosomes translocated to the fourth. Spreading can also occur in trans to a paired homologue that lacks the initiation region. In the related species Drosophila busckii, POF paints the entire X chromosome exclusively in males, suggesting relationships between the fourth chromosome and the X and between POF complexes and dosage-compensation complexes.

International comparison of resource allocation in health sciences : an analysis of expenditures on biomedical research in 19 industrialized countries /

Item 507

Proceedings of the High school conference.

1910-1917 issued as University of Illinois. School of Education. Bulletin no. 4,6,9,10,13,15,17,19.

The effects of the new 65 mile-per-hour speed limit on rural highway fatalities: a state-by-state analysis. Final grant report.

National Highway Traffic Safety Administration, Office of Research and Development, Washington, D.C.

Annual report of the Museum of Fine Arts Boston.

Reports for 1902-08 have imprint: Cambridge, The University Press, 1903-09.

Journal of education.

Description based on: Vol. 165, no. 4 (fall 1983); title from cover.

Catalogue of paintings.

Mode of access: Internet.

An analysis of the domestic electric business of the Hartford electric light company, 1914-1926.

Cover title.

Study of elementary school libraries--phase I : report on inquiry no. 1, April 1, 1959.

Includes bibliographical references.

Preliminary report of an archæological journey made in Asia Minor during the summer of 1884,

The complete report forms v. 2 of the Papers of the school.

Annual report of the Museum of Fine Arts Boston.

Reports for 1902-1908 have imprint: Cambridge, The University Press, 1903-1909.

American journal of archaeology : the journal of the Archaeological Institute of America.

Imprint varies: Boston, MA : Archaeological Institute of America,

High school scholastic contests in South Dakota : a report covering the results of the program during a ten-year period from 1935 to 1944 /

Mode of access: Internet.

Handbook of the Museum of Fine Arts, Boston.

Mode of access: Internet.

The Journal of education.

Editors: 1875-Mar. 4, 1886, T. W. Bicknell.--Mar. 11, 1886-Feb. 1933, A. E. Winship and others.--Mar. 1933- A. W. Belding.