Cooperativity in the inhibition of oxidative phosphorylation by chlorophenoxyisobutyrate

The kinetics of inhibition of oxidative phosphorylation by the antihypercholes-terolaemic compound p-chlorophenoxyisobutyrate reveal cooperativity characteristic of allosteric interactions. Hill plots and Dixon plots give clear indication that the compound interferes with two distinct steps in the energy-transfer pathway. The values of interaction coefficients calculated from the Hill plots were two and four in the direction of ATP synthesis and one and two in the reverse direction. This could mean either that the pathways of synthesis and breakdown of ATP are different, or that if the pathways are the same, only half the inhibitor-binding sites function in the reverse direction.

Jerusalem City Museum Commemorative Medal

Obverse: Stylized design of the Tower of David. Reverse: The emblem of Jerusalem in the center, the word 'Jerusalem' in different languages.

Sir Moses Montefiore Commemorative Medal

Obverse: Portraits of Sir Moses Montefiore and Judith Montefiore. Reverse: The house of Mishkenot Shaanim, in the background the windmill of Yemin Moshe in Jerusalem.

Los Angeles Olympics Commemorative Medal

Obverse: Stylized figure of a sportsman in motion. Reverse: Official emblem of the Israeli Olympic team.

Masada Commemorative Medal

Obverse: In the center, an ancient shield and on its raised center, an inscription. Reverse: Design of Masada. At the mountain base, the signs of the Roman legions siege.

Los Angeles Olympics Commemorative Medal

Obverse: Stylized figure of a sportsman in motion. Reverse: The official emblem of the Israeli Olympic team.

Bethlehem Commemorative Medal

Obverse: A panoramic view of the city of Bethlehem with her typical spires. Reverse: David the Shepherd playing the harp.

Resistance Struggle Against Nazis Commemorative Medal

Obverse: The symbol of the World Assembly to Commemorate Jewish Resistance and Combat Against Nazis. Man and woman wearing a stylized Star of David. Reverse: Symbol of the State of Israel, inscription. Emblem of 35 years of the state of Israel.

Blessed be the Healer Commemorative Medal

Obverse: In the center, a stylized design of the sun shining on a young branch. Reverse: Stylized inscription.

Revolt Commemorative Medal

Obverse: Stylized number 40, in the "0" is the Eze emblem. Reverse: Betar emblem and inscription

Am Yisroel Chai Commemorative Medal

Obverse: Stylized inscription. Reverse: In the center, burning bush.

Certified Accountants of Israel Medal

Obverse: Inscription. Reverse: Stylized inscription.

From Holocaust to Rebirth Commemorative Medal

Obverse: A fading Star of David imprisoned behind bars, above the bars clear Star of David. Reverse: The emblem of the State of Israel, inscription.

Pidyon HaBen Medal

Obverse: A chalice that served the Temple and five pomegranates. Around a crown based upon the seven varieties. Reverse: Inscription.

25th Anniversary of the Linked Life Insurance Commemorative Medal

Obverse: Inscription. Reverse: The life insurance emblem, a house with family inside, shekel coin on the roof of the house.