Cooperativity in the inhibition of oxidative phosphorylation by chlorophenoxyisobutyrate
Data(s) |
18/10/1974
|
---|---|
Resumo |
The kinetics of inhibition of oxidative phosphorylation by the antihypercholes-terolaemic compound p-chlorophenoxyisobutyrate reveal cooperativity characteristic of allosteric interactions. Hill plots and Dixon plots give clear indication that the compound interferes with two distinct steps in the energy-transfer pathway. The values of interaction coefficients calculated from the Hill plots were two and four in the direction of ATP synthesis and one and two in the reverse direction. This could mean either that the pathways of synthesis and breakdown of ATP are different, or that if the pathways are the same, only half the inhibitor-binding sites function in the reverse direction. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/23333/1/13.pdf Panini, SR and Kurup, CKR (1974) Cooperativity in the inhibition of oxidative phosphorylation by chlorophenoxyisobutyrate. In: Biochimica et Biophysica Acta (BBA) - Bioenergetics, 368 (1). pp. 29-38. |
Publicador |
Elsevier Science |
Relação |
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1S-47PP1GH-F2&_user=512776&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000025298&_version=1&_urlVersion=0&_userid=512776&md5=99eef8ad4934edd8a945d72d9bcdbb84 http://eprints.iisc.ernet.in/23333/ |
Palavras-Chave | #Biochemistry |
Tipo |
Journal Article PeerReviewed |