Tomus quartus D. Thomae Aquinatis doctoris angelici, complectens expositionem, in duodecim libros metaphysices, Aristotelis. Tractatum de Ente, & Essentia D. Thomae [Texto impreso]

Este tomo forma parte de una "Opera omnia" de Tomás de Aquino que consta de 17 v., publicada en Roma entre 1570-1571 por los herederos de Antonio Blado & Giovanni Gigliotti socios y algunos de Giulio Acconti , según el catalogo de la ICCU

Por la insigne Ciudad de Valencia, franceses y estrangeros legitimamente auezindados en ella con el Procurador patrimonial de su magestad y arrendadores de los drechos reales [Texto impreso]

Sign.: A-M2

Sentencia

Al comienzo del texto esc. xil. de Valencia

Virtual reconstruction of the 400 toneladas nao from Diego García de Palacio’s Instrucción náutica (1587)

The period between 1570-1620 has left a remarkable amount of documents related to shipbuilding in the Iberian Peninsula. Among them, the Instrucción nautica written by Diego García de Palacio in 1587 is widely recognized as the first published book that includes an extensive discussion of ship design and construction. García de Palacio centres his discussion on a 400 toneladas nao, a series of woodcuts that illustrate the shape and dimensions of the ship accompany the explanation. In the late XVI century ship hulls were designed following procedures based upon an old shipwrightry tradition born in the Mediterranean. By simple rules the master shipwright plots the central frame and tail frames and complete the hull body using wooden ribbands. Computer software for 3D modelling using NURBs surfaces helps to recreate ships hulls. In this work the 400 toneladas nao is reconstructed and her hydrostatic parameters are compared with other ships.

Smi. D.N.D. Urbani... Papae VIII, Confirmatio, extensio & declaratio Constitutionum Apostolicarum, prohibentium ciuitates, castra & alia tan iurisdictionalia quam non iurisdictionalia... [Texto impreso]

Port. con esc. papal xil

Urbanus Papa VIII... Olium felicis recordationis Sixtus V... prospiceret ciuitates, castra, oppida, iurisdictiones, feuda & bona quaecumque stabilia seu immobilia in dicto statu Ecclesiastico consistentia... [Texto impreso]

Precede al tít. : "Ad perpetuam rei memoriam"

Decisio Sacra Rotae Romanae, coram R.P.D. Ghislerio in causa Valentina Iuris Sedendi [Texto impreso]

Port. con esc. xil. del Papa Urbano VIII

Summa Sacramentorum Ecclesiae [Texto impreso]

Colofón

FORMAÇÃO E ATUAÇÃO DAS PROFESSORAS INDÍGENAS DA ALDEIA PIAÇAGÜERA

O presente trabalho investiga a formação e a atuação das professoras indígenas da Escola Estadual Indígena Tupi-Guarani Ywy Pyaú, localizada no município de Peruíbe, Litoral Sul do Estado de São Paulo. Trata-se de uma pesquisa qualitativa, que assume a perspectiva narrativa na medida em que recorram à história oral dos sujeitos envolvidos, contemplando aspectos significativos para a sua formação profissional que venham ajudar a compreender sua prática cotidiana. a presente pesquisa evidencia que apesar do aporte legal emanado a partir de 1988, o direito à educação escolar indígena - específica e diferenciada - ainda não está garantido. Através das entrevistas e nas visitas efetuadas na escola da aldeia Piaçagüera pude observar a existência de demandas que merecem e necessitam de soluções eficazes e urgentes por parte do poder público, pois se constituem em entraves significativos para a consecução do projeto político pedagógico das escolas indígenas. Além disso, a condição do professor indígena como portador da tradição do grupo e ao mesmo tempo como representante do saber instituído coloca paradoxos à formação e ao exercício da profissão docente. Estas questões devem ser equacionadas a partir da visão dos povos indígenas numa perspectiva de autonomia e respeito à diversidade.

UM ESTUDO SOBRE A IMPORTÂNCIA DO USO DAS FERRAMENTAS DE CONTROLE GERENCIAL NAS MICRO, PEQUENAS E MÉDIAS EMPRESAS INDUSTRIAIS NO MUNICÍPIO DE SÃO CAETANO DO SUL

O objetivo desse estudo foi evidenciar o uso das ferramentas de controle gerencial que auxiliam no processo de tomada de decisão nas Micros, Pequenas e Médias Empresas, no município de SCSul. Entende-se, que na atualidade esses instrumentos devem ser alinhados com a realidade dessas organizações e as informações extraídas por estas devem ser a base para a tomada de decisão que perpetuem a riqueza dos investidores. O procedimento metodológico aplicado na escolha das empresas pesquisadas foi o critério de conveniência, utilizando o método de raciocínio dedutivo, através de aplicação de um questionário em 296 empresas, pelo a qual 18,6% destas se depuseram a responder o questionário. As empresas foram classificadas de acordo com o faturamento bruto anual estabelecido pela Receita Federal. Após a análise dos resultados, foi possível detectar que cerca de 41% dessas organizações estão a mais de 20 anos no mercado, o que demonstra uma boa consolidação no mercado. Detecta-se, também, que estes empresários-gerentes possuem uma forte formação superior: 31,27% pós-graduados e 22,22% graduados, o que pode ser um diferencial na gestão desses negócios. Como o pressuposto dessa pesquisa foi de analisar: se as MPME s industriais no município de SCSul estão utilizando as ferramentas de controle gerencial em seu processo de gestão para tomada de decisão, diante das análises efetuadas, tanto pelo o estudo de campo com bibliográfica, conclui-se que a tomada de decisão nessas empresas está baseada nas ferramentas de controle e que estas possuem um bom controle dos seus negócios contrariando o que se esperava.

Adjustment of conformational flexibility is a key event in the thermal adaptation of proteins

3-Isopropylmalate dehydrogenase (IPMDH, E.C. 1.1.1.85) from the thermophilic bacterium Thermus thermophilus HB8 is homologous to IPMDH from the mesophilic Escherichia coli, but has an approximately 17°C higher melting temperature. Its temperature optimum is 22–25°C higher than that of the E. coli enzyme; however, it is hardly active at room temperature. The increased conformational rigidity required to stabilize the thermophilic enzyme against heat denaturation might explain its different temperature-activity profile. Hydrogen/deuterium exchange studies were performed on this thermophilic-mesophilic enzyme pair to compare their conformational flexibilities. It was found that Th. thermophilus IPMDH is significantly more rigid at room temperature than E. coli IPMDH, whereas the enzymes have nearly identical flexibilities under their respective optimal working conditions, suggesting that evolutionary adaptation tends to maintain a “corresponding state” regarding conformational flexibility. These observations confirm that conformational fluctuations necessary for catalytic function are restricted at room temperature in the thermophilic enzyme, suggesting a close relationship between conformational flexibility and enzyme function.

Gonadotropin-releasing hormone analogue conjugates with strong selective antitumor activity

Conjugation of gonadotropin-releasing hormone (GnRH) analogues GnRH-III, MI-1544, and MI-1892 through lysyl side chains and a tetrapeptide spacer, Gly-Phe-Leu-Gly (X) to a copolymer, poly(N-vinylpyrrolidone-co-maleic acid) (P) caused increased antiproliferative activity toward MCF-7 and MDA-MB-231 breast, PC3 and LNCaP prostate, and Ishikawa endometrial cancer cell lines in culture and against tumor development by xenografts of the breast cancer cells in immunodeficient mice. MCF-7 cells treated with P-X-1544 and P-X-1892 displayed characteristic signs of apoptosis, including vacuoles in the cytoplasm, rounding up, apoptotic bodies, bleb formation, and DNA fragmentation. Conjugates, but not free peptides, inhibited cdc25 phosphatase and caused accumulation of Ishikawa and PC3 cells in the G2/M phase of the cell cycle after 24 h at lower doses and in the G1 and G2 phases after 48 h. Since P-X-peptides appear to be internalized, the increased cytotoxicity of the conjugates is attributed to protection of peptides from proteolysis, enhanced interaction of the peptides with the GnRH receptors, and/or internalization of P-X-peptide receptor complexes so that P can exert toxic effects inside, possibly by inhibiting enzymes involved in the cell cycle. The additional specificity of P-X-peptides compared with free peptides for direct antiproliferative effects on the cancer cells but not for interactions in the pituitary indicates the therapeutic potential of the conjugates.

Temporal distribution of the ganglion cell volleys in the normal rat optic nerve

We describe experiments on behaving rats with electrodes implanted on the cornea, in the optic chiasm, and on the visual cortex; in addition, two red light-emitting diodes (LED) are permanently attached to the skull over the left eye. Recordings timelocked to the LED flashes reveal both the local events at each electrode site and the orderly transfer of visual information from retina to cortex. The major finding is that every stimulus, regardless of its luminance, duration, or the state of retinal light adaptation, elicits an optic nerve volley with a latency of about 10 ms and a duration of about 300 ms. This phenomenon has not been reported previously, so far as we are aware. We conclude that the retina, which originates from the forebrain of the developing embryo, behaves like a typical brain structure: it translates, within a few hundred milliseconds, the chemical information in each pattern of bleached photoreceptors into a corresponding pattern of ganglion cell neuronal information that leaves via the optic nerve. The attributes of each rat ganglion cell appear to include whether the retinal neuropile calls on it to leave after a stimulus and, if so when, within a 300-ms poststimulus epoch. The resulting retinal analysis of the scene, on arrival at the cortical level, is presumed to participate importantly in the creation of visual perceptual experiences.

Using the damage from 2010 Haiti earthquake for calibrating vulnerability models of typical structures in Port-au-Prince (Haiti)

After the 2010 Haiti earthquake, that hits the city of Port-au-Prince, capital city of Haiti, a multidisciplinary working group of specialists (seismologist, geologists, engineers and architects) from different Spanish Universities and also from Haiti, joined effort under the SISMO-HAITI project (financed by the Universidad Politecnica de Madrid), with an objective: Evaluation of seismic hazard and risk in Haiti and its application to the seismic design, urban planning, emergency and resource management. In this paper, as a first step for a structural damage estimation of future earthquakes in the country, a calibration of damage functions has been carried out by means of a two-stage procedure. After compiling a database with observed damage in the city after the earthquake, the exposure model (building stock) has been classified and through an iteratively two-step calibration process, a specific set of damage functions for the country has been proposed. Additionally, Next Generation Attenuation Models (NGA) and Vs30 models have been analysed to choose the most appropriate for the seismic risk estimation in the city. Finally in a next paper, these functions will be used to estimate a seismic risk scenario for a future earthquake.